Arasaki Kohei

Profile Information

Affiliation: School of Life Science, Tokyo University of Pharmacy and Life Science

J-GLOBAL ID: 201101099574664147
researchmap Member ID: 6000027957

External link: http://www.ls.toyaku.ac.jp/Life-Science/lmcb-6/

Research Interests

Research Areas

Research History

Apr, 2018 - Present

School of Life Science, Tokyo University of Pharmacy and Life Sciences
Apr, 2015 - Mar, 2018

School of Life Science, Tokyo University of Pharmacy and Life Sciences
Apr, 2011 - Mar, 2015

School of Life Science, Tokyo University of Pharmacy and Life Sciences
Apr, 2007 - Mar, 2011

博士研究員, 医学部・感染症発症部門, Yale大学
Apr, 2006 - Mar, 2007

School of Life Science, Tokyo University of Pharmacy and Life Sciences

Education

Apr, 2003 - Mar, 2006

Graduate School of Life Science, Tokyo University of Pharmacy and Life Sciences
Apr, 2001 - Mar, 2003

Graduate School of Life Science, Tokyo University of Pharmacy and Life Sciences
Apr, 1998 - Mar, 2001

School of Life Science, School of Life Science, Tokyo University of Pharmacy and Life Sciences

Awards

Dec, 2017

奨励賞, 小胞体SNAREの多様な生理機能, 日本生化学会

新崎恒平

Papers

Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics

Tomoko Kubori, Kohei Arasaki, Tomoe Kitao, Hiroki Nagai

Aug 8, 2023
Requirement of phosphatidic acid binding for distribution of the bacterial protein Lpg1137 targeting syntaxin 17.

Misaki Murata, Riku Kanamori, Tomoe Kitao, Tomoko Kubori, Hiroki Nagai, Mitsuo Tagaya, Kohei Arasaki

Journal of cell science, 135(6), Mar 15, 2022
Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms

Shun Kato, Kohei Arasaki, Natsuki Tokutomi, Yuzuru Imai, Tsuyoshi Inoshita, Nobutaka Hattori, Taeko Sasaki, Miyuki Sato, Yuichi Wakana, Hiroki Inoue …

Journal of Cell Science, 134(22), Nov 15, 2021
Protocol for imaging proteins associated with Legionella-containing vacuoles in host cells.

Tomoe Kitao, Kohei Arasaki, Hiroki Nagai, Tomoko Kubori

STAR protocols, 2(2) 100410-100410, Jun 18, 2021
Legionella hijacks the host Golgi-to-ER retrograde pathway for the association of Legionella-containing vacuole with the ER.

Mio Kawabata, Honoka Matsuo, Takumi Koito, Misaki Murata, Tomoko Kubori, Hiroki Nagai, Mitsuo Tagaya, Kohei Arasaki

PLoS pathogens, 17(3) e1009437, Mar, 2021
The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites.

Yuichi Wakana, Kaito Hayashi, Takumi Nemoto, Chiaki Watanabe, Masato Taoka, Jessica Angulo-Capel, Maria F Garcia-Parajo, Hidetoshi Kumata, Tomonari Umemura, Hiroki Inoue …

The Journal of cell biology, 220(1), Jan 4, 2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena …

Autophagy, 17(1) 1-382, Jan, 2021
Legionella Manipulates Non-canonical SNARE Pairing Using a Bacterial Deubiquitinase.

Tomoe Kitao, Kyoichiro Taguchi, Shintaro Seto, Kohei Arasaki, Hiroki Ando, Hiroki Nagai, Tomoko Kubori

Cell reports, 32(10) 108107-108107, Sep 8, 2020
MT1-MMP recruits the ER-Golgi SNARE Bet1 for efficient MT1-MMP transport to the plasma membrane.

Takuya Miyagawa, Kana Hasegawa, Yoko Aoki, Takuya Watanabe, Yuka Otagiri, Kohei Arasaki, Yuichi Wakana, Kenichi Asano, Masato Tanaka, Hideki Yamaguchi …

The Journal of cell biology, 218(10) 3355-3371, Oct 7, 2019 Peer-reviewed
Syntaxin 17 Recruits ACSL3 to Lipid Microdomains in Lipid Droplet Biogenesis

Hana Kimura, Kohei Arasaki, Moe Iitsuka, Mitsuo Tagaya

Contact, Apr, 2019 Peer-reviewed
Legionella remodels the plasma membrane-derived vacuole by utilizing exocyst components as tethers.

Kohei Arasaki, Hana Kimura, Mitsuo Tagaya, Craig R Roy

The Journal of cell biology, 217(11) 3863-3872, Nov 5, 2018 Peer-reviewed
Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy.

Masashi Sugo, Hana Kimura, Kohei Arasaki, Toshiki Amemiya, Naohiko Hirota, Naoshi Dohmae, Yuzuru Imai, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Nobutaka Hattori …

The EMBO journal, 37(21), Nov 2, 2018 Peer-reviewed
MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules.

