MISC

2015年6月

The human cathelicidin antimicrobial peptide LL-37 and mimics are potential anticancer drugs

FRONTIERS IN ONCOLOGY
  • Kengo Kuroda
  • ,
  • Kazuhiko Okumura
  • ,
  • Hiroshi Isogai
  • ,
  • Emiko Isogai

5
記述言語
英語
掲載種別
書評論文,書評,文献紹介等
DOI
10.3389/fonc.2015.00144
出版者・発行元
FRONTIERS MEDIA SA

Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge and is amphiphilic, and can eliminate pathogenic microbes directly via electrostatic attraction toward negatively charged bacterial membranes. A number of studies have shown that LL-37 participates in various host immune systems, such as inflammatory responses and tissue repair, in addition to its antibacterial properties. Moreover, recent evidence suggests that it is also involved in the regulation of cancer. Indeed, previous studies have suggested that human LL-37 is involved in carcinogenesis via multiple reporters, such as FPR2 (FPRL1), epidermal growth factor receptor, and ERBb2, although LL-37 and its fragments and analogs also show anticancer effects in various cancer cell lines. This discrepancy can be attributed to peptide-based factors, host membrane-based factors, and signal regulation. Here, we describe the association between AMPs and cancer with a focus on anticancer peptide functions and selectivity in an effort to understand potential therapeutic implications.

リンク情報
DOI
https://doi.org/10.3389/fonc.2015.00144
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000359148400001&DestApp=WOS_CPL
ID情報
  • DOI : 10.3389/fonc.2015.00144
  • ISSN : 2234-943X
  • Web of Science ID : WOS:000359148400001

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