Toshiro Niki

Profile Information

Affiliation: 助教, 医学部, 香川大学

Degree: PhD (Science)(Hiroshima University)

J-GLOBAL ID: 201001088664331334
researchmap Member ID: 6000023459

Research Interests

Research Areas

Life sciences / Immunology /

Research History

Education

- 1994

Hiroshima University
- 1989

Hiroshima University

Papers

111

Plasma N-Cleaved Galectin-9 Is a Surrogate Marker for Determining the Severity of COVID-19 and Monitoring the Therapeutic Effects of Tocilizumab.

Hiroko Iwasaki-Hozumi, Yosuke Maeda, Toshiro Niki, Haorile Chagan-Yasutan, Gaowa Bai, Takashi Matsuba, Daisuke Furushima, Yugo Ashino, Toshio Hattori

International journal of molecular sciences, 24(4), Feb 10, 2023
Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner

Asif J. Iqbal, Franziska Krautter, Isobel A. Blacksell, Rachael D. Wright, Shani N. Austin‐Williams, Mathieu‐Benoit Voisin, Mohammed T. Hussain, Hannah L. Law, Toshiro Niki, Mitsuomi Hirashima, Michele Bombardieri, Costantino Pitzalis, Alok Tiwari, Gerard B. Nash, Lucy V. Norling, Dianne Cooper

The FASEB Journal, 36(1), Jan, 2022 Peer-reviewed
Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity

Natasha Ustyanovska Avtenyuk, Ghizlane Choukrani, Emanuele Ammatuna, Toshiro Niki, Ewa Cendrowicz, Harm Jan Lourens, Gerwin Huls, Valerie R. Wiersma, Edwin Bremer

Biomedicines, 10(1) 66-66, Dec 29, 2021 Peer-reviewed
Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2

Tomokazu Nunoue, Satoshi Yamaguchi, Sanae Teshigawara, Akihiro Katayama, Atsuko Nakatsuka, Jun Eguchi, Toshiro Niki, Jun Wada

Scientific Reports, 11(1) 1-12, Dec, 2021 Peer-reviewed
Author Correction: Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.

Tomokazu Nunoue, Satoshi Yamaguchi, Sanae Teshigawara, Akihiro Katayama, Atsuko Nakatsuka, Jun Eguchi, Toshiro Niki, Jun Wada

Scientific reports, 11(1) 18611-18611, Sep 14, 2021
Efficient Production of Osteopontin-Encapsulating Exosome by LPS Stimulated THP-1 Macrophages

Gaowa Bai, Takashi Matsuba, Toshiro Niki, Toshio Hattori

Recent Research Advances in Biology, 11 83-96, Jul 5, 2021 Peer-reviewed
High Levels of the Cleaved Form of Galectin-9 and Osteopontin in the Plasma Are Associated with Inflammatory Markers That Reflect the Severity of COVID-19 Pneumonia

Gaowa Bai, Daisuke Furushima, Toshiro Niki, Takashi Matsuba, Yosuke Maeda, Atsushi Takahashi, Toshio Hattori, Yugo Ashino

International Journal of Molecular Sciences, 22(9) 4978-4978, May 7, 2021 Peer-reviewed
Galectin‑9 suppresses the tumor growth of colon cancer in vitro and in vivo

Asahiro Morishita, Kei Nomura, Joji Tani, Koji Fujita, Hisakazu Iwama, Kei Takuma, Mai Nakahara, Tomoko Tadokoro, Kyoko Oura, Taiga Chiyo, Shintaro Fujihara, Toshiro Niki, Mitsuomi Hirashima, Akira Nishiyama, Takashi Himoto, Tsutomu Masaki

Oncology Reports, 45(6), Apr 16, 2021 Peer-reviewed
Stimulation of THP-1 Macrophages with LPS Increased the Production of Osteopontin-Encapsulating Exosome

Gaowa Bai, Takashi Matsuba, Toshiro Niki, Toshio Hattori

International Journal of Molecular Sciences, 21(22) 8490-8490, Nov 11, 2020 Peer-reviewed
Plasma Levels of a Cleaved Form of Galectin-9 Are the Most Sensitive Biomarkers of Acquired Immune Deficiency Syndrome and Tuberculosis Coinfection

Shirley T. Padilla, Toshiro Niki, Daisuke Furushima, Gaowa Bai, Haorile Chagan-Yasutan, Elizabeth Freda Telan, Rosario Jessica Tactacan-Abrenica, Yosuke Maeda, Rontgene Solante, Toshio Hattori

