Masahito Hagio

Profile Information

Affiliation: Kanagawa Prefectural Institute of Public Health

Degree: 博士（農学）(北海道大学)

Researcher number: 00623927
J-GLOBAL ID: 201101081817495822
researchmap Member ID: 6000029423

Research Interests

Research Areas

Education

- 2010

Hokkaido University
- 2003

Faculty of Agriculture, Hokkaido University

Papers

12α-Hydroxylated bile acid induces hepatic steatosis with dysbiosis in rats

Ja Young Lee, Hidehisa Shimizu, Masahito Hagio, Satoru Fukiya, Masamichi Watanabe, Yasutake Tanaka, Ga Hyun Joe, Hitoshi Iwaya, Reika Yoshitsugu, Keidai Kikuchi …

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1865(12), Dec, 2020
Correlation between 12α-hydroxylated bile acids and insulin secretion during glucose tolerance tests in rats fed a high-fat and high-sucrose diet.

Reika Yoshitsugu, Keidai Kikuchi, Shota Hori, Hitoshi Iwaya, Masahito Hagio, Hidehisa Shimizu, Tohru Hira, Satoshi Ishizuka

Lipids in health and disease, 19(1) 9-9, Jan 15, 2020 Peer-reviewed
Isolation of six novel 7-oxo- or urso-type secondary bile acid-producing bacteria from rat cecal contents

Sarinya Tawthep, Satoru Fukiya, Ja-Young Lee, Masahito Hagio, Yoshitoshi Ogura, Tetsuya Hayashi, Atsushi Yokota

JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 124(5) 514-522, Nov, 2017 Peer-reviewed
Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C-12-homoserine lactone

Hidehisa Shimizu, Nanako Baba, Takuma Nose, Ryoko Taguchi, Shinya Tanaka, Ga-Hyun Joe, Hideaki Maseda, Nobuhiko Nomura, Masahito Hagio, Ja-Young Lee …

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 79(6) 937-942, Jun, 2015 Peer-reviewed
Inhibition of nestin suppresses stem cell phenotype of glioblastomas through the alteration of post-translational modification of heat shock protein HSPA8/HSC71

Yoko Matsuda, Toshiyuki Ishiwata, Hisashi Yoshimura, Masahito Hagio, Tomio Arai

CANCER LETTERS, 357(2) 602-611, Feb, 2015 Peer-reviewed
Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to gamma-radiation

Masahito Hagio, Hidehisa Shimizu, Ga-Hyun Joe, Manami Takatsuki, Maiko Shiwaku, Hong Xu, Ja-Young Lee, Nobuyuki Fujii, Satoru Fukiya, Hiroshi Hara …

TOXICOLOGY LETTERS, 232(1) 246-252, Jan, 2015 Peer-reviewed
Deoxycholic Acid Is Involved in the Proliferation and Migration of Vascular Smooth Muscle Cells

Hidehisa Shimizu, Masahito Hagio, Hitoshi Iwaya, Ikuya Tsuneki, Ja-Young Lee, Satoru Fukiya, Atsushi Yokota, Hitoshi Miyazaki, Hiroshi Hara, Satoshi Ishizuka

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 60(6) 450-454, Dec, 2014 Peer-reviewed
Long-Term Oral Feeding of Lutein-Fortified Milk Increases Voluntary Running Distance in Rats

Megumi Matsumoto, Masahito Hagio, Ryo Inoue, Tomohiro Mitani, Masako Yajima, Hiroshi Hara, Takaji Yajima

PLOS ONE, 9(4) e93529, Apr, 2014 Peer-reviewed
Contribution of Dipeptidyl Peptidase IV to the Severity of Dextran Sulfate Sodium-Induced Colitis in the Early Phase

Hitoshi Iwaya, Nobuyuki Fujii, Masahito Hagio, Hiroshi Hara, Satoshi Ishizuka

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77(7) 1461-1466, Jul, 2013 Peer-reviewed
Nestin regulates epithelial-mesenchymal transition marker expression in pancreatic ductal adenocarcinoma cell lines.

