茶山 一彰

J-GLOBALへ         更新日: 18/10/15 15:51
 
アバター
研究者氏名
茶山 一彰
 
チャヤマ カズアキ
所属
広島大学
部署
大学院医歯薬学総合研究科 大学院医歯薬学総合研究科
職名
教授
学位
医学博士(東京大学)
その他の所属
独立行政法人理化学研究所横浜研究所 遺伝子多型研究センター

プロフィール

・昭和61年~平成2年国家公務員共済組合連合会虎の門病院内科
  消化器内科学(肝臓病学)に関する臨床研究を行った。
・平成2年~平成12年国家公務員共済組合連合会虎の門病院内科 医長
  消化器内科学(肝臓病学)に関する臨床研究を行いつつ、肝炎ウイルスに関する分子生物学的研究を行った。
・平成12年9月~文部科学教官教授(広島大学内科学第一講座)
消化器内科、循環器内科に関する診療、臨床研究を行いつつ、肝炎ウイルスに関する分子生物学的研究、ヒトの遺伝素因と疾患に関する研究、動物を用いた肝炎ウイルス肝炎モデルに関する研究を開始した。
・平成13年~平成29年、理化学研究所、消化器疾患チームチームリーダーを併任
・平成14年4月~広島大学大学院・医歯薬学総合研究科・創生医科学専攻・先進医療開発科学講座・分子病態制御内科学(旧内科学第一講座)教授
消化器内科の診療、臨床研究を行いつつ、肝炎ウイルスに関する分子生物学的研究、ヒトの遺伝素因と疾患に関する研究、動物を用いた肝炎ウイルス肝炎モデルに関する研究を展開している。最近は癌の研究、動物モデルを使用した難治性疾患の研究にも取り組んでいる。

研究分野

 
 

学歴

 
 