Biomolecules, 10(11) 1495-1495, Oct 30, 2020 Peer-reviewedCorresponding author
Elevated Levels of Galectin-9 but Not Osteopontin in HIV and Tuberculosis Infections Indicate Their Roles in Detecting MTB Infection in HIV Infected Individuals

Ashwini Shete, Shubhangi Bichare, Vishwanath Pujari, Rashmi Virkar, Madhuri Thakar, Manisha Ghate, Sandip Patil, Annapurna Vyakarnam, Raman Gangakhedkar, Gaowa Bai, Toshiro Niki, Toshio Hattori

Frontiers in Microbiology, 11, Jul 17, 2020 Peer-reviewed
Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis

Haorile Chagan-Yasutan, Firmanto Hanan, Toshiro Niki, Gaowa Bai, Yugo Ashino, Shinichi Egawa, Elizabeth Freda O. Telan, Toshio Hattori

Diagnostics, 10(7) 439-439, Jun 29, 2020 Peer-reviewed
New Development of Disaster-Related and Tropical Infectious Diseases Control

Gaowa Bai, Toshiro Niki, Haruhisa Kikuchi, Ayako Sumi, Nobuyuki Kobayashi, Takahiro Haruyama, Jing Zhang, Haorile Chagan-Yasutan, Toshio Hattori

Reports — Medical Cases, Images, and Videos, 3(1) 5-5, Mar 17, 2020 Peer-reviewed
Galectin-9の十二指腸癌に対する増殖抑制効果 in vitroの検討

河野寿明, 藤田直樹, 琢磨慧, 波間大輔, 山名浩喜, 小林聖幸, 加藤清人, 鎌田英紀, 仁木敏朗, 平島光臣, 岩間久和, 正木勉

日本消化器病学会雑誌, 116(臨増大会) A765-A765, Nov, 2019
Galectin-9の十二指腸癌に対する増殖抑制効果 in vitroの検討

河野寿明, 藤田直樹, 琢磨慧, 波間大輔, 山名浩喜, 小林聖幸, 加藤清人, 鎌田英紀, 仁木敏朗, 平島光臣, 岩間久和, 正木勉

日本消化器病学会雑誌, 116(臨増大会) A765-A765, Nov, 2019 Peer-reviewed
Intracellular Galectin-9 Controls Dendritic Cell Function by Maintaining Plasma Membrane Rigidity

Querol Cano L, Tagit O, Dolen Y, van Duffelen A, Dieltjes S, Buschow SI, Niki T, Hirashima M, Joosten B, van den Dries K, Cambi A, Figdor CG, van Spriel AB

iScience, 22 240-255, Nov, 2019 Peer-reviewed
Galectin-9 Induces Mitochondria-Mediated Apoptosis of Esophageal Cancer In Vitro and In Vivo in a Xenograft Mouse Model.

Taiga Chiyo, Koji Fujita, Hisakazu Iwama, Shintaro Fujihara, Tomoko Tadokoro, Kyoko Ohura, Takanori Matsui, Yasuhiro Goda, Nobuya Kobayashi, Noriko Nishiyama, Tatsuo Yachida, Asahiro Morishita, Hideki Kobara, Hirohito Mori, Toshiro Niki, Mitsuomi Hirashima, Takashi Himoto, Tsutomu Masaki

International journal of molecular sciences, 20(11) E2634-E2634, May 29, 2019 Peer-reviewed
Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion.

Bertino P, Premeaux TA, Fujita T, Haun BK, Marciel MP, Hoffmann FW, Garcia A, Yiang H, Pastorino S, Carbone M, Niki T, Berestecky J, Hoffmann PR, Ndhlovu LC

Oncoimmunology, 8(8) 1601482-1601482, Apr, 2019 Peer-reviewed
Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling.

Colomb F, Giron LB, Premeaux TA, Mitchell BI, Niki T, Papasavvas E, Montaner LJ, Ndhlovu LC, Abdel-Mohsen M

Front Immunol, 10(267), Feb, 2019 Peer-reviewed
Characterization of neutralizing antibodies reacting with the 213-224 amino-acid segment of human galectin-9.

Lhuillier C, Barjon C, Baloche V, Niki T, Gelin A, Mustapha R, Cla?r L, Hoos S, Chiba Y, Ueno M, Hirashima M, Wei M, Morales O, Raynal B, Delhem N, Dellis O, Busson P

PLoS One, 13(9) e0202512, Sep, 2018 Peer-reviewed

Misc.

