Yukio Sasaki

Profile Information

Affiliation: 准教授, 機能構造部門機能構造科学研究室, 横浜市立大学大学院生命医科学研究科

Degree: Ph.D.(Kobe University)

J-GLOBAL ID: 201101047494975800
researchmap Member ID: 6000026818

External link: http://en.sasakilab.org

Neuroscience researcher. In 1993, I got PhD degree from Kobe University in research on protein kinase C. After joining a pharmaceutical company, I engaged in the development of an antagonist for vasoconstrictor endothelin. After studying the axon guidance factor semaphorin at Yokohama City University School of Pharmacology, I studied abroad in the United States and engaged in research on RNA binding protein. After returning to Japan, I am currently studying the relationship between RNA binding protein and neural circuit formation.

Research Interests

Research Areas

Research History

Apr, 2013 - Present

Associate Professor, Functional Structure Laboratory, Division of Functional Structure, Yokohama City University Graduate School of Medical Life Scicence
Sep, 2009 - Apr, 2013

Contract Associate Professor, Department of Molecular Neuroscience and Neurobiology, Yokohama City University Graduate School of Medicine
Aug, 2005 - Aug, 2009

Instractor, Department of Cell Biology, Emory University School of Medicine
Sep, 2002 - Jul, 2005

Research associate, Department of Neuroscience, Albert Einstein College of Medicine
Jan, 2001 - Aug, 2002

Lecturer, Department of Pharmacology, Yokohama City University School of Medicine
Apr, 1997 - Jan, 2001

Instractor, Department of Pharmacology, Yokohama City University School of Medicine
Apr, 1993 - Mar, 1997

Research scientist, Ciba-Geigy Japan Limited

Papers

Local Translation in Growth Cones and Presynapses, Two Axonal Compartments for Local Neuronal Functions.

Yukio Sasaki

Biomolecules, 10(5), Apr 25, 2020 Peer-reviewed
Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway.

Masaru Takabatake, Yoshio Goshima, Yukio Sasaki

Frontiers in neural circuits, 14 5-5, 2020 Peer-reviewed
Fragile X mental retardation protein regulates accumulation of the active zone protein Munc18-1 in presynapses via local translation in axons during synaptogenesis

Shumaia Parvin, Renoma Takeda, Yu Sugiura, Makiko Neyazaki, Terukazu Nogi, Yukio Sasaki

Neuroscience Research, 146 36-47, Sep, 2019 Peer-reviewed
Presynapse Formation Assay Using Presynapse Organizer Beads and "Neuron Ball" Culture.

Parvin S, Takeda R, Sasaki Y

Journal of visualized experiments : JoVE, (150), Aug, 2019 Peer-reviewed
Regulation of dendritic development by semaphorin 3A through novel intracellular remote signaling

Yoshio Goshima, Naoya Yamashita, Fumio Nakamura, Yukio Sasaki

CELL ADHESION & MIGRATION, 10(6) 627-640, 2016 Peer-reviewed
Plexin-A4-dependent retrograde semaphorin 3A signalling regulates the dendritic localization of GluA2-containing AMPA receptors

Naoya Yamashita, Hiroshi Usui, Fumio Nakamura, Sandy Chen, Yukio Sasaki, Tomonobu Hida, Fumikazu Suto, Masahiko Taniguchi, Kohtaro Takei, Yoshio Goshima

NATURE COMMUNICATIONS, 5 3424, Mar, 2014 Peer-reviewed
Identification of Axon-Enriched MicroRNAs Localized to Growth Cones of Cortical Neurons

Yukio Sasaki, Christina Gross, Lei Xing, Yoshio Goshima, Gary J. Bassell

DEVELOPMENTAL NEUROBIOLOGY, 74(3) 397-406, Mar, 2014 Peer-reviewed
Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones

Masumi Iketani, Akira Iizuka, Kumiko Sengoku, Yuji Kurihara, Fumio Nakamura, Yukio Sasaki, Yasufumi Sato, Masayuki Yamane, Masayuki Matsushita, Angus C. Nairn, Ken Takamatsu, Yoshio Goshima, Kohtaro Takei

