TOMOYOSHI KOMIYAMA

Profile Information

Affiliation: 准教授, 医学部, 東海大学

Degree: 理学(Mar, 2004, 総合研究大学院大学)

Researcher number: 60439685
ORCID ID: https://orcid.org/0000-0003-2138-0084
J-GLOBAL ID: 201101062586726481
researchmap Member ID: 6000028420

External link: https://www.cp-tokai.com/staff/english/

Research Interests

Research Areas

Papers

Onset Mechanisms and Prognosis of Neurally Mediated Syncope

Tomoyoshi Komiyama, Kengo Ayabe, Misaki Hasegawa, Marie Yoshikawa, Susumu Sakama, Kyong-Hee Lee, Atsuhiko Yagishita, Mari Amino, Eiichiro Nagata, Yuji Ikari …

Reports, 6(4) 56-56, Nov 30, 2023 Peer-reviewedLead authorCorresponding author
Effects of Genetic Mutation Sites in ADR Genes on Modern Chickens Produced and Domesticated by Artificial Selection

Tomoyoshi Komiyama

Biology, 12(2) 169-169, Jan 20, 2023 Peer-reviewedLead authorCorresponding author
Gender Differences in Takotsubo Syndrome

Tsutomu Murakami, Tomoyoshi Komiyama, Hiroyuki Kobayashi, Yuji Ikari

Biology, 11(5) 653-653, Apr 24, 2022 Peer-reviewedLead authorCorresponding author
RNA-seq and Mitochondrial DNA Analysis of Adrenal Gland Metastatic Tissue in a Patient with Renal Cell Carcinoma

Tomoyoshi Komiyama, Hakushi Kim, Masayuki Tanaka, Sanae Isaki, Keiko Yokoyama, Akira Miyajima, Hiroyuki Kobayashi

Biology, 11(4) 589-589, Apr 13, 2022 Peer-reviewedLead authorCorresponding author
Clinical Significance of the Head-Up Tilt Test in Improving Prognosis in Patients with Possible Neurally Mediated Syncope

Kengo Ayabe, Tomoyoshi Komiyama, Misaki Hasegawa, Tetsuri Sakai, Masahiro Morise, Susumu Sakama, Atsuhiko Yagishita, Mari Amino, Yuji Ikari, Koichiro Yoshioka

Biology, 10(9) 919-919, Sep 15, 2021 Peer-reviewedCorresponding author
Diagnosis and prevention of the vasodepressor type of neurally mediated syncope in Japanese patients

Misaki Hasegawa, Tomoyoshi Komiyama, Kengo Ayabe, Susumu Sakama, Tetsuri Sakai, Kyong Hee Lee, Masahiro Morise, Atsuhiko Yagishita, Mari Amino, Ayumi Sasaki …

PLOS ONE, 16(6) e0251450-e0251450, Jun 25, 2021 Peer-reviewedCorresponding author
Examination of gender differences in patients with takotsubo syndrome according to left ventricular biopsy: two case reports

Tsutomu Murakami, Tomoyoshi Komiyama, Shingo Matsumoto, Hiroshi Kajiwara, Hiroyuki Kobayashi, Yuji Ikari

Journal of Medical Case Reports, 15(281) 281-281, May, 2021 Peer-reviewedLead authorCorresponding author
Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss

Akira Oka, Atsushi Takagi, Etsuko Komiyama, Nagisa Yoshihara, Shuhei Mano, Kazuyoshi Hosomichi, Shingo Suzuki, Yuko Haida, Nami Motosugi, Tomomi Hatanaka …

EBioMedicine, 57 102810-102810, Jul, 2020 Peer-reviewed
Analysis of the source of aggressiveness in gamecocks

Komiyama, T., Yoshikawa, M., Yokoyama, K., Kobayashi, H.

Scientific Reports, 10(1), Apr 24, 2020 Peer-reviewedLead authorCorresponding author
Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice.

Oka A, Takagi A, Komiyama E, Mano S, Hosomichi K, Suzuki S, Motosugi N, Hatanaka T, Kimura M, Takahashi Ueda M …

EBioMedicine, 57, 2020 Peer-reviewed
Whole genome sequencing of Entamoeba nuttalli reveals mammalian host-related molecular signatures and a novel octapeptide-repeat surface protein.

