Naoaki Shinzawa

Profile Information

Affiliation: Assistant Professor, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

Degree: 博士（薬学）(東京大学)

J-GLOBAL ID: 201101030245050367
researchmap Member ID: 6000029506

External link: https://reins.tmd.ac.jp/html/100025653_ja.html

Research Areas

Life sciences / Parasitology /

Research History

Jan, 2023 - Present

Lecturer, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Jul, 2017 - Dec, 2022

Assistant Professor, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Jun, 2013 - Jun, 2017

Research Institute for Microbial Diseases, Osaka University
Apr, 2010 - May, 2013

Graduate School of Medicine, Ehime University

Education

- 2010

The University of Tokyo
- 2010

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
- 2007

The University of Tokyo
- 2007

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
- 2005

Faculty of Pharmaceutical Sciences, The University of Tokyo
- 2005

Faculty of Pharmaceutical Science, The University of Tokyo

Awards

2009

第９回森脇大五郎賞

Papers

Identification of a novel protein localized to the crystalloid of the plasmodium ookinete.

Mayumi Tachibana, Minami Baba, Hideyuki Iriko, Naoaki Shinzawa, Motomi Torii, Tomoko Ishino

Parasitology international, 102892-102892, Mar 31, 2024
Complete genome sequences of nine Burkholderia pseudomallei strains

Takashi Nishida, Yukihiro Hiramatsu, Naoaki Shinzawa, Atsuko Horino, Shigetarou Mori, Yasuhiko Horiguchi

Microbiology Resource Announcements, 12(9) e0040023, Jul, 2023 Peer-reviewed
Genome-wide functional screening of drug-resistance genes in Plasmodium falciparum

Shiroh Iwanaga, Rie Kubota, Tsubasa Nishi, Sumalee Kamchonwongpaisan, Somdet Srichairatanakool, Naoaki Shinzawa, Din Syafruddin, Masao Yuda, Chairat Uthaipibull

Nature Communications, 13(1), Dec, 2022
Generation of Transgenic Mosquitoes Harboring a Replication-Restricted Virus

Naoaki Shinzawa, Chisako Kashima, Hiroka Aonuma, Kei Takahashi, Masayuki Shimojima, Shinya Fukumoto, Erisha Saiki, Daisuke S. Yamamoto, Shigeto Yoshida, Hiroyuki Matsuoka …

Frontiers in Tropical Diseases, 3, May 19, 2022 Peer-reviewedLead author
Evaluation of the Effect of Gene Duplication by Genome Editing on Drug Resistance in Plasmodium falciparum.

Rie Kubota, Tomoko Ishino, Shiroh Iwanaga, Naoaki Shinzawa

Frontiers in cellular and infection microbiology, 12 915656-915656, 2022 Peer-reviewedLast authorCorresponding author
Chromosome splitting of Plasmodium berghei using the CRISPR/Cas9 system.

Daniel Addo-Gyan, Haruka Matsushita, Enya Sora, Tsubasa Nishi, Masao Yuda, Naoaki Shinzawa, Shiroh Iwanaga

PloS one, 17(2) e0260176, 2022 Peer-reviewedCorresponding author
Highly efficient CRISPR/Cas9 system in Plasmodium falciparum using Cas9-expressing parasites and a linear donor template.

Tsubasa Nishi, Naoaki Shinzawa, Masao Yuda, Shiroh Iwanaga

Scientific reports, 11(1) 18501-18501, Sep 16, 2021 Peer-reviewed
AGIA Tag System for Ultrastructural Protein Localization Analysis in Blood-Stage Plasmodium falciparum.

Masayuki Morita, Bernard N Kanoi, Naoaki Shinzawa, Rie Kubota, Hiroyuki Takeda, Tatsuya Sawasaki, Takafumi Tsuboi, Eizo Takashima

Frontiers in cellular and infection microbiology, 11 777291-777291, 2021 Peer-reviewed
Improvement of CRISPR/Cas9 system by transfecting Cas9-expressing Plasmodium berghei with linear donor template.