DEVELOPMENTAL NEUROBIOLOGY, 73(3) 230-246, Mar, 2013 Peer-reviewed
Class 3 semaphorins as a therapeutic target

Yoshio Goshima, Yukio Sasaki, Naoya Yamashita, Fumio Nakamura

EXPERT OPINION ON THERAPEUTIC TARGETS, 16(9) 933-944, Sep, 2012 Peer-reviewed
GSK3 beta/Axin-1/beta-Catenin Complex Is Involved in Semaphorin3A Signaling

Tomonobu Hida, Naoya Yamashita, Hiroshi Usui, Fumio Nakamura, Yukio Sasaki, Akira Kikuchi, Yoshio Goshima

JOURNAL OF NEUROSCIENCE, 32(35) 11905-11918, Aug, 2012 Peer-reviewed
Regulation of chemotropic guidance of nerve growth cones by microRNA

Liang Han, Zhexing Wen, Rachel C. Lynn, Marie-Laure Baudet, Christine E. Holt, Yukio Sasaki, Gary J. Bassell, James Q. Zheng

MOLECULAR BRAIN, 4(1) 40, Nov, 2011 Peer-reviewed
CRMP5 (Collapsin Response Mediator Protein 5) Regulates Dendritic Development and Synaptic Plasticity in the Cerebellar Purkinje Cells

Naoya Yamashita, Bedrich Mosinger, Arpita Roy, Mari Miyazaki, Kozue Ugajin, Fumio Nakamura, Yukio Sasaki, Kazuhiko Yamaguchi, Pappachan Kolattukudy, Yoshio Goshima

JOURNAL OF NEUROSCIENCE, 31(5) 1773-1779, Feb, 2011 Peer-reviewed
Phosphorylation of Zipcode Binding Protein 1 Is Required for Brain-Derived Neurotrophic Factor Signaling of Local beta-Actin Synthesis and Growth Cone Turning

Yukio Sasaki, Kristy Welshhans, Zhexing Wen, Jiaqi Yao, Mei Xu, Yoshio Goshima, James Q. Zheng, Gary J. Bassell

JOURNAL OF NEUROSCIENCE, 30(28) 9349-9358, Jul, 2010 Peer-reviewed
Fragile X mental retardation protein is involved in protein synthesis-dependent collapse of growth cones induced by Semaphorin-3A

Chanxia Li, Gary Bassell, Yukio Sasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 112 241P-241P, 2010 Peer-reviewed
Semaphorin3A Signaling Mediated by Fyn-dependent Tyrosine Phosphorylation of Collapsin Response Mediator Protein 2 at Tyrosine 32

Yutaka Uchida, Toshio Ohshima, Naoya Yamashita, Miyuki Ogawara, Yukio Sasaki, Fumio Nakamura, Yoshio Goshima

JOURNAL OF BIOLOGICAL CHEMISTRY, 284(40) 27393-27401, Oct, 2009 Peer-reviewed
Fragile X mental retardation protein is involved in protein synthesis-dependent collapse of growth cones induced by Semaphorin-3A

Chanxia Li, Gary J. Bassell, Yukio Sasaki

FRONTIERS IN NEURAL CIRCUITS, 3, Sep, 2009 Peer-reviewed
Single molecule-sensitive probes for imaging RNA in live cells

Philip J. Santangelo, Aaron W. Lifland, Paul Curt, Yukio Sasaki, Gary J. Bassell, Michael E. Lindquist, James E. Crowe

NATURE METHODS, 6(5) 347-U46, May, 2009 Peer-reviewed
CRMP family protein: Novel targets for Cdk5 that regulates axon guidance, synapse maturation, and cell migration

Yoshio Goshima, Yukio Sasaki, Yutaka Uchida, Naoya Yamashita, Fumio Nakamura

Cyclin Dependent Kinase 5 (Cdk5), 9-24, 2008 Peer-reviewed
Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs

Dianna E. Willis, Erna A. van Niekerk, Yukio Sasaki, Mariano Mesngon, Tanuia I. Merianda, Gervan G. Williams, Marvin Kendall, Deanna S. Smith, Gary J. Bassell, Jeffery L. Twiss

JOURNAL OF CELL BIOLOGY, 178(6) 965-980, Sep, 2007 Peer-reviewed
An essential role for beta-actin mRNA localization and translation in Ca2+-dependent growth cone guidance

Jiaqi Yao, Yukio Sasaki, Zhexing Wen, Gary J. Bassell, James Q. Zheng

NATURE NEUROSCIENCE, 9(10) 1265-1273, Oct, 2006 Peer-reviewed

Misc.

