2011年11月
Study of the Response of Superoxide Dismutase in Mouse Organs to Radon Using a New Large-scale Facility for Exposing Small Animals to Radon
JOURNAL OF RADIATION RESEARCH
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- 巻
- 52
- 号
- 6
- 開始ページ
- 775
- 終了ページ
- 781
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1269/jrr.10072
- 出版者・発行元
- JAPAN RADIATION RESEARCH SOC
We examined dose dependent or dose rate dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m(3) for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day.Bq/m(3), activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on, radon effects.
- リンク情報
- ID情報
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- DOI : 10.1269/jrr.10072
- ISSN : 0449-3060
- eISSN : 1349-9157
- Web of Science ID : WOS:000297565800011