 - 
1981年
広島大学 医学部 内科学
 

受賞

 
2012年
社団法人日本肝臓学会第16回織田賞
 
2011年11月
広島県知事感謝状「肝移植に関する調査及び研究に努力、広島県の移植医療の推進」
 
2011年10月
厚生労働大臣感謝状「移植医療の普及・向上のために努力、臓器移植対策の推進についての功績が顕著」
 
2010年
肝臓学会研究奨励賞
 
2010年
広仁会基礎医学賞
 

論文

 
Kodama K, Kawaoka T, Aikata H, Uchikawa S, Inagaki Y, Hatooka M, Morio K, Nakahara T, Murakami E, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Masaki K, Honda Y, Mori N, Takaki S, Tsuji K, Kohno H, Kohno H, Moriya T, Nonaka M, Hyogo H, Aisaka Y, Chayama K
Journal of gastroenterology and hepatology   33(10) 1780-1786   2018年10月   [査読有り]
Bazerbachi F, Haffar S, Wang Z, González JC, Arias-Loste MT, Crespo J, Darwish-Murad S, Ikram MA, Olynyk JK, Gan E, Petta ES, Berzuini A, Prati D, de Lédinghen V, Wai-Sun Wong V, Del Poggio P, Chávez-Tapia NC, Chen YP, Cheng PN, Yuen MF, Das K, Chowdhury A, Caballeria L, Fabrellas N, Ginès P, Kumar M, Sarin SK, Conti F, Andreone P, Sirli R, Cortez-Pinto H, Carvalhana S, Sugihara T, Kim SU, Parikh P, Chayama K, Corpechot C, Kim KM, Papatheodoridis G, Alsebaey A, Kamath PS, Murad MH, Watt KD
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association      2018年9月   [査読有り]
Urabe Y, Kagemoto K, Nakamura K, Mizumoto T, Sanomura Y, Oka S, Ochi H, Tanaka S, Chayama K
Esophagus : official journal of the Japan Esophageal Society      2018年9月   [査読有り]
Shiromoto F, Aly HH, Kudo H, Watashi K, Murayama A, Watanabe N, Zheng X, Kato T, Chayama K, Muramatsu M, Wakita T
Biochemical and biophysical research communications   503(3) 1854-1860   2018年9月   [査読有り]
Uchikawa S, Kawaoka T, Aikata H, Kodama K, Nishida Y, Inagaki Y, Hatooka M, Morio K, Nakahara T, Murakami E, Hiramatsu A, Tsuge M, Imamura M, Kawakami Y, Chayama K
Hepatology research : the official journal of the Japan Society of Hepatology   48(10) 814-820   2018年9月   [査読有り]
Akuta N, Toyota J, Karino Y, Ikeda F, Ido A, Tanaka K, Takaguchi K, Naganuma A, Tomita E, Chayama K, Fujiyama S, Inada Y, Yoshiji H, Watanabe H, Ishikawa H, McPhee F, Noviello S, Kumada H
Journal of gastroenterology   53(9) 1089-1097   2018年9月   [査読有り]
Furuta M, Tanaka H, Shiraishi Y, Uchida T, Imamura M, Fujimoto A, Fujita M, Sasaki-Oku A, Maejima K, Nakano K, Kawakami Y, Arihiro K, Aikata H, Ueno M, Hayami S, Ariizumi SI, Yamamoto M, Gotoh K, Ohdan H, Yamaue H, Miyano S, Chayama K, Nakagawa H
Oncotarget   9(60) 31789   2018年8月   [査読有り]
Teraoka Y, Uchida T, Imamura M, Hiraga N, Osawa M, Kan H, Saito Y, Tsuge M, Abe-Chayama H, Hayes CN, Makokha GN, Aikata H, Miki D, Ochi H, Ishida Y, Tateno C, Chayama K
The Journal of general virology   99(8) 1058-1065   2018年8月   [査読有り]
Nakano R, Ohira M, Kobayashi T, Ide K, Tahara H, Kuroda S, Shimizu S, Kimura T, Nagata Y, Aikata H, Chayama K, Ohdan H
Surgery   164(2) 219-226   2018年8月   [査読有り]
Matsui S, Kajikawa M, Maruhashi T, Hashimoto H, Kihara Y, Chayama K, Goto C, Aibara Y, Yusoff FM, Kishimoto S, Nakashima A, Noma K, Kawaguchi T, Matsumoto T, Higashi Y
International journal of cardiology   265 24-29   2018年8月   [査読有り]
Ishida Y, Chung TL, Imamura M, Hiraga N, Sen S, Yokomichi H, Tateno C, Canini L, Perelson AS, Uprichard SL, Dahari H, Chayama K
Hepatology (Baltimore, Md.)   68(2) 473-484   2018年8月   [査読有り]
Tari A, Kitadai Y, Mouri R, Takigawa H, Asaoku H, Mihara K, Takata K, Fujihara M, Yoshino T, Koga T, Fujimori S, Tanaka S, Chayama K