Hagio M, Matsuda Y, Suzuki T, Ishiwata T

Molecular and clinical oncology, 1(1) 83-87, Jan, 2013 Peer-reviewed
Nestin: A novel angiogenesis marker and possible target for tumor angiogenesis

Yoko Matsuda, Masahito Hagio, Toshiyuki Ishiwata

WORLD JOURNAL OF GASTROENTEROLOGY, 19(1) 42-48, Jan, 2013 Peer-reviewed
Clinicopathological Features of 30 Autopsy Cases of Pancreatic Carcinoma

Yoko Matsuda, Masahito Hagio, Zenya Naito, Toshiyuki Ishiwata

JOURNAL OF NIPPON MEDICAL SCHOOL, 79(6) 459-467, Dec, 2012 Peer-reviewed
Expression of cancer stem cell markers in pancreatic intraepithelial neoplasias and pancreatic ductal adenocarcinomas

Shoko Kure, Yoko Matsuda, Masahito Hagio, Junji Ueda, Zenya Naito, Toshiyuki Ishiwata

INTERNATIONAL JOURNAL OF ONCOLOGY, 41(4) 1314-1324, Oct, 2012 Peer-reviewed
Fibroblast Growth Factor Receptor 2 IIIc as a Therapeutic Target for Colorectal Cancer Cells

Yoko Matsuda, Masahito Hagio, Tomoko Seya, Toshiyuki Ishiwata

MOLECULAR CANCER THERAPEUTICS, 11(9) 2010-2020, Sep, 2012 Peer-reviewed
Glycochenodeoxycholic acid promotes proliferation of intestinal epithelia via reduction of cyclic AMP and increase in H2AX phosphorylation after exposure to gamma-rays

Satoshi Ishizuka, Maiko Shiwaku, Masahito Hagio, Takuya Suzuki, Tohru Hira, Hiroshi Hara

BIOMEDICAL RESEARCH-TOKYO, 33(3) 159-165, Jun, 2012 Peer-reviewed
Comparison of tumor-forming ability in different fractions of pancreatic ductal adenocarcinoma cells

Hagio Masahito, Matsuda Yoko, Kawamoto Yoko, Yanagisawa Yuji, Makino Hiroshi, Naito Zenya, Ishiwata Toshiyuki

CANCER RESEARCH, 72, Apr 15, 2012 Peer-reviewed
The stem cell marker nestin inhibits growth and invasion of malignant melanoma

Akiyama Michiko, Matsuda Yoko, Hagio Masahito, Kawahara Kiyoko, Suzuki Taeko, Ishiwata Toshiyuki, Kawana Seiji, Naito Zenya

CANCER RESEARCH, 72, Apr 15, 2012 Peer-reviewed
Nestin regulates stem cell functions of pancreatic cancer cells

Matsuda Yoko, Hagio Masahito, Yanagisawa Yuji, Suzuki Taeko, Kawamoto Yoko, Kawahara Kiyoko, Naito Zenya, Ishiwata Toshiyuki

CANCER RESEARCH, 72, Apr 15, 2012 Peer-reviewed
Expression of cancer stem cell markers in pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias

Kure Shoko, Matsuda Yoko, Hagio Masahito, Suzuki Taeko, Ueda Junji, Yamahatsu Kazuya, Yamamoto Tetsushi, Naito Zenya, Ishiwata Toshiyuki

CANCER RESEARCH, 72, Apr 15, 2012 Peer-reviewed
Is bile acid a determinant of the gut microbiota on a high-fat diet?

Atsushi Yokota, Satoru Fukiya, Tadasuke Ooka, Yoshitoshi Ogura, Tetsuya Hayashi, Satoshi Ishizuka

Gut Microbes, 3(5) 455-459, 2012 Peer-reviewed

Misc.

