Kimura Keiji

J-GLOBAL         Last updated: Sep 19, 2019 at 02:52
 
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Name
Kimura Keiji
E-mail
kekimuratara.tsukuba.ac.jp
Affiliation
University of Tsukuba
Section
Faculty of Life and Environmental Sciences
Job title
Associate Professor

Research Areas

 
 

Published Papers

 
Lu, Weizhe; Kim, Jun-Dal; Tabara, Saori; Kwon, Chulwon; Mizukami, Hayase; Kimura, Keiji; Fukamizu, Akiyoshi
Biochemical and Biophysical Research Communications   514(4) 1185-1191   May 2019
Protein arginine methyltransferase PRMT5 synthesizes the symmetric dimethylarginine in nuclear and cytoplasmic proteins such as histone H2A, H4 and several non-histone proteins that are required for a variety of biological processes. Currently, tw...
Hayashi, Yuki; Fujimura, Akiko; Kato, Kazashi; Udagawa, Rina; Hirota, Toru; Kimura, Keiji
Science advances   4(6) eaap7777   Jun 2018   [Refereed]
The nucleolus is a dynamic nuclear body that has been demonstrated to disassemble at the onset of mitosis; the relationship between cell cycle progression and nucleolar integrity, however, remains poorly understood. We studied the role of nucleola...
Ohkuro, Masayoshi; Kim, Jun-Dal; Kuboi, Yoshikazu; Hayashi, Yuki; Mizukami, Hayase; Kobayashi-Kuramochi, Hiroko; Muramoto, Kenzo; Shirato, Manabu; Michikawa-Tanaka, Fumiko; Moriya, Jun; Kozaki, Teruya; Takase, Kazuma; Chiba, Kenichi; Agarwala, Kishan Lal; Kimura, Takayuki; Kotake, Makoto; Kawahara, Tetsuya; Yoneda, Naoki; Hirota, Shinsuke; Azuma, Hiroshi; Ozasa-Komura, Nobuko; Ohashi, Yoshiaki; Muratani, Masafumi; Kimura, Keiji; Hishinuma, Ieharu; Fukamizu, Akiyoshi
Nature Communications   9(1) 1982   May 2018   [Refereed]
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a chronic intestinal inflammatory condition initiated by integrins-mediated leukocyte adhesion to the activated colonic microvascular endothelium. Calreticulin ...
Hayashi, Yuki; Kato, Kazashi; Kimura, Keiji
Biochemical and biophysical research communications   493(2) 1043-1049   Sep 2017   [Refereed]
The perichromosomal layer (PCL) is a structure that surrounds mitotic chromosomes, found in both animal and plant cells. It comprises various proteins and RNAs, mainly derived from the nucleolus. Several functions for the PCL have been suggested; ...
Tsuchiya, M.;Nakajima, Y.;Waku, T.;Hiyoshi, H.;Morishita, T.;Furumai, R.;Hayashi, Y.;Kishimoto, H.;Kimura, K. (Corresponding Author);Yanagisawa, J.
ONCOGENE   34(35) 4656-4663   Aug 2015   [Refereed]
Kumazawa, Takuya;Nishimura, Kazuho;Katagiri, Naohiro;Hashimoto, Sayaka;Hayashi, Yuki;Kimura, Keiji
SCIENTIFIC REPORTS   5 10854   Jun 2015   [Refereed]
Nishimura, Kazuho;Kumazawa, Takuya;Kuroda, Takao;Katagiri, Naohiro;Tsuchiya, Mai;Goto, Natsuka;Furumai, Ryohei;Murayama, Akiko;Yanagisawa, Junn;Kimura, Keiji
Cell Reports   10(8) 1310-1323   Mar 2015   [Refereed]
The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress. Here, we show that the 5S RNP contributes to p53 activation and promotes cellular senescence in respon...
Katagiri, Naohiro;Kuroda, Takao;Kishimoto, Hiroyuki;Hayashi, Yuki;Kumazawa, Takuya;Kimura, Keiji
