NAKANO HARUO

Profile Information

Affiliation: School of Life Science, Tokyo University of Pharmacy and Life Sciences

J-GLOBAL ID: 201101013624721994
researchmap Member ID: 6000027966

Research Interests

Research Areas

Life sciences / Molecular biology /

Research History

Apr, 2012 - Present

School of Life Science, Tokyo University of Pharmacy and Life Sciences
Nov, 2010 - Mar, 2012

School of Life Science, Tokyo University of Pharmacy and Life Sciences
Oct, 2006 - Oct, 2010

嘱託社員, 協和発酵キリン（株）
Jul, 2004 - Sep, 2006

ポストドクター研究員, カルガリー大学
Jan, 2002 - Jun, 2004

日本学術振興会科学技術特別研究員, 農業生物資源研究所
Feb, 1999 - Dec, 2001

科学技術振興事業団重点支援研究員, 農業生物資源研究所
Apr, 1998 - Jan, 1999

非常勤講師, 国立生理学研究所

Education

Apr, 1995 - Mar, 1998

The Graduate University for Advanced Studies
Apr, 1993 - Mar, 1995

Tohoku University
Apr, 1989 - Mar, 1993

Faculty of Agriculture, Tohoku University

Papers

Nescient helix-loop-helix 1 (Nhlh1) is a novel activating transcription factor 5 (ATF5) target gene in olfactory and vomeronasal sensory neurons in mice.

Chiharu Ishii, Haruo Nakano, Riko Higashiseto, Yusaku Ooki, Mariko Umemura, Shigeru Takahashi, Yuji Takahashi

Cell and tissue research, 396(1) 85-94, Apr, 2024 Peer-reviewedCorresponding author
Activating transcription factor 5 (ATF5) controls intestinal tuft and goblet cell expansion upon succinate-induced type 2 immune responses in mice.

Haruo Nakano, Ayano Hata, Usato Ishimura, Ryo Kosugi, Eina Miyamoto, Kota Nakamura, Takumi Muramatsu, Moe Ogasawara, Motohiro Yamada, Mariko Umemura …

Cell and tissue research, 393(2) 343-355, May 31, 2023 Peer-reviewedLead authorCorresponding author
Functional validation of epitope-tagged ATF5 knock-in mice generated by improved genome editing of oviductal nucleic acid delivery (i-GONAD).

Haruo Nakano, Shiori Kawai, Yusaku Ooki, Tomoki Chiba, Chiharu Ishii, Takumi Nozawa, Hisako Utsuki, Mariko Umemura, Shigeru Takahashi, Yuji Takahashi

Cell and tissue research, 385(1) 239-249, Jul, 2021 Peer-reviewedLead authorCorresponding author
Co-expression of C/EBPγ and ATF5 in mouse vomeronasal sensory neurons during early postnatal development.

Nakano H, Iida Y, Murase T, Oyama N, Umemura M, Takahashi S, Takahashi Y

Cell and tissue research, 378(3) 427-440, Jul, 2019 Peer-reviewedLead authorCorresponding author
Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice

Mariko Umemura, Tae Ogura, Ayako Matsuzaki, Haruo Nakano, Keizo Takao, Tsuyoshi Miyakawa, Yuji Takahashi

FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 11 125, Jul, 2017 Peer-reviewed
Two Alkaloids from Bulbs of Lycoris sanguinea M-AXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB

Young Sook Yun, Miki Tajima, Shigeru Takahashi, Yuji Takahashi, Mariko Umemura, Haruo Nakano, Hyun Sun Park, Hideshi Inoue

PHYTOTHERAPY RESEARCH, 30(10) 1689-1695, Oct, 2016 Peer-reviewed
Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons

Haruo Nakano, Yoshitaka Iida, Makoto Suzuki, Marie Aoki, Mariko Umemura, Shigeru Takahashi, Yuji Takahashi

CELL AND TISSUE RESEARCH, 363(3) 621-633, Mar, 2016 Peer-reviewedLead author
Activating transcription factor 5 is required for mouse olfactory bulb development via interneuron

Mariko Umemura, Kanako Tsunematsu, Yusuke I. Shimizu, Haruo Nakano, Shigeru Takahashi, Yasutomo Higashiura, Masaru Okabe, Yuji Takahashi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 79(7) 1082-1089, Jul, 2015 Peer-reviewed
N-terminal Hydrophobic Amino Acids of Activating Transcription Factor 5 (ATF5) Protein Confer Interleukin 1 beta (IL-1 beta)-induced Stabilization

Takanori Abe, Masaki Kojima, Satoshi Akanuma, Hiromi Iwashita, Takashi Yamazaki, Ryuichi Okuyama, Kenji Ichikawa, Mariko Umemura, Haruo Nakano, Shigeru Takahashi …

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(7) 3888-3900, Feb, 2014 Peer-reviewed
The 5 '-untranslated region regulates ATF5 mRNA stability via nonsense-mediated mRNA decay in response to environmental stress

Masaya Hatano, Mariko Umemura, Natsumi Kimura, Takashi Yamazaki, Hitoshi Takeda, Haruo Nakano, Shigeru Takahashi, Yuji Takahashi

FEBS JOURNAL, 280(18) 4693-4707, Sep, 2013 Peer-reviewed
Gain-of-function microRNA screens identify miR-193a regulating proliferation and apoptosis in epithelial ovarian cancer cells