高脂肪食摂取ラットの盲腸内菌叢の変化における胆汁酸の寄与:「胆汁酸仮説」の証明にむけて

渡辺真通, 萩尾真人, 李慈英, 小椋義俊, 林哲也, 清水英寿, 石塚敏, 吹谷智, 横田篤

腸内細菌学雑誌, 30(2), 2016
高脂肪食摂取ラットの盲腸内菌叢の変化における腸内細菌の胆汁酸耐性の寄与

渡辺真通, 萩尾真人, LEE Ja-Young, 小椋義俊, 林哲也, 清水英寿, 石塚敏, 吹谷智, 横田篤

日本農芸化学会大会講演要旨集(Web), 2016, 2016
高脂肪食摂取がラット盲腸内容物の胆汁酸分泌および菌叢変化に与える影響

渡辺真通, 萩尾真人, 藤田祐己, LEE Ja-Young, 馬場菜那子, 小椋義俊, 小椋義俊, 林哲也, 林哲也, 清水英寿 …

日本農芸化学会大会講演要旨集(Web), 2015, 2015
コール酸長期摂取ラットにおける腸内細菌叢変動を介した非肥満性脂肪肝の発症

横田篤, 李慈英, 清水英寿, 萩尾真人, 吹谷智, 大岡唯祐, 小椋義俊, 林哲也, 石塚敏

日本未病システム学会学術総会抄録集, 22nd, 2015
コール酸経口負荷による肝脂質蓄積

辻美咲, 吉次玲香, 菊地慧大, 野勢琢馬, 清水英寿, 李慈英, 馬場菜那子, 萩尾真人, 吹谷智, 横田篤 …

肥満研究, 20(Supplement), 2014
コール酸長期摂取ラットにおける糞便中胆汁酸組成の変化と腸内細菌叢との関係

馬場菜那子, 萩尾真人, LEE Ja-Young, 吹谷智, 小椋義俊, 小椋義俊, 清水英寿, 大岡唯祐, 林哲也, 林哲也 …

日本農芸化学会大会講演要旨集(Web), 2014, 2014
胆汁酸と腸内フローラ:メタボリックシンドローム発症との関連性

横田篤, 吹谷智, ISLAM K.B.M. Saiful, 大岡唯祐, 小椋義俊, 小椋義俊, 林哲也, 林哲也, 萩尾真人, 石塚敏

日本農芸化学会大会講演要旨集(Web), 2014, 2014
Skatoleの経口負荷が肝Cyp7a1発現と二次胆汁酸排泄の亢進を誘導する

野勢琢馬, 清水英寿, 萩尾真人, 吹谷智, 横田篤, 原博, 石塚敏

肥満研究, 20(Supplement), 2014
腸内細菌代謝物スカトールは肝臓でのCyp7a1の発現と糞中二次胆汁酸増加を誘導する

野勢琢馬, 清水英寿, 萩尾真人, 吹谷智, 横田篤, 原博, 石塚敏

日本分子生物学会年会プログラム・要旨集(Web), 37th, 2014
1P-117 Effect of fumarate on the cholic acid metabolism in Clostridium hiranonis

Torii Tsuyoshi, Honda Nozomi, Hagio Masahito, Fukiya Satoru, Yokota Atsushi

66 46-46, 2014
Oral administration of cholic acid modulates the gut microbiota and epithelial proliferation

Satoshi Ishizuka, Manami Takatsuki, Maiko Shiwaku, Masahito Hagio, Reika Yoshitsugu, Keidai Kikuchi, Nobuyuki Fujii, Ga-Hyun Joe, Hidehisa Shimizu, Hiroshi Hara …

FASEB JOURNAL, 27, Apr, 2013
Deoxycholic acid is involved in the initiation and progression of atherosclerosis.

