MISC

2012年

Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes

FEBS OPEN BIO
  • Hiroshi Matsuzaki
  • ,
  • Takahiro Fujimoto
  • ,
  • Takeharu Ota
  • ,
  • Masahiro Ogawa
  • ,
  • Toshiyuki Tsunoda
  • ,
  • Keiko Doi
  • ,
  • Masato Hamabashiri
  • ,
  • Masatoshi Tanaka
  • ,
  • Senji Shirasawa

2
開始ページ
255
終了ページ
259
記述言語
英語
掲載種別
DOI
10.1016/j.fob.2012.08.005
出版者・発行元
ELSEVIER SCIENCE LONDON

Tespa1 has been recently reported to be a critical molecule in T-cell development, however, the precise molecular mechanisms of Tespa1 remain elusive. Here, we demonstrate that Tespa1 shows amino-acid sequence homology to KRAS-induced actin-interacting protein (KRAP), an inositol 1,4,5-trisphosphate receptor (IP3R) binding protein, and that Tespa1 physically associates with IP3R in T and B lymphocytes. Two-consecutive phenylalanine residues (Phe185/Phe186) in Tespa1, which are conserved between Tespa1 and KRAP, are indispensable for the association between Tespa1 and IP3R. These findings suggest that Tespa1 plays critical roles in the immune system through the regulation of the IP3R. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

Web of Science ® 被引用回数 : 19

リンク情報
DOI
https://doi.org/10.1016/j.fob.2012.08.005
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000209007200038&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.fob.2012.08.005
  • ISSN : 2211-5463
  • Web of Science ID : WOS:000209007200038

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