Masayuki Tanaka, Takashi Makiuchi, Tomoyoshi Komiyama, Takashi Shiina, Ken Osaki, Hiroshi Tachibana

PLoS neglected tropical diseases, 13(12) e0007923, Dec, 2019 Peer-reviewed
D-loop Mutations in Renal Cell Carcinoma Improve Predictive Accuracy for Cancer-Related Death by Integrating with Mutations in the NADH Dehydrogenase Subunit 1 Gene

Kim H, Tomoyoshi Komiyama, Nitta M, Kawamura Y, Hasegawa M, Shoji S, Orihashi Y, Inomoto C, Kajiwara H, Nakamura N …

Genes, 10(12) 998-998, Dec, 2019 Peer-reviewedLead authorCorresponding author
Impact of rhabdoid differentiation on postoperative outcome for patients with N0M0 renal cell carcinoma

Kim, H., Inomoto, C., Uchida, T., Kajiwara, H., Komiyama, T., Kobayashi, H., Nakamura, N., Miyajima, A.

Urologic Oncology: Seminars and Original Investigations, 37(10), Jun, 2019 Peer-reviewed
Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients

Komiyama, T., Nagata, E., Hashida, T., Sakama, S., Ayabe, K., Kamiguchi, H., Sasaki, A., Yoshioka, K., Kobayashi, H.

PLoS ONE, 14(4), Apr, 2019 Peer-reviewedLead authorCorresponding author
Analysis of candidate idarubicin drug resistance genes in MOLT-3 cells using exome nuclear DNA

Tomoyoshi Komiyama, Atsushi Ogura, Takehito Kajiwara, Yoshinori Okada, Hiroyuki Kobayashi

Genes, 9(8), Aug 1, 2018 Peer-reviewedLead authorCorresponding author
Verification of the international society of urological pathology recommendations in Japanese patients with clear cell renal cell carcinoma

Kim, H., Inomoto, C., Uchida, T., Furuya, H., Komiyama, T., Kajiwara, H., Kobayashi, H., Nakamura, N., Miyajima, A.

International Journal of Oncology, 52(4), Feb, 2018 Peer-reviewed
The Study of Adenylate Cyclase Activity in NMS Patients

The Autonomic Nervous System, 54(4) 322-325, Dec, 2017 Peer-reviewedLead authorCorresponding author
Relationship between adenylate cyclase activity and polymorphic sites on α2B-AR gene in neurally mediated syncope

Tomoyoshi Komiyama

The Japanese Society of Clinical Physiology, 47(3) 157-164, Aug, 2017 Peer-reviewedLead authorCorresponding author
The study of adenylate cyclase activity in NMS patients based on heterotype of α2B-AR gene

Tomoyoshi Komiyama, Eiichiro Nagata, Hiroshi Kamiguchi, Tadashi Hashida, Susumu Sakama, Kyoko Sato, Hiroshi Sakura, Koichiro Yoshioka, Hiroyuki Kobayashi

54(1) 34-39, Mar, 2017 Peer-reviewedLead authorCorresponding author
Analysis to estimate genetic variations in the idarubicin-resistant derivative MOLT-3

Tomoyoshi Komiyama, Atsushi Ogura, Takatsugu Hirokawa, Miao Zhijing, Hiroshi Kamiguchi, Satomi Asai, Hayato Miyachi, Hiroyuki Kobayashi

International Journal of Molecular Sciences, 18(1), Jan 1, 2017 Peer-reviewedLead authorCorresponding author

Misc.

中年以降で神経調節制失神が疑われる患者におけるヘッドアップチルト検査の有用性

綾部健吾, 小見山智義, 長谷川実咲, 酒井哲理, 坂間晋, 柳下敦彦, 網野真理, 吉岡公一郎

日本臨床生理学会雑誌, 51(4) 62-62, Oct, 2021
Entamoeba species common gene cluster and species-specific novel surface protein by whole-genome analysis of monkey intestinal parasitic amoeba

Tomoyoshi Komiyama

43rd, 2020
Study of adenylate cyclase activity in NMS patients based on

Tomoyoshi Komiyama, Eiichiro Nagata, Hiroshi Kamiguchi, Tadashi Hashida, Susumu Sakama, Kyoko Sato, Hiroshi Sakura, Koichiro Yoshioka, Hiroyuki Kobayashi

Autonomic Neuroscience, 210 85-86, Mar, 2018 Peer-reviewedLead authorCorresponding author
Genome-wide sequencing analysis of Entamoeba nuttalli using long-read and short-read high-throughput sequencers

