町田崇 (Takashi Machida) - マイポータル

基本情報

所属: 久留米大学医学部医学科救急医学講座助教

学位: 学士（芸術工学）
学士（薬学）
学位（薬学）(福岡大学)
学士（医学）(鹿児島大学)

研究者番号: 30586144
J-GLOBAL ID: 201001034827173780
researchmap会員ID: 6000022929

研究キーワード

血液脳関門

研究分野

経歴

学歴

- 2010年

福岡大学, 薬学研究科, 薬物副作用学
- 2010年

福岡大学

論文

Oncostatin M-induced blood-brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro.

Takata F, Dohgu S, Matsumoto J, Machida T, Sakaguchi S, Kimura I, Yamauchi A, Kataoka Y

J Cell Biochem. 119(11) 9055-9063 2018年11月
TNF-alpha-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IkappaB-NFkappaB and JAK-STAT3 pathways.

Matsumoto J, Dohgu S, Takata F, Machida T, Hatip FFB, Hatip-Al-Khatib I, Yamauchi A, Kataoka Y

Brain Res 1692 34-44 2018年8月1日
Role of thrombin-PAR1-PKCθ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood-brain barrier dysfunction in vitro.

Machida T, Dohgu S, Takata F, Matsumoto J, Kimura I, Koga M, Nakamoto K, Yamauchi A, Kataoka Y

Neuroscience 350 146-157 2017年5月査読有り
Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model

Takashi Machida, Fuyuko Takata, Junichi Matsumoto, Tomoyuki Miyamura, Ryosuke Hirata, Ikuya Kimura, Yasufumi Kataoka, Shinya Dohgu, Atsushi Yamauchi

PLOS ONE 12(5) 2017年5月査読有り
Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood-brain barrier in vitro.

Machida T, Takata F, Matsumoto J, Takenoshita H, Kimura I, Yamauchi A, Dohgu S, Kataoka Y

Neurosci Lett. 599 109-114 2015年7月10日査読有り
Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons.

Takahashi H, Takata F, Matsumoto J, Machida T, Yamauchi A, Dohgu S, Kataoka Y

Biochem Biophys Res Commun. 457(4) 532-537 2015年2月20日査読有り
Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation.

Matsumoto J, Takata F, Machida T, Takahashi H, Soejima Y, Funakoshi M, Futagami K, Yamauchi A, Dohgu S, Kataoka Y

Neurosci Lett. 578(133) 133-138 2014年8月査読有り

MISC

Nicotinic acetylcholine receptors modulate TNF-alpha-induced MMP-9 release from brain pericytes

Ikuya Kimura, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Atsushi Yamauchi, Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 209P-209P 2014年
Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells

Fuyuko Takata, Shinya Dohgu, Junichi Matsumoto, Takashi Machida, Shuji Kaneshima, Mai Matsuo, Shinya Sakaguchi, Yuki Takeshige, Atsushi Yamauchi, Yasufumi Kataoka

Biochemical and Biophysical Research Communications 433(4) 586-590 2013年4月19日
In Vitro Blood-Brain Barrier Models Using Brain Capillary Endothelial Cells Isolated from Neonatal and Adult Rats Retain Age-Related Barrier Properties

Fuyuko Takata, Shinya Dohgu, Atsushi Yamauchi, Junichi Matsumoto, Takashi Machida, Kayoko Fujishita, Keisuke Shibata, Youichi Shinozaki, Kaoru Sato, Yasufumi Kataoka …

PLoS ONE 8(1) e55166 2013年1月31日
Adenosine stimulates brain pericytes to release matrix metalloproteinase-9 through A3 adenosine receptor

Makoto Shougakiuchi, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Yui Yamamoto, Haruka Aikawa, Satomi Nagata, Shinya Dohgu, Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 215P-215P 2013年
Alpha7 nicotinic acetylcholine receptor mediates MMP-9 release from brain pericytes

Ikuya Kimura, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Atsushi Noriyuki, Atsushi Yamauchi, Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 215P-215P 2013年
Brain pericyte-derived soluble factors induce the blood-brain barrier dysfunction under pathological conditions

Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Hiroyuki Takahashi, Atsushi Yamauchi, Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 25P-25P 2013年
Brain pericytes contribute to the blood-brain barrier disruption induced by thrombin

Takashi Machida, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Hisayo Takenoshita, Atsushi Yamauchi, Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 214P-214P 2013年
In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties.

Takata F, Dohgu S, Yamauchi A, Matsumoto J, Machida T, Fujishita K, Shibata K, Shinozaki Y, Sato K, Kataoka Y …

PLoS One. 8(1) e55166 2013年
Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells.

Takata F, Dohgu S, Matsumoto J, Machida T, Kaneshima S, Matsuo M, Sakaguchi S, Takeshige Y, Yamauchi A, Kataoka Y

Biochem Biophys Res Commun. 433(4) 586-590 2013年
In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties.

