講演・口頭発表等

国際会議
2018年9月16日

Workshop in Computational Pathology - Construction of a Generative Model of H&E Stained Pathology Images of Pancreas Tumors Conditioned by a Voxel Value of MRI Image

21st International Conference on Medical Image Computing & Computer Assisted Intervention
  • Tomoshige Shimomura
  • ,
  • Mauricio Kugler

記述言語
英語
会議種別
ポスター発表
開催地
Granada, Spain

In this paper, we propose a method for constructing a multiscale model of pancreas tumor of a KrasLSL.G12D/+; p53R172H/+; PdxCretg/+ (KPC) mouse that is a genetically engineered mouse model of pancreas tumor. The model represents the correlation between the value at each voxel in the MRI image of the tumor and the pathology image patches that are observed at each portion corresponds to the location of the voxel in the MRI image. The model is represented by a cascade of image generators trained by a Laplacian Pyramid of Generative Adversarial Network (LAPGAN). When some voxel in a pancreas tumor region in an MRI image is selected, the cascade of generators outputs patches of the pathology images that can be observed at the location corresponds to the selected voxel. We trained the generators by using an MRI image and a 3D pathology image, the latter was first reconstructed from a spatial series of the 2D pathology images and was then registered to the MRI image.