TSUJI Motonori

J-GLOBAL         Last updated: Jun 24, 2018 at 20:49
 
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Name
TSUJI Motonori
E-mail
motonorimolfunction.com
URL
http://www.molfunction.com/tsuji/
Affiliation
Institue of Molecular Function
Job title
President
Degree
PhD (Pharmacy)(University of Tokyo)
Other affiliation
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
Research funding number
90772591
ORCID ID
0000-0003-0734-0334

Research Areas

 
 

Academic & Professional Experience

 
Apr 2017
 - 
Today
Part-time Lecturer, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
 
Jul 2003
 - 
Today
President, Institute of Molecular Function
 
Dec 2008
 - 
Sep 2014
Senior Researcher, R&D Department, Hodogaya Chemical Co., Ltd.
 
Jun 2007
 - 
Aug 2007
Invited Researcher, Graduate School of Medicine, Chiba University
 
Apr 2001
 - 
Jun 2003
Research Scientist, Drug Discovery Department, Institute of Medicinal Molecular Design, Inc.
 
Sep 1999
 - 
Mar 2001
Institute of Medicinal Molecular Design, Inc. (University of Tokyo) Postdooctoral Fellow
 
Apr 1998
 - 
Mar 2001
Researcher, The Organization for Pharmaceutical Safety and Research
 
Apr 1998
 - 
Mar 2001
Researcher, Institute of Molecular and Cellular Bioscience, University of Tokyo
 
Jun 1997
 - 
Mar 2001
Research Assistant, Graduate School of Pharmaceutical Sciences, University of Tokyo
 

Education

 
Apr 1992
 - 
May 1997
Graduate School of Pharmaceutical Sciences, University of Tokyo
 
Apr 1990
 - 
Mar 1992
Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
 
Apr 1986
 - 
Mar 1990
Environmental Chemistry, Faculty of Engineering, Kyushu Kyoritsu University
 

Published Papers

 
Antagonist-Perturbation Mechanism for Activation Function-2 Fixed Motifs: Active Conformation and Docking Mode of Retinoid X Receptor Antagonists
Motonori Tsuji*
J. Comput. Aided Mol. Des.   31 577-585   Jun 2017   [Refereed]
Identifying the Receptor Subtype Selectivity of Retinoid X and Retinoic Acid Receptors via Quantum Mechanics
Motonori Tsuji*, Koichi Shudo, Hiroyuki Kagechika
FEBS Open Bio.   7 391-396   Feb 2017   [Refereed]
Motonori Tsuji*
J. Mol. Graph. Model.   62 262-275   Nov 2015   [Refereed]
Motonori Tsuji*, Koichi Shudo, Hiroyuki Kagechika
J. Comput. Aided Mol. Des.   29 975-988   Oct 2015   [Refereed]
Motonori Tsuji*
J. Struct. Biol.   185 355-365   Mar 2014   [Refereed]
ChemInform Abstract: A Remote Substituent Can Determine Magnitude of Facial Selectivity in Benzobicyclo[2.2.2]octatrienes
Tomohiko Ohwada, Motonori Tsuji, Iwao Okamoto, Koichi Shudo
ChemInform.   27    Jul 2010   [Refereed]
ChemInformAbstract: Polyenylidene Thiazolidine Derivatives with Retinoidal Activities.
Toshihiko Tashima, Hiroyuki Kagechika, Motonori Tsuji, Hiroshi Fukasawa, Emiko Kawachi, Yuichi Hashimoto, Koichi Shudo
ChemInform.   29    May 2010   [Refereed]
Development of the Structure-based Drug Design Systems, HMHC and DSHC.
Motonori Tsuji*
Mol. Sci.   1 NP004   Jun 2007   [Invited]
Motonori Tsuji*
J. Org. Chem.   69(12) 4063-4074   May 2004   [Refereed]
Motonori Tsuji*
J. Org. Chem.   68(25) 9589-9597   Nov 2003   [Refereed]
Motonori Tsuji, Yukiko Koiso, Hiroyasu Takahashi, Yuichi Hashimoto, Yasuyuki Endo
Biol. Pharm. Bull.   23(4) 513-516   Apr 2000   [Refereed]
Masayuki Ebisawa, Hiroki Umemiya, Kiminori Ohta, Hiroshi Fukasawa, Emiko Kawachi, Ghislaine Christoffel, Hinrich Gronemeyer, Motonori Tsuji, Yuichi Hashimoto, Koichi Shudo, Hiroyuki Kagechika
Chem. Pharm. Bull.   47(12) 1778-1786   Dec 1999   [Refereed]
Yasuyuki Endo, Kyoko Yaguchi, Motonori Tsuji, Kentaro Yamaguchi, Koichi Shudo
Chem. Pharm. Bull.   47(5) 699-701   May 1999   [Refereed]
Toru Iijima, Yasuyuki Endo, Motonori Tsuji, Emiko Kawachi, Hiroyuki Kagechika, Koichi Shudo
Chem. Pharm. Bull.   47(3) 398-404   Mar 1999   [Refereed]
Kiminori Ohta, Motonori Tsuji, Emiko Kawachi, Hiroshi Fukasawa, Yuichi Hashimoto, Koichi Shudo, Hiroyuki Kagechika
Biol. Pharm. Bull.   21(5) 544-546   May 1998   [Refereed]
Orbital Interactions Determining the Facial Selectivity in Bicyclic and Spiro Olefins
Motonori Tsuji*
The University of Tokyo   1-172   Mar 1998   [Refereed]
Motonori Tsuji, Tomohiko Ohwada, Koichi Shudo
Tetrahedron Lett.   39(5/6) 403-406   Jan 1998   [Refereed]
Toshihiko Tashima, Hiroyuki Kagechika, Motonori Tsuji, Hiroshi Fukasawa, Emiko Kawachi, Yuichi Hashimoto, Koichi Shudo
Chem. Pharm. Bull.   45(11) 1805-1813   Nov 1997   [Refereed]
Motonori Tsuji, Tomohiko Ohwada, Koichi Shudo
Tetrahedron Lett.   38(38) 6693-6696   Sep 1997   [Refereed]