Journal of gastroenterology and hepatology   33(8) 1461-1468   2018年8月   [査読有り]
Kubo K, Kimura T, Aikata H, Takahashi S, Takeuchi Y, Takahashi I, Nishibuchi I, Murakami Y, Chayama K, Nagata Y
Hepatology research : the official journal of the Japan Society of Hepatology   48(9) 701-707   2018年8月   [査読有り]
Mizumoto T, Hiyama T, Quach DT, Sanomura Y, Urabe Y, Oka S, Arihiro K, Tanaka S, Chayama K
Digestion   98(4) 249-256   2018年7月   [査読有り]
Shi L, Fujioka K, Sakurai-Ozato N, Fukumoto W, Satoh K, Sun J, Awazu A, Tanaka K, Ishida M, Ishida T, Nakano Y, Kihara Y, Hayes CN, Aikata H, Chayama K, Ito T, Awai K, Tashiro S
Radiation research      2018年7月   [査読有り]
Kawaoka T, Aikata H, Kobayashi T, Uchikawa S, Ohya K, Kodama K, Nishida Y, Daijo K, Osawa M, Teraoka Y, Inagaki Y, Honda F, Hatooka M, Morio K, Morio R, Fujino H, Nakahara T, Murakami E, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Baba Y, Awai K, Chayama K
Hepatology research : the official journal of the Japan Society of Hepatology      2018年7月   [査読有り]
Izumi N, Takehara T, Chayama K, Yatsuhashi H, Takaguchi K, Ide T, Kurosaki M, Ueno Y, Toyoda H, Kakizaki S, Tanaka Y, Kawakami Y, Enomoto H, Ikeda F, Jiang D, De-Oertel S, McNabb BL, Camus G, Stamm LM, Brainard DM, McHutchison JG, Mochida S, Mizokami M
Hepatology international   12(4) 356-367   2018年7月   [査読有り]
Morio K, Imamura M, Kawakami Y, Nakamura Y, Hatooka M, Morio R, Fujino H, Nakahara T, Murakami E, Kawaoka T, Tsuge M, Hiramatsu A, Aikata H, Hayes CN, Miki D, Ochi H, Katamura Y, Arataki K, Moriya T, Ito H, Tsuji K, Kohno H, Waki K, Tamura T, Nakamura T, Chayama K, Hiroshima Liver Study Group.
Journal of medical virology      2018年7月   [査読有り]
Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Mohamad Yusoff F, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y
Journal of the American Heart Association   7(14)    2018年7月   [査読有り]
Yoshiji H, Karino Y, Suzuki Y, Suzuki F, Uejima M, Aikata H, Chayama K, Iwai H, Suzuki E, Kumada H
Hepatology research : the official journal of the Japan Society of Hepatology      2018年7月   [査読有り]
Nomura M, Tsuge M, Uchida T, Hiraga N, Kurihara M, Tsushima K, Fujino H, Nakahara T, Murakami E, Abe-Chayama H, Kawaoka T, Miki D, Hiramatsu A, Imamura M, Kawakami Y, Aikata H, Ochi H, Zhang Y, Makokha GN, Hayes CN, Tanaka S, Chayama K
Journal of viral hepatitis      2018年7月   [査読有り]
Kawaguchi T, Tokushige K, Hyogo H, Aikata H, Nakajima T, Ono M, Kawanaka M, Sawada K, Imajo K, Honda K, Takahashi H, Mori K, Tanaka S, Seko Y, Nozaki Y, Kamada Y, Fujii H, Kawaguchi A, Takehara T, Yanase M, Sumida Y, Eguchi Y, Seike M, Yoneda M, Suzuki Y, Saibara T, Karino Y, Chayama K, Hashimoto E, George J, Torimura T
Scientific reports   8(1) 10434   2018年7月   [査読有り]
Lund Laursen T, Brøckner Siggard C, Kazankov K, Damgaard Sandahl T, Møller HJ, Ong A, Douglas MW, George J, Tarp B, Hagelskjaer Kristensen L, Lund Laursen A, Hiramatsu A, Nakahara T, Chayama K, Grønbaek H
Scandinavian journal of gastroenterology   1-8   2018年7月   [査読有り]
Nakano Y, Ochi H, Sairaku A, Onohara Y, Tokuyama T, Motoda C, Matsumura H, Tomomori S, Amioka M, Hironobe N, Ohkubo Y, Okamura S, Makita N, Yoshida Y, Chayama K, Kihara Y
Circulation. Genomic and precision medicine   11(7) e001980   2018年7月   [査読有り]
