2020年5月
Chemical Synthesis and Biological Effect on Xylem Formation of Xylemin and Its Analogues
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 2020
- 号
- 18
- 開始ページ
- 2745
- 終了ページ
- 2753
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/ejoc.202000322
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
Xylemin (6) and its designed structural analogues 18-23, N-(4-aminobutyl)alkylamines, were synthesized by 2-nitrobenzenesulfonamide (Ns) strategy. Investigation of the improved synthesis of 20-23 resulted in the development of one-step synthesis of these analogues from the commercially available corresponding ketones. Biological assessment of the synthetic molecules elucidated that xylemin (6) and the analogue N-(4-aminobutyl)cyclopentylamine (21) promoted the expression level of thermospermine synthase ACAULIS5 (ACL5) and enhanced xylem formation. In addition, xylemin (6) was found to significantly promote lateral root formation, whereas xylemin analogues 18-23 including 21 did not. These results indicate that the analogue 21 has the potential as a novel inhibitor of thermospermine synthesis to work specifically in xylem differentiation.
- リンク情報
- ID情報
-
- DOI : 10.1002/ejoc.202000322
- ISSN : 1434-193X
- eISSN : 1099-0690
- Web of Science ID : WOS:000526147300001