Takata F, Dohgu S, Yamauchi A, Matsumoto J, Machida T, Fujishita K, Shibata K, Shinozaki Y, Sato K, Kataoka Y …

PLoS One. 8(1) e55166 2013年
Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis

Tsuyoshi Nishioku, Shinya Dohgu, Mitsuhisa Koga, Takashi Machida, Takuya Watanabe, Teppei Miura, Kousuke Tsumagari, Mariko Terasawa, Atsushi Yamauchi, Yasufumi Kataoka

JOURNAL OF INFLAMMATION-LONDON 9(1) 44 2012年11月
Lipopolysaccharide-activated microglia lower P-glycoprotein function in brain microvascular endothelial cells

Junichi Matsumoto, Shinya Dohgu, Fuyuko Takata, Tsuyoshi Nishioku, Noriko Sumi, Takashi Machida, Hiroyuki Takahashi, Atsushi Yamauchi, Yasufumi Kataoka

NEUROSCIENCE LETTERS 524(1) 45-48 2012年8月
Brain pericytes-specific TNF-alpha-induced MMP-9 release is mediated by ROS and delayed activation of ERK1/2 and Akt

Takashi Machida, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Hiroyuki Takahashi, Haruki Miyaji, Yui Sonogi, Atsushi Yamauchi, Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 111P-111P 2012年
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-alpha, releasing matrix metalloproteinase-9 and migrating in vitro

Fuyuko Takata, Shinya Dohgu, Junichi Matsumoto, Takashi Machida, Hiroyuki Takahashi, Atsushi Yamauchi, Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 112P-112P 2012年
Brain pericytes prevent migration of the inflammatory cells across the blood-brain barrier

Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Hiroyuki Takahashi, Takashi Machida, Natsuko Ichiki, Natsuko Seki, Atsushi Yamauchi, Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 111P-111P 2012年
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro.

Takata F, Dohgu S, Matsumoto J, Takahashi H, Machida T, Wakigawa T, Harada E, Miyaji H, Koga M, Nishioku T …

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro. 8 106 2011年8月
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro

Takata F, Dohgu S, Matsumoto J, Takahashi H, Machida T, Wakigawa T, Harada E, Miyaji H, Koga M, Nishioku T …

Journal of neuroinflammation 8(1) 106 2011年8月
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-alpha, releasing matrix metalloproteinase-9 and migrating in vitro

Fuyuko Takata, Shinya Dohgu, Junichi Matsumoto, Hiroyuki Takahashi, Takashi Machida, Tomoya Wakigawa, Eriko Harada, Haruki Miyaji, Mitsuhisa Koga, Tsuyoshi Nishioku …

JOURNAL OF NEUROINFLAMMATION 8 106 2011年8月
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-alpha, releasing matrix metalloproteinase-9 and migrating in vitro

Fuyuko Takata, Shinya Dohgu, Junichi Matsumoto, Hiroyuki Takahashi, Takashi Machida, Tomoya Wakigawa, Eriko Harada, Haruki Miyaji, Mitsuhisa Koga, Tsuyoshi Nishioku …

JOURNAL OF NEUROINFLAMMATION 8(1) 106 2011年8月
Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells

Toshiyuki Tsunoda, Yasuo Takashima, Yasuhiro Yoshida, Keiko Doi, Yoko Tanaka, Takahiro Fujimoto, Takashi Machida, Takeharu Ota, Midori Koyanagi, Masahide Kuroki …

ANTICANCER RESEARCH 31(7) 2453-2459 2011年7月

もっとみる

講演・口頭発表等

Adenosine stimulates brain pericytes to release matrix metalloproteinase-9 through A3 adenosine receptor

第86回日本薬理学会年 2013年
Alpha7 nicotinic acetylcholine receptor mediates MMP-9 release from brain pericytes

第86回日本薬理学会年 2013年
Brain pericytes contribute to the blood-brain barrier disruption induced by thrombin

第86回日本薬理学会年 2013年
Adenosine stimulates brain pericytes to release matrix metalloproteinase-9 through A3 adenosine receptor

第86回日本薬理学会年 2013年
Alpha7 nicotinic acetylcholine receptor mediates MMP-9 release from brain pericytes

第86回日本薬理学会年 2013年
Brain pericytes contribute to the blood-brain barrier disruption induced by thrombin

第86回日本薬理学会年 2013年
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro

第85回日本薬理学会年 2012年
Brain pericytes prevent migration of the inflammatory cells across the blood-brain barrier

第85回日本薬理学会年 2012年
Brain pericytes-specific TNF-a-induced MMP-9 release is mediated by ROS and delayed activation of ERK1/2 and Akt

第85回日本薬理学会年 2012年
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro

第85回日本薬理学会年 2012年
Brain pericytes prevent migration of the inflammatory cells across the blood-brain barrier

第85回日本薬理学会年 2012年
Brain pericytes-specific TNF-a-induced MMP-9 release is mediated by ROS and delayed activation of ERK1/2 and Akt

第85回日本薬理学会年 2012年
Calcineurin/NFAT signaling regulates MMP-9 expression in brain pericytes

第83回日本薬理学会年 2010年
NADPH oxidase-derived reactive oxygen species (ROS) facilitate TNF-alpha-induced up-regulation of MMP-9 production in the brain pericytes through Akt activation.

13th International Blood-Brain Barrier Symposium 2010年
Calcineurin/NFAT signaling regulates MMP-9 expression in brain pericytes

2010年
NADPH oxidase-derived reactive oxygen species (ROS) facilitate TNF-alpha-induced up-regulation of MMP-9 production in the brain pericytes through Akt activation.

13th International Blood-Brain Barrier Symposium 2010年
Activation of Microglia and Migration of Brain Pericytes are Involved in Disruption of the Blood-brain Barrier Caused by Lipopolysaccharide

The 1st Meeting of the Asian College of Neuropsychopharmacology 2009年
Activation of Microglia and Migration of Brain Pericytes are Involved in Disruption of the Blood-brain Barrier Caused by Lipopolysaccharide

The 1st Meeting of the Asian College of Neuropsychopharmacology 2009年

町田崇

基本情報

研究キーワード

研究分野

経歴

学歴

論文

MISC

講演・口頭発表等

メニュー

共著者の一覧