Masayuki Tanaka, Takashi Makiuchi, Tomoyoshi Komiyama, Takashi Shiina, Hiroshi Tachibana

The Japanese Society of Parasitology, 87th 87, Feb 16, 2018 Peer-reviewed
Elucidation of molecular interaction mechanism between neurally mediate syncope and ADRA2B gene polymorphism

Tomoyoshi Komiyama

68th, 2015 Lead authorCorresponding author
Diversity and evolution of mitochondrial DNA regulatory regions based on repetitive sequence mutations

14th, 2012 Last authorCorresponding author
The evolutional relationship between the domestication of fighting cocks and the repeat variation of dopamine receptor D4

Tomoyoshi Komiyama, Hisakazu Iwama, Yoji Nakamura, Kyoko Sato, Kazuho Ikeo, Hiroyuki Kobayashi, Hidetoshi Inoko, Takashi Gojobori

GENES & GENETIC SYSTEMS, 85(6) 400-400, Dec, 2010 Lead authorCorresponding author
ドーパミンレセプターDRD4遺伝子の多型と進化にみる闘争心の起源

小見山智義, 岩間久和, 中村洋路, 佐藤恭子, 池尾一穂, 小林広幸, 猪子英俊, 五條堀孝

日本遺伝学会大会プログラム・予稿集, 82nd, 2010
Diversity and evolution of mitochondrial DNA regulatory regions in Hexanchiformes sharks

12th, 2010 Last authorCorresponding author
A novel method for obtaining meaningful association between gene clusters in the data analysis of gene expression

Suharnan Sivasundaram, Gunathilaka Prabhath, Tomoyoshi Komiyama, Hirotada Mori, Takashi Gojobori

GENES & GENETIC SYSTEMS, 81(6) 428-428, Dec, 2006
今月の解説軍鶏は鶏からどう作られたのか?--軍鶏の遺伝的成立にいたる人の文化的な介在における一考察

小見山智義, 池尾一穂, 五條堀孝

遺伝, 57(1) 76-82,4, Jan, 2003

Presentations

Examination of resting adenylate cyclase activity in orthostatic dysregulation

Sugiyama Nobuyoshi, Tomoyoshi Komiyama

The 65th Annual Meeting of the Japanese Society of Cild Neurology, May 27, 2023
Analysis of RNA-seq and mitochondrial DNA mutation in adrenal gland metastatic tissue from renal cell carcinoma

Hakushi Kim, Tomoyoshi Komiyama

The 110th Annual Meeting of the Japanese Urological Association, Apr 22, 2023
Relationship between adenylate cyclase activity and glutamic acid repeat number polymorphism in NMS patients during HUT

Tomoyoshi Komiyama, Susumu Sakama, Kengo Ayabe, Misaki Hasegawa, Eiichiro Nagata, Koichiro Yoshioka, Hiroyuki Kobayashi

The 59th Annual Meeting of the Japanese Society of Clinical Physiology, Oct 21, 2022
Fluctuations in adenylate cyclase activity in patients with childhood orthostatic dysregulation

Nobuyoshi Sugiyama, Shinichi Matsuda, Mariko Ikegami, Yoshihiro Miyashita, Eri Shigematsu, Tomoyoshi Komiyama

Oct 21, 2022
Diagnosis and preventative treatment of patients with neuromodulated syncope (vasodepressor type)

Misaki Hasegawa, Tomoyoshi Komiyama, Kengo Ayabe,Susumu Sakama, Atsuhiko Yagishita, Mari Amino, Hiroyuki Kobayashi, Eiichiro Nagata, Koichiro Yoshioka, Yuji Ikari

The 59th Annual Meeting of the Japanese Society of Clinical Physiology, Oct 21, 2022
The study of adenylate cyclase activity in orthostatic dysregulation

Nobuyoshi Sugiyama, Shinichi Matsuda, Mariko Ikegami, Yoshihiro Miyashita, Tomoyoshi Komiyama

Jun 4, 2022
Usefulness of head-up tilt test in patients with suspected neurally mediate syncope after middle age

Ayabe K, Komiyama T, Hasegawa M, Sakai T, Sakama S, Yagishita A, Amino M, Yoshioka K

The 58th Annual Meeting of the Japanese Society of Clinical Physiology, Nov 13, 2021
Relationship between mitochondrial ND1 gene mutation and pathological factors of renal cell carcinoma

Kim H, Komiyama T, Kasai S, Ootaki T, Kuroda S, Kawakami M, Nitta M, Hasegawa M, Shoji S, Zakouji H, Miyajima T

The 86th AnnualMeeting of the Eastern Section of Japanese Urological Association, Sep 3, 2021
Are Mitochondrial D-loop Mutations Useful as Prognostic Factors in Localized Renal Cell Carcinoma?