SCIENTIFIC REPORTS   5 8903   Mar 2015   [Refereed]
Tsuchiya, Mai;Nakajima, Yuka;Hirata, Naoya;Morishita, Tamaki;Kishimoto, Hiroyuki;Kanda, Yasunari;Kimura, Keiji
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   452(4) 928-932   Oct 2014   [Refereed]
Hayashi, Yuki;Kuroda, Takao;Kishimoto, Hiroyuki;Wang, Changshan;Iwama, Atsushi;Kimura, Keiji
PLOS ONE   9(5)    May 2014   [Refereed]
Oie,Shohei;Matsuzaki,Kazuya;Yokoyama,Wataru;Tokunaga,Shinji;Waku,Tsuyoshi;Han,Song-Iee;Iwasaki,Naoya;Mikogai,Aya;Yasuzawa-Tanaka,Kayoko;Kishimoto,Hiroyuki;Hiyoshi,Hiromi;Nakajima,Yuka;Araki,Toshiyuki;Kimura,Keiji;Yanagisawa,Junn;Murayama,Akiko
CELL REPORTS   7(3) 807-820   May 2014   [Refereed]
Ono,Wakana;Hayashi,Yuki;Yokoyama,Wataru;Kuroda,Takao;Kishimoto,Hiroyuki;Ito,Ichiaki;Kimura,Keiji;Akaogi,Keisuke;Waku,Tsuyoshi;Yanagisawa,Junn
JOURNAL OF BIOLOGICAL CHEMISTRY   289(8) 4928-4940   Feb 2014   [Refereed]
Background: Nucleolar disruption is involved in cellular stress response and is sufficient for p53 activation. p53 tetramerization is crucial to exert its activity. Results: The nucleolar protein MYBBP1A enhanced p53 tetramerization by directly in...
Ono,Wakana;Akaogi,kensuke;Tsuyoshi,Waku;Kuroda,Takao;Yokoyama,Wataru;Hayashi,Yuki;Kimura,Keiji;Kishimoto,Hiroyuki;Yanagisawa,Junn
Biochem Biophys Res Commun.   434(3) 659-663   May 2013   [Refereed]
Nucleolar dynamics are important for cellular stress response. We previously demonstrated that nucleolar stress induces nucleolar protein Myb-binding protein 1A (MYBBP1A) translocation from the nucleolus to the nucleoplasm and enhances p53 activit...
Fujimura, Akiko;Kishimoto, Hiroyuki;Yanagisawa, Junn;Kimura, Keiji
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   423(3) 588-592   Jul 2012   [Refereed]
Kumazawa, Takuya;Nishimura, Kazuho;Kuroda, Takao;Ono, Wakana;Yamaguchi, Chie;Katagiri, Naohiro;Tsuchiya, Mai;Masumoto, Hiroshi;Nakajima, Yuka;Murayama, Akiko;Kimura, Keiji;Yanagisawa, Junn
JOURNAL OF BIOLOGICAL CHEMISTRY   286(23) 20861-20869   Jun 2011   [Refereed]
Tsuchiya,Mai;Katagiri,Naohiro;Kuroda,Takao;Kishimoto,Hiroyuki;Nishimura,Kazuho;Kumazawa,Takuya;Iwasaki,Naoya;Kimura,Keiji;Yanagisawa,Junn
Biochemical and Biophysical Research Communications   (407) 378-382   Apr 2011   [Refereed]
Nakajima, Yuka;Akaogi, Kensuke;Suzuki, Takashi;Osakabe, Asami;Yamaguchi, Chie;Sunahara, Nanae;Ishida, Junji;Kako, Koichiro;Ogawa, Sonoko;Fujimura, Tetsuya;Homma, Yukio;Fukamizu, Akiyoshi;Murayama, Akiko;Kimura, Keiji;Inoue, Satoshi;Yanagisawa, Junn
SCIENCE SIGNALING   4(168) ra22-0   Apr 2011   [Refereed]
Kuroda,Takao;Murayama,Akiko;Katagiri,Naohiro;Ohta,Yu-mi;Fujita,Etsuko;Masumoto,Hiroshi;Ema,Masatsugu;Takahashi,Satoru;Kimura,Keiji;Yanagisawa,Junn
EMBO JOURNAL   30(6) 1054-1066   Mar 2011   [Refereed]
Takemoto, Ai;Maeshima, Kazuhiro;Ikehara, Tsuyoshi;Yamaguchi, Kazumitsu;Murayama, Akiko;Imamura, Shihoko;Imamoto, Naoko;Yokoyama, Shigeyuki;Hirano, Tatsuya;Watanabe, Yoshinori;Hanaoka, Fumio;Yanagisawa, Junn;Kimura, Keiji
NATURE STRUCTURAL & MOLECULAR BIOLOGY   16(12) 1302-1308   Dec 2009   [Refereed]
