OKAZAKI Tomoki

J-GLOBAL         Last updated: Jul 2, 2018 at 19:02
 
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Name
OKAZAKI Tomoki
Affiliation
Teikyo University
Section
Faculty of Medicine
Job title
Professor

Research Areas

 
 

Academic & Professional Experience

 
Jul 2006
 - 
Today
Professor, School of Medicine Dept. of Biochemistry, Teikyo University
 
Apr 1998
 - 
Jun 2006
Associate Professor, Nephrology and Endocrine Unit, University of Tokyo
 

Education

 
 
 - 
1979
Faculty of Medicine, University of Tokyo
 

Published Papers

 
Tamamori-Adachi M, Koga A, Susa T, Fujii H, Tsuchiya M, Okinaga H, Hisaki H, Iizuka M, Kitajima S, Okazaki T
Scientific reports   8(1) 9636   Jun 2018   [Refereed]
Susa T, Iizuka M, Okinaga H, Tamamori-Adachi M, Okazaki T
Scientific reports   8(1) 9024   Jun 2018   [Refereed]
Maeba R, Kojima KI, Nagura M, Komori A, Nishimukai M, Okazaki T, Uchida S
Atherosclerosis   270 102-109   Mar 2018   [Refereed]
Masayoshi IIZUKA, Takao SUSA, Mimi TAMAMORI-ADACHI, Hiroko OKINAGA, Tomoki OKAZAKI
Proc. Jpn. Acad., Ser. B 93 (2017)   93 498-510   Aug 2017   [Refereed]
ATAT1 is essential for regulation of homeostasis-retaining cellular responses in corticotrophs along hypothalamic-pituitary-adrenal axis.
Nakakura T, Suzuki T, Torii S, Asano-Hoshino A, Nekooki-Machida Y, Tanaka H, Arisawa K, Nishijima Y, Susa T, Okazaki T, Kiuchi Y, Hagiwara H.
Cell Tissue Res.   in press    2017   [Refereed]
An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA near the PTH Gene Characterize an Ectopic PTH-Producing Tumor
Kosuke Uchida, Yuji Tanaka, Hitoshi Ichikawa, Masato Watanabe, Sachiyo Mitani, Koji Morita, Hiroko Fujii, Mayumi Ishikawa, Gen Yoshino, Hiroko Okinaga, Genta Nagae, Hiroyuki Aburatani, Yoshifumi Ikeda, Takao Susa, Mimi Tamamori-Adachi, Toshio Fukusato, Hiroshi Uozaki, Tomoki Okazaki, and Masayoshi Iizuka
J. Endocrine Society   1(6)    Jun 2017   [Refereed]
Maeba R, Araki A, Ishii K, Ogawa K, Tamura Y, Yasunaga M, Minami U, Komori A, Okazaki T, Nishimukai M, Hara H, Fujiwara Y.
Clin. Chim. Acta.   453 134-140   2016   [Refereed]
Kuribayashi-Okuma E, Shibata S, Arai S, Ota T, Watanabe S, Hisaki H, Okazaki T, Toda T, Uchida S.
Ther Apher Dial.   20(174) 182-OT004893   2016   [Refereed]
Susa T, Ikaga R, Kajitani T, Iizuka M, Okinaga H, Tamamori-Adachi M, Okazaki T
Journal of cellular physiology   30 1494-1506   Jul 2015   [Refereed]
Nishimukai M, Maeba R, Ikuta A, Asakawa N, Kamiya K, Yamada S, Yokota T, Sakakibara M, Tsutsui H, Sakurai T, Takahashi Y, Hui SP, Chiba H, Okazaki T, Hara H
Clinica chimica acta; international journal of clinical chemistry   437 147-154   Nov 2014   [Refereed]
Nishimukai M, Maeba R, Yamazaki Y, Nezu T, Sakurai T, Takahashi Y, Hui SP, Chiba H, Okazaki T, Hara H
Journal of lipid research   55 956-965   May 2014   [Refereed]
Fujii H, Tamamori-Adachi M, Uchida K, Susa T, Nakakura T, Hagiwara H, Iizuka M, Okinaga H, Tanaka Y, Okazaki T
PloS one   9 e110543   2014   [Refereed]
Iizuka M, Susa T, Takahashi Y, Tamamori-Adachi M, Kajitani T, Okinaga H, Fukusato T, Okazaki T
Cancer science   104 1647-1655   Dec 2013   [Refereed]
