MISC

2009年5月

Sept5 deficiency exerts pleiotropic influence on affective behaviors and cognitive functions in mice

HUMAN MOLECULAR GENETICS
  • Go Suzuki
  • Kathryn M. Harper
  • Takeshi Hiramoto
  • Takehito Sawamura
  • MoonSook Lee
  • Gina Kang
  • Kenji Tanigaki
  • Mahalah Buell
  • Mark A. Geyer
  • William S. Trimble
  • Soh Agatsuma
  • Noboru Hiroi
  • 全て表示

18
9
開始ページ
1652
終了ページ
1660
記述言語
英語
掲載種別
DOI
10.1093/hmg/ddp086
出版者・発行元
OXFORD UNIV PRESS

Deletion or duplication of the human chromosome 22q11.2 is associated with many behavioral traits and neuropsychiatric disorders, including autism spectrum disorders and schizophrenia. However, why phenotypes vary widely among individuals with identical deletions or duplications of 22q11.2 and which specific 22q11.2 genes contribute to these phenotypes are still poorly understood. Previous studies have identified a similar to 200 kb 22q11.2 region that contributes to behavioral phenotypes in mice. We tested the role of Septin 5 (Sept5), a gene encoded in the similar to 200 kb region, in affective behaviors, cognitive capacities and motor activity. To evaluate the impact of genetic backgrounds on behavioral phenotypes of Sept5 deficiency, we used mice on two genetic backgrounds. Our data show that Sept5 deficiency decreased affiliative active social interaction, but this phenotypic expression was influenced by genetic backgrounds. In contrast, Sept5 deficiency decreased anxiety-related behavior, increased prepulse inhibition and delayed acquisition of rewarded goal approach, independent of genetic background. These data suggest that Sept5 deficiency exerts pleiotropic effects on a select set of affective behaviors and cognitive processes and that genetic backgrounds could provide an epistatic influence on phenotypic expression.

リンク情報
DOI
https://doi.org/10.1093/hmg/ddp086
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000265096100011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1093/hmg/ddp086
  • ISSN : 0964-6906
  • Web of Science ID : WOS:000265096100011

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