Soichiro Yamaguchi

Profile Information

Affiliation: Associate Professor, Graduate School of Veterinary Medicine, Department of Basic Veterinary Sciences, Laboratory of Physiology, Hokkaido University

Degree: Ph.D (Veterinary Medicine)(Mar, 2009, Hokkaido University)

Researcher number: 50596864
J-GLOBAL ID: 201101008731937823
researchmap Member ID: 6000027085

Research Interests

Research Areas

Research History

Aug, 2018 - Present

Associate Professor, Department of Basic Veterinary Sciences, Laboratory of Physiology, Hokkaido University, Faculty of Veterinary Medicine
Nov, 2013 - Aug, 2018

Assistant Professor, Laboratory of Pharmacology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
Oct, 2012 - Oct, 2013

(Specially Appointed) Assistant Professor, Hokkaido University, Graduate School of Veterinary Medicine, Department of Biomedical Science, Laboratory of Pharmacology
Sep, 2010 - Oct, 2012

新潟大学医歯学総合研究科器官生理学分野助教
Apr, 2009 - Aug, 2010

Postdoc Researcher, University of Texas, Southwestern Medical Center at Dallas

Education

Apr, 2005 - Mar, 2009

Graduate School of Veterinary Medicine, Hokkaido University
Apr, 1999 - Mar, 2005

Faculty of Veterinary Medicine, Hokkaido University

Awards

Sep, 2011

生理学・生化学分科会奨励賞, 日本獣医学会生理学・生化学分科会

山口聡一郎

Papers

The cytosolic N-terminal region of heterologously-expressed transmembrane channel-like protein 1 (TMC1) can be cleaved in HEK293 cells.

Soichiro Yamaguchi, Maho Kamino, Maho Hamamura, Ken-Ichi Otsuguro

PloS one, 18(6) e0287249, 2023
Opposing functions of α- and β-adrenoceptors in the formation of processes by cultured astrocytes.

Taisuke Kitano, Ryota Eguchi, Yuko Okamatsu-Ogura, Soichiro Yamaguchi, Ken-Ichi Otsuguro

Journal of pharmacological sciences, 145(3) 228-240, Mar, 2021 Peer-reviewed
Hydrogen sulfide induces Ca2+ release from the endoplasmic reticulum and suppresses ATP-induced Ca2+ signaling in rat spinal cord astrocytes.

Takeshi Nii, Ryota Eguchi, Soichiro Yamaguchi, Ken-Ichi Otsuguro

European journal of pharmacology, 891 173684-173684, Jan 15, 2021 Peer-reviewed
A Mechanosensitive Channel, Mouse Transmembrane Channel-Like Protein 1 (Mtmc1) Is Translated from a Splice Variant mTmc1ex1 but Not from the Other Variant mTmc1ex2.

Soichiro Yamaguchi, Maho Hamamura, Ken-Ichi Otsuguro

International journal of molecular sciences, 21(18), Sep 4, 2020 Peer-reviewed
TRPM4 and TRPM5 Channels Share Crucial Amino Acid Residues for Ca2+ Sensitivity but Not Significance of PI(4,5)P2.

Soichiro Yamaguchi, Akira Tanimoto, Shinsuke Iwasa, Ken-Ichi Otsuguro

International journal of molecular sciences, 20(8), Apr 24, 2019 Peer-reviewed
The α_2A -adrenoceptor subtype plays a key role in the analgesic and sedative effects of xylazine.

Kitano T, Kobayashi T, Yamaguchi S, Otsuguro KI

Journal of veterinary pharmacology and therapeutics, 42(2) 243-247, Mar, 2019 Peer-reviewed
Fibroblast growth factor 2 modulates extracellular purine metabolism by upregulating ecto-5'-nucleotidase and adenosine deaminase in cultured rat spinal cord astrocytes.

