論文

査読有り
2016年5月

Current status of extended spectrum beta-lactamase-producing Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis in Okinawa prefecture, Japan

JOURNAL OF INFECTION AND CHEMOTHERAPY
  • Rika Nakama
  • Aoi Shingaki
  • Hiroko Miyazato
  • Rikako Higa
  • Chota Nagamoto
  • Kouta Hamamoto
  • Shuhei Ueda
  • Teruyuki Hachiman
  • Yuki Touma
  • Kazufumi Miyagi
  • Ryuji Kawahara
  • Takehiko Toyosato
  • Itaru Hirai
  • 全て表示

22
5
開始ページ
281
終了ページ
286
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jiac.2016.01.008
出版者・発行元
ELSEVIER SCIENCE BV

Enterobacteriaceae producing extended spectrum beta-lactamase (ESBL) are distributed worldwide. In this study, 114 ESBL-producing Enterobacteriaceae were isolated by analyzing 1672 clinical isolates of Enterobacteriaceae collected from an Okinawa prefectural hospital in Japan between June 2013 and July 2014. The overall prevalence of ESBL-producing Enterobacteriaceae was 6.8%; the prevalence of different bacterial species among the ESBL-producing isolates was as follows: 11.5% Escherichia coli (90 of 783 isolates), 6.2% Klebsiella pneumoniae (19 of 307 isolates), and 11.1% Proteus mirabilis (5 of 45 isolates). The ESBL types bla(CTX-M-1, -3, -15, -2, -14, -27), and mutants of bla(SHV-1) were detected. Among them, bla(CTX-M-15) (33.3%), bla(CTX-M-14) (27.8%) and bla(CTX-M-27) (33.3%) were dominant in the E. coli isolates, whereas a bla(SHV) mutant which possessed four mutations (Tyr7Phe, Leu35Gln, Gly238Ser and Glu240Lys) in the amino acid sequence of SHV-1 dominated in the K. pneumoniae isolates (11 of 19, 57.9%). The pandemic E. coli ST131 clone was found to constitute 3.3% of the overall examined isolates and 62.2% of the ESBL-producing E. coli isolates. Our results suggest that the genetic combination of bla(CTX-M), and bla(SHV) and antibiotics-resistant profile were different from that in other regions such as other areas of Japan, Asia, Europe, and North America, especially in the ESBL-producing K. pneumoniae isolates and in the E. coli B2-O25b-ST131 isolates possessing bla(CTX-M-15) (40.7% of the E. coli B2-O25b-ST131 isolates). Taken together, our results indicate that the ESBL-producing Enterobacteriaceae in Okinawa, Japan, might be of a unique nature. (C) 2016, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.jiac.2016.01.008
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000375006000002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.jiac.2016.01.008
  • ISSN : 1341-321X
  • eISSN : 1437-7780
  • Web of Science ID : WOS:000375006000002

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