Yamashita K, Oka S, Tanaka S, Boda K, Hirano D, Sumimoto K, Mizumoto T, Ninomiya Y, Tamaru Y, Shigita K, Hayashi N, Sanomura Y, Chayama K
Endoscopy international open   6(7) E857-E864   2018年7月   [査読有り]
Hatooka M, Kawaoka T, Aikata H, Inagaki Y, Morio K, Nakahara T, Murakami E, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Awai K, Masaki K, Waki K, Kohno H, Kohno H, Moriya T, Nagaoki Y, Tamura T, Amano H, Katamura Y, Chayama K
BMC cancer   18(1) 633   2018年6月   [査読有り]
Tatsukawa Y, Tsuge M, Kawakami Y, Murakami E, Kurihara M, Nomura M, Tsushima K, Uchida T, Nakahara T, Miki D, Kawaoka T, Abe-Chayama H, Imamura M, Aikata H, Ochi H, Hayes CN, Kawakami H, Chayama K
Antiviral therapy      2018年6月   [査読有り]
Matsui S, Kajikawa M, Maruhashi T, Iwamoto Y, Oda N, Kishimoto S, Hashimoto H, Hidaka T, Kihara Y, Chayama K, Hida E, Goto C, Aibara Y, Nakashima A, Yusoff FM, Noma K, Kuwahara Y, Matsubara A, Higashi Y
International journal of cardiology   261 196-203   2018年6月   [査読有り]
Kishimoto S, Matsumoto T, Maruhashi T, Iwamoto Y, Kajikawa M, Oda N, Matsui S, Hashimoto H, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Yusoff FBM, Nakashima A, Noma K, Higashi Y
International journal of cardiology   260 178-183   2018年6月   [査読有り]
Teraoka Y, Uchida T, Imamura M, Osawa M, Tsuge M, Abe-Chayama H, Hayes CN, Makokha GN, Aikata H, Miki D, Ochi H, Ishida Y, Tateno C, Chayama K, Hiroshima Liver Study Group.
Biochemical and biophysical research communications   500(2) 152-157   2018年6月   [査読有り]
Yuge R, Kitadai Y, Takigawa H, Naito T, Oue N, Yasui W, Tanaka S, Chayama K
Translational oncology   11(3) 575-584   2018年6月   [査読有り]
Kaishima T, Akita T, Ohisa M, Sakamune K, Kurisu A, Sugiyama A, Aikata H, Chayama K, Tanaka J
Hepatology research : the official journal of the Japan Society of Hepatology   48(7) 509-520   2018年6月   [査読有り]
Kawanaka M, Tomiyama Y, Hyogo H, Koda M, Shima T, Tobita H, Hiramatsu A, Nishino K, Okamoto T, Sato S, Hara Y, Nishina S, Kawamoto H, Chayama K, Okanoue T, Hino K
Hepatology research : the official journal of the Japan Society of Hepatology   48(7) 521-528   2018年6月   [査読有り]
Furuta M, Tanaka H, Shiraishi Y, Unida T, Imamura M, Fujimoto A, Fujita M, Sasaki-Oku A, Maejima K, Nakano K, Kawakami Y, Arihiro K, Aikata H, Ueno M, Hayami S, Ariizumi SI, Yamamoto M, Gotoh K, Ohdan H, Yamaue H, Miyano S, Chayama K, Nakagawa H
Oncotarget   9(38) 25075-25088   2018年5月   [査読有り]
Ishiba H, Sumida Y, Tanaka S, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Suzuki Y, Yoneda M, Takahashi H, Nakahara T, Seko Y, Mori K, Kanemasa K, Shimada K, Imai S, Imajo K, Kawaguchi T, Nakajima A, Chayama K, Saibara T, Shima T, Fujimoto K, Okanoue T, Itoh Y, Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD).
Journal of gastroenterology      2018年5月   [査読有り]
Ishiba H, Sumida Y, Tanaka S, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Suzuki Y, Yoneda M, Takahashi H, Nakahara T, Seko Y, Mori K, Kanemasa K, Shimada K, Imai S, Imajo K, Kawaguchi T, Nakajima A, Chayama K, Saibara T, Shima T, Fujimoto K, Okanoue T, Itoh Y, Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD).
Journal of gastroenterology      2018年5月   [査読有り]
Boot A, Huang MN, Ng AWT, Ho SC, Lim JQ, Kawakami Y, Chayama K, Teh BT, Nakagawa H, Rozen SG
Genome research   28(5) 654-665   2018年5月   [査読有り]