Eguchi R, Yamaguchi S, Otsuguro KI

Journal of pharmacological sciences, 139(2) 98-104, Feb, 2019 Peer-reviewed
IL-1β augments H2S-induced increase in intracellular Ca2+ through polysulfides generated from H2S/NO interaction

Ayako Ujike, Tomoki Kuraishi, Soichiro Yamaguchi, Ryota Eguchi, Taisuke Kitano, Jumpei Kamise, Shigeo Ito, Ken-ichi Otsuguro

European Journal of Pharmacology, 821 88-96, Feb 15, 2018 Peer-reviewed
A mechanically activated ion channel is functionally expressed in the MrgprB4 positive sensory neurons, which detect stroking of hairy skin in mice

Soichiro Yamaguchi, Ken-ichi Otsuguro

NEUROSCIENCE LETTERS, 653 139-145, Jul, 2017 Peer-reviewed
Hydrogen sulfide activates TRPA1 and releases 5-HT from epithelioid cells of the chicken thoracic aorta

Dugar Delgermurun, Soichiro Yamaguchi, Osamu Ichii, Yasuhiro Kon, Shigeo Ito, Ken-ichi Otsuguro

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 187 43-49, Sep, 2016 Peer-reviewed
Endogenous 5-HT outflow from chicken aorta by 5-HT uptake inhibitors and amphetamine derivatives

Dugar Delgermurun, Shigeo Ito, Toshio Ohta, Soichiro Yamaguchi, Ken-ichi Otsuguro

JOURNAL OF VETERINARY MEDICAL SCIENCE, 78(1) 71-76, Jan, 2016 Peer-reviewed
An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat

Ken-ichi Otsuguro, Yuki Tomonari, Saori Otsuka, Soichiro Yamaguchi, Yasuhiro Kon, Shigeo Ito

NEUROPHARMACOLOGY, 97 160-170, Oct, 2015 Peer-reviewed
Bidirectional effects of hydrogen sulfide via ATP-sensitive K+ channels and transient receptor potential A1 channels in RIN14B cells

Ayako Ujike, Ken-ichi Otsuguro, Ryo Miyamoto, Soichiro Yamaguchi, Shigeo Ito

EUROPEAN JOURNAL OF PHARMACOLOGY, 764 463-470, Oct, 2015 Peer-reviewed
Contribution of alpha(2A)-adrenoceptor subtype to effect of dexmedetomidine and xylazine on spinal synaptic transmission of mice

Takeshi Kobayashi, Ken-ichi Otsuguro, Soichiro Yamaguchi, Shigeo Ito

EUROPEAN JOURNAL OF PHARMACOLOGY, 761 321-329, Aug, 2015 Peer-reviewed
Neuronal regulation of expression of hydrogen sulfide-producing enzyme cystathionine beta-synthase in rat spinal cord astrocytes

Ryo Miyamoto, Ken-ichi Otsuguro, Soichiro Yamaguchi, Shigeo Ito

NEUROSCIENCE RESEARCH, 97 52-59, Aug, 2015 Peer-reviewed
Different mechanisms of extracellular adenosine accumulation by reduction of the external Ca2+ concentration and inhibition of adenosine metabolism in spinal astrocytes

Ryota Eguchi, Sanae Akao, Ken-ichi Otsuguro, Soichiro Yamaguchi, Shigeo Ito

JOURNAL OF PHARMACOLOGICAL SCIENCES, 128(1) 47-53, May, 2015 Peer-reviewed
Negatively Charged Amino Acids Near and in Transient Receptor Potential (TRP) Domain of TRPM4 Channel Are One Determinant of Its Ca2+ Sensitivity

Soichiro Yamaguchi, Akira Tanimoto, Ken-ichi Otsuguro, Hiroshi Hibino, Shigeo Ito

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(51) 35265-35282, Dec, 2014 Peer-reviewed
Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons

Ryo Miyamoto, Ken-ichi Otsuguro, Soichiro Yamaguchi, Shigeo Ito

JOURNAL OF NEUROCHEMISTRY, 130(1) 29-40, Jul, 2014 Peer-reviewed
AHCYL2 (long-IRBIT) as a potential regulator of the electrogenic Na+-HCO3- cotransporter NBCe1-B

Soichiro Yamaguchi, Toru Ishikawa

FEBS LETTERS, 588(5) 672-677, Mar, 2014 Peer-reviewed
The mechanism underlying maintenance of the endocochlear potential by the K+ transport system in fibrocytes of the inner ear

Naoko Adachi, Takamasa Yoshida, Fumiaki Nin, Genki Ogata, Soichiro Yamaguchi, Toshihiro Suzuki, Sizuo Komune, Yasuo Hisa, Hiroshi Hibino, Yoshihisa Kurachi

JOURNAL OF PHYSIOLOGY-LONDON, 591(18) 4459-4472, Sep, 2013 Peer-reviewed

Misc.