Mizuno Y, Ninomiya Y, Nakachi Y, Iseki M, Iwasa H, Akita M, Tsukui T, Shimozawa N, Ito C, Toshimori K, Nishimukai M, Hara H, Maeba R, Okazaki T, Alodaib AN, Al Amoudi M, Jacob M, Alkuraya FS, Horai Y, Watanabe M, Motegi H, Wakana S, Noda T, Kurochkin IV, Mizuno Y, Schönbach C, Okazaki Y
PLoS genetics   9 e1003286   2013   [Refereed]
Hisaki H, Matsuda J, Tadano-Aritomi K, Uchida S, Okinaga H, Miyagawa M, Tamamori-Adachi M, Iizuka M, Okazaki T
American journal of physiology. Renal physiology   303 F1049-59   Oct 2012   [Refereed]
Maeba R, Yamazaki Y, Nezu T, Okazaki T
Annals of clinical biochemistry   49 86-93   Jan 2012   [Refereed]
Yamada K, Tamamori-Adachi M, Goto I, Iizuka M, Yasukawa T, Aso T, Okazaki T, Kitajima S
The Journal of biological chemistry   286 44057-44066   Dec 2011   [Refereed]
Kajitani T, Tamamori-Adachi M, Okinaga H, Chikamori M, Iizuka M, Okazaki T
Biochemical and biophysical research communications   407 472-478   Apr 2011   [Refereed]
Nakajima K, Okazaki T, Okamoto T, Kimura H, Takano K, Sato K
Endocrine journal   57 153-159   2010   [Refereed]
Hisaki H, Okazaki T, Kubota M, Nakane M, Fujimaki T, Nakayama H, Nakagomi T, Tamura A, Masuda H
Neurological research   30 979-984   Nov 2008   [Refereed]
Maeba R, Hara H, Ishikawa H, Hayashi S, Yoshimura N, Kusano J, Takeoka Y, Yasuda D, Okazaki T, Kinoshita M, Teramoto T
Journal of nutritional science and vitaminology   54 196-202   Jun 2008   [Refereed]
Maeba R, Maeda T, Kinoshita M, Takao K, Takenaka H, Kusano J, Yoshimura N, Takeoka Y, Yasuda D, Okazaki T, Teramoto T
Journal of atherosclerosis and thrombosis   14 12-18   Feb 2007   [Refereed]
[PTH-related protein producing tumor].
Okazaki T
Nihon rinsho. Japanese journal of clinical medicine   Suppl 3 317-323   Sep 2006   [Refereed]
Makita N, Iiri T, Sato J, Fukumoto S, Okazaki T, Yamazaki K, Obara T, Fujita T
Endocrine journal   53 311-316   Jun 2006   [Refereed]
[Asymptomatic hyperparathyroidism].
Okazaki T
Nihon rinsho. Japanese journal of clinical medicine   Suppl 2 10-15   Jun 2006   [Refereed]
[Parathyroid hormone--its localization and transcriptional regulation].
Okazaki T
Nihon rinsho. Japanese journal of clinical medicine   63 Suppl 10 284-291   Oct 2005   [Refereed]
Yoshida N, Omoto Y, Inoue A, Eguchi H, Kobayashi Y, Kurosumi M, Saji S, Suemasu K, Okazaki T, Nakachi K, Fujita T, Hayashi S
Cancer science   95 496-502   Jun 2004   [Refereed]
Okazaki T, Nishimori S, Ogata E, Fujita T
Biochemical and biophysical research communications   304 632-637   May 2003   [Refereed]
Sekine, N., S. Fukumoto, T. Ishikawa T. Okazaki, and T. Fujita.
Endocrinology   142 3909-3916   2001   [Refereed]
Gonadotropins stimulate growth of MCF-7 human breast cancer cells by promoting intracellular conversion of adrenal androgens to estrogens.
Tanaka, Y., K. Kuwabara, T. Okazaki, T. Fujita, I. Oizumi, S. Kaiho, and E. Ogata.
Oncology.   59 (Suppl 1) 19-23   2000   [Refereed]
T. Okazaki.
Endocrine J.   46 1-9   1999   [Refereed][Invited]
Nishishita, T., T. Okazaki, T. Ishikawa, T. Igarashi, K. Hata, E. Ogata and T. Fujita
J. Biol. Chem.   273 10901-10907   1998   [Refereed]
Okazaki, T., T. Ishikawa, S. Nishimori, T. Igarashi, K. Hata and T. Fujita
J. Biol. Chem.   272 32274-32279   1997   [Refereed]
Tyrosine kinase dependent expression of TGFβ induced by stretch in mesangial cells.