Kohei Arasaki, Haruki Nagashima, Yuri Kurosawa, Hana Kimura, Naoki Nishida, Naoshi Dohmae, Akitsugu Yamamoto, Shigeru Yanagi, Yuichi Wakana, Hiroki Inoue …

EMBO reports, 19(8), Aug, 2018 Peer-reviewed
Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3.

Hana Kimura, Kohei Arasaki, Yuki Ohsaki, Toyoshi Fujimoto, Takayuki Ohtomo, Junji Yamada, Mitsuo Tagaya

Journal of lipid research, 59(5) 805-819, May, 2018 Peer-reviewed
Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.

Kohei Arasaki, Yumi Mikami, Stephanie R Shames, Hiroki Inoue, Yuichi Wakana, Mitsuo Tagaya

Nature communications, 8 15406-15406, May 15, 2017 Peer-reviewed
Regulation of Mitochondrial Dynamics and Autophagy by the Mitochondria-Associated Membrane.

Mitsuo Tagaya, Kohei Arasaki

Advances in experimental medicine and biology, 997 33-47, 2017 Peer-reviewed
Legionella blocks autophagy by cleaving STX17 (syntaxin 17).

Kohei Arasaki, Mitsuo Tagaya

Autophagy, 13(11) 2008-2009, 2017 Peer-reviewed
CARTS biogenesis requires VAP-lipid transfer protein complexes functioning at the endoplasmic reticulum-Golgi interface.

Yuichi Wakana, Richika Kotake, Nanako Oyama, Motohide Murate, Toshihide Kobayashi, Kohei Arasaki, Hiroki Inoue, Mitsuo Tagaya

Molecular biology of the cell, 26(25) 4686-99, Dec 15, 2015 Peer-reviewed
γ-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways.

Hiroki Inoue, Yuka Matsuzaki, Ayaka Tanaka, Kaori Hosoi, Kaoru Ichimura, Kohei Arasaki, Yuichi Wakana, Kenichi Asano, Masato Tanaka, Daisuke Okuzaki …

Journal of cell science, 128(15) 2781-94, Aug 1, 2015 Peer-reviewed
A role for the ancient SNARE syntaxin 17 in regulating mitochondrial division.

Kohei Arasaki, Hiroaki Shimizu, Hirofumi Mogari, Naoki Nishida, Naohiko Hirota, Akiko Furuno, Yoshihisa Kudo, Misuzu Baba, Norio Baba, Jinglei Cheng …

Developmental cell, 32(3) 304-17, Feb 9, 2015 Peer-reviewed

Misc.

Syntaxin 17 promotes lipid droplet formation by regulating the distribution of ACSL3, a key enzyme for lipid droplet biogenesis.

H. Kimura, K. Arasaki, M. Tagaya

MOLECULAR BIOLOGY OF THE CELL, 27, 2016
MAP1B-LC1 regulates autophagosome formation by interacting with the autophagy-related SNARE syntaxin 17.

K. Arasaki, M. Tagaya, N. Dohmae, Y. Kurosawa, H. Nagashima

MOLECULAR BIOLOGY OF THE CELL, 27, 2016
Host SNAREs mediate fusion of vacuoles containing Legionella pneumophila with vesicles exiting the endoplasmic reticulum

Kohei Arasaki, Craig Roy

FASEB JOURNAL, 23, Apr, 2009

Professional Memberships

Research Projects

Management of PLAMP research

Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (B), Grant-in-Aid for Transformative Research Areas (B), Japan Society for the Promotion of Science, Oct, 2020 - Mar, 2023
レジオネラの宿主細胞内における自己化PLAMPの解明

科学研究費助成事業学術変革領域研究(B), 学術変革領域研究(B), 日本学術振興会, Oct, 2020 - Mar, 2023

新崎恒平
Identification of intracellular survival mechanisms of Legionella inside the host cell

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Arasaki Kohei
病原菌感染や結合タンパク質を介したsyntaxin17の生理機能の解明

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2016 - Mar, 2018

新崎恒平
Analysis of intracellular pathogenic pathway of Legionella pneumophila

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Arasaki Kohei
レジオネラ菌によるSyntaxin17分解機構とその生理的意義の解明

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2014 - Mar, 2016

新崎恒平
Roles of syntaxin 17 in the formation and function of the mitochondria-associated ER membrane

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

TAGAYA MITSUO, INOUE Hiroki, HASHIMOTO Yoshitami, ARASAKI Kohei
Analysis of intracellular pathogenesis of Legionella in the host

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

ARASAKI Kohei
紡錘体形成チェックポイントに関与するZW10の間期における機能とその活性制御機構

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2005 - 2006

新崎恒平
レジオネラ菌感染におけるLCV膜とER小胞との繋留及び融合反応の解明

Profile Information

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Research Areas

Research History

Education

Awards

Papers

Misc.

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