Naoaki Shinzawa, Tsubasa Nishi, Fumiya Hiyoshi, Daisuke Motooka, Masao Yuda, Shiroh Iwanaga

Communications biology, 3(1) 426-426, Aug 5, 2020 Peer-reviewedLead author
The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis.

Kentaro Tsukamoto, Naoaki Shinzawa, Akito Kawai, Masahiro Suzuki, Hiroyasu Kidoya, Nobuyuki Takakura, Hisateru Yamaguchi, Toshiki Kameyama, Hidehito Inagaki, Hiroki Kurahashi …

Nature communications, 11(1) 3571-3571, Jul 16, 2020 Peer-reviewed
Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor.

Shihono Teruya, Yukihiro Hiramatsu, Keiji Nakamura, Aya Fukui-Miyazaki, Kentaro Tsukamoto, Noriko Shinoda, Daisuke Motooka, Shota Nakamura, Keisuke Ishigaki, Naoaki Shinzawa …

mBio, 11(2), Mar 24, 2020 Peer-reviewed
Rab5b-Associated Arf1 GTPase Regulates Export of N-Myristoylated Adenylate Kinase 2 From the Endoplasmic Reticulum in Plasmodium falciparum.

Izumi Taku, Tomohiro Hirai, Takashi Makiuchi, Naoaki Shinzawa, Shiroh Iwanaga, Takeshi Annoura, Kisaburo Nagamune, Tomoyoshi Nozaki, Yumiko Saito-Nakano

Frontiers in cellular and infection microbiology, 10 610200-610200, 2020 Peer-reviewed
Identification of Bordetella dermonecrotic toxin receptor

照屋志帆乃, 平松征洋, 篠田典子, 塚本健太郎, 中村佳司, 福井理, 石垣佳祐, 新澤直明, 堀口安彦

Apr, 2019
CRISPR/Cas9 system in Plasmodium falciparum using the centromere plasmid.

Tongchai Payungwoung, Naoaki Shinzawa, Akina Hino, Tubasa Nishi, Yuho Murata, Masao Yuda, Shiroh Iwanaga

Parasitology international, 67(5) 605-608, Oct, 2018 Peer-reviewed
The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of Bordetella bronchiseptica and B. parapertussis, but Not B. pertussis.

Aya Fukui-Miyazaki, Hirono Toshima, Yukihiro Hiramatsu, Keisuke Okada, Keiji Nakamura, Keisuke Ishigaki, Naoaki Shinzawa, Hiroyuki Abe, Yasuhiko Horiguchi

mBio, 9(4) e00628-18, Aug 28, 2018 Peer-reviewed
Ectopic expression of O antigen in Bordetella pertussis by a novel genomic integration system

Keisuke Ishigaki, Naoaki Shinzawa, Sayaka Nishikawa, Koichiro Suzuki, Aya Fukui-Miyazaki, Yasuhiko Horiguchi

mSphere, 3(1) e00417-17, Jan 24, 2018 Peer-reviewed
Protective effects of in vivo-expressed autotransporters against Bordetella pertussis infection.

Koichiro Suzuki, Naoaki Shinzawa, Keisuke Ishigaki, Keiji Nakamura, Hiroyuki Abe, Aya Fukui-Miyazaki, Kazuyoshi Ikuta, Yasuhiko Horiguchi

Microbiology and immunology, 61(9) 371-379, Sep, 2017 Peer-reviewed
生体RNAシークエンス分析から明らかになったBordetella pertussis感染に対する新規の抗原(In vivo RNA-seq reveals novel antigens against Bordetella pertussis infection)

鈴木孝一朗, 新澤直明, 元岡大祐, 中村昇太, 石垣佳祐, 生田和良, 山西弘一, 堀口安彦

日本細菌学雑誌, 72(1) 60-60, Feb, 2017
新規のゲノム統合合成システムを用いたBordetella pertussisにおけるO抗原の異所性発現(Ectopic expression of O-antigen in Bordetella pertussis by a novel genomic integration system)

石垣佳祐, 新澤直明, 西川明芳, 鈴木孝一朗, 堀口安彦

日本細菌学雑誌, 72(1) 64-64, Feb, 2017
百日咳毒素の感染における役割の分析(Analysis of roles of pertussis toxin in infection)

新居佑規, 中村佳司, 鈴木孝一朗, 安倍裕順, 新澤直明, 堀口安彦

日本細菌学雑誌, 71(1) 74-74, Feb, 2016

Misc.