Kim H, KomiyamaT, Kawakami M, Nitta M, Hasegawa M, Kawamura Y, Shoji S, Inomoto T, Orihashi Y, Kajiwara H, Nakamura N, Kobayashi H, Miyajima

Dec, 2020
Relationship between adenylate cyclase activity and blood pressure in neurally mediated syncope patients using the head up tilt test

Tomoyoshi Komiyama, Eiichiro Nagata, Kengo Ayabe, Susumu Sakama, Misaki Hasegawa, Ayumi Sasaki, Hiroshi Kamiguchi, Koichiro Yoshioka, Hiroyuki Kobayashi

The 72nd Annual Meeting of the Autonomic Neurology Society, Nov 2, 2019
Changes in Adenylate Cyclase Activity in patients with Neurally Mediated Syncope

Komiyama T, Nagata E, Ayabe K, Sakama S, Hasegawa M, Sasaki A, Kobayashi H, Yoshioka K

Jul 6, 2019
Changes in Adenylate Cyclase activity at rest in patients with Neurally Mediated Syncope

Komiyama T, Nagata E, Hashida T, Sakama S, Ayabe K, Kamiguchi H, Yoshioka K, Kobayashi H

The 71nd Annual Meeting of the Autonomic Neurology Society, Oct 25, 2018
Clear cell renal cell carcinoma: evaluation of the pathological prognostic parameters recommended by the 2012 International Society of Urological Pathology Consensus Conference

Hakushi Kim, Chie Inomoto, Takato Uchida, Yuki Shimizu, Masayoshi Kawakami, Nobuyuki Nakajima, Masahiro Nitta, Masanori Hasegawa, Yoshiaki Kawamura, Hiroyuki Furuya, Tomoyoshi Komiyama, Hiroshi Kajiwara, Hiroyuki Kobayashi, Naoya Nakamura, Akira Miyajima

Oct 18, 2018
Somatic Mutations in Mitochondrial DNA Predict Postoperative Recurrence in Renal Cell Carcinoma

Hakushi Kim, Tomoyoshi Komiyama, Takato Uchida, Tatsuo Kano, Souichiro Yuzuriha, Tatsuya Ootaki, Tatsuya Umemoto, Yuki Shimizu, Masayoshi Kawakami, Nobuyuki Nakajima, Masahiro Nitta, Kazuya Hanai, Yoshiaki Kawamura, Hiroshi Kamiguchi, Chie Inomoto, Hiroshi Kajiwara, Naoya Nakamura, Hiroyuki Kobayashi, Akira Miyajima

113th AUA Annual Meeting, San Francisco, Apr 20, 2018, The American Urological Association and our affiliated foundation the Urology Care Foundation
Relationship between α2B-AR gene polymorphisms and differences in Adenylate Cyclase activity in Neurally Mediated Syncope

Tomoyoshi Komiyama, Eiichiro Nagata, Hiroshi Kamiguchi, Susumu Sakama, Tadashi Hashida, Ayabe Kengo, Hiroyuki Kobayashi, Koichiro Yoshioka

Nov 4, 2017
Correlation between mitochondrial ND1 gene mutation and recurrence after renal cell carcinoma

Kim H, KomiyamaT, Shimizu Y, Kawakami M, Nakajima N, Nitta M, Hanai K, Kawamura Y, Inomoto T, Kamiguchi, Kajiwara H, Nakamura N, Miyajima A

Oct, 2017
Clinicopathological study of renal cell carcinoma with rhabdoid differentiation

Kim H, Inomoto T, Shimizu Y, Kawakami M, Nakajima N, Nitta M, Hanai K, Kawamura Y, Kajiwara H, KomiyamaT, Nakamura N, Miyajima A

Sep, 2017
The Clinical Study for adenylate cyclase activity in Neurally Mediated Syncope

Tomoyoshi Komiyama, Eiichiro Nagata, Tadashi Hashida, Susumu Sakama, Hiroshi Kamiguchi, Koichiro Yoshioka, Hiroyuki Kobayashi

