2005年12月
Expression of SIP1 in oral squamous cell carcinomas: Implications for E-cadherin expression and tumor progression
International Journal of Oncology
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- 巻
- 27
- 号
- 6
- 開始ページ
- 1535
- 終了ページ
- 1541
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
Loss of E-cadherin expression allows carcinoma cells to liberate from the primary site and enhances invasion and metastasis. The genetic aberration of E-cadherin is a rare event in sporadic carcinomas, and transcription repressors are considered to take a central role in E-cadherin loss. However, expression of E-cadherin repressors is largely dependent on tissue and cell type. To identify the repressor expressed in oral squamous carcinomas, we compared the expression levels of E-cadherin and repressors by real-time RT-PCR. Among the repressors including SNAIL, SLUG, SJP1, E12 and E47, SIP1 was inversely correlated to E-cadherin (P<0.05). Chromatin immunoprecipitation showed that SIP1 specifically bound to the E-cadherin promoter region. SIP1 expression was immunohistochemically detected in 27.7% of 47 oral carcinomas, and SIPl-positive carcinomas did not express E-cadherin (P<0.01). Thirteen patients with SIP1 staining showed a lower disease specific survival rate (P<0.05). Multivariate risk factor analysis demonstrated that SIP1 expression was an independent prognostic value for disease-specific overall survival (P<0.05). These results suggest that SIP1 contributes to the loss of E-cadherin expression and that detection of SIP1 expression is a predictive and prognostic tool in clinical management of oral carcinomas.
- リンク情報
- ID情報
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- ISSN : 1019-6439
- eISSN : 1791-2423
- PubMed ID : 16273209
- SCOPUS ID : 33644821962