岡田義清 (Yoshikiyo Okada) - マイポータル

基本情報

所属: 防衛省防衛医科大学校医学教育部医学科専門課程助教
: 東京農業大学非常勤講師

学位: 博士(畜産学)

研究者番号: 90531137
J-GLOBAL ID: 201101094812200543
researchmap会員ID: 6000028545

研究キーワード

研究分野

主要な論文

161

Establishment of an in vitro evaluation method for immunomodulatory functions of yeast strains.

Ying Chuin Yee, Akihiro Nakamura, Yoshikiyo Okada, Takeshi Mori, Yoshiki Katayama

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2024年8月3日
Probiotic Yeast from Miso Ameliorates Stress-Induced Visceral Hypersensitivity by Modulating the Gut Microbiota in a Rat Model of Irritable Bowel Syndrome.

Nao Sugihara, Yoshikiyo Okada, Akira Tomioka, Suguru Ito, Rina Tanemoto, Shin Nishii, Akinori Mizoguchi, Kenichi Inaba, Yoshinori Hanawa, Kazuki Horiuchi …

Gut and liver 18(3) 465-475 2024年5月15日査読有り責任著者
Transgenerational impacts of oral probiotic administration in pregnant mice on offspring gut immune cells and colitis susceptibility.

Yoshikiyo Okada, Nao Sugihara, Shin Nishii, Suguru Itoh, Akinori Mizoguchi, Rina Tanemoto, Kazuki Horiuchi, Akira Tomioka, Hiroyuki Nishimura, Masaaki Higashiyama …

Journal of gastroenterology and hepatology 2022年11月8日査読有り筆頭著者責任著者
Novel probiotic yeast from Miso promotes regulatory dendritic cell IL-10 production and attenuates DSS-induced colitis in mice

Yoshikiyo Okada, Yoshikazu Tsuzuki, Nao Sugihara, Shin Nishii, Naoki Shibuya, Akinori Mizoguchi, Suguru Itoh, Rina Tanemoto, Kenichi Inaba, Yoshinori Hanawa …

Journal of Gastroenterology 56(9) 829-842 2021年9月査読有り筆頭著者責任著者
Novel probiotics isolated from a Japanese traditional fermented food, Funazushi, attenuates DSS-induced colitis by increasing the induction of high integrin αv/β8-expressing dendritic cells.

Okada Y, Tsuzuki Y, Takeshi T, Furuhashi H, Higashiyama M, Watanabe C, Shirakabe K, Kurihara C, Komoto S, Tomita K …

Journal of gastroenterology 53(3) 407-418 2018年3月1日査読有り筆頭著者責任著者
伝統的発酵食品中に存在するプロバイオティクスの大腸炎治療への応用とその作用機序

岡田義清, 都築義和, 安武優一, 丸田紘史, 好川謙一, 冨田謙吾, 栗原千枝, 高本俊介, 渡辺知佳子, 永尾重昭 …

消化と吸収 37(1) 42-42 2014年10月
プロバイオティクス・腸内細菌と消化器免疫ふなずし由来新規ラクトバシラス属菌が有する強力な大腸炎抑制の作用機序

岡田義清, 都築義和, 佐藤宏和, 成松和幸, 安武優一, 穂苅量太, 冨田謙吾, 栗原千枝, 高本俊介, 渡辺知佳子 …

消化器と免疫 (50) 42-44 2014年3月
Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization

Y. Okada, Y. Tsuzuki, H. Sato, K. Narimatsu, R. Hokari, C. Kurihara, C. Watanabe, K. Tomita, S. Komoto, A. Kawaguchi …

CLINICAL AND EXPERIMENTAL IMMUNOLOGY 174(3) 459-471 2013年12月査読有り筆頭著者
1,4-Dihydroxy-2-naphthoic acid from Propionibacterium freudenreichii reduces inflammation in interleukin-10-deficient mice with colitis by suppressing macrophage-derived proinflammatory cytokines

Yoshikiyo Okada, Yoshikazu Tsuzuki, Kazuyuki Narimatsu, Hirokazu Sato, Toshihide Ueda, Hideaki Hozumi, Shingo Sato, Ryota Hokari, Chie Kurihara, Shunsuke Komoto …