Identification of axon-enriched MicroRNAs localized to growth cones of cortical neurons (vol 74, pg 397, 2014)

Yukio Sasaki, Christina Gross, Lei Xing, Yoshio Goshima, Gary J. Bassell

DEVELOPMENTAL NEUROBIOLOGY, 74(4) 481-481, Apr, 2014
Immunohistochemical examination of OA1, a receptor candidate for L-3,4-dihydroxyphenylalanine, in the CNS

Marina Kamiya, Naoya Yamashita, Yukio Sasaki, Fumio Nakamura, Yoshio Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 118 134P-134P, 2012
Regulation of Local Translation for Neuronal Functions in Axons and Growth Cones

31(6) 677-682, 2012
Semaphorin3A facilitates the axonal transport of PlexinA4 through interaction of PlexinA4 with TrkA

Masayuki Yamane, Naoya Yamashita, Yukio Sasaki, Fumio Nakamura, Yoshio Goshima

NEUROSCIENCE RESEARCH, 71 E119-E119, 2011
Identification of microRNAs enriched in axons and growth cones

Yukio Sasaki, Gary J. Basse, Lei Xing, Christina Gross, Yoshio Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 115 240P-240P, 2011
Brain-derived neurotrophic factor regulates localization of microRNA-720 in growth cones

Yukio Sasaki, Lei Xing, Christina Gross, Yoshio Goshima, Gary J. Bassell

NEUROSCIENCE RESEARCH, 71 E224-E225, 2011
Profiling of microRNAs enriched in axons

Yukio Sasaki, Lei Xing, Christina Gross, Yoshio Goshima, Gary J. Bassell

NEUROSCIENCE RESEARCH, 68 E354-E354, 2010
Semaphorin3A selectively facilitates the axonal transport of its receptor and intracellular signaling molecules

Naoya Yamashita, Taiichirou Gotoh, Hiroshi Usui, Aiko Yamamoto, Yukio Sasaki, Fumio Nakamura, Kohtaro Takei, Yoshio Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 91P-91P, 2008
RNAと神経疾患

佐々木幸生, BASSELL Gary J

Clin Neurosci, 24(8) 950-951, Aug 1, 2006
Semaphorin3A selectively facilitates the axonal transport of its receptor and intracellular signaling molecules

N Yamashita, T Gotoh, H Usui, A Yamamoto, Y Sasaki, F Nakamura, K Takei, Y Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 100 117P-117P, 2006
Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E

CX Li, Y Sasaki, K Takei, H Yamamoto, M Shouji, Y Sugiyama, T Kawakami, F Nakamura, T Yagi, T Ohshima, Y Goshima

JOURNAL OF NEUROSCIENCE, 24(27) 6161-6170, Jul, 2004
Role of local protein synthesis within nerve growth cone in Sema3A-induced neurite retraction and NGF-induced neurite outgrowth

Kohtaro Takei, Chanxia Li, Kumiko Sengoku, Yukio Sasaki, Furnio Nakamura, Yoshio Goshima

CELL STRUCTURE AND FUNCTION, 29 21-21, May, 2004
Signaling at the growth cone and regenerative medicine

Y Goshima, Y Sasaki, F Nakamura, KI Ogura, K Takei

JOURNAL OF PHARMACOLOGICAL SCIENCES, 94 42P-42P, 2004
Phosphorylation of CRMPs by Cdk5 plays a critical role in Semaphorin-3A signaling.

