Akira Nakajima - My portal

Profile Information

Affiliation: Faculty of Agriculture and Life Science, Hirosaki University

Degree: 博士（医学）(名古屋大学)

J-GLOBAL ID: 201001036142969509
researchmap Member ID: 6000026129

Research Areas

Research History

Apr, 2017 - Present

Faculty of Agriculture and Life Science, Hirosaki University
Apr, 2012 - Mar, 2017

Lecturer, Nagoya University Graduate School of Medicine
Nov, 2009 - Mar, 2012

Graduate School of Medicine, Nagoya University
Apr, 2007 - Oct, 2009

Graduate School of Pharmaceutical Sciences, Tohoku University
Jun, 2005 - Mar, 2007

Graduate School of Pharmaceutical Sciences, Tohoku University
Jun, 2003 - Jun, 2005

米国シカゴ大学神経精神科学分野・リサーチアソシエイト

Papers

A Narrative Review of the Effects of Citrus Peels and Extracts on Human Brain Health and Metabolism.

Kentaro Matsuzaki, Akira Nakajima, Yuanqiang Guo, Yasushi Ohizumi

Nutrients, 14(9), Apr 28, 2022
IFITM3による細胞内輸送の制御機構

伊藤教道, 永井拓, 衣斐大祐, 中島晶, 鍋島俊隆, 山田清文

応用薬理, 90(5-6) 164-164, Jun, 2016
Candidate genes or compounds for therapeutic tools against methamphetamine and/or morphine-induced dependence

Atsumi Nitta, Yu-Ichiro Yamada, Akira Nakajima, Yukihiro Noda, Kiyofumi Yamada, Toshitaka Nabeshima

Folia Pharmacologica Japonica, 122(1) 81P-83P, 2003 Peer-reviewed

Misc.

An evaluation of the genotoxicity and subchronic toxicity of the peel extract of Ponkan cultivar 'Ohta ponkan' (Citrus reticulata Blanco) that is rich in nobiletin and tangeretin with anti-dementia activity.

Nakajima A, Nemoto K, Ohizumi Y

Regul Toxicol Pharmacol., 114 104670-104670, Jul, 2020 Peer-reviewedLead authorCorresponding author
Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer's Disease and Parkinson's Disease.

Nakajima A, Ohizumi Y

Int J Mol Sci., 20(14) 3380, Jul, 2019 Peer-reviewedLead authorCorresponding author
Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes.

Akira Sobue, Norimichi Ito, Taku Nagai, Wei Shan, Kazuhiro Hada, Akira Nakajima, Yuki Murakami, Akihiro Mouri, Yasuko Yamamoto, Toshitaka Nabeshima …

Glia, 66(5) 1034-1052, May, 2018 Peer-reviewed
Fluoroquinolones and propionic acid derivatives induce inflammatory responses in vitro.

Nakajima A, Sato H, Oda S, Yokoi T

Cell Biol Toxicol., 34 65-77, 2018 Peer-reviewedLead authorCorresponding author
アストロサイトに由来するMHC classIの機能解析

伊藤教道, 祖父江顕, 永井拓, シャンウェイ, 中島晶, 村上由希, 毛利彰宏, 山本康子, 鍋島俊隆, 斎藤邦明 …

日本薬理学雑誌, 152(Supplement), 2018
Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3.

Yamada S, Itoh N, Nagai T, Nakai T, Ibi D, Nakajima A, Nabeshima T, Yamada K

J Neuroinflammation., 15(1) 295-295, 2018 Peer-reviewed
Behavioral alterations accompanied by neuropathological changes induced by the expression of MHCI in the prefrontal cortex of mice

Akira Sobue, Norimichi Ito, Kazuhiro Hada, Akira Nakajima, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3) S177-S177, Mar, 2017
Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells

Akira Nakajima, Shingo Oda, Tsuyoshi Yokoi

JOURNAL OF APPLIED TOXICOLOGY, 36(9) 1120-1128, Sep, 2016 Peer-reviewedLead author
A novel cell-based assay for the evaluation of immune-and inflammatory-related gene expression as biomarkers for the risk assessment of drug-induced liver injury

Shingo Oda, Kentaro Matsuo, Akira Nakajima, Tsuyoshi Yokoi

TOXICOLOGY LETTERS, 241 60-70, Jan, 2016 Peer-reviewed
Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble A beta levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)

Akira Nakajima, Yuki Aoyama, Eun-Joo Shin, Yunsung Nam, Hyoung-Chun Kim, Taku Nagai, Akihito Yokosuka, Yoshihiro Mimaki, Tsuyoshi Yokoi, Yasushi Ohizumi …