Rolt A, Le D, Hu Z, Wang AQ, Shah P, Singleton M, Hughes E, Dulcey AE, He S, Imamura M, Uchida T, Chayama K, Xu X, Marugan JJ, Liang TJ
The Journal of infectious diseases   217(11) 1761-1769   2018年5月   [査読有り]
Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Michiaki K, Kawakami Y, Aikata H, Ueno M, Hayami S, Gotoh K, Ariizumi SI, Yamamoto M, Yamaue H, Chayama K, Miyano S, Getz G, Scarpa A, Hirano S, Nakamura T, Nakagawa H
Journal of hepatology   68(5) 959-969   2018年5月   [査読有り]
Kumada H, Watanabe T, Suzuki F, Ikeda K, Sato K, Toyoda H, Atsukawa M, Ido A, Takaki A, Enomoto N, Kato K, Alves K, Burroughs M, Redman R, Pugatch D, Pilot-Matias TJ, Krishnan P, Oberoi RK, Xie W, Chayama K
Journal of gastroenterology   53(5) 689   2018年5月   [査読有り]
Reddy KR, Pol S, Thuluvath PJ, Kumada H, Toyota J, Chayama K, Levin J, Lawitz EJ, Gadano A, Ghesquiere W, Gerken G, Brunetto MR, Peng CY, Silva M, Strasser SI, Heo J, McPhee F, Liu Z, Yang R, Linaberry M, Noviello S
Liver international : official journal of the International Association for the Study of the Liver   38(5) 821-833   2018年5月   [査読有り]
Van Renne N, Roca Suarez AA, Duong FHT, Gondeau C, Calabrese D, Fontaine N, Ababsa A, Bandiera S, Croonenborghs T, Pochet N, De Blasi V, Pessaux P, Piardi T, Sommacale D, Ono A, Chayama K, Fujita M, Nakagawa H, Hoshida Y, Zeisel MB, Heim MH, Baumert TF, Lupberger J
Gut   67(5) 953-962   2018年5月   [査読有り]
Yamauchi M, Urabe Y, Ono A, Miki D, Ochi H, Chayama K
International journal of cancer   142(7) 1418-1426   2018年4月   [査読有り]
Kumada H, Watanabe T, Suzuki F, Ikeda K, Sato K, Toyoda H, Atsukawa M, Ido A, Takaki A, Enomoto N, Kato K, Alves K, Burroughs M, Redman R, Pugatch D, Pilot-Matias TJ, Krishnan P, Oberoi RK, Xie W, Chayama K
Journal of gastroenterology   53(4) 566-575   2018年4月   [査読有り]
Otani I, Oka S, Tanaka S, Tsuboi A, Kunihara S, Nagaoki Y, Aikata H, Chayama K
Journal of gastroenterology and hepatology   33(4) 825-830   2018年4月   [査読有り]
Chayama K, Suzuki F, Karino Y, Kawakami Y, Sato K, Atarashi T, Naganuma A, Watanabe T, Eguchi Y, Yoshiji H, Seike M, Takei Y, Kato K, Alves K, Burroughs M, Redman R, Pugatch DL, Pilot-Matias TJ, Krishnan P, Oberoi RK, Xie W, Kumada H
Journal of gastroenterology   53(4) 557-565   2018年4月   [査読有り]
Kawakami Y, Ochi H, Hayes CN, Imamura M, Tsuge M, Nakahara T, Katamura Y, Kohno H, Kohno H, Tsuji K, Takaki S, Mori N, Honda Y, Arataki K, Takahashi S, Kira S, Tamura T, Masuda K, Nakamura T, Kikkawa M, Chayama K
Journal of gastroenterology   53(4) 548-556   2018年4月   [査読有り]
Iwamoto Y, Maruhashi T, Kajikawa M, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Yusoff FM, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Higashi Y
International journal of cardiology   254 284-290   2018年3月   [査読有り]
Nagaoki Y, Aikata H, Daijyo K, Teraoka Y, Honda F, Nakamura Y, Hatooka M, Morio K, Fujino H, Nakahara T, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Ochi H, Chayama K
Hepatology research : the official journal of the Japan Society of Hepatology   48(4) 264-274   2018年3月   [査読有り]
Boda K, Oka S, Tanaka S, Nagata S, Kunihiro M, Kuwai T, Hiraga Y, Furudoi A, Terasaki M, Nakadoi K, Higashiyama M, Okanobu H, Akagi M, Chayama K
Gastrointestinal endoscopy   87(3) 714-722   2018年3月   [査読有り]