Haruo Nakano, Yoji Yamada, Tatsuya Miyazawa, Tetsuo Yoshida

INTERNATIONAL JOURNAL OF ONCOLOGY, 42(6) 1875-1882, Jun, 2013 Peer-reviewedLead author
A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta

Jinhua Lu, Shuang Zhang, Haruo Nakano, David G. Simmons, Shumin Wang, Shuangbo Kong, Qiang Wang, Lianju Shen, Zhaowei Tu, Weixiang Wang …

PLoS Biology, 11(4) e1001536, Apr, 2013 Peer-reviewed
A potent 2 '-O-methylated RNA-based microRNA inhibitor with unique secondary structures

Takeshi Haraguchi, Haruo Nakano, Takanobu Tagawa, Tokimitsu Ohki, Yoshihito Ueno, Tetsuo Yoshida, Hideo Iba

NUCLEIC ACIDS RESEARCH, 40(8) e58, Apr, 2012 Peer-reviewed
Functional screening identifies a microRNA, miR-491 that induces apoptosis by targeting Bcl-X-L in colorectal cancer cells

Haruo Nakano, Tatsuya Miyazawa, Keita Kinoshita, Yoji Yamada, Tetsuo Yoshida

INTERNATIONAL JOURNAL OF CANCER, 127(5) 1072-1080, Sep, 2010 Peer-reviewedLead author
Gene expression and maintenance of pregnancy in bovine: Roles of trophoblastic binucleate cell-specific molecules

Kazuyoshi Hashizume, Koichi Ushizawa, Osman V. Patel, Keiichiro Kizaki, Kei Imai, Osamu Yamada, Haruo Nakano, Toru Takahashi

REPRODUCTION FERTILITY AND DEVELOPMENT, 19(1) 79-90, 2007 Peer-reviewed
Branching morphogenesis during development of placental villi

James C. Cross, Haruo Nakano, David R. C. Natale, David G. Simmons, Erica D. Watson

DIFFERENTIATION, 74(7) 393-401, Sep, 2006 Peer-reviewed
Bovine trophoblast cell culture systems: a technique to culture bovine trophoblast cells without feeder cells.

Hashizume K, Shimada A, Nakano H, Takahashi T

Methods in molecular medicine, 121 179-188, 2006 Peer-reviewed
The cytoplasmic expression of E-cadherin and beta-catenin in bovine trophoblasts during binucleate cell differentiation

H Nakano, A Shimada, K Imai, T Takahashi, K Hashizume

PLACENTA, 26(5) 393-401, May, 2005 Peer-reviewedLead authorCorresponding author
Differential regulation of the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases by cytokines and growth factors in bovine endometrial stromal cells and trophoblast cell line BT-1 in vitro

M Hirata, T Sato, M Tsumagari, A Shimada, H Nakano, K Hashizume, A Ito

BIOLOGY OF REPRODUCTION, 68(4) 1276-1281, Apr, 2003 Peer-reviewed
ATP-evoked increase in intracellular calcium via the P2Y receptor in proliferating bovine trophoblast cells

H Nakano, A Shimada, K Imai, T Takahashi, K Hashizume

CELL AND TISSUE RESEARCH, 313(2) 227-236, 2003 Peer-reviewedLead author

Misc.

Transcription factor ATF5 controls the maturation and survival of mouse vomeronasal sensory neurons

Haruo Nakano, Yoshitaka Iida, Marie Aoki, Makoto Suzuki, Miyu Yamamoto, Takahiro Murase, Mariko Umemura, Shigeru Takahashi, Yuji Takahashi

CHEMICAL SENSES, 41(9) E152-E152, Nov, 2016
DYNAMICS OF IMPLANTATION AND PLACENTAL FORMATION IN THE BONIVE : ROLE OF THE BINUCLEATE CELL

HASHIZUME Kazuyoshi, NAKANO Haruo, IMAI Kei, TAKAHASHI Toru

(17) 11-11, Dec 1, 2002
子宮内膜および栄養膜細胞におけるEMMPRINの発現とその分子機能解析

平田美智子, 佐藤隆, 野口泰, 原鐵晃, 大濱紘三, 中野春男, 嶋田新, 橋爪一善, 伊東晃

Connective tissue, 34(1) 73-73, Apr, 2002
Establishment of in vitro co-culture system of bovine endometrial fibroblasts, epithelial cells, and trophoblasts and the regulation of matrix metalloproteinases and their inhibitors, timps production in the co-culture.

M Hirata, T Sato, A Shimada, H Nakano, K Hashizume, A Ito

BIOLOGY OF REPRODUCTION, 66 321-321, 2002
コラーゲンゲル培養によるウシ栄養膜細胞の二核細胞への分化誘導

中野春男, 嶋田新, 今井敬, 竹澤俊明, 高橋透, 橋爪一善

日本細胞生物学会大会講演要旨集, 54回 63-63, May, 2001

Professional Memberships

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Research Projects

腸刷子細胞の２型免疫応答に関わるストレス応答因子 ATF5 の新規機能の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

中野春男
Starvation stress-responsive transcription factor is involved in the regulation of memory-independent social behavior of mouse

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

TAKAHASHI YUJI, MARIKO Umemura, HARUO Nakano

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