Galectin-9の十二指腸癌に対する増殖抑制効果;in Vitroの検討

河野寿明, 藤田直樹, 琢磨慧, 波間大輔, 山名浩喜, 小林聖幸, 加藤清人, 鎌田英紀, 仁木敏朗, 平島光臣, 岩間久和, 正木勉

日本消化器病学会雑誌(Web), 116, 2019
Serum galectin-9 levels are correlated to liver fibrosis regardless of chronic inflammation or hepatocellular carcinoma complications.

Koji Fujita, Toshiro Niki, Takashi Himoto, Tsutomu Masaki

HEPATOLOGY, 66 241A-241A, Oct, 2017
Galectin-9 Controls the Activity of DR3 (TNFRSF25) in Suppressing Immunity

Shravan Madireddi, So-Young Eun, Amit K. Mehta, Aruna Birta, Dirk M. Zajonc, Nozomu Nishi, Toshiro Niki, Mitsuomi Hirashima, Taylor H. Schreiber, Eckhard R. Podack, Michael Croft

JOURNAL OF IMMUNOLOGY, 196, May, 2016
Exploration of the signaling pathways triggered by exogenous galectin-9 in human T and B cells

Claire Lhuillier, Clement Barjon, Toshiro Niki, Aurore Gelin, Nadira Delhem, Mitsuomi Hirashima, Ming Wei, Olivier Dellis, Pierre Busson

CANCER IMMUNOLOGY RESEARCH, 4(1), Jan, 2016
Galectin‐9は重症敗血症の免疫・炎症反応に関連する可能性がある

浩日勒, 浩日勒, 山内聡, 山内聡, 工藤大介, 工藤大介, 仁木敏朗, 芦野有悟, 芦野有悟, 服部俊夫, 服部俊夫, 久志本成樹, 久志本成樹

エンドトキシン血症救命治療研究会誌, 19(1) 121, Oct 31, 2015
High levels of OPN, IP-10 and neutrophilia in LAMP confirmed TB patients in Manila

SHIRATORI BEATA, SHIRATORI BEATA, LEANO SUSAN, NAKAJIMA CHIE, CHAGAN-YASUTAN HAORILE, NIKI TOSHIRO, SUZUKI YASUHIKO, TELAN ELISABETH, HATTORI TOSHIO

日本細菌学雑誌, 69(1) 140, Feb 25, 2014
Galectin-9 induces apoptosis of HCC in vitro and in vivo through up-regulation of miR-1246

Koji Fujita, Teppei Sakamoto, Asahiro Morishita, Toshiro Niki, Hisakazu Iwama, Mitsuomi Hirashima, Tsutomu Masaki

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 34 S21-S21, 2014
Increased frequency of Tim-3+T cells is associated with symptomatic WNV disease clinical outcome

Marion Lanteri, Michael Diamond, Jennifer Govero, Amelia Pinto, Jacqueline Law, Glen Chew, Shiquan Wu, Toshiro Niki, Heather Inglis, Mitsuomi Hirashima, Michael Busch, Philip Norris, Lishomwa Ndhlovu

JOURNAL OF IMMUNOLOGY, 190, May, 2013
Rapid Galectin-9 release occurs following HIV-1 acquisition in acute HIV-1 infection

Ravi Tandon, Tsuyoshi Fujita, Glen Chew, Mary Margaret Byron, Toshiro Niki, Mitsuomi Hirashima, Jason Barbour, Mario Ostrowski, Kiera Clayton, Marion Lanteri, Naoto Ishii, Persephone Borrow, Philip Norris, Frederick Hecht, Lishomwa Ndhlovu

JOURNAL OF IMMUNOLOGY, 190, May, 2013
Galectin-9 controls the activity of 4-1BB (CD137)

Shravan Madireddi, So-Young Eun, Amit Mehta, Ivana Nemcovicova, Seung-Woo Lee, Toshiro Niki, Mitsuomi Hirashima, Dirk Zajonc, Michael Croft

JOURNAL OF IMMUNOLOGY, 190, May, 2013
ガレクチン-9誘導形質細胞アポトーシスによるループス腎炎モデルの症状改善

守時政宏, 門脇健, 仁木敏朗, 中野大介, 河野雅和, 平島光臣

日本腎臓学会誌, 55(3) 341-341, Apr, 2013
Serum Galectin-9 Associated with Mortality from Drug-Induced Acute Liver Failure