Protein-Protein interactome analysis of Plasmodium parasites using AirID, the novel proximity biotinylation enzyme

窪田理恵, 関根崇, GYAN Daniel Kweku Addo, 小迫英尊, 澤崎達也, 新澤直明, 石野智子

日本寄生虫学会大会プログラム・抄録集, 92nd, 2023
大腸菌の細胞外小胞によるマクロファージのエキソソームを介した炎症反応(Escherichia coli-derived outer membrane vesicles cause the proinflammatory signal mediated by exosomes)

岡真優子, 木村唯, 矢倉大介, 新澤直明, 堀口安彦, 市川寛, 南山幸子

日本細菌学雑誌, 72(1) 68-68, Feb, 2017
めざせ!細菌学の★2016 百日咳の病態発生機序解明に向けた感染動物モデルの確立

中村佳司, 神谷重樹, 安倍裕順, 新澤直明, 堀口安彦

日本細菌学雑誌, 71(1) 31-31, Feb, 2016
再興する百日咳の制御に向けた新規感染防御抗原の探索研究

鈴木孝一朗, 鈴木孝一朗, 新澤直明, 石垣佳祐, 元岡大祐, 中村昇太, 中村昇太, 生田和良, 山西弘一, 堀口安彦

日本小児感染症学会総会・学術集会プログラム・抄録集, 48th, 2016
百日せきワクチンにおける新規感染防御抗原の探索研究

鈴木孝一朗, 鈴木孝一朗, 新澤直明, 石垣佳祐, 元岡大祐, 中村昇太, 中村昇太, 生田和良, 山西弘一, 堀口安彦

日本ワクチン学会学術集会プログラム・抄録集, 20th, 2016
THE FUNCTIONAL ANALYSES OF A PLASMODIUM ALVEOLIN PROTEIN DURING MOSQUITO STAGE PARASITE DEVELOPMENT

Natcha Lorsuwannarat, Naoaki Shinzawa, Mayumi Tachibana, Riko Katsube, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 93(4) 60-60, Oct, 2015
ハエ類による病原細菌の摂食媒介メカニズム

岡戸清, 新澤直明, 福本晋也, 嘉糠洋陸

衛生動物, 63(2) 149, Jun 30, 2012
ショウジョウバエによる病原細菌の摂食媒介

岡戸清, 新澤直明, 福本晋也, 嘉糠洋陸

日本分子生物学会年会プログラム・要旨集(Web), 34th 2P-0565 (WEB ONLY), 2011
Legionella metaeffector exploits host proteasome to temporally regulate cognate effector.

Tomoko Kubori, Naoaki Shinzawa, Hirotaka Kanuka, Hiroki Nagai

PLoS pathogens, 6(12) e1001216, Dec 2, 2010 Peer-reviewed
感染に対する宿主側トレランス機構の発見

生化学, 82(11) 1051-1055, 2010
ショウジョウバエは病原体を嗅覚で認識し摂食媒介する

岡戸清, 新澤直明, 福本晋也, 嘉糠洋陸

生化学, ROMBUNNO.1T11-4, 2010
p38 MAPK-dependent phagocytic encapsulation confers infection tolerance in Drosophila.