Misc

 
Acute hepatitis B virus infection in humanized chimeric mice has multiphasic viral kinetics.
Ishida Y, Chung TL, Imamura M, Hiraga N, Sen S, Yokomichi H, Tateno C, Canini L, Perelson AS, Uprichard SL, Dahari H and Chayama K.
Hepatology.   68 473-484   2018年   [査読有り]
miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis.
Van Renne N, Roca Suarez AA, Duong FHT, Gondeau C, Calabrese D, Fontaine N, Ababsa A, Bandiera S, Croonenborghs T, Pochet N, De Blasi V, Pessaux P, Piardi T, Sommacale D, Ono A, Chayama K, Fujita M, Nakagawa H, Hoshida Y, Zeisel MB, Heim MH, Baumert TF and Lupberger J.
Gut.   67 953-962   2018年   [査読有り]
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Michiaki K, Kawakami Y, Aikata H, Ueno M, Hayami S, Gotoh K, Ariizumi SI, Yamamoto M, Yamaue H, Chayama K, Miyano S, Getz G, Scarpa A, Hirano S, Nakamura T and Nakagawa H.
J Hepatol.   68 959-969   2018年   [査読有り]
Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages.
Cheng X, Xia Y, Serti E, Block PD, Chung M, Chayama K, Rehermann B and Liang TJ.
Hepatology.   66 1779-1793   2017年   [査読有り]
Whole genome sequencing discriminates hepatocellular carcinoma with intrahepatic metastasis from multi-centric tumors.
Furuta M, Ueno M, Fujimoto A, Hayami S, Yasukawa S, Kojima F, Arihiro K, Kawakami Y, Wardell CP, Shiraishi Y, Tanaka H, Nakano K, Maejima K, Sasaki-Oku A, Tokunaga N, Boroevich KA, Abe T, Aikata H, Ohdan H, Gotoh K, Kubo M, Tsunoda T, Miyano S, Chayama K, Yamaue H and Nakagawa H.
J Hepatol.   66 363-373   2017年   [査読有り]
Individual patient data meta-analysis of controlled attenuation parameter (CAP) technology for assessing steatosis.
Karlas T, Petroff D, Sasso M, Fan JG, Mi YQ, de Ledinghen V, Kumar M, Lupsor-Platon M, Han KH, Cardoso AC, Ferraioli G, Chan WK, Wong VW, Myers RP, Chayama K, Friedrich-Rust M, Beaugrand M, Shen F, Hiriart JB, Sarin SK, Badea R, Jung KS, Marcellin P, Filice C, Mahadeva S, Wong GL, Crotty P, Masaki K, Bojunga J, Bedossa P, Keim V and Wiegand J.
J Hepatol.   66 1022-1030   2017年   [査読有り]
Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 2 hepatitis C virus infection.
Toyoda H, Chayama K, Suzuki F, Sato K, Atarashi T, Watanabe T, Atsukawa M, Naganuma A, Notsumata K, Osaki Y, Nakamuta M, Takaguchi K, Saito S, Kato K, Pugatch D, Burroughs M, Redman R, Alves K, Pilot-Matias TJ, Oberoi RK, Fu B and Kumada H.
Hepatology.      2017年   [査読有り]
Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection.
Yamamoto N, Sato Y, Munakata T, Kakuni M, Tateno C, Sanada T, Hirata Y, Murakami S, Tanaka Y, Chayama K, Hatakeyama H, Hyodo M, Harashima H and Kohara M.
J Hepatol.   64 547-555   2016年   [査読有り]
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, Tanaka H, Taniguchi H, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Wardell CP, Hayami S, Nakamura T, Aikata H, Arihiro K, Boroevich KA, Abe T, Nakano K, Maejima K, Sasaki-Oku A, Ohsawa A, Shibuya T, Nakamura H, Hama N, Hosoda F, Arai Y, Ohashi S, Urushidate T, Nagae G, Yamamoto S, Ueda H, Tatsuno K, Ojima H, Hiraoka N, Okusaka T, Kubo M, Marubashi S, Yamada T, Hirano S, Yamamoto M, Ohdan H, Shimada K, Ishikawa O, Yamaue H, Chayama K, Miyano S, Aburatani H, Shibata T and Nakagawa H.
Nat Genet.   48 500-509   2016年   [査読有り]
TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.
Aizawa S, Okamoto T, Sugiyama Y, Kouwaki T, Ito A, Suzuki T, Ono C, Fukuhara T, Yamamoto M, Okochi M, Hiraga N, Imamura M, Chayama K, Suzuki R, Shoji I, Moriishi K, Moriya K, Koike K and Matsuura Y.
Nat Commun.   7 11379   2016年   [査読有り]
Erratum: Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, Tanaka H, Taniguchi H, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Wardell CP, Hayami S, Nakamura T, Aikata H, Arihiro K, Boroevich KA, Abe T, Nakano K, Maejima K, Sasaki-Oku A, Ohsawa A, Shibuya T, Nakamura H, Hama N, Hosoda F, Arai Y, Ohashi S, Urushidate T, Nagae G, Yamamoto S, Ueda H, Tatsuno K, Ojima H, Hiraoka N, Okusaka T, Kubo M, Marubashi S, Yamada T, Hirano S, Yamamoto M, Ohdan H, Shimada K, Ishikawa O, Yamaue H, Chayama K, Miyano S, Aburatani H, Shibata T and Nakagawa H.
Nat Genet.   48 700-700   2016年   [査読有り]
Pan-genotypic cell culture system for propagation of hepatitis C virus clinical isolates.
Abe-Chayama H, Hayes CN and Chayama K.
Hepatology.   64 1356-1358   2016年   [査読有り]
Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.
Fujimoto A, Furuta M, Shiraishi Y, Gotoh K, Kawakami Y, Arihiro K, Nakamura T, Ueno M, Ariizumi S, Nguyen HH, Shigemizu D, Abe T, Boroevich KA, Nakano K, Sasaki A, Kitada R, Maejima K, Yamamoto Y, Tanaka H, Shibuya T, Shibata T, Ojima H, Shimada K, Hayami S, Shigekawa Y, Aikata H, Ohdan H, Marubashi S, Yamada T, Kubo M, Hirano S, Ishikawa O, Yamamoto M, Yamaue H, Chayama K, Miyano S, Tsunoda T and Nakagawa H.
Nat Commun.   6 6120   2015年   [査読有り]