Akaogi, K.;Nakajima, Y.;Ito, I.;Kawasaki, S.;Oie, S-H;Murayama, A.;Kimura, K.;Yanagisawa, J.
ONCOGENE   28(32) 2894-2902   Aug 2009   [Refereed]
Kajiro, Masashi;Hirota, Ryuichi;Nakajima, Yuka;Kawanowa, Kaori;So-ma, Kae;Ito, Ichiaki;Yamaguchi, Yuri;Ohie, Sho-hei;Kobayashi, Yasuhito;Seino, Yuko;Kawano, Miwako;Kawabe, Yoh-ichi;Takei, Hiroyuki;Hayashi, Shin-ichi;Kurosumi, Masafumi;Murayama, Akiko;Kimura, Keiji;Yanagisawa, Junn
NATURE CELL BIOLOGY   11(3) 312-319   Mar 2009   [Refereed]
Komatsu, Y;Ito, I;Wayama, M;Fujimura, A;Akaogi, K;Machida, H;Nakajima, Y;Kuroda, T;Ohmori, K;Murayama, A;Kimura, K;Yanagisawa, J.
Biochem Biophys Res Commun.   370 145-148   May 2008   [Refereed]
Murayama, Akiko;Ohmori, Kazuji;Fujimura, Akiko;Minami, Hiroshi;Yasuzawa-Tanaka, Kayoko;Kuroda, Takao;Oie, Shohei;Daitoku, Hiroaki;Okuwaki, Mitsuru;Nagata, Kyosuke;Fukamizu, Akiyoshi;Kimura, Keiji;Shimizu, Toshiyuki;Yanagisawa, Junn
CELL   133(4) 627-639   May 2008   [Refereed]
Lee, CP;Chen, JY;Wang, JT;Kimura, K;Takemoto, A;Lu, CC;Chen, MR.
J Virol.   81(10) 5166-5180   May 2007   [Refereed]
Takemoto, Ai;Murayama, Akiko;Katano, Miyuki;Urano, Takeshi;Furukawa, Koichi;Yokoyama, Shigeyuki;Yanagisawa, Junn;Hanaoka, Fumio;Kimura, Keiji
NUCLEIC ACIDS RESEARCH   35(7) 2403-2412   Apr 2007   [Refereed]
Tsuyama, T;Inou, K;Seki, M;Seki, T;Kumata, Y;Kobayashi, T;Kimura, K;Hanaoka, F;Enomoto, T;Tada, S.
Biochem Biophys Res Commun.   351 935-939   Dec 2006   [Refereed]
Takemoto, Ai;Kimura, Keiji (Co-First author, Co-Corresponding author);Yanagisawa, Junn;Yokoyama, Shigeyuki;Hanaoka, Fumio
EMBO JOURNAL   25(22) 5339-5348   Nov 2006   [Refereed]
Li, X;Sakashita, G;Matsuzaki, H;Sugimoto, K;Kimura, K;Hanaoka, F;Taniguchi, H;Furukawa, K;;Urano, T.
J Biol Chem.   279 47201-47211   Nov 2004   [Refereed]
Takemoto, A;Kimura, K (Co-First author);S, Yokoyama;Hanaoka, F.
J Biol Chem.   279 4551-4559   Jan 2004   [Refereed]
Bazett-Jones, DP;Kimura, K;;Hirano, T.
Mol Cell   9 1183-1190   Jun 2002   [Refereed]
Kimura,K;Cuvier,O;Hirano,T.
J Biol Chem.   276 5417-5420   Jan 2001   [Refereed]
Kimura, K;Hirano, T.
Proc Natl Acad Sci USA.   97 11972-11977   Oct 2000   [Refereed]
Kimura, K;Rybenkov, VV;Crisona, NJ;Hirano, T;Cozzarelli, NR.
Cell   98 239-248   Jul 1999   [Refereed]
Kimura, K;Hirano, M;Kobayashi, R;Hirano, T.
Science   282 487-490   Oct 1998   [Refereed]
Kimura, K;Nozaki, N;Enomoto, T;Tanaka, M;Kikuchi, A.
J Biol Chem.   271 21439-21445   Aug 1996   [Refereed]
Kimura, K;Saijo, M;Tanaka, M;Enomoto, T.
J Biol Chem.   271 10990-10995   May 1996   [Refereed]
Identification of the nature of modification that causes the shift of DNA topoisomerase II beta to apparent higher molecular weight forms in the M phase.
Kimura, K;Nozaki, N;Saijo, M;Kikuchi, A;Ui, M;Enomoto, T.
J Biol Chem.   269 24523-24526   Oct 1994   [Refereed]
Growth state- and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase II and possible specific modification of the higher molecular weight form in the M phase.
Kimura, K;Saijo, M;Ui, M;Enomoto, T
J Biol Chem.   269 1173-1176   Jan 1994   [Refereed]

