Matsuyuki Shirota

Profile Information

Affiliation: Senior Assistant Professor, Graduate School of Medicine United Centers for Advanced Research and Translational Medicine Center for Neuroscience Interdisciplinary Medical Science, Tohoku University

Degree: 博士（生命科学）(The University of Tokyo)

J-GLOBAL ID: 201001029922447028
researchmap Member ID: 6000024824

External link: http://db.tohoku.ac.jp/whois/e_detail/7304c9a50a372c986ee0f709e3a21349.html

Research Areas

Life sciences / Morphology, anatomy / 生物情報学

Papers

Nuclear pore pathology underlying multisystem proteinopathy type 3-related inclusion body myopathy.

Rumiko Izumi, Kensuke Ikeda, Tetsuya Niihori, Naoki Suzuki, Matsuyuki Shirota, Ryo Funayama, Keiko Nakayama, Hitoshi Warita, Maki Tateyama, Yoko Aoki …

Annals of clinical and translational neurology, Dec 29, 2023
jMorp: Japanese Multi-Omics Reference Panel update report 2023.

Shu Tadaka, Junko Kawashima, Eiji Hishinuma, Sakae Saito, Yasunobu Okamura, Akihito Otsuki, Kaname Kojima, Shohei Komaki, Yuichi Aoki, Takanari Kanno …

Nucleic acids research, Nov 1, 2023 Peer-reviewed
Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation.

Zhenzhou Fang, Xingming Li, Yuki Yoshino, Moe Suzuki, Huicheng Qi, Hinari Murooka, Riko Katakai, Matsuyuki Shirota, Thi Anh Mai Pham, Ayako Matsuzawa …

Cell reports, 42(8) 112850-112850, Jul 21, 2023
Neonatal developmental and epileptic encephalopathy with movement disorders and arthrogryposis: A case report with a novel missense variant of SCN1A.

Yukimune Okubo, Moriei Shibuya, Haruhiko Nakamura, Aritomo Kawashima, Kaori Kodama, Wakaba Endo, Takehiko Inui, Noriko Togashi, Yu Aihara, Matsuyuki Shirota …

Brain & development, Jul 11, 2023
A novel variant in the transmembrane 4 domain of ANO3 identified in a two-year-old girl with developmental delay and tremor.

Yu Aihara, Matsuyuki Shirota, Atsuo Kikuchi, Yu Katata, Yu Abe, Tetsuya Niihori, Ryo Funayama, Keiko Nakayama, Yoko Aoki, Shigeo Kure

Journal of human genetics, Sep 27, 2022
Novel POLE mutations identified in patients with IMAGE-I syndrome cause aberrant subcellular localisation and protein degradation in the nucleus.

Tomohiro Nakano, Yoji Sasahara, Atsuo Kikuchi, Kunihiko Moriya, Hidetaka Niizuma, Tetsuya Niihori, Matsuyuki Shirota, Ryo Funayama, Keiko Nakayama, Yoko Aoki …

Journal of medical genetics, 59(11) 1116-22, May 9, 2022
幅広い臨床症状を呈したMECOM遺伝子変異を同定した2家系

新堀哲也, 田野島玲大, 笹原洋二, 佐藤篤, 入江正寛, 南條由佳, 舟山亮, 城田松之, 阿部太紀, 奥山祐子 …

日本小児科学会雑誌, 126(2) 230-230, Feb, 2022
Heterozygous calcyclin-binding protein/Siah1-interacting protein (CACYBP/SIP) gene pathogenic variant linked to a dominant family with paucity of interlobular bile duct.

Miyako Kanno, Mitsuyoshi Suzuki, Ken Tanikawa, Chikahiko Numakura, Shu-Ichi Matsuzawa, Tetsuya Niihori, Yoko Aoki, Yoichi Matsubara, Satoshi Makino, Gen Tamiya …

Journal of human genetics, 67(7) 393-397, Jan 28, 2022
Structural basis of the selective sugar transport in sodium-glucose cotransporters.