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.
He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang AQ, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer M, Zheng W, Chayama K, Marugan JJ and Liang TJ.
Sci Transl Med.   7 282-249   2015年   [査読有り]
Ratio of serum levels of AGEs to soluble form of RAGE is a predictor of endothelial function.
Kajikawa M, Nakashima A, Fujimura N, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Oda N, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Noma K, Takeuchi M, Matsui T, Yamagishi S and Higashi Y.
Diabetes Care.   38 119-125   2015年   [査読有り]
A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers.
Kamada Y, Ono M, Hyogo H, Fujii H, Sumida Y, Mori K, Tanaka S, Yamada M, Akita M, Mizutani K, Fujii H, Yamamoto A, Takamatsu S, Yoshida Y, Itoh Y, Kawada N, Chayama K, Saibara T, Takehara T and Miyoshi E.
Hepatology.   62 1433-1443   2015年   [査読有り]
Randomized trial of interferon- and ribavirin-free ombitasvir/paritaprevir/ritonavir in treatment-experienced hepatitis C virus-infected patients.
Chayama K, Notsumata K, Kurosaki M, Sato K, Rodrigues L, Jr., Setze C, Badri P, Pilot-Matias T, Vilchez RA and Kumada H.
Hepatology.   61 1523-1532   2015年   [査読有り]
Randomized phase 3 trial of ombitasvir/paritaprevir/ritonavir for hepatitis C virus genotype 1b-infected Japanese patients with or without cirrhosis.
Kumada H, Chayama K, Rodrigues L, Jr., Suzuki F, Ikeda K, Toyoda H, Sato K, Karino Y, Matsuzaki Y, Kioka K, Setze C, Pilot-Matias T, Patwardhan M, Vilchez RA, Burroughs M and Redman R.
Hepatology.   63 1037-1046   2015年   [査読有り]
Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A.
Akamatsu S, Hayes CN, Ochi H, Uchida T, Kan H, Murakami E, Abe H, Tsuge M, Miki D, Akiyama R, Hiraga N, Imamura M, Aikata H, Kawaoka T, Kawakami Y and Chayama K.
J Hepatol.   63 554-563   2015年   [査読有り]
Quantitative effect of natural killer-cell licensing on hepatocellular carcinoma recurrence after curative hepatectomy.
Tanimine N, Tanaka Y, Kobayashi T, Tashiro H, Miki D, Imamura M, Aikata H, Tanaka J, Chayama K and Ohdan H.
Cancer Immunol Res.   2 1142-1147   2014年   [査読有り]
Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection.
Kumada H, Suzuki Y, Ikeda K, Toyota J, Karino Y, Chayama K, Kawakami Y, Ido A, Yamamoto K, Takaguchi K, Izumi N, Koike K, Takehara T, Kawada N, Sata M, Miyagoshi H, Eley T, McPhee F, Damokosh A, Ishikawa H and Hughes E.
Hepatology.   59 2083-2091   2014年   [査読有り]
New insight into the enhanced effect of pegylated interferon-alpha.
Abe H, Hayes CN and Chayama K.
Hepatology.   60 1435-1437   2014年   [査読有り]
A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.
Urabe Y, Ochi H, Kato N, Kumar V, Takahashi A, Muroyama R, Hosono N, Otsuka M, Tateishi R, Lo PH, Tanikawa C, Omata M, Koike K, Miki D, Abe H, Kamatani N, Toyota J, Kumada H, Kubo M, Chayama K, Nakamura Y and Matsuda K.
J Hepatol.   58 875-882   2013年   [査読有り]
Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.
Shi N, Hiraga N, Imamura M, Hayes CN, Zhang Y, Kosaka K, Okazaki A, Murakami E, Tsuge M, Abe H, Aikata H, Takahashi S, Ochi H, Tateno-Mukaidani C, Yoshizato K, Matsui H, Kanai A, Inaba T, McPhee F, Gao M and Chayama K.
Gut.   62 1055-1061   2013年   [査読有り]
Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers.
Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chayama K and Hijikata M.
Gastroenterology.   145 658-667   2013年   [査読有り]
Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir.
Karino Y, Toyota J, Ikeda K, Suzuki F, Chayama K, Kawakami Y, Ishikawa H, Watanabe H, Hernandez D, Yu F, McPhee F and Kumada H.
J Hepatol.   58 646-654   2013年   [査読有り]
Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options.
Suzuki Y, Ikeda K, Suzuki F, Toyota J, Karino Y, Chayama K, Kawakami Y, Ishikawa H, Watanabe H, Hu W, Eley T, McPhee F, Hughes E and Kumada H.
J Hepatol.   58 655-662   2013年   [査読有り]
A translational study of resistance emergence using sequential direct-acting antiviral agents for hepatitis C using ultra-deep sequencing.
Abe H, Hayes CN, Hiraga N, Imamura M, Tsuge M, Miki D, Takahashi S, Ochi H and Chayama K.
Am J Gastroenterol.   108 1464-1472   2013年   [査読有り]
Change in malpractice claims in Japanese gastroenterological practice.
Hiyama T, Yoshihara M, Tanaka S and Chayama K.
Am J Gastroenterol.   107 143-144   2012年   [査読有り]
Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan.
Kumada H, Toyota J, Okanoue T, Chayama K, Tsubouchi H and Hayashi N.
J Hepatol.   56 78-84   2012年   [査読有り]
Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.
Sainz B, Jr., Barretto N, Martin DN, Hiraga N, Imamura M, Hussain S, Marsh KA, Yu X, Chayama K, Alrefai WA and Uprichard SL.
Nat Med.   18 281-285   2012年   [査読有り]
Genetics of IL28B and HCV--response to infection and treatment.
