2013年8月
Relapse of multiple sclerosis in a patient retaining CCR7-expressing T cells in CSF under fingolimod therapy
MULTIPLE SCLEROSIS JOURNAL
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- 巻
- 19
- 号
- 9
- 開始ページ
- 1230
- 終了ページ
- 1233
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1177/1352458513481395
- 出版者・発行元
- SAGE PUBLICATIONS LTD
Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor, and it traps lymphocytes in secondary lymphoid organs and precludes their migration into the central nervous system. We report the case of a patient who suffered a relatively severe relapse of multiple sclerosis (MS) during the initial 3 months of fingolimod therapy, with retention of CCR7 expression on CD4(+) T cells in the cerebrospinal fluid (CSF) despite decreased numbers of lymphocytes and decreased expression of CCR7 on CD4(+) T cells in the blood. These data suggest that fingolimod may cause differential effects on the CSF and blood lymphocytes of patients with MS during the initial months of therapy.
- リンク情報
- ID情報
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- DOI : 10.1177/1352458513481395
- ISSN : 1352-4585
- eISSN : 1477-0970
- PubMed ID : 23519973
- SCOPUS ID : 84881081081
- Web of Science ID : WOS:000329573700021