Kazuyo Kamitori, Matsuyuki Shirota, Yuichiro Fujiwara

Journal of molecular biology, 167464-167464, Jan 22, 2022
Phenotypic heterogeneity in individuals with MECOM variants in 2 families.

Tetsuya Niihori, Reo Tanoshima, Yoji Sasahara, Atsushi Sato, Masahiro Irie, Yuka Saito-Nanjo, Ryo Funayama, Matsuyuki Shirota, Taiki Abe, Yuko Okuyama …

Blood advances, 6(18) 5257-5261, Jan 12, 2022
Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator

Mitsuhiro Yamada, Ikuko N. Motoike, Kaname Kojima, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Fumiki Katsuoka, Shu Tadaka, Matsuyuki Shirota, Miyuki Sakurai …

Communications Biology, 4(1), Dec, 2021
代謝プロファイルに影響を与える遺伝要因の網羅的解析

小柴生造, 元池育子, 三枝大輔, 井上仁, 菱沼英史, 青木裕一, 田高周, 城田松之, 木下賢吾, 山本雅之

日本生化学会大会プログラム・講演要旨集, 94回 [P-837], Nov, 2021
BRCA1/ATF1-mediated transactivation is involved in resistance to PARP inhibitors and cisplatin

Shino Endo, Yuki Yoshino, Matsuyuki Shirota, Gou Watanabe, Natsuko Chiba

Cancer Research Communications, 1(2) 90-105, Nov, 2021 Peer-reviewed
Wnt5a in cancer-associated fibroblasts promotes colorectal cancer progression.

Tomoaki Hirashima, Hideaki Karasawa, Takashi Aizawa, Takashi Suzuki, Akihiro Yamamura, Hideyuki Suzuki, Taiki Kajiwara, Hiroaki Musha, Ryo Funayama, Matsuyuki Shirota …

Biochemical and biophysical research communications, 568 37-42, Sep 3, 2021
Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer.

Yasushi Mochizuki, Ryo Funayama, Matsuyuki Shirota, Yuna Kikukawa, Masahiro Ohira, Hideaki Karasawa, Minoru Kobayashi, Shinobu Ohnuma, Michiaki Unno, Keiko Nakayama

International journal of cancer, 149(10) 1787-1800, Aug 4, 2021
Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations

Shio Mitsuzawa, Naoki Suzuki, Tetsuya Akiyama, Mitsuru Ishikawa, Takefumi Sone, Jiro Kawada, Ryo Funayama, Matsuyuki Shirota, Hiroaki Mitsuhashi, Satoru Morimoto …

Stem Cell Reports, 16(6) 1527-1541, Jun 8, 2021
GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals.

Kosuke Shido, Kaname Kojima, Matsuyuki Shirota, Kenshi Yamasaki, Ikuko N Motoike, Atsushi Hozawa, Soichi Ogishima, Naoko Minegishi, Kozo Tanno, Fumiki Katsuoka …

The Journal of investigative dermatology, 141(11) 2749-2752, Apr 14, 2021
A novel deletion in the C-terminal region of HSPB8 in a family with rimmed vacuolar myopathy.

Aya Inoue-Shibui, Tetsuya Niihori, Michio Kobayashi, Naoki Suzuki, Rumiko Izumi, Hitoshi Warita, Kenju Hara, Matsuyuki Shirota, Ryo Funayama, Keiko Nakayama …

Journal of human genetics, 66(10) 965-972, Mar 20, 2021
jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population.

Shu Tadaka, Eiji Hishinuma, Shohei Komaki, Ikuko N Motoike, Junko Kawashima, Daisuke Saigusa, Jin Inoue, Jun Takayama, Yasunobu Okamura, Yuichi Aoki …

Nucleic acids research, 49(D1) D536-D544, Jan 8, 2021
Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia.

