論文

査読有り
2012年

Inhibition of ENNG-Induced Pyloric Stomach and Small Intestinal Carcinogenesis in Mice by High Temperature- and Pressure-Treated Garlic

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Takaaki Kaneko
  • ,
  • Kan Shimpo
  • ,
  • Takeshi Chihara
  • ,
  • Hidehiko Beppu
  • ,
  • Akiko Tomatsu
  • ,
  • Masanori Shinzato
  • ,
  • Takamasa Yanagida
  • ,
  • Tsutomu Ieike
  • ,
  • Shigeru Sonoda
  • ,
  • Akihiko Futamura
  • ,
  • Akihiro Ito
  • ,
  • Takashi Higashiguchi

13
5
開始ページ
1983
終了ページ
1988
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.7314/APJCP.2012.13.5.1983
出版者・発行元
ASIAN PACIFIC ORGANIZATION CANCER PREVENTION

High temperature- and pressure-treated garlic (HTPG) has been shown to have enhanced antioxidative activity and polyphenol contents. Previously, we reported that HTPG inhibited 1,2-dimethylhydrazine-induced mucin depleted foci (premalignant lesions) and O-6-methylguanine DNA adduct formation in the rat colorectum. In the present study, we investigated the modifying effects of HTPG on N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG)-induced pyloric stomach and small intestinal carcinogenesis in mice. Male C57BL/6 mice were given ENNG (100 mg/l) in drinking water for the first 4 weeks, then a basal diet or diet containing 2% or 5% HTPG for 30 weeks. The incidence and multiplicity of pyloric stomach and small intestinal (duodenal and jejunal) tumors in the 2% HTPG group (but not in the 5% HTPG group) were significantly lower than those in the control group. Cell proliferation of normal-appearing duodenal mucosa was assessed by MIB-5 immunohistochemistry and shown to be significantly lower with 2% HTPG (but again not 5% HTPG) than in controls. These results in dicate that HTPG, at 2% in the diet, inhibited ENNG-induced pyloric stomach and small intestinal (especially duodenal) tumorigenesis in mice, associated with suppression of cell proliferation.


リンク情報
DOI
https://doi.org/10.7314/APJCP.2012.13.5.1983
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22901158
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000309470100050&DestApp=WOS_CPL

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