城村由和 (Yoshikazu Johmura) - マイポータル

基本情報

所属: 金沢大学がん進展制御研究所教授 (博士 (薬学))

J-GLOBAL ID: 201101075529668100
researchmap会員ID: 6000028531

研究キーワード

個体老化、寿命、がん、細胞老化、細胞周期、プロテオスタシス

研究分野

経歴

2022年4月 - 現在

金沢大学がん進展制御研究所教授
2016年8月 - 2022年3月

東京大学医科学研究所助教
2011年5月 - 2016年7月

名古屋市立大学大学院医学研究科助教
2008年11月 - 2011年4月

米国国立衛生研究所米国国立癌研究所博士研究員
2008年4月 - 2008年10月

名古屋市立大学大学院薬学研究科研究員

学歴

2003年4月 - 2008年3月

名古屋市立大学大学院薬学研究科
1999年4月 - 2003年3月

名古屋市立大学薬学部製薬学科

論文

Transcriptomic characterization of Lonrf1 at the single-cell level under pathophysiological conditions

Dan Li, Teh-Wei Wang, Sae Aratani, Satotaka Omori, Maho Tamatani, Yoshikazu Johmura, Makoto Nakanishi

The Journal of Biochemistry 2023年3月8日
Targeting cellular senescence as a therapeutic approach in non-alcoholic steatohepatitis

Yasuhiro Nakano, Yoshikazu Johmura

Annals of Hepatology 28(2) 100900-100900 2023年3月
【セノリティクス】老化細胞の代謝特性によるセノリティクス

中野泰博, 城村由和

細胞 55(2) 76-79 2023年2月
Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes

Teh-Wei Wang, Yoshikazu Johmura, Narumi Suzuki, Satotaka Omori, Toshiro Migita, Kiyoshi Yamaguchi, Seira Hatakeyama, Satoshi Yamazaki, Eigo Shimizu, Seiya Imoto, Yoichi Furukawa, Akihiko Yoshimura, Makoto Nakanishi

Nature 611(7935) 358-364 2022年11月2日
Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.

Nabora S Reyes, Maria Krasilnikov, Nancy C Allen, Jin Young Lee, Ben Hyams, Minqi Zhou, Supriya Ravishankar, Monica Cassandras, Chaoqun Wang, Imran Khan, Peri Matatia, Yoshikazu Johmura, Ari Molofsky, Michael Matthay, Makoto Nakanishi, Dean Sheppard, Judith Campisi, Tien Peng

Science (New York, N.Y.) 378(6616) 192-201 2022年10月14日
Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance.

Jing Zhu, Wenwen Wu, Yukiko Togashi, Naoe Taira Nihira, Yoshikazu Johmura, Dajiang Zhu, Makoto Nakanishi, Yasuo Miyoshi, Tomohiko Ohta

Breast cancer (Tokyo, Japan) 29(6) 1076-1087 2022年7月27日
TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis.

Narumi Suzuki, Yoshikazu Johmura, Teh-Wei Wang, Toshiro Migita, Wenwen Wu, Rei Noguchi, Kiyoshi Yamaguchi, Yoichi Furukawa, Shuhei Nakamura, Ichiro Miyoshi, Tamotsu Yoshimori, Tomohiko Ohta, Makoto Nakanishi

Autophagy 17(11) 3776-3793 2021年11月
Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts

Kojiro Suda, Yohsuke Moriyama, Yumiko Masukagami, Nurhanani Binti Razali, Yatzu Chiu, Koutarou Nishimura, Hunter Barbee, Hiroshi Takase, Shinju Sugiyama, Yoshikatsu Sato, Tetsuya Higashiyama, Yoshikazu Johmura, Makoto Nakanishi, Keiko Kono

2021年3月27日
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.

Yoshikazu Johmura, Takehiro Yamanaka, Satotaka Omori, Teh-Wei Wang, Yuki Sugiura, Masaki Matsumoto, Narumi Suzuki, Soichiro Kumamoto, Kiyoshi Yamaguchi, Seira Hatakeyama, Tomoyo Takami, Rui Yamaguchi, Eigo Shimizu, Kazutaka Ikeda, Nobuyuki Okahashi, Ryuta Mikawa, Makoto Suematsu, Makoto Arita, Masataka Sugimoto, Keiichi I Nakayama, Yoichi Furukawa, Seiya Imoto, Makoto Nakanishi

Science (New York, N.Y.) 371(6526) 265-270 2021年1月15日
A 3D tissue model-on-a-chip for studying the effects of human senescent fibroblasts on blood vessels.

Joris Pauty, Shizuka Nakano, Ryo Usuba, Tadaaki Nakajima, Yoshikazu Johmura, Satotaka Omori, Naoya Sakamoto, Akihiko Kikuchi, Makoto Nakanishi, Yukiko T Matsunaga

Biomaterials science 9(1) 199-211 2021年1月5日
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo.