Hirakata, M., S. Kaname, U. Chung, N. Joki, Y. Hori, M. Noda, Y. Takuwa, T. Okazaki, T. Fujita, T. Katoh and K. Kurokawa
Kidney Int.   51 1028-1036   1997   [Refereed]
Chung, U., T. Igarashi, T. Nishishita, H. Iwanari, A. Iwamatsu, A. Suwa, T. Mimori, K. Hata, S. Ebisu, E. Ogata, T. Fujita and T. Okazaki:
J. Biol. Chem.   271 8593-8598   1996   [Refereed]
A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium.
Okazaki, T., U. Chung, T. Nishishita, S. Ebisu, S. Mishiro, S. Xanthoudakis, T. Igarashi and E. Ogata:
J. Biol. Chem.   269 27855-27862   1994   [Refereed]
Conserved mechanism of negative gene regulation by extracellular calcium-parathyroid hormone gene versus atrial natriuretic polypeptide gene.
Okazaki, T., K. Ando, T. Igarashi, E. Ogata and T. Fujita:
89 1268-1273   1992   [Refereed]
Negative regulatory elements in the human parathyroid hormone gene.
Okazaki T, Zajac JD, Igarashi T, Ogata E, Kronenberg HM
The Journal of biological chemistry   266 21903-21910   Nov 1991   [Refereed]
Inherited primary hypothyroidism with thyrotrophin resistance in Japanese cats.
Tanase H, Kudo K, Horikoshi H, Mizushima H, Okazaki T, Ogata E
The Journal of endocrinology   129 245-251   May 1991   [Refereed]
[Structure and regulation of the expression of the parathyroid hormone gene and processing of the precursors].
Okazaki T, Igarashi T
Nihon rinsho. Japanese journal of clinical medicine   47 2225-2230   Oct 1989   [Refereed]
5'-flanking region of the parathyroid hormone gene mediates negative regulation by 1,25-(OH)2 vitamin D3.
Okazaki T, Igarashi T, Kronenberg HM
The Journal of biological chemistry   263 2203-2208   Feb 1988   [Refereed]
Variation among mouse ribosomal RNA genes within and between chromosomes.
Sasaki T, Okazaki T, Muramatsu M, Kominami R
Molecular biology and evolution   4 594-601   Nov 1987   [Refereed]
Cell-specific expression of the human parathyroid hormone gene in rat pituitary cells.
Igarashi T, Okazaki T, Potter H, Gaz R, Kronenberg HM
Molecular and cellular biology   6 1830-1833   May 1986   [Refereed]
Structure and expression of the human parathyroid hormone gene.
Kronenberg HM, Igarashi T, Freeman MW, Okazaki T, Brand SJ, Wiren KM, Potts JT Jr
Recent progress in hormone research   42 641-663   1986   [Refereed]
Propylthiouracil-induced diffuse interstitial pneumonitis.
Miyazono K, Okazaki T, Uchida S, Totsuka Y, Matsumoto T, Ogata E, Terakawa K, Kurihara N, Takeda T
Archives of internal medicine   144 1764-1765   Sep 1984   [Refereed]
Ossification of the paravertebral ligaments: a frequent complication of hypoparathyroidism.
Okazaki T, Takuwa Y, Yamamoto M, Matsumoto T, Igarashi T, Kurokawa T, Ogata E
Metabolism: clinical and experimental   33 710-713   Aug 1984   [Refereed]
[Mechanism of synthesis, secretion, and metabolism of parathyroid hormones].
Okazaki T, Takuwa Y, Ogata E
Nihon rinsho. Japanese journal of clinical medicine   40 2608-2616   1982   [Refereed]
[A case of non-Hodgkin's lymphoma with huge splenomegaly, pancreatic pseudocyst, and intracystic bleeding (author's transl)].
Okazaki T, Hirai H, Ozawa K, Shionoya S, Urabe A, Hashimoto Y, Kosaka K
[Rinsho ketsueki] The Japanese journal of clinical hematology   22 1595-1602   Oct 1981   [Refereed]