Misc

 
Rational Drug Design for Organic Chemists
Motonori Tsuji*
Institute of Molecular function   1-9   Sep 2006

Books etc

 
Docking Study with HyperChem Manual 2
Motonori Tsuji*
Institute of Molecular Function   Feb 2018   ISBN:987-4-9902513-5-2
Homology Modeling professional for HyperChem Manual 2
Motonori Tsuji*
Institute of Molecular Function   Feb 2018   ISBN:978-4-9902513-4-5
AutoDock Vina In Silico Screenings Interface
Motonori Tsuji*
Institute of Molecular Function   Feb 2018   
Homology Modeling Professional for HyperChem, Rev. H1
Motonori Tsuji*
Institute of Molecular Function   Feb 2018   
ONIOM Interface for Receptor, Rev. H1
Motonori Tsuji*
Institute of Molecular Function   Feb 2018   
Gaussian Interface for HyperChem, Rev. H1
Motonori Tsuji*
Institute of Molecular Function   Feb 2018   
Virtual Screening System Rev. H1
Motonori Tsuji*
Institute of Molecular Function   Feb 2018   
Docking Study with HyperChem, Rev. H1
Motonori Tsuji*
Institute of Molecular Function   Feb 2018   
Gaussian Interface for HyperChem, Rev. G1.2
Motonori Tsuji*
Institute of Molecular Function   Apr 2017   
ONIOM Interface for Receptor, Rev. G1.2
Motonori Tsuji*
Institute of Molecular Function   Apr 2017   
Homology Modeling Professional for HyperChem, Rev. G1.2
Motonori Tsuji*
Institute of Molecular Function   Apr 2017   
Homology Modeling Professional for HyperChem, Rev. G1.1
Motonori Tsuji*
Institute of Molecular Function   Mar 2016   
ONIOM Interface for Receptor, Rev. G1.1
Motonori Tsuji*
Institute of Molecular Function   Mar 2016   
Gaussian Interface for HyperChem, Rev. G1.1
Motonori Tsuji*
Institute of Molecular Function   Mar 2016   
Docking Study with HyperChem, Rev. G1.1
Motonori Tsuji*
Institute of Molecular Function   Mar 2016   
Virtual Screening System, Rev. G1.1
Motonori Tsuji*
Institute of Molecular Function   Mar 2016   
Gaussian Interface for HyperChem, Rev. G1
Motonori Tsuji*
Institute of Molecular Function   Jan 2015   
ONIOM Interface for Receptor, Rev. G1
Motonori Tsuji*
Institute of Molecular Function   Jan 2015   
Homology Modeling Professional for HyperChem, Rev. G1
Motonori Tsuji*
Institute of Molecular Function   Jan 2015   
Docking Study with HyperChem, Rev. G1
Motonori Tsuji*
Institute of Molecular Function   Jan 2015   