The 70nd Annual Meeting of the Autonomic Neurology Society, Sep 1, 2017
Correlation between mitochondrial DNA mutation and prognosis in patients with recurrent renal cell carcinoma

Kim H, Komiyama T, Inomoto T, Kamiguchi H, Kajiwara H, Nakamura N, Terachi T

Apr 21, 2017
The study of adenylate cyclase activity in NMS patients based on heterotype of α2B-AR gene

Tomoyoshi Komiyama, Eiichiro Nagata, Hiroshi Kamiguchi, Tadashi Hashida, Susumu Sakama, Sato Kyoko, Koichiro Yoshioka, Hiroyuki Kobayashi

The 69nd Annual Meeting of the Autonomic Neurology Society, Nov 11, 2016

Books and Other Publications

Visual Reference Book of GENE

KOMIYAMA TOMOYOSHI (Role: Contributor)

Oct, 2013
A Statical Approach to Genetic Epidemiology(second edition

KOMIYAMA TOMOYOSHI (Role: Joint translator)

Tokai University Press, May, 2013
How was Shamo (game cock) made from chickens? -A study on the cultural intervention of Japanese ancient people related to the genetic formation of game cocks-

Tomoyoshi Komiyama (Role: Joint author)

2003

Awards

Committee Memberships

May, 2020 - Present

;Editorial Board, PLOS ONE
Mar, 2020 - Present

;Topical Advisory Panel Members, biology (MDPI)
Nov, 2016 - Present

Councillor, Japan Society of Neurovegetative Research
Nov, 2020 - May, 2021

;Guest Editor, Frontiers in Genetics

Professional Memberships

Nov, 2021 - Present

The Japanese Society of Child Neurology
Jul, 2014 - Present

The Japan Neuroscience Society
Jul, 2012 - Present

JAPAN SOCIETY OF NEUROVEGETATIVE RESEARCH
Oct, 2009 - Present

The Japanese Pharmacological Sciences
- Present

JAPANESE SOCIETY OF CLINICAL PHYSIOLOGY
- Present

The Molecular Biology Society of Japan
- Present

The Genetics Society of Japan
- Present

SOCIETY OF EVOLUTIONARY STUDIES, JAPAN
- Present

The Japanese Circulation Society

Education

Apr, 1991 - Mar, 1993

Agricultural Science, Graduate School of Agriculture,, Tokyo University of Agriculture,
Apr, 1987 - Mar, 1991

Department of Agriculture, Faculty of Agriculture,, Tokyo University of Agriculture,

Major Teaching Experience

Apr, 2020 - Present

Medical Informatics (Tokai University School of Medicine)
Apr, 2009 - Present

Basics of pharmacology (Tokai University School of Medicine)
Apr, 2009 - Present

Basics of genomic medicine (Tokai University School of Medicine)
Apr, 2009 - Present

Medical informatics (Tokai University School of Medicine)
Apr, 2009 - Present

Bioinformatics Literacy (Tokai University School of Medicine)

Research Projects

Development of a novel kidney cancer drug targeting mitochondrial molecules

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Diagnosis and therapeutic effect of neurally mediate syncope patients using adenylate cyclase activity fluctuation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023

Tomoyoshi Komiyama
The effect of the low ND1 expression in renal cancer cells on the intracellular ROS, tumor metastasis and proliferation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

KIM Hakushi
Candidate biomarkers for predicting drug response in cancer treatment

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

KOBAYASHI Hiroyuki, Yu Shyr, Hande Kenneth R.
The role of dysautonomia and ADR in Takotsubo Cardiomyopathy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Sato Kyoko
The acquisition methods for radiation-resistance by means of light irradiation.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Sakakibara Manabu
Study on distribution and genomic diversity of new Asian pathogen amoeba

Apr, 2012 - Mar, 2017
Basic research on therapeutic development targeting antitumor drug resistance factors

Apr, 2012 - Mar, 2015
Origin of fighting spirit in polymorphism and evolution of dopamine receptor genes

Apr, 2009 - Mar, 2012
The Role of Adrenaline in Neurally Mediated Syncope

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

SATO Kyoko, KOBAYASHI Hiroyuki, KOMIYAMA Tomoyoshi, MIKAMI Ayako, ISOZAKI Mitsuhiro

Profile Information

Research Interests

Research Areas

Papers

Misc.

Presentations

Books and Other Publications

Awards

Committee Memberships

Professional Memberships

Education

Major Teaching Experience

Research Projects

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