Misc

 
ヒト前立腺癌LNCaP細胞における25(OH)D3のビタミンD3活性の評価
諏佐 崇生, 飯塚 眞由, 安達 三美, 岡崎 具樹
日本内分泌学会雑誌   94(1) 369-369   Apr 2018
saposin D欠損マウスの過剰飲水行動とGPR19およびAgt1Rの関係
久樹 晴美, 宮川 誠, 安達-玉盛 三美, 内田 俊也, 岡崎 具樹
生命科学系学会合同年次大会   2017年度 [1P-1280]   Dec 2017
プロテオミクスの手法を用いたIgA腎症扁桃摘出術の有用性に関する検討
栗林 恵美子, 柴田 茂, 久樹 晴美, 戸田 年総, 藤垣 嘉秀, 岡崎 具樹, 浅川 信一郎, 山崎 ちひろ, 古西 純子, 藤巻 道孝, 内田 俊也
日本腎臓学会誌   59(3) 300-300   Apr 2017
ペリリピン4の発現抑制が3T3-L1脂肪細胞の脂肪滴形成および代謝に与える影響
小谷 実祐, 長谷川 千織, 山辺 智代, 岡崎 具樹, 田中 光, 田中 直子
日本薬学会年会要旨集   137年会(3) 119-119   Mar 2017
Saposin D欠損マウスの原発性多飲症とadropin その受容体GPR19との関係
久樹 晴美, 只野 桂子[有冨], 宮川 誠, 玉盛 三美[安達], 内田 俊也, 岡崎 具樹
日本生化学会大会プログラム・講演要旨集   89回 [1P-313]   Sep 2016

Conference Activities & Talks

 
RT-PCRの基礎と応用. [Invited]
OKAZAKI Tomoki
第40回組織細胞化学講習会   2015   

Research Grants & Projects

 
異所性PTH産生腫瘍の副甲状腺特異的新規lncRNAの発現/Ca感知受容体の欠落
文部科学省: 基盤研究(C)(一般
Project Year: Apr 2017 - Mar 2020    Investigator(s): OKAZAKI Tomoki
加齢による糖質コルチコイド合成系の変化と老化への影響の解析
文部科学省: 
Project Year: Apr 2016 - Mar 2017    Investigator(s): 安達三美 (分担者)岡崎具樹
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2010 - 2011    Investigator(s): Tomoki OKAZAKI
There is a common, at least in part, mechanism whereby PTHrP gene is negatively regulated by various steroid hormones. We analyzed molecular players involved in the crosstalk among nuclear receptors, hedgehog signal and ERBB2 oncogene expression w...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1999 - 2001    Investigator(s): Tomoki OKAZAKI
By introducing the negative vitamin response element (nVDRE) in the PTHrP gene into the cultured cells, we obtained the following results. 1) Chromatin immunoprecipitation (ChIP) assay revealed that vitamin D recruited VDR (vitamin D receptor) and...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C), 基盤研究(C))
Project Year: 1995 - 1996    Investigator(s): Tomoki OKAZAKI
Through the specific binding of a negative calcium responsive element (nCaRE) to its binding protein (nCaREB) in response to extracellular Ca (Ca^2+_e), nCaRE-bearing genes, such as the human parathyroid hormone (PTH) gene, are negatively regulate...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1993 - 1994    Investigator(s): Tetsuya IGARASHI
By using the negative calcium-responsive element (nCaRE) which is found in the human PTH gene and required for calcium-dependent suppression of the gene's transcription, we could detect the cellular nuclear factor, nCaRE-binding protein (nCaREB). ...
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