岩本紀之 (IWAMOTO NORIYUKI) - マイポータル

基本情報

所属: 独立行政法人国立循環器病研究センター研究所糖尿病代謝内科医師

J-GLOBAL ID: 201001083209791228
researchmap会員ID: 6000025714

研究キーワード

研究分野

受賞

2010年

奨励賞, 日本心臓財団

岩本紀之
2009年

循環器分子細胞研究, 日本心臓財団

岩本紀之
2008年7月

若手研究者奨励賞最優秀賞, 日本動脈硬化学会

岩本紀之
2007年

奨励賞, 日本心臓財団

岩本紀之
2006年6月

若手研究者奨励賞, 国際動脈硬化学会 HDLシンポジウム

岩本紀之

論文

HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7

Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L. Fitzgerald, Shinji Yokoyama

ATHEROSCLEROSIS 217(2) 407-414 2011年8月査読有り
Calpain-mediated ABCA1 degradation: Post-translational regulation of ABCA1 for HDL biogenesis.

Yokoyama S, Arakawa R, Wu CA, Iwamoto N, Lu R, Tsujita M, Abe-Dohmae S

Biochimica et biophysica acta 2011年7月査読有り
Protein kinase D regulates the adiponectin gene expression through phosphorylation of AP-2: A common pathway to the ABCA1 gene regulation

Noriyuki Iwamoto, Shinji Yokoyama

ATHEROSCLEROSIS 216(1) 90-96 2011年5月査読有り
Roles of ATP-Binding Cassette Transporter A7 in Cholesterol Homeostasis and Host Defense System

Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Shinji Yokoyama

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 18(4) 274-281 2011年査読有り
Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7

Nobukiyo Tanaka, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Michael L. Fitzgerald, Shinji Yokoyama

JOURNAL OF LIPID RESEARCH 51(9) 2591-2599 2010年9月査読有り
Calmodulin Interacts With ATP Binding Cassette Transporter A1 to Protect From Calpain-Mediated Degradation and Upregulates High-Density Lipoprotein Generation

Noriyuki Iwamoto, Rui Lu, Nobukiyo Tanaka, Sumiko Abe-Dohmae, Shinji Yokoyama

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 30(7) 1446-1452 2010年7月査読有り
Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis

Reijiro Arakawa, Maki Tsujita, Noriyuki Iwamoto, Chisato Ito-Ohsumi, Rui Lu, Chen-Ai Wu, Kenji Shimizu, Tomoji Aotsuka, Hashime Kanazawa, Sumiko Abe-Dohmae …

JOURNAL OF LIPID RESEARCH 50(11) 2299-2305 2009年11月査読有り
FGF-1 induces expression of LXR alpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes

Rui Lu, Jinichi Ito, Noriyuki Iwamoto, Tomoko Nishimaki-Mogami, Shinji Yokoyama

JOURNAL OF LIPID RESEARCH 50(6) 1156-1164 2009年6月査読有り
Involvement of Protein Kinase D in Phosphorylation and Increase of DNA Binding of Activator Protein 2 alpha to Downregulate ATP-Binding Cassette Transporter A1

Noriyuki Iwamoto, Sumiko Abe-Dohmae, Rui Lu, Shinji Yokoyama

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 28(12) 2282-2287 2008年12月査読有り
ApoA-I facilitates ABCA1 recycle/accumulation to cell surface by inhibiting its intracellular degradation and increases HDL generation

Rui Lu, Reijiro Arakawa, Chisato Ito-Osumi, Noriyuki Iwamoto, Shinji Yokoyama

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 28(10) 1820-1824 2008年10月査読有り
Biogenesis of HDL by SAA is dependent on ABCA1 in the liver in vivo

Wei Hu, Sumiko Abe-Dohmae, Maki Tsujita, Noriyuki Iwamoto, Osamu Ogikubo, Takanobu Otsuka, Yositaka Kumon, Shinji Yokoyama

JOURNAL OF LIPID RESEARCH 49(2) 386-393 2008年2月査読有り
ATP-binding cassette transporter A1 gene transcription is downregulated by activator protein 2 alpha - Doxazosin inhibits activator protein 2 alpha and increases high-density lipoprotein biogenesis independent of alpha 1-adrenoceptor blockade

Noriyuki Iwamoto, Sumiko Abe-Dohmae, Makoto Ayaori, Nobukiyo Tanaka, Masatoshi Kusuhara, Fumitaka Ohsuzu, Shinji Yokoyama

CIRCULATION RESEARCH 101(2) 156-165 2007年7月査読有り
Telmisartan enhances cholesterol eff lux from THP-1 macrophages by activating PPAR gamma

Kazuhiro Nakaya, Makoto Ayaori, Tetsuya Hisada, Shojiro Sawada, Nobukiyo Tanaka, Noriyuki Iwamoto, Masatsune Ogura, Emi Yakushiji, Masatoshi Kusuhara, Haruo Nakamura …

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 14(3) 133-141 2007年6月査読有り
ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis

Noriyuki Iwamoto, Sumiko Abe-Dohmae, Ryuichiro Sato, Shinji Yokoyama

JOURNAL OF LIPID RESEARCH 47(9) 1915-1927 2006年9月査読有り
Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner

Sumiko Abe-Dohmae, Koichi H. Kato, Yoshitaka Kumon, Wei Hu, Hideaki Ishigami, Noriyuki Iwamoto, Mitsuyo Okazaki, Chen-Ai Wu, Maki Tsujita, Kazumitsu Ueda …

JOURNAL OF LIPID RESEARCH 47(7) 1542-1550 2006年7月査読有り
Glucocorticoid receptor regulates ATP-binding cassette transporter-A1 expression and apolipoprotein-mediated cholesterol efflux from macrophages

M Ayaori, S Sawada, A Yonemura, N Iwamoto, M Ogura, N Tanaka, K Nakaya, M Kusuhara, H Nakamura, F Ohsuzu

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 26(1) 163-168 2006年1月査読有り
Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques detected by noninvasive magnetic resonance Imaging

A Yonemura, Y Momiyama, ZA Fayad, M Ayaori, R Ohmori, K Higashi, T Kihara, S Sawada, N Iwamoto, M Ogura …

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 45(5) 733-742 2005年3月査読有り
Characterization of the expression of TLR2 (Toll-like receptor 2) and TLR4 on circulating monocytes in coronary artery disease

K Ashida, K Miyazaki, E Takayama, H Tsujimoto, M Ayaori, T Yakushiji, N Iwamoto, A Yonemura, K Isoda, H Mochizuki …

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 12(1) 53-60 2005年2月査読有り

所属学協会

共同研究・競争的資金等の研究課題

分子標的による機能性HDL増加薬の開発-副作用の少ない新規抗動脈硬化剤の創製-

文部科学省科学研究費補助金(基盤研究(C)) 基盤研究(C) 2011年 - 2011年

岩本紀之
ABCA1を標的としたHDL増加薬の開発

文部科学省科学研究費補助金(若手研究(B)) 若手研究(B) 2009年 - 2010年

岩本紀之
動脈硬化脂質代謝創薬