Satotaka Omori, Teh-Wei Wang, Yoshikazu Johmura, Tomomi Kanai, Yasuhiro Nakano, Taketomo Kido, Etsuo A Susaki, Takuya Nakajima, Shigeyuki Shichino, Satoshi Ueha, Manabu Ozawa, Kisho Yokote, Soichiro Kumamoto, Atsuya Nishiyama, Takeharu Sakamoto, Kiyoshi Yamaguchi, Seira Hatakeyama, Eigo Shimizu, Kotoe Katayama, Yasuhiro Yamada, Satoshi Yamazaki, Kanako Iwasaki, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa, Hiroo Ueno, Seiya Imoto, Yoichi Furukawa, Nobuaki Yoshida, Kouji Matsushima, Hiroki R Ueda, Atsushi Miyajima, Makoto Nakanishi

Cell metabolism 32(5) 814-828 2020年11月3日
FBXO22, an epigenetic multiplayer coordinating senescence, hormone signaling, and metastasis.

Yoshikazu Johmura, Alexander S Harris, Tomohiko Ohta, Makoto Nakanishi

Cancer science 111(8) 2718-2725 2020年8月
Two mouse models carrying truncating mutations in Magel2 show distinct phenotypes.

Daisuke Ieda, Yutaka Negishi, Tomomi Miyamoto, Yoshikazu Johmura, Natsuko Kumamoto, Kohji Kato, Ichiro Miyoshi, Makoto Nakanishi, Shinya Ugawa, Hisashi Oishi, Shinji Saitoh

PloS one 15(8) e0237814 2020年
Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.

Keiko Nakanishi, Hiroyuki Niida, Hidenori Tabata, Tsuyoshi Ito, Yuki Hori, Madoka Hattori, Yoshikazu Johmura, Chisato Yamada, Takashi Ueda, Kosei Takeuchi, Kenichiro Yamada, Koh-Ichi Nagata, Nobuaki Wakamatsu, Masashi Kishi, Y Albert Pan, Shinya Ugawa, Shoichi Shimada, Joshua R Sanes, Yujiro Higashi, Makoto Nakanishi

Cerebral cortex (New York, N.Y. : 1991) 29(9) 3738-3751 2019年8月14日
Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.

Koutarou Nishimura, Yoshikazu Johmura, Katashi Deguchi, Zixian Jiang, Kazuhiko S K Uchida, Narumi Suzuki, Midori Shimada, Yoshie Chiba, Toru Hirota, Shige H Yoshimura, Keiko Kono, Makoto Nakanishi

Nature communications 10(1) 981-981 2019年2月28日
Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.

Yoshikazu Johmura, Ichiro Maeda, Narumi Suzuki, Wenwen Wu, Atsushi Goda, Mariko Morita, Kiyoshi Yamaguchi, Mizuki Yamamoto, Satoi Nagasawa, Yasuyuki Kojima, Koichiro Tsugawa, Natsuko Inoue, Yasuo Miyoshi, Tomo Osako, Futoshi Akiyama, Reo Maruyama, Jun-Ichiro Inoue, Yoichi Furukawa, Tomohiko Ohta, Makoto Nakanishi

The Journal of clinical investigation 128(12) 5603-5619 2018年12月3日
Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation.

Luna Yamaguchi, Atsuya Nishiyama, Toshinori Misaki, Yoshikazu Johmura, Jun Ueda, Kyohei Arita, Koji Nagao, Chikashi Obuse, Makoto Nakanishi

Scientific reports 7(1) 55-55 2017年3月3日
A combination of genetic and biochemical analyses for the diagnosis of PI3K-AKT-mTOR pathway-associated megalencephaly.

Yutaka Negishi, Fuyuki Miya, Ayako Hattori, Yoshikazu Johmura, Motoo Nakagawa, Naoki Ando, Ikumi Hori, Takao Togawa, Kohei Aoyama, Kei Ohashi, Shinobu Fukumura, Seiji Mizuno, Ayako Umemura, Yoko Kishimoto, Nobuhiko Okamoto, Mitsuhiro Kato, Tatsuhiko Tsunoda, Mami Yamasaki, Yonehiro Kanemura, Kenjiro Kosaki, Makoto Nakanishi, Shinji Saitoh

BMC medical genetics 18(1) 4-4 2017年1月13日
The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy.

Tsutomu Iwata, Tairin Uchino, Ayako Koyama, Yoshikazu Johmura, Kenichi Koyama, Takuya Saito, Seiji Ishiguro, Takashi Arikawa, Shunichiro Komatsu, Masahiko Miyachi, Tsuyoshi Sano, Makoto Nakanishi, Midori Shimada

PloS one 12(5) e0178221 2017年
Multiple facets of p53 in senescence induction and maintenance.

Yoshikazu Johmura, Makoto Nakanishi

Cancer science 107(11) 1550-1555 2016年11月