Y Uchida, Y Sasaki, T Fuchikawa, F Nakamura, Y Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 91 127P-127P, 2003
細胞骨格・細胞運動制御の情報伝達神経軸索誘導の分子機序セマフォリンファミリーを中心に

佐々木幸生, 五嶋良郎

月刊メディカル・サイエンス・ダイジェスト, 28(13) 525-529, Dec 25, 2002
Isolation and characterization of a receptor candidate for L-DOPA in Caenorhabditis elegans

Y Goshima, T Miyamae, M Ibi, F Nakamura, Y Sasaki, K Ogura, T Ishihara, Y Misu, Katsura, I

JAPANESE JOURNAL OF PHARMACOLOGY, 88 157P-157P, 2002
ガイダンス分子のシグナル伝達 (特集いかにして脳は作られるのか--神経細胞の形態と運動制御から見たネットワーク形成)

佐々木幸生, 五嶋良郎

細胞工学, 20(4) 530-537, Apr, 2001
前立腺癌の増殖・進展におけるendothelin receptor-Aの発現の意義

郷司和男, 佐々木幸生, 北澤荘平, 玉田博, 三宅秀明, 勝岡洋治, 中島元夫

日本泌尿器科學會雜誌, 92(2), Feb 20, 2001
ラット脳グリア細胞におけるinducible NOS(iNOS)誘導に対するendothelin(ET)の作用

小田温子, 村山俊彦, 佐々木幸生, 岡田敏一, 野村靖幸

神経化学, 35(3) 562-563, Sep 5, 1996
エンドセリン受容体サブタイプ特異的抗体の作成

瀧本京, 堀清次, 佐々木幸生, 大前恭子, 岡田敏一

日本分子生物学会年会プログラム・講演要旨集, 19, Aug, 1996

Books and Other Publications

Cyclin Dependent Kinase 5 (Cdk5)

Nancy Y. Ip, Li-Huei Tsai

Springer, Aug 19, 2008 (ISBN: 0387788867)

Research Projects

Regulation of neural circuit by Fragile X Mental Retardation Protein - its relation to ubiquitination and local translation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019
Role of local protein synthesis regulated by Fragile X Mental Retardation Protein during presynapse formation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

SASAKI Yukio, KAWAKAMI Takao
マイクロRNAの輸送マシナリーの解明と軸索機能における役割

科学研究費補助金(新学術領域研究(研究領域提案型)), 文部科学省, 2012 - 2012

佐々木幸生
軸索ガイダンスにおける成長円錐の自律性と翻訳トランス因子の役割

科学研究費補助金(基盤研究(C)), 文部科学省, 2010 - 2012

佐々木幸生
神経細胞死における成長円錐と細胞体のダイアログ

科学研究費補助金(奨励研究(A), 若手研究(B)), 文部科学省, 2001 - 2002

佐々木幸生
The relation between LAR class protein tyrosine phosphates and Semaphorin-Plexin signaling

Grants-in-Aid for Scientific Research(基盤研究(C)), Ministry of Education, Culture, Sports, Science and Technology, 2001 - 2002

Fumio NAKAMURA, 小倉顕一, 佐々木幸生
軸索伸長抑制因子Nogoの受容体同定とセマフォリンの細胞内情報伝達系の解明

科学研究費補助金(特定領域研究(C)), 文部科学省, 2000 - 2000

中村史雄, 佐々木幸生
コラプシンによる細胞運動抑制とチロシンリン酸化相関の解析

科学研究費補助金(奨励研究(A)), 文部科学省, 1999 - 2000

佐々木幸生
L-DOPA Plays a role as a neurotransmitter regulating blood pressure in the lower brain stem, and endogenously evoked L-DOPA is a casual factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in rats

Grants-in-Aid for Scientific Research(基盤研究(B)), Ministry of Education, Culture, Sports, Science and Technology, 1998 - 1999

三須良実, Yoshio GOSHIMA, 古川信也, 五嶋良郎, 佐々木幸生, 宮前丈明
ドーパはグルタミン酸遊離-神経細胞死の上流因子か? ドーパ新競合的拮抗薬の保護作用

科学研究費補助金(特定領域研究(A)), 文部科学省, 1998 - 1998

三須良實, 古川信也, 宮前丈明, 佐々木幸生, 五嶋良郎

Industrial Property Rights

特開2000-236879 可溶性ニューロピリン

五嶋良郎, 佐々木幸生