Yasuo Uchida, Tomoya Higuchi, Matsuyuki Shirota, Satoshi Kagami, Daisuke Saigusa, Seizo Koshiba, Jun Yasuda, Gen Tamiya, Shinichi Kuriyama, Kengo Kinoshita …

Biological & pharmaceutical bulletin, 44(6) 804-815, 2021

Misc.

幅広い臨床症状を呈したMECOM遺伝子変異を同定した2家系

新堀哲也, 田野島玲大, 笹原洋二, 佐藤篤, 入江正寛, 南條由佳, 舟山亮, 城田松之, 阿部太紀, 奥山祐子 …

日本小児科学会雑誌, 126(2) 230-230, Feb, 2022
代謝プロファイルに影響を与える遺伝要因の網羅的解析

小柴生造, 小柴生造, 小柴生造, 元池育子, 元池育子, 三枝大輔, 三枝大輔, 井上仁, 井上仁, 井上仁 …

日本生化学会大会(Web), 94th, 2021
満期産脳性麻痺群の網羅的遺伝学的解析 17例中9例で候補遺伝子変異を同定

竹澤祐介, 菊池敦生, 萩野谷和裕, 新堀哲也, 沼田有里佳, 松, 乾健彦, 山村菜絵子, 宮林拓矢, 安西真衣 …

日本小児科学会雑誌, 123(6) 1069-1070, Jun, 2019
次世代型プロテオミクスによる妊娠高血圧腎症の診断マーカーの同定

樋口友也, 内田康雄, 内田康雄, 加賀美智史, 城田松之, 城田松之, 三枝大輔, 三枝大輔, 小柴生造, 小柴生造 …

日本薬学会東北支部大会講演要旨集, 58th, 2019
ゲノム情報と連携した日本人多層オミックス参照パネルの意義

小柴生造, 小柴生造, 元池育子, 元池育子, 三枝大輔, 三枝大輔, 井上仁, 井上仁, 城田松之, 城田松之 …

糖尿病(Web), 61(Suppl), 2018
A study of dynamics of palmitoylated Ankyrin-G around a lipid bilayer by coarse-grained simulations

Kondo XH, Fujiwara Y, Shirota M, Kinoshita K

Journal of Physiological Sciences, 67(Supplement1) S43, 2017 Peer-reviewed
多系統プロテイノパチー連鎖性hnRNPA1変異に起因する孤立性封入体ミオパチー(Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation)

井泉瑠美子, 割田仁, 新堀哲也, 高橋俊明, 竪山真規, 鈴木直輝, 西山亜由美, 城田松之, 舟山亮, 中山啓子 …

臨床神経学, 56(Suppl.) S280-S280, Dec, 2016
マルチオミクスが解き明かす疾患生物学日本人多層オミックス参照パネルの拡張

小柴生造, 三枝大輔, 元池育子, 小島要, 城田松之, 齋藤智, 勝岡史城, 河合洋介, 山口由美, 田邉修 …

日本生化学会大会プログラム・講演要旨集, 89回 [1S05-5], Sep, 2016
日本人多層オミックス参照パネルの公開

小柴生造, 加藤恭丈, 三枝大輔, 元池育子, 城田松之, 斎藤智, 田邉修, 安田純, 木下賢吾, 山本雅之

日本生化学会大会(Web), 88th 4T21L-07(3P0816) (WEB ONLY)-07(3P0816)], Dec, 2015
Plasma proteome analysis for a large-scale population-based cohort study

Katoh Yasutake, Koshiba Seizo, Igarashi Kazuhiko, Yamamoto Masayuki, Tanabe Osamu, Ebina Masayuki, Shirota Matsuyuki, Motoike Ikuko, Kinoshita Kengo, Kudo Hisaaki …

Abstracts for Annual Meeting of Japanese Proteomics Society, 2015 62-62, 2015
Effect of protein structure and genome sequence in variant analysis

