2015年12月
Combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice
JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY
- ,
- ,
- ,
- ,
- 巻
- 52
- 号
- 12
- 開始ページ
- 1512
- 終了ページ
- 1518
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1080/00223131.2015.1014875
- 出版者・発行元
- TAYLOR & FRANCIS LTD
It has been reported that radon inhalation activates antioxidative functions in liver and has an antioxidative effect against hepatopathy similar to that of the antioxidative effects of ascorbic acid (VC) or -tocopherol (VE). In this study, we examined the combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice. ICR mice were subjected to intraperitoneal (i.p.) administration of alcohol after pretreating with air only (sham) or radon at a concentration of approximately 2000 Bq/m(3) for 24 hours and i.p. administration of VC (300 mg/kg body weight) or VE (300 mg/kg body weight). In mice injected with alcohol, the combined radon and antioxidant vitamins treatment significantly decreased the activities of glutamic oxaloacetic transaminase in serum compared to not only the alcohol-administered group (sham group), but also the radon inhalation with alcohol administration group or the vitamin and alcohol administration group. In addition, radon inhalation significantly increased the antioxidant level, in such as the catalase activity and the total glutathione content in liver compared to the sham group. These results suggested that the combined radon and antioxidant vitamin treatment could effectively inhibit alcohol-induced hepatopathy in mice without any antagonizing action.
- リンク情報
- ID情報
-
- DOI : 10.1080/00223131.2015.1014875
- ISSN : 0022-3131
- eISSN : 1881-1248
- Web of Science ID : WOS:000362845300007