Conference Activities & Talks

 
Advancement of Drug Design Technology via In Silico Drug Design System, Docking Study with HyperChem(DSHC) and Homology Modeling Professional for HyperChem(HMHC)
Motonori Tsuji*(Institute of Molecular Function)
Society of Computer Chemistry, Japan   Jun 2018   
Antagonist-Perturbation Mechanism for Activation Function-2 Fixed Motifs: Active Conformation and Docking Mode of Retinoid X Receptor Antagonists.
Motonori Tsuji*(Institute of Molecular Function)
The Pharmaceutical Society of Japan   Mar 2018   
Identifying the receptor subtype selectivity of retinoids via docking, QM/MM, and quantum mechanics calculations: ATRA can act as an endogenous RXR ligand
Motonori Tsuji*(Institute of Molecular Function, Tokyo Medical and Dental University), Koichi Shudo(Japan Pharmaceutical Information Center), Hiroyuki Kagechika(Tokyo Medical and Dental University)
The 28th Symposium of Retinoids   19 Nov 2017   
Helix H3 Three-Point Initial-Binding Hypothesis: Understanding of Both the Ligand-Trapping Mechanism and the Simultaneous Structural Transition from Apo-Form to Holo-Form of the Ligand-Binding Domain in the Nuclear Receptor Superfamily
Motonori Tsuji*
The Pharmaceutical Society of Japan   Mar 2017   
Geometrical Dependence of the Highest Occupied Molecular Orbital in Bicyclic Systems: The Origin of the Facial Stereoselectivity of Bicyclic Olefins
Motonori Tsuji*
The Pharmaceutical Society of Japan   Mar 2016   
Structure and function of the local motifs in the canonical structure of the ligand-binding domain in the nuclear receptor superfamily
Motonori Tsuji*
The Pharmaceutical Society of Japan   Mar 2015   
Structure-based Drug Design System (Virtual Screening System, Docking Study with HyperChem, Homology Modeling for HyperChem, ONIOM Interface for Receptor, Gaussian Interface for HyperChem)
Motonori Tsuji*, et al
Protein Science Society of Japan   Jun 2008   
Structure-based Drug Design System
Motonori Tsuji*, et al
The Pharmaceutical Society of Japan   Mar 2008   
Orbital Interaction Theory for Facial Selectivity, Local Motif Theory Controlling Canonical Fold of Ligand-binding Domains in the Nuclear Receptor Superfamily, Origin of the Driving Forces for the Ligand Recognition of the Nuclear Receptors, and Developme [Invited]
Motonori Tsuji*
Business Research Institute   Jan 2008   
Structure-based Drug Design System
Motonori Tsuji*, et al
The Biophysical Society of Japan   Dec 2007   
Structure-based Drug Design System
Motonori Tsuji*, et al
The Molecular Biology Society of Japan & The Japanese Biochemical Society   Nov 2007   
Structure-based Drug Design System
Motonori Tsuji*, et al
The Pharmaceutical Society of Japan   Mar 2007   
Structure-based Drug Design System
Motonori Tsuji*, et al
The Molecular Biology Society of Japan   Dec 2006   
Structure-based Drug Design System
Motonori Tsuji*, et al
Society of Computer Chemistry, Japan   Jun 2006   
Pyrimidine Carboxylic Acids Acting Nuclear Retinoid Receptor
Kiminori Ohta, Motonori Tsuji, Emiko Kawachi, Hiroshi Fukasawa, Hiroyuki Kagechika, Yuichi Hashimoto
The Pharmaceutical Society of Japan   Mar 2000   
Novel Diphenylamine Derivatives with Potent Retinoid Synergistic Activity
Kiminori Ohta, Motonori Tsuji, Emiko Kawachi, Hiroshi Fukasawa, Yuichi Hashimoto, Koichi Shudo, Hiroyuki Kagechika
216th ACS National Meeting   Aug 1998   
Novel Retinoids Having a Thiazolidinedione Group
Masayuki Ebisawa, Toshihiko Tashima, Motonori Tsuji, Hiroshi Fukasawa, Emiko Kawachi, Yuichi Hashimoto, Koichi Shudo, Hiroyuki Kagechika
216th ACS National Meeting   Aug 1998   
Development of Novel Retinoid-controlling Compounds
Kiminori Ohta, Motonori Tsuji, Emiko Kawachi, Hiroshi Fukasawa, Hiroyuki Kagechika, Koichi Shudo, Yuichi Hashimoto
The Pharmaceutical Society of Japan   Mar 1998   
Pai Facial Selectivity of Diels-Alder Dienes
Motonori Tsuji*, Tomohiko Ohwada, Koichi Shudo
The Pharmaceutical Society of Japan   Mar 1997   
Effect of Cyclopropane Ring on Pai Facial Selectivity in Bicyclo[2.2.2]octenes
Motonori Tsuji*, Tomohiko Ohwada, Masanobu Uchiyama, Koichi Shudo, Kentarou Yamaguchi
The Pharmaceutical Society of Japan   Mar 1996   

