MISC

2006年9月

Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli

HUMAN MOLECULAR GENETICS
  • Soh Agatsuma
  • ,
  • MoonSook Lee
  • ,
  • Hongwen Zhu
  • ,
  • Kevin Chen
  • ,
  • Jean C. Shih
  • ,
  • Isabelle Seif
  • ,
  • Noboru Hiroi

15
18
開始ページ
2721
終了ページ
2731
記述言語
英語
掲載種別
書評論文,書評,文献紹介等
DOI
10.1093/hmg/ddl206
出版者・発行元
OXFORD UNIV PRESS

Nicotine is thought to act on brain monoamine systems that normally mediate diverse motivational behaviors. How monoamine-related genes contribute to behavioral traits (e.g. responses to novel stimuli) comorbid with the susceptibility to nicotine addiction is still poorly understood. We examined the impact of constitutive monoamine oxidase A (MAOA) deficiency in mice on nicotine reward and responses to novel stimuli. Age-matched, male Maoa-knockout (KO) mice and wild-type (WT) littermates were tested for nicotine-induced conditioned place preference (CPP); voluntary oral nicotine preference/intake; spontaneous locomotor activity in a novel, inescapable open field; and novelty place preference. Nicotine preference in WT mice was reduced in Maoa-KO mice in the CPP and oral preference/intake tests. Control experiments showed that these phenotypes were not due to abnormalities in nicotine metabolism, fluid intake or response to taste. In contrast, Maoa-KO mice were normal in their behavioral response to a novel, inescapable open field and in their preference for a novel place. The observed phenotypes suggest that a constitutive deficiency of MAOA reduces the rewarding effects of nicotine without altering behavioral responses to novel stimuli in mice. Constitutive MAOA activity levels are likely to contribute to the vulnerability or resiliency to nicotine addiction by altering the rewarding effects of nicotine.

リンク情報
DOI
https://doi.org/10.1093/hmg/ddl206
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000240590400007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1093/hmg/ddl206
  • ISSN : 0964-6906
  • Web of Science ID : WOS:000240590400007

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