2008年1月
Prevalence of herpes B virus genome in the trigeminal ganglia of seropositive cynomolgus macaques
LABORATORY ANIMALS
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 42
- 号
- 1
- 開始ページ
- 99
- 終了ページ
- 103
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1258/la.2007.006031
- 出版者・発行元
- ROYAL SOC MEDICINE PRESS LTD
Herpes B virus infection is almost asymptomatic in macaques (Macaca spp.), which are the natural hosts of this pathogen, but is the cause of high mortality in humans. Reactivation of the latent virus in the trigeminal ganglia (TG) results in the shedding of infectious particles into the oral mucosal membrane. Saliva contaminated with the reactivated virus from the ganglia of the natural host is considered to be important for viral transmission to humans and other monkeys. In the present study, we investigated the prevalence of the herpes B virus genome in the left and right TG of seropositive asymptomatic cynomolgus macaques. The latent virus genome was detected using a polymerase chain reaction and microplate hybridization assay. We found that the virus DNA was present in one or both TG of 12 of the 30 macaques (40%) tested, with the virus being detected from both TG in five of the 12 macaques and from a single TG in the remaining seven.
- リンク情報
-
- DOI
- https://doi.org/10.1258/la.2007.006031
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/18348771
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000254044000011&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=42249107832&origin=inward
- ID情報
-
- DOI : 10.1258/la.2007.006031
- ISSN : 0023-6772
- PubMed ID : 18348771
- SCOPUS ID : 42249107832
- Web of Science ID : WOS:000254044000011