Research Grants & Projects

 
Experimental Investigation of Increasing Accuracy and Efficacy for Computer-aided Molecular Modeling
Organization for Pharmaceutical Safety: 
Project Year: Apr 1998 - Mar 2001    Investigator(s): Yuichi Hashimoto

Patents

 
特開2007-299125 : Seitaikoubunnsi niokeru Sougosayoubui no Yosokuhouhou
Motonori Tsuji*
特開WO2012102137 : CHARGE CONTROL AGENT AND TONER USING SAME
Ikuo Kimura, Motonori Tsuji, Masaya Tojo, Masashi Asakai
特開WO2014077288 : Polymerized Toner Comprising Cyclic Phenol Sulfide
Masaki Okubo, Motonori Tsuji, Masashi Asakai, Masaya Tojo, Masami Ito, Takeshi Yamamoto, Tetsuya Yoshida
特開WO2013129015 : CHARGE CONTROL AGENT AND TONER USING SAME
Ikuo Kimura, Motonori Tsuji, Masaya Tojo, Masashi Asakai
特開WO2013179536 : Organic Electroluminesence Device
Makoto Nagaoka, Shuichi Hayashi, Motonori Tsuji, Yoshikazu Aoki
特開WO2015046214 : CHARGE CONTROL AGENT AND TONER USING SAME
Masaki Okubo, Ikuo Kimura, Masami Ito, Motonori Tsuji, Takeshi Yamamoto, Masaya Tojo, Masashi Asakai, Tetsuya Yoshida
特願2014-120386 : CHARGE CONTROL AGENT AND TONER USING SAME
Motonori Tsuji, Tatsuya Yoshida, Masaya Asakai, Masaya Tojo, Jyunn Watanabe, Hideyuki Otsuka, Shusaku Ebisui, Masaki Okubo
特開WO2014017298 : CHARGE CONTROL AGENT AND TONER USING SAME
Masaki Okubo, Motonori Tsuji, Masashi Asakai, Masaya Tojo, Masami Ito
特許6263059 : CHARGE CONTROL AGENT AND TONER USING SAME
Masaki Okubo, Masami Ito, Motonori Tsuji, Masashi Asakai, Tatsuya Yoshida