BEHAVIOURAL BRAIN RESEARCH, 289 69-77, Aug, 2015 Peer-reviewedLead author
Induction of interferon-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes

Akira Nakajima, Daisuke Ibi, Taku Nagai, Shinnosuke Yamada, Toshitaka Nabeshima, Kiyofumi Yamada

EUROPEAN JOURNAL OF PHARMACOLOGY, 745 166-175, Dec, 2014 Peer-reviewedLead author
Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes

Shinnosuke Yamada, Taku Nagai, Tsuyoshi Nakai, Daisuke Ibi, Akira Nakajima, Kiyofumi Yamada

BRAIN BEHAVIOR AND IMMUNITY, 38 272-282, May, 2014 Peer-reviewed
Expression of the G72/G30 gene in transgenic mice induces behavioral changes

Cheng L, Hattori E, Nakajima A, Woehrle NS, Opal MD, Zhang C, Grennan K, Dulawa SC, Tang YP, Gershon ES, Liu C

MOLECULAR PSYCHIATRY, 19(2) 175-183, Feb, 2014 Peer-reviewed
アルツハイマー病モデルマウスに対するノビレチンの効果

青山雄紀, 中島晶, SHIN Eun-Joo, KIM Hyoung-Chun, 永井拓, 横須賀章人, 三巻祥浩, 大泉康, 大泉康, 山田清文

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 24th-44th, 2014
Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action

Ichiro Kawahata, Masaaki Yoshida, Wen Sun, Akira Nakajima, Yanxin Lai, Naoya Osaka, Kentaro Matsuzaki, Akihito Yokosuka, Yoshihiro Mimaki, Akira Naganuma …

JOURNAL OF NEURAL TRANSMISSION, 120(10) 1397-1409, Oct, 2013 Peer-reviewed
Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse

Akira Nakajima, Yuki Aoyama, Thuy-Ty Lan Nguyen, Eun-Joo Shin, Hyoung-Chun Kim, Shinnosuke Yamada, Tsuyoshi Nakai, Taku Nagai, Akihito Yokosuka, Yoshihiro Mimaki …

Behavioural Brain Research, 250 351-360, Aug 1, 2013 Peer-reviewedLead author
SLC10A4 is a protease-activated transporter that transports bile acids

Takuya Abe, Yoshitomi Kanemitu, Masateru Nakasone, Ichiro Kawahata, Tohru Yamakuni, Akira Nakajima, Naoto Suzuki, Masazumi Nishikawa, Takanori Hishinuma, Yoshihisa Tomioka

JOURNAL OF BIOCHEMISTRY, 154(1) 93-101, Jul, 2013 Peer-reviewed
Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice

Daisuke Ibi, Taku Nagai, Akira Nakajima, Hiroyuki Mizoguchi, Takahiro Kawase, Daisuke Tsuboi, Shin-Ichi Kano, Yoshiaki Sato, Masahiro Hayakawa, Ulrike C. Lange …

GLIA, 61(5) 679-693, May, 2013 Peer-reviewed
Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization

Akira Nakajima, Yukari Kinugasa, Jun Torii, Takanori Hishinuma, Yoshihisa Tomioka, Kiyofumi Yamada, Tohru Yamakuni

NEUROSCIENCE LETTERS, 524(2) 133-138, Aug, 2012 Peer-reviewedLead author
CapZを介したV-1によるチロシン水酸化酵素遺伝子発現の新規調節メカニズムの解析

森田淳一, 金京梅, 中島晶, 阿部誠也, 山岸佑輔, 陳嘉俊, 大泉康, 富岡佳久, 山國徹

日本薬学会年会要旨集, 130年会(3) 69-69, Mar, 2010

Professional Memberships

Research Projects

内分泌かく乱物質である臭素系難燃剤の脳神経系に対する影響の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

中島晶
合成カチノン類による神経毒性発現メカニズムの解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2014 - Mar, 2017
神経発達障害に関連するサイトカイン誘導性膜タンパク質ＩＦＩＴＭ３のシグナル解析

科学研究費助成事業, 若手研究(B), 日本学術振興会, Apr, 2011 - Mar, 2013
新規脳内薬物トランスポーターの機能解析と中枢神経疾患治療への応用

科学研究費助成事業, 基盤研究 (B), May, 2008 - Mar, 2011
生薬成分ノビレチン誘導体の記憶・学習障害改善効果における構造活性相関研究

科学研究費助成事業, 若手研究 (B), Apr, 2006 - Mar, 2008
Elucidation of physiological significance of a novel regulator of neuronal functions and its application to functional regeneration of brain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

YAMAKUNI Tohru, OHIZUMI Yasushi, NAKAJIMA Akira, SAITO Shin-ya