2022年10月14日
Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
Science (New York, N.Y.)
- 巻
- 378
- 号
- 6616
- 開始ページ
- 192
- 終了ページ
- 201
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.abf3326
We engineered an ultrasensitive reporter of p16INK4a, a biomarker of cellular senescence. Our reporter detected p16INK4a-expressing fibroblasts with certain senescent characteristics that appeared shortly after birth in the basement membrane adjacent to epithelial stem cells in the lung. Furthermore, these p16INK4a+ fibroblasts had enhanced capacity to sense tissue inflammation and respond through their increased secretory capacity to promote epithelial regeneration. In addition, p16INK4a expression was required in fibroblasts to enhance epithelial regeneration. This study highlights a role for p16INK4a+ fibroblasts as tissue-resident sentinels in the stem cell niche that monitor barrier integrity and rapidly respond to inflammation to promote tissue regeneration.
- リンク情報
- ID情報
-
- DOI : 10.1126/science.abf3326
- PubMed ID : 36227993
- PubMed Central 記事ID : PMC10621323