Hugo R. Rosen, Toshiro Niki, Jane Gralla, Mitsuomi Hirashima, William M. Lee

HEPATOLOGY, 56 958A-958A, Oct, 2012
マウス好酸球性気道炎症モデルにおけるガレクチン9の役割

加藤茂樹, 大水総一, 仁木敏朗, 清水大樹, 尾長谷靖, 是永正敬, 平島光臣, 岡三喜男

アレルギー, 61(9-10) 1457-1457, Oct, 2012
Elevated levels of circulating galectin-9, a novel immune-modulator, in acute dengue virus Infection reflects disease severity

Haorile Chagan-Yasutan, Lishomwa C. Ndhlovu, Talitha Lea Lacuesta, Prisca Susan A. Leano, Elizabeth Freda O. Telan, Toshiro Niki, Mitsuomi Hirashima, Efren M. Dimaano, Toshio Hattori

JOURNAL OF IMMUNOLOGY, 188, May, 2012
A role for Galectin-9 in neutrophil trafficking

Dianne Cooper, Asif J. Iqbal, Toshiro Niki, Mitsuomi Hirashima, Mauro Perretti

FASEB JOURNAL, 26, Apr, 2012
Tim-3, a Novel Immune Receptor, Is Constitutively Expressed on Human Natural Killer Cells and Functions as An Activating Coreceptor

Michelle Gleason, Todd Lenvik, Valarie McCullar, Sarah Cooley, Michael Verneris, Toshiro Niki, Mitsuomi Hirashima, Bruce R. Blazar, Jeffrey S. Miller

BLOOD, 116(21) 52-53, Nov, 2010
GALECTIN-9 CONTRIBUTES TO THE POLARIZATION OF NATURAL KILLER (NK) CELL FUNCTION TOWARDS A CYTOTOXIC PHENOTYPE IN CHRONIC HCV INFECTION

Lucy Golden-Mason, Jessica Randall, Linling Cheng, Toshiro Niki, Mitsuomi Hirashima, Hugo R. Rosen

HEPATOLOGY, 52(4) 391A-392A, Oct, 2010
ガレクチン9はLPS刺激によるマスト細胞からのサイトカイン産生を増強する

小島令嗣, 大野建州, 飯倉元保, 仁木敏朗, 平島光臣, 松原修, 野々山恵章, 松本健治, 斎藤博久, 中江進

アレルギー, 59(9-10) 1428-1428, Oct, 2010
TIM3-TIM3 LIGAND INTERACTION AMELIORATE HERPES SIMPLEX VIRUS-INDUCED BEHCET'S DISEASE-LIKE SYMPTOMS

Ju A. Shim, Sun Park, Eun-so Lee, Toshiro Niki, Mitsuomi Hirashima, Seonghyang Sohn

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 28(4) S121-S121, Jul, 2010
マクロファージのシグナル伝達ガレクチン9によるマクロファージのFcgレセプター発現制御とコラーゲン抗体誘導関節炎への効果(Galectin-9 ameliorates immune complex-induced arthritis by regulating FcgR expression on macrophages)

有川智博, 渡邊浩大, 松川昭博, 大水総一, 仁木敏朗, 山内清明, 平島光臣

日本免疫学会総会・学術集会記録, 39 105-105, Nov, 2009

Professional Memberships

日本免疫学会

Research Projects

Functional elucidation of two forms of Galectin-9 and their potential application to diagnosis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
転移性肝癌に対するGalectin-9の抗腫瘍効果とそのmicroRNA基盤

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

正木勉, 小原英幹, 岩間久和, 坂本鉄平, 仁木敏朗, 藤田浩二, 田所智子, 森下朝洋, 野村貴子, 米山弘人, 大浦杏子
Matricellular proteins as severity markers for disaster or tropical infectious diseases

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020
A study on preparation of single receptor specific lectin and its usefulness

Grant-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

NIKI Toshiro
A study on the clinical significance of matri-cellular proteins in tropical and disaster infections

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Hattori Toshio, Krudsood Srivicha, Telan Elizabeth, Alsijahbana Bachti
Th17-suppressing novel regulatory T cells and the use thereof

Grant-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

NIKI Toshiro
Clinical Utilities of new biomarker for dengue virus infection

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

HATTORI Toshio, NIKI Toshiro, HIRASHIMA Mitsuomi, HAORILE Chagan-Yasutan, KUBO Toru
The alteration of sugar chain profiling during the differentiation into IL-17-producing helper T cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

OOMIZU Souichi, HIRASHIMA Mitsuomi, NIKI Toshiro
Possible mechanisms of galectin-9-induced immunoregulatory macrophages

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

HIRASHIMA Mitsuomi, OOMIZU Souichi, NIKI Toshiro
免疫制御因子ガレクチン９の機能に関する研究

2004

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