JOURNAL OF LEUKOCYTE BIOLOGY 94(3) 473-480 2013年9月査読有り筆頭著者
Anti-inflammatory effects of the genus Bifidobacterium on macrophages by modifacation of phospho-I kappa B and SOCS gene expression

Yoshikiyo Okada, Yoshikazu Tsuzuki, Ryota Hokari, Shunsuke Komoto, Chie Kurihara, Atsushi Kawaguchi, Shigeaki Nagao, Soichiro Miura

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 90(2) 131-140 2009年4月査読有り筆頭著者
Pressure loading and ethanol exposure differentially modulate rat hepatic stellate cell activation

Yoshikiyo Okada, Yoshikazu Tsuzuki, Ryota Hokari, Jyunichi Miyazaki, Koji Matsuzaki, Norikazu Mataki, Shunsuke Komoto, Chikako Watanabe, Atsushi Kawaguchi, Shigeaki Nagao …

JOURNAL OF CELLULAR PHYSIOLOGY 215(2) 472-480 2008年5月査読有り筆頭著者
Propionibacterium freudenreichii component 1.4-dihydroxy-2-naphthoic acid (DHNA) attenuates dextran sodium sulphate induced colitis by modulation of bacterial flora and lymphocyte homing

Y Okada, Y Tsuzuki, J Miyazaki, K Matsuzaki, R Hokari, S Komoto, S Kato, A Kawaguchi, S Nagao, K Itoh …

GUT 55(5) 681-688 2006年5月査読有り筆頭著者

もっとみる

MISC

ANTIOXIDANT EFFECT OF URIC ACID AMELIORATES NSAIDS INDUCED ENTEROPATHY AND CHANGES GUT MICROBIOTA

Akinori Wada, Masaaki Higashiyama, Suguru Ito, Rina Tanemoto, Akinori Mizoguchi, Shin Nishii, Kenichi Inaba, Nao Sugihara, Yoshinori Hanawa, Kazuki Horiuchi …

GASTROENTEROLOGY 158(6) S504-S504 2020年5月
HYPERURICEMIA AMELIORATES INTESTINAL INFLAMMATION ALONG WITH ALTERED GUT MICROBIOTA

Akinori Wada, Masaaki Higashiyama, Akinori Mizoguchi, Shin Nishii, Kenichi Inaba, Nao Sugihara, Yoshinori Hanawa, Kazuki Horiuchi, Hirotaka Furuhashi, Naoki Shibuya …

GASTROENTEROLOGY 156(6) S707-S707 2019年5月
Reducing free cholesterol accumulation specifically in hepatic stellate cells, by using either SREBP2-siRNA-bearing or anti-miR-33 alpha-bearing vitamin A-coupled liposomes, ameliorates liver fibrosis in mice.

Kengo Tomita, Hirotaka Furuhashi, Masaaki Higashiyama, Kazuhiko Shirakabe, Koji Maruta, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Ryota Hokari

HEPATOLOGY 66 211A-212A 2017年10月
Chitinase 3-like 1 plays a key role in the progression of nonalcoholic steatohepatitis in mice.

Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Koji Maruta, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Ryota Hokari

HEPATOLOGY 66 1039A-1040A 2017年10月
DIETARY EMULSIFIER POLYSORBATE-80 INCREASES THE GENUS PROTEUS AND CAUSES INTESTINAL INFLAMMATION ON INDOMETHACIN-INDUCED INTESTINAL LESIONS

Hirotaka Furuhashi, Masaaki Higashiyama, Yoshikiyo Okada, Takeshi Takajo, Koji Maruta, Kazuhiko Shirakabe, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita …

GASTROENTEROLOGY 152(5) S814-S814 2017年4月
CARAMEL FOOD COLORANT 2-ACCETYL-4-TETRAHYDROXYBUTYL IMIDAZOLE (THI) AMELIORATES DEXTRAN SULFATE SODIUM (DSS)-INDUCED COLITIS VIA SUPPRESSION OF SPHINGOSINE-1-PHOSPHATE (S1P) LYASE

Kazuhiko Shirakabe, Masaaki Higashiyama, Hirotaka Furuhashi, Takeshi Takajo, Koji Maruta, Chie Kurihara, Yoshikiyo Okada, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita …

