2000年11月9日
Expression of a system L neutral amino acid transporter at the blood-brain barrier
NeuroReport
- 巻
- 11
- 号
- 16
- 開始ページ
- 3507
- 終了ページ
- 3511
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1097/00001756-200011090-00021
- 出版者・発行元
- Lippincott Williams and Wilkins
Amino acid transport system L has been proposed to be one of the major nutrient transport systems at the blood-brain barrier. Using immunohistochemical analyses, a system L transporter LAT1 was shown to be expressed in the brain capillary endothelial cells in rats. Because LAT1 was co-expressed with 4F2 heavy chain which brings LAT1 to the plasma membrane, LATI is proposed to be functional in the plasma membrane of brain capillary endothelial cells. Both LAT1 and 4F2hc immunoreactivities were detected in a double line appearance surrounding endothelial cell nuclei, suggesting both proteins are present in the luminal and abluminal membranes. LAT1 is, thus, a blood-brain barrier system L transporter responsible for the permeation of aromatic or branched-chain amino acids and amino acid-related drugs such as L-DOPA. (C) 2000 Lippincott Williams and Wilkins.
- リンク情報
- ID情報
-
- DOI : 10.1097/00001756-200011090-00021
- ISSN : 0959-4965
- PubMed ID : 11095508
- SCOPUS ID : 0034626856