Books etc

 
M期を制御するホスファターゼとその新規機能
竹本, 愛 木村 圭志;+木村, 圭志
細胞工学   May 2011   
染色体凝縮因子コンデンシンの活性を抑制する新たな制御機構
竹本, 愛 木村 圭志 花岡 文雄;+木村, 圭志
実験医学、羊土社、Vol. 25, No. 4   Mar 2007   
染色体凝縮因子コンデンシンのアフィニティー精製法
竹本, 愛 木村 圭志 花岡 文雄;+木村, 圭志
タンパク質実験マニュアル、朝倉書店   Oct 2006   
ヒト培養細胞からのトポイソメラーゼの精製
竹本, 愛 木村 圭志 花岡 文雄;+木村, 圭志
タンパク質実験マニュアル、朝倉書店   Oct 2006   
ヒストンのリン酸化
木村, 圭志 花岡 文雄
わかる実験医学シリーズ 注目のエピジェネティクスがわかる   Aug 2004   

Conference Activities & Talks

 
Nucleolar structure during interphase determines mitotic entry
Hayashi, Yuki;Fujimura, Akiko;Kato, Kazashi;Udagawa, Rina;Hirora, Toru;Kimura, Keiji
11th 3R & 3C Symposium   12 Nov 2018   
核小体の構造変化は分裂期(M期)を制御する
林優樹;藤村亜紀子;加藤かざし;宇田川里奈;広田亨;木村, 圭志
第36回染色体ワークショップ 第17回核ダイナミクス研究会   23 Jan 2019   
核小体構造は分裂期(M期)開始を制御する
林優樹;加藤かざし;宇田川里奈;広田亨;木村, 圭志
第41回日本分子生物学会年会   28 Nov 2018   
核小体タンパク質MYBBP1Aによる染色体ダイナミクスの制御
小暮祐一朗;加藤かざし;林優樹;木村, 圭志
第41回日本分子生物学会年会   28 Nov 2018   
rRNAプロセシング因子による分裂期制御機構
宇田川里奈;林優樹;木村, 圭志
第41回日本分子生物学学会年会   28 Nov 2018