Naoaki Shinzawa, Bryce Nelson, Hiroka Aonuma, Kiyoshi Okado, Shinya Fukumoto, Masayuki Miura, Hirotaka Kanuka

Cell host & microbe, 6(3) 244-52, Sep 17, 2009 Peer-reviewed
p38 MAPK-Dependent Phagocytic Encapsulation Confers Infection Tolerance in Drosophila

Naoaki Shinzawa, Bryce Nelson, Hiroka Aonuma, Kiyoshi Okado, Shinya Fukumoto, Masayuki Miura, Hirotaka Kanuka

CELL HOST & MICROBE, 6(3) 244-252, Sep, 2009
蚊・マラリア原虫・腸内細菌の三者の相互作用

伴戸寛徳, 青沼宏佳, 岡戸清, 新澤直明, 福本晋也, 嘉糠洋陸

日本獣医学会学術集会講演要旨集, 148th 186, 2009
細菌感染に対する宿主側トレランス機能の解明

新澤直明, 青沼宏佳, 岡戸清, 福本晋也, 三浦正幸, 嘉糠洋陸

日本獣医学会学術集会講演要旨集, 148th 194, 2009
トランスジェニック蚊を用いたウイルス生ワクチン産生の試み

鹿島千紗子, 新澤直明, 高橋慧, 福本晋也, 下島昌幸, 河岡義裕, 嘉糠洋陸

日本分子生物学会年会講演要旨集, 32nd(Late-Breaking Abstracts) 125, 2009
ハエ不顕性感染モデル貪食性囲い込みは細菌感染に対するトレランス機能を制御する

新澤直明, NELSON Bryce, 青沼宏佳, 岡戸清, 福本晋也, 三浦正幸, 嘉糠洋陸

日本分子生物学会年会講演要旨集, 32nd(Vol.4) 209, 2009
機械的な病原体伝播と自然免疫の相互作用

岡戸清, 新澤直明, 福本晋也, 嘉糠洋陸

日本分子生物学会年会講演要旨集, 32nd(Vol.4) 209, 2009
貪食細胞による囲い込みは細菌感染に対するtolerance機能を宿主に付与する

新澤直明, 青沼宏佳, 福本晋也, 三浦正幸, 嘉糠洋陸

生化学, 4T20-8, 2008
What Drosophila can teach us about infectious disease : Genetic dissection of host resistance

62(1) 48-48, Feb 25, 2007

Professional Memberships

Research Projects

A comprehensive study of parasite and host multigene families involved in malaria onset using patient blood samples in West Africa

Jul, 2023 - Mar, 2026
Interdisciplinary Research on the Molecular Basis of the Liver Specificity on Malaria Parasite Infection.

AMED, Jun, 2023 - Mar, 2026
スポロゾイトと肝細胞の相互作用に着目したマラリア原虫感染成立の分子基盤の解明

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2025

石野智子, 橘真由美, 新澤直明, 長岡ひかる
Post-transcriptional regulation by CCCH-type zinc finger family of Plasmodium parasites

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Genetic dissection of artemisinin resistance of malaria parasites by combination of genetics and bioinformatics with field-isolate strains.

AMED, Dec, 2020 - Mar, 2023
Identification of factors associated with severe malaria in residents of disease endemic areas for development of new control measures.

AMED, Jul, 2020 - Mar, 2023
Genetic dissection of merozoite invasion by taeget gene analysis of merozoite-specific transcription factors in malaria parasites

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Shinzawa Naoaki
Preparation of Bordetella pertussis that infects experimental animals by introduction of large DNA fragments from B. bronchiseptica

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Horiguchi Yasuhiko, SHINZAWA Naoaki, NAKAMURA Keiji
Identification of novel virulence factors involved in invasiveness of Burkholderia pseudomallei

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

SHINZAWA Naoaki
Analyses for the mechanism by which Bordetella pertussis causes paroxysmal coughing

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Yasuhiko Horiguchi, SHINZAWA Naoaki, NAKAMURA Keiji
Analysis of bacteria-host neuron interactions to study the mechanism of whooping cough

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Shinzawa Naoaki
Development of the detection method for Plasmodium vivax hypnozoites

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2010 - 2012

ISHINO Tomoko, SHINZAWA Naoaki, TACHIBANA Mayumi
Parasites-adaptation to vector environments in Plasmodium

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up, Grant-in-Aid for Research Activity start-up, Japan Society for the Promotion of Science, 2010 - 2011

SHINZAWA Naoaki
細菌感染における抵抗性を左右する宿主側レジスタンス・ファクターの網羅的解明

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2007 - 2009

新澤直明

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