牛耳下腺腺房細胞の管腔側膜にCI-/HCO3-交換輸送体であるSLC26A6が機能発現する

井上龍生, 山口聡一郎, 矢野沙織[梨本]

日本獣医学会学術集会講演要旨集, 164回 [IO-27], Sep, 2021
強制発現系におけるtransmembrane channel-like protein 1(TMC1)の細胞内N端領域の核移行と転写調節(A cytosolic N-terminal region of Transmembrane Channel-like protein 1 (TMC1) is cleaved and imported into the nucleus in an overexpression system)

Yamaguchi Soichiro, Kamino Maho, Hamamura Maho, Otsuguro Ken-ichi

The Journal of Physiological Sciences, 70(Suppl.1) S107-S107, Mar, 2020
TMC1の細胞内N端領域における核移行機序および切断部位の同定

神野真帆, 濱村眞帆, 山口聡一郎, 乙黒兼一

日本獣医学会学術集会講演要旨集, 162回 497-497, Aug, 2019
アストロサイトの突起形成におけるα2アドレナリン受容体の役割

北野泰佑, 江口遼太, 山口聡一郎, 乙黒兼一

日本獣医学会学術集会講演要旨集, 162回 499-499, Aug, 2019
ラット脊髄アストロサイトにおけるH2S誘発性Ca2+上昇機構

新居剛, 江口遼太, 山口聡一郎, 乙黒兼一

日本獣医学会学術集会講演要旨集, 162回 499-499, Aug, 2019
TRPM4およびTRPM5チャネルのCa2+結合部位に関する機能分析(Functional analyses for a Ca2+ binding site of TRPM4 and TRPM5 channels)

Yamaguchi Soichiro, Tanimoto Akira, Iwasa Shinsuke, Otsuguro Ken-ichi

The Journal of Physiological Sciences, 69(Suppl.1) S166-S166, Jun, 2019
FGF2によるアストロサイトの細胞外アデノシンデアミナーゼ発現および活性の増強作用

江口遼太, 山口聡一郎, 乙黒兼一

日本獣医学会学術集会講演要旨集, 161回 465-465, Aug, 2018
低Ca2+によるアストロサイトの細胞外アデノシン蓄積に対するFGF2の影響

江口遼太, 山口聡一郎, 乙黒兼一

日本獣医学会学術集会講演要旨集, 160回 503-503, Aug, 2017
キシラジンによるブタα2Aアドレナリン受容体活性化作用

北野泰佑, 小林武志, 山口聡一郎, 乙黒兼一

日本獣医学会学術集会講演要旨集, 160回 503-503, Aug, 2017
鶏胸大動脈におけるグロムス細胞からの5-HT放出に対するH2Sの作用(Effect of H2S on 5-HT release from glomus cells in the chicken thoracic aorta)

Delgermurun Dugar, 山口聡一郎, 市居修, 昆泰寛, 伊藤茂男, 乙黒兼一

日本獣医学会学術集会講演要旨集, 159回 495-495, Aug, 2016
5-HT取り込み阻害剤とamphetamine誘導体がトリ大動脈体の5-HT流出に与える影響(Effects of 5-HT uptake inhibitors and amphetamine derivatives on 5-HT outflow from chicken aortic body)

Dugar Delgermurun, Ito Shigeo, Yamaguchi Soichiro, Ohta Toshio, Otsuguro Ken-ichi

Journal of Pharmacological Sciences, 130(3Suppl.) S190-S190, Mar, 2016
ラット脊髄アストロサイトでの虚血刺激によるadenosineの細胞外蓄積(Extracellular accumulation of adenosine by ischemic stimulations in rat spinal astrocytes)

