A microstructure evolution based on the processing and heat-treatment conditions was investigated for Ti-13Al-2Nb-2Zr (at%) alloy, which has a promising oxidation resistance. Three processing temperatures, 900 degrees C and 1000 degrees C in the alpha+beta phase field, and 1080 degrees C in the beta phase field, and two rolling reduction ratios, 93% and 67%, were selected as the processing conditions. In the samples processed and heat-treated in the alpha+beta phase field, an almost fully equiaxed structure, i.e., the equiaxed or ellipsoid alpha phase surrounded by the beta phase, was formed through furnace cooling, and a bi-modal structure was formed using air cooling. The morphology of the alpha phase in the near fully equiaxed and lamellar structure depends on the rolling reduction ratio; in other words, the equiaxed and ellipsoid alpha phases are formed at rolling reduction ratios of 93% and 67%, respectively. The volume fraction of the equiaxed alpha phase in the bi-modal structure is processed at 900 degrees C, which is higher than that of the bi-modal structure processed at 1000 degrees C despite the same heat-treatment temperature applied. This is because the induced strain when processed at 1000 degrees C is smaller than that when processed at 900 degrees C. By contrast, in the samples processed in the beta phase field and heat-treated in either the alpha+beta or beta phase field, a lamellar structure is formed. The creep behavior of the bi-modal structure obtained upon processing at 900 degrees C and 1000 degrees C for up to a 93% rolling reduction ratio was investigated. The creep life of the sample processed at 1000 degrees C was two-times longer than the sample processed at 900 degrees C. This is because a smaller volume fraction of the equiaxed alpha phase in the sample processed at 1000 degrees C than that of the sample processed at 900 degrees C.