GASTROENTEROLOGY 152(5) S572-S572 2017年4月
PSYCHOLOGICAL STRESS INDUCES DIFFERENT PATTERNS OF THE GUT MICROBIOTA ACCORDING WITH CHARACTERISTIC CHANGES IN BEHAVIOR AND VISCERAL PERCEPTION IN AN EXPERIMENTAL RAT MODEL

Takeshi Takajo, Kunio Shimizu, Shingo Enomoto, Masaaki Tanichi, Hiroyuki Toda, Kengo Tomita, Yoshikiyo Okada, Chie Kurihara, Kazuhiko Shirakabe, Hirotaka Furuhashi …

GASTROENTEROLOGY 152(5) S818-S819 2017年4月
Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity in mice

T. Teratani, K. Tomita, T. Suzuki, H. Furuhashi, R. Irie, S. Hida, Y. Okada, C. Kurihara, H. Ebinuma, N. Nakamoto …

JOURNAL OF HEPATOLOGY 66(1) S398-S399 2017年
Anti-Inflammatory Effect of Novel Probiotic Yeasts Isolated From Japanese "Miso" on DSS-Induced Colitis

Yoshikiyo Okada, Yoshikazu Tsuzuki, Yuichi Yasutake, Koji Maruta, Takeshi Takajo, Hirotaka Furuhashi, Masaaki Higashiyama, Kenichi Yoshikawa, Kengo Tomita, Chikako Watanabe …

GASTROENTEROLOGY 150(4) S1008-S1008 2016年4月
Suppressive effect of nicotine on expression of MAdCAM-1 in colitis

Koji Maruta, Chie Kurihara, Hirotaka Furuhashi, Takeshi Takajo, Yuichi Yasutake, Yoshikiyo Okada, Kenichi Yoshikawa, Masaaki Higashiyama, Chikako Watanabe, Shunsuke Komoto …

FASEB JOURNAL 30 2016年4月
Psychological Stress Exacerbates Indomethacin-Induced Small Intestinal Injury Possibly via Changes in Intestinal Microbiota

Kenichi Yoshikawa, Chie Kurihara, Hirotaka Furuhashi, Takeshi Takajo, Koji Maruta, Yuichi Yasutake, Yoshikiyo Okada, Masaaki Higashiyama, Chikako Watanabe, Shunsuke Komoto …

GASTROENTEROLOGY 150(4) S541-S542 2016年4月
Platelets Interaction With Lymphatics Aggravates Intestinal Inflammation via Suppression of Lymphangiogenesis

Masaaki Higashiyama, Hirokazu Sato, Hirotaka Furuhashi, Hideaki Hozumi, Takeshi Takajo, Koji Maruta, Yuichi Yasutake, Kenichi Yoshikawa, Chie Kurihara, Yoshikiyo Okada …

GASTROENTEROLOGY 150(4) S964-S964 2016年4月
Uric Acid Inhibits Lipid Peroxidation and Protects Small Intestinal Injury Induced by Indomethacin

Yuichi Yasutake, Hirotaka Furuhashi, Takeshi Takajo, Koji Maruta, Chie Kurihara, Yoshikiyo Okada, Kenichi Yoshikawa, Masaaki Higashiyama, Chikako Watanabe, Shunsuke Komoto …

GASTROENTEROLOGY 150(4) S896-S897 2016年4月
Nicotine Ameliorates Colonic Inflammation via Inhibition of Leukocyte Interaction to Colonic Microvessels and Down-Regulation of MAdCAM-1

Koji Maruta, Chie Kurihara, Hirotaka Furuhashi, Takeshi Takajo, Yuichi Yasutake, Yoshikiyo Okada, Kenichi Yoshikawa, Masaaki Higashiyama, Chikako Watanabe, Shunsuke Komoto …

GASTROENTEROLOGY 150(4) S965-S965 2016年4月
Dietary Emulsifier Polysorbate-80 Exacerbates Indomethacin-Induced Small Intestinal Lesions in Mice