Eguchi Ryota, Yamaguchi Soichiro, Otsuguro Ken-ichi

Journal of Pharmacological Sciences, 130(3Suppl.) S227-S227, Mar, 2016
炎症性サイトカインがRIN14B細胞におけるH2S誘発性のCa2+反応に及ぼす影響(Effect of pro-inflammatory cytokine on H2S-induced Ca2+ responses in RIN14B cells)

Ujike Ayako, Yamaguchi Soichiro, Ito Shigeo, Otsuguro Ken-ichi

Journal of Pharmacological Sciences, 130(3Suppl.) S251-S251, Mar, 2016
MrgprB4陽性後根神経節神経における細胞膨張によるCa2+流入経路(A swelling-induced Ca2+ entry pathway in MrgprB4+ dorsal root ganglion neurons)

Yamaguchi Soichiro, Otsuguro Ken-ichi

The Journal of Physiological Sciences, 66(Suppl.1) S159-S159, Mar, 2016
ラット脊髄における硫化水素産生酵素CBSの発現はニューロンにより維持される

宮本亮, 乙黒兼一, 山口聡一郎, 伊藤茂男

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [1P0515]-[1P0515], Dec, 2015
ニューロンによるラット脊髄アストロサイトの硫化水素産生酵素の発現調節

宮本亮, 乙黒兼一, 山口聡一郎, 伊藤茂男

日本獣医学会学術集会講演要旨集, 158回 436-436, Aug, 2015
5-HT取り込み阻害剤とアンフェタミン誘導体による鶏大動脈からの5-HT流出(5-HT outflow from chicken aorta by 5-HT uptake inhibitors and amphetamine derivatives)

Dugar Delgermurun, 山口聡一郎, 太田利男, 乙黒兼一, 伊藤茂男

日本獣医学会学術集会講演要旨集, 158回 436-436, Aug, 2015
ラット脊髄アストロサイトにおける細胞外Ca2+低下によるアデノシンの細胞外蓄積に対するギャップ結合ヘミチャネルの関与(Gap junction hemichannels contribute to extracellular accumulation of adenosine by external Ca2+ reduction in rat spinal astrocytes)

Eguchi Ryota, Akao Sanae, Otsuguro Ken-ichi, Yamaguchi Soichiro, Ito Shigeo

Journal of Pharmacological Sciences, 128(3Suppl.) S157-S157, Jul, 2015
ラット脊髄アストロサイトにおける硫化水素産生は神経シグナルにより制御される(Hydrogen sulfide production is controled by neuronal signals in rat spinal cord astrrocytes)

Miyamoto Ryo, Otsuguro Ken-ichi, Yamaguchi Soichiro, Ito Shigeo

Journal of Pharmacological Sciences, 128(3Suppl.) S158-S158, Jul, 2015
TRPM4チャネルの一過性受容器電位(TRP)ドメイン内及び近辺の酸性アミノ酸はその正常なCa2+感受性の維持に必要である(Acidic amino acids near and in Transient Receptor Potential (TRP) domain of TRPM4 channel are required for maintaining its normal Ca2+ sensitivity)

Yamaguchi Soichiro, Tanimoto Akira, Otsuguro Ken-ichi, Hibino Hiroshi, Ito Shigeo

The Journal of Physiological Sciences, 65(Suppl.1) S113-S113, Mar, 2015

Professional Memberships

Research Projects

熱産生する褐色脂肪細胞に新規H+チャネルが高発現する生理的意義の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2026

山口聡一郎, 岡松優子
Research on a possible novel transcriptional regulation by a membrane protein

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2020

Yamaguchi Soichiro
Gliotransmitter release and its protective effects in spinal astrocytes

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Otsuguro Ken-ichi, YAMAGUCHI Soichiro
Molecular mechanisms of pleasant tactile sensation.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2014 - 2015

YAMAGUCHI Soichiro
Research on the system of pH regulation in endocochlear epithelium

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2011

YAMAGUCHI Soichiro, HIBINO Hiroshi, YAMAGUCHI Kenichi
ウシ耳下腺でのナトリウム重炭酸イオン共輸送体の分子基盤の解明:複合体形成の可能性

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2006 - 2008

山口聡一郎

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