Matsuyuki Shirota, Kengo Kinoshita

GENES & GENETIC SYSTEMS, 89(6) 292-292, Dec, 2014
大規模住民コホート研究のためのLC‐MS/MS血漿プロテオーム解析の標準化

加藤恭丈, 蝦名真行, 城田松之, 木下賢吾, 五十嵐和彦, 田邉修, 山本雅之

日本生化学会大会(Web), 87th 3P-505 (WEB ONLY)-505], Oct, 2014
LC/MSによる分離技術を基盤とした高感度メタボローム解析手法の開発と臨床応用に関する研究

三枝大輔, 城田松之, 小柴正造, 菅原準一, 田邉修, 本橋ほづみ, 山本雅之

BMSコンファレンス講演要旨集, 41st 122-126, Jul 7, 2014
The standardization of parameters for plasma proteome samples in a large clinical cohort

Katoh Yasutake, Ebina Masayuki, Shirota Matsuyuki, Kinoshita Kengo, Igarashi Kazuhiko, Tanabe Osamu

Abstracts for Annual Meeting of Japanese Proteomics Society, 2014 111-111, 2014
Exploring the proton permeation pathway by using homology modeling and molecular dynamics simulation of the Hv1 proton channel

Matsuyuki Shirota, Susumu Chiba, Kota Kasahara, Kengo Kinoshita

JOURNAL OF PHYSIOLOGICAL SCIENCES, 63 S55-S55, 2013
Prediction of Protein-Protein Complex Structures Using a Docking Server, surFit

Eiji Kanamori, Yuko Tsuchiya, Yoichi Murakami, Joy Sarmiento, Shide Liang, Daron Standley, Matsuyuki Shirota, Kengo Kinoshita, Haruki Nakamura

PROTEIN SCIENCE, 21 178-178, Aug, 2012
Analysis of the Constraints on Amino Acid Pairs in Proteins

Matsuyuki Shirota, Kengo Kinoshita

IPSJ SIG technical reports, 2012(18) 1-2, Mar 21, 2012
ヒトゲノム構造・機能アノテーションデータベースSAHG(Structural Atlas of Human Genome)の構築

本野千恵, 中田淳一, 清水佳奈, 富井健太郎, 長野希美, 野口保, 廣明秀一, 雨宮崇之, 城田松之, 小池亮太郎 …

日本蛋白質科学会年会プログラム・要旨集, 10th, 2010

Professional Memberships

Research Projects

Protein Structure Prediction

Apr, 2006 - Present
Prediction and validation of regulatory variants based on DNA/RNA-protein complex structures

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
中心体異常とDNA損傷によるゲノム不安定性を標的とする新しいがん治療法の開発

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2025

千葉奈津子, 吉野優樹, 渡部剛, 城田松之
Development of Targeting therapy for centrosome dysregulation in cancer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Chiba Natsuko
Multi-layer informatics analysis on brain and personality focused on microexons

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2021
Development of information system for functional annotation of genomic sequence alterations by using protein 3D structures

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Shirota Matsuyuki
Elucidation of the signaling pathways that induce gene amplification

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2020

NAKAYAMA Keiko
Elucidation of the mechanism of transcription elongation rate control by histone code

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

NAKAYAMA Keiko
Elucidation of regulatory mechanism to maintain genome stability by novel BRCA1-interacting molecules and development of cancer therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

CHIBA Natsuko
Refinement of protein structure prediction by using simulation and database analyses

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Shirota Matsuyuki
Verification of genomic diversity required for tumorigenesis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2017

NAKAYAMA Keiko
Genome wide analysis of epigenetic regulation of enhancer activity via H3K27 modifications

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

HOSOGANE Masaki, NAKAYAMA Keiko, FUNAYAMA Ryo, SHIROTA Matuyuki
Development of a database of buried polar residues in protein structures

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Shirota Matsuyuki

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