2011
Effects of High Temperature- and Pressure-Treated Garlic on 1, 2-Dimethylhydrazine-Induced Premalignant Lesions in the Rat Colorectum at the Post-Initiation Stage
JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI
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- Volume
- 58
- Number
- 3
- First page
- 131
- Last page
- 135
- Language
- Japanese
- Publishing type
- DOI
- 10.3136/nskkk.58.131
- Publisher
- JAPAN SOC FOOD SCIENCE TECHNOLOGY
We examined the effects of high temperature- and pressure-treated garlic (HITPG), which has enhanced anti-oxidative activity, on 1, 2-dimethylhydrazine (DMH)-induced mucin-depleted foci (MDF), as premalignant lesions, in the rat colorectum at the post-initiation stage. Male F344 rats (5 weeks old) were injected s.c. with DMH (40 mg/kg, once weekly for 2 weeks). Rats were fed basal diet or experimental diets containing 1% or 3% HTPG for 6 weeks, starting 1 week after the last injection of DMH. At sacrifice, the number of MDF in the 3% HTPG diet group was significantly lower than that in the basal diet group. In addition, we also studied the influence of 3% HTPG diet ingestion. Rats were fed basal diet or 3% HTPG diet under the above conditions without DMH treatment. The 3% HTPG diet did not affect most hematological and plasma biochemical parameters. These results, combined with our previous work (APJCP, 2009), suggest that HTPG may be useful as a health supplement.
- Link information
- ID information
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- DOI : 10.3136/nskkk.58.131
- ISSN : 1341-027X
- CiNii Articles ID : 10027868993
- Web of Science ID : WOS:000288726900009