Hirotaka Furuhashi, Masaaki Higashiyama, Takeshi Takajo, Koji Maruta, Yuichi Yasutake, Kenichi Yoshikawa, Chie Kurihara, Yoshikiyo Okada, Chikako Watanabe, Shunsuke Komoto …

GASTROENTEROLOGY 150(4) S200-S200 2016年4月
Neutrophil Trafficking to Microvessels Is Largely Enhanced by PepT1 Mediated Bacterial Peptide Transport in TNF-alpha-Challenged Murine Colonic Mucosa In Vivo

Chikako Watanabe, Kenichi Yoshikawa, Yoshikiyo Okada, Hirotaka Furuhashi, Takeshi Takajo, Koji Maruta, Yuichi Yasutake, Shunsuke Komoto, Soichiro Miura, Ryota Hokari

GASTROENTEROLOGY 150(4) S896-S896 2016年4月
Stress Induced Different Psychological Disorders Showed Characteristic Patterns of Gut Microbiota Leading to Bowel Movement Disturbance in Rats

Takeshi Takajo, Yoshikiyo Okada, Chie Kurihara, Kenichi Yoshikawa, Hirotaka Furuhashi, Koji Maruta, Shingo Enomoto, Masaaki Tanichi, Yuichi Yasutake, Masaaki Higashiyama …

GASTROENTEROLOGY 150(4) S525-S526 2016年4月
Investigation of Mismatch Cases Between Magnetic Resonance Enterocolonography and Endoscopy in Intestinal Lesion of Patients with Crohn's Disease

Kenichi Yoshikawa, Hirokazu Sato, Takeshi Takajo, Koji Maruta, Yuichi Yasutake, Kazuyuki Narimatsu, Chie Kurihara, Yoshikiyo Okada, Masaaki Higashiyama, Chikako Watanabe …

INFLAMMATORY BOWEL DISEASES 22 S46-S46 2016年3月
Nicotine Significantly Affects the Expression of Vascular Endothelial Adhesion Molecules and Ameliorates DSS Induced Colitis

Koji Maruta, Chie Kurihara, Hideaki Hozumi, Takeshi Takajo, Yuichi Yasutake, Hirokazu Sato, Kazuyuki Narimatsu, Yoshikiyo Okada, Kenichi Yoshikawa, Chikako Watanabe …

GASTROENTEROLOGY 148(4) S686-S686 2015年4月
Protective Role of Uric Acid Excretion to the Intestinal Tract on Small Intestinal Injury Induced by Indomethacin

Yuichi Yasutake, Ryota Hokari, Yasushi Inoue, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Chie Kurihara, Yoshikiyo Okada, Kenichi Yoshikawa …

GASTROENTEROLOGY 148(4) S916-S916 2015年4月

もっとみる

担当経験のある科目(授業)

所属学協会

主要な共同研究・競争的資金等の研究課題

プロバイオティクス摂取が腸管免疫と腸内細菌のトランスジェネレーションへ及ぼす影響

科学研究費助成事業(学術研究助成基金助成金) (基盤研究C) 2019年4月

岡田義清
ヒトiPS細胞の奇形腫を介した分化細胞の誘導法開発と病態解明への応用

日本学術振興会科学研究費助成事業挑戦的萌芽研究 2015年4月 - 2018年3月

松村耕治, 宮平靖, 石原美弥, 水野博司, 石原雅之, 岡田義清, 新井仁明, 市来やよい, 梅山悠伊
ふなずし由来新規ラクトバシラス属菌が有する強力な抗炎症効果の作用機序

日本学術振興会科学研究費助成事業基盤研究(C) 2011年4月 - 2017年3月

岡田義清, 穂苅量太, 三浦総一郎, 都築義和

産業財産権

特許4876262 抗炎症効果を有する新規植物性乳酸菌株､該菌株を用いた炎症性腸疾患又は慢性下痢症に対する予防及び治療剤､抑制剤並びに添加剤

岡田義清
特許US7241809B2 Method for treating inflammatory bowel diseases

Yoshikiyo Okada, Yoshikazu Tsuzuki, Soichiro Miura

岡田義清

基本情報

研究キーワード

研究分野

主要な論文

MISC

担当経験のある科目(授業)

所属学協会

主要な共同研究・競争的資金等の研究課題

産業財産権

メニュー

共著者の一覧