A macroporous silica-based supramolecular recognition absorbent (Calix[4] + Dodecanol)/SiO2-P, was prepared by successive impregnation and fixing the 1,3-[(2,4-diethylheptylethoxy)oxy]-2,4-crown-6-Calix[4]arene (Calix[4]arene-R14) and its molecule modifier 1-Dodecanol onto SiO2 silica-based polymer support. The characterization of (Calix[4] + Dodecanol)/SiO2-P was examined by thermal gravimetry and differential thermal analysis and electron probe microanalysis. Relatively large separation factors of Cs and other metal ions (alpha (Cs/M) (n+) ) above 60 were obtained in the presence of 3 M HNO3. The adsorption data of Cs(I) fitted well with Langmuir isotherm and the maximum adsorption capacity was estimated to be 0.19 mmol g(-1). The Cs(I) in 3 M HNO3 were also effectively adsorption on (Calix[4] + Dodecanol)/SiO2-P in the column operation, and the loaded Cs(I) was successfully eluted with an eluent of H2O. The column packed with (Calix[4] + Dodecanol)/SiO2-P had excellent reusability after three cycles.