Hidehisa Shimizu, Masahito Hagio, Reika Yoshitsugu, Keidai Kikuchi, Ga Hyun Joe, Hiroshi Hara, Satoshi Ishizuka

FASEB JOURNAL, 27, Apr, 2013
COMPARISON OF FERMENTATION LEVELS IN LARGE INTESTINE OF RATS FED DIFFERENT CARBOHYDRATE-SOURCE DIETS BY ANALYZING FECES USING LC/MS

M. Hagio, M. Matsumoto, A. Shinoki, A. Yokota, S. Ishizuka

ANNALS OF NUTRITION AND METABOLISM, 63 362-363, 2013
膵癌細胞のサイドポピュレーションは腫瘍を高頻度に形成する(Side Population of Pancreatic Ductal Adenocarcinoma Cells Form Tumors at a High Frequency)

萩尾真人, 松田陽子, 吉村久志, 河本陽子, 柳澤祐次, 石渡俊行

日本癌学会総会記事, 71回 137-137, Aug, 2012
ネスチンは肺腺癌患者の術後予後不良に関連する(Nestin Expression Associated with the Poor Prognosis of Postoperative Patients Diagnosed with Lung Adenocarcinoma)

成田宏介, 萩尾真人, 松田陽子, 清家正博, 弦間昭彦, 内藤善哉, 石渡俊行

日本癌学会総会記事, 71回 164-164, Aug, 2012
免疫不全マウスを用いたヒト膵癌の同所移植モデルにおけるin vivoイメージング(In vivo imaging of orthotopic implantation of human pancreatic cancer in nude, NOG, and SHO mice)

吉村久志, 松田陽子, 萩尾真人, 鈴木妙子, 河本陽子, 柳澤祐次, 川原清子, 石渡俊行

日本癌学会総会記事, 71回 396-396, Aug, 2012
悪性黒色腫の増殖、浸潤、転移におけるネスチンの役割の検討(Nestin Plays Important Roles in Cell Growth, Invasion and the Metastasis of Malignant Melanoma)

秋山美知子, 松田陽子, 萩尾真人, 川原清子, 鈴木妙子, 山本哲志, 川名誠司, 石渡俊行, 内藤善哉

日本癌学会総会記事, 71回 423-424, Aug, 2012
膵癌転移巣における癌幹細胞および上皮間葉転換マーカーの発現(Pancreatic cancer cells from metastatic foci of NOG mice possess high-level stemness and EMT characteristics)

松田陽子, 萩尾真人, 吉村久志, 鈴木妙子, 河本陽子, 柳澤祐次, 川原清子, コーク・マレー, 石渡俊行

日本癌学会総会記事, 71回 489-489, Aug, 2012
膵癌細胞株におけるnestin発現関連遺伝子の網羅的解析

萩尾真人, 松田陽子, 鈴木妙子, 柳澤祐次, 河本陽子, 川原清子, 内藤善哉, 石渡俊行

すい臓, 27(3) 534-534, May 30, 2012
悪性黒色腫におけるnestin抑制効果の検討

秋山美知子, 松田陽子, 萩尾真人, 川原清子, 石渡俊行, 内藤善哉, 川名誠司

日本皮膚科学会雑誌, 122(4) 1237-1237, Apr 15, 2012

Research Projects

Establishment of simple evaluation system for intestinal environment and elucidation of effect of running exercise on intestinal environment

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2020

HAGIO Masahito
Influence of intestinal fermentation products caused by excessive animal protein intake on intestinal and various organs.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Shimizu Hidehisa, MIYAZAKI Hitoshi, ISHIZUKA Satoshi
Elucidation of the role of cytoskeletal proteins in circulating tumor cells of pancreatic cancer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

HAGIO Masahito
LC/MSを用いた膵癌組織中nestinタンパク定量法の検討

共同研究, 2011

Industrial Property Rights

特開2018-119859 糞便中の化学物質の抽出方法、及びキット

萩尾真人

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