論文

査読有り 招待有り 筆頭著者 本文へのリンクあり 国際共著 国際誌
2022年2月

Macrophage meets the circadian clock: Implication of the circadian clock in the role of macrophages in acute lower respiratory tract infection

Frontiers in Cellular and Infection Microbiology
  • Ken Shirato
  • ,
  • Shogo Sato

12
開始ページ
826738 (16 pages)
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fcimb.2022.826738
出版者・発行元
Frontiers Media SA

The circadian rhythm is a biological system that creates daily variations of physiology and behavior with a 24-h cycle, which is precisely controlled by the molecular circadian clock. The circadian clock dominates temporal activity of physiological homeostasis at the molecular level, including endocrine secretion, metabolic, immune response, coupled with extrinsic environmental cues (<italic>e.g.</italic>, light/dark cycles) and behavioral cues (<italic>e.g.</italic>, sleep/wake cycles and feeding/fasting cycles). The other side of the clock is that the misaligned circadian rhythm contributes to the onset of a variety of diseases, such as cancer, metabolic diseases, and cardiovascular diseases, the acceleration of aging, and the development of systemic inflammation. The role played by macrophages is a key mediator between circadian disruption and systemic inflammation. At the molecular level, macrophage functions are under the direct control of the circadian clock, and thus the circadian misalignment remodels the phenotype of macrophages toward a ‘killer’ mode. Remarkably, the inflammatory macrophages induce systemic and chronic inflammation, leading to the development of inflammatory diseases and the dampened immune defensive machinery against infectious diseases such as COVID-19. Here, we discuss how the circadian clock regulates macrophage immune functions and provide the potential risk of misaligned circadian rhythms against inflammatory and infectious diseases.

リンク情報
DOI
https://doi.org/10.3389/fcimb.2022.826738 本文へのリンクあり
URL
https://www.frontiersin.org/articles/10.3389/fcimb.2022.826738/full 本文へのリンクあり
ID情報
  • DOI : 10.3389/fcimb.2022.826738
  • eISSN : 2235-2988

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