Hayes CN, Imamura M, Aikata H and Chayama K.
Nat Rev Gastroenterol Hepatol.   9 406-417   2012年   [査読有り]
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.
Fujimoto A, Totoki Y, Abe T, Boroevich KA, Hosoda F, Nguyen HH, Aoki M, Hosono N, Kubo M, Miya F, Arai Y, Takahashi H, Shirakihara T, Nagasaki M, Shibuya T, Nakano K, Watanabe-Makino K, Tanaka H, Nakamura H, Kusuda J, Ojima H, Shimada K, Okusaka T, Ueno M, Shigekawa Y, Kawakami Y, Arihiro K, Ohdan H, Gotoh K, Ishikawa O, Ariizumi S, Yamamoto M, Yamada T, Chayama K, Kosuge T, Yamaue H, Kamatani N, Miyano S, Nakagama H, Nakamura Y, Tsunoda T, Shibata T and Nakagawa H.
Nat Genet.   44 760-764   2012年   [査読有り]
Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome.
Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Kihara Y, Chayama K, Noma K, Nakashima A, Tomiyama H, Takase B, Yamashina A and Higashi Y.
Circulation.   126 598-603   2012年   [査読有り]
Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse.
Okazaki A, Hiraga N, Imamura M, Hayes CN, Tsuge M, Takahashi S, Aikata H, Abe H, Miki D, Ochi H, Tateno C, Yoshizato K, Ohdan H and Chayama K.
Hepatology.   56 555-566   2012年   [査読有り]
Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension.
Fujimura N, Noma K, Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Mikami S, Maruhashi T, Iwamoto Y, Kihara Y, Chayama K, Kato H, Liao JK and Higashi Y.
Clin Pharmacol Ther.   91 289-297   2012年   [査読有り]
Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders.
Chayama K, Takahashi S, Toyota J, Karino Y, Ikeda K, Ishikawa H, Watanabe H, McPhee F, Hughes E and Kumada H.
Hepatology.   55 742-748   2012年   [査読有り]
HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.
Hayes CN, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y and Chayama K.
Gut.   60 261-267   2011年   [査読有り]
Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir.
Suzuki F, Suzuki Y, Akuta N, Sezaki H, Hirakawa M, Kawamura Y, Hosaka T, Kobayashi M, Saito S, Arase Y, Ikeda K, Kobayashi M, Chayama K, Kamatani N, Nakamura Y, Miyakawa Y and Kumada H.
Hepatology.   53 415-421   2011年   [査読有り]
Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.
Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H and Chayama K.
J Hepatol.   54 408-414   2011年   [査読有り]
A single nucleotide polymorphism in activated Cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients.
Fujimoto Y, Ochi H, Maekawa T, Abe H, Hayes CN, Kumada H, Nakamura Y and Chayama K.
J Hepatol.   54 629-639   2011年   [査読有り]
Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma.
Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, Tsuge M and Chayama K.
Hepatology.   53 1237-1245   2011年   [査読有り]
Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice.
Ohara E, Hiraga N, Imamura M, Iwao E, Kamiya N, Yamada I, Kono T, Onishi M, Hirata D, Mitsui F, Kawaoka T, Tsuge M, Takahashi S, Abe H, Hayes CN, Ochi H, Tateno C, Yoshizato K, Tanaka S and Chayama K.
J Hepatol.   54 872-878   2011年   [査読有り]
IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.
Abe H, Hayes CN, Ochi H, Maekawa T, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y and Chayama K.
J Hepatol.   54 1094-1101   2011年   [査読有り]
ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo.
Abe H, Imamura M, Hiraga N, Tsuge M, Mitsui F, Kawaoka T, Takahashi S, Ochi H, Maekawa T, Hayes CN, Tateno C, Yoshizato K, Murakami S, Yamashita N, Matsuhira T, Asai K and Chayama K.
J Hepatol.   55 11-18   2011年   [査読有り]
Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses.
Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T and Hotta H.
Gastroenterology.   141 e1-5   2011年   [査読有り]
In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis.
Saeed M, Shiina M, Date T, Akazawa D, Watanabe N, Murayama A, Suzuki T, Watanabe H, Hiraga N, Imamura M, Chayama K, Choi Y, Krawczynski K, Liang TJ, Wakita T and Kato T.
Hepatology.   54 425-433   2011年   [査読有り]
Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.
Miki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, Kumada H, Toyota J, Morizono T, Tsunoda T, Kubo M, Nakamura Y, Kamatani N and Chayama K.
Nat Genet.   43 797-800   2011年   [査読有り]
Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus.
Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, Tateno C, Yoshizato K, Nakamura Y, Kamatani N and Chayama K.
Hepatology.   54 764-771   2011年   [査読有り]
Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo.
Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, Takahashi S, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, Kanai A, Inaba T, Tanaka S and Chayama K.
Hepatology.   54 781-788   2011年   [査読有り]

書籍等出版物

 
C型肝炎治療の現状と課題
MSD(Medical Scirnce Digest)   2018年   
食道胃接合部早期癌に対するESDの実際
消化器の臨床   2018年   
肝癌治療総論
日本臨牀   2018年   
グレカプレビル/ピブレンタスビル治療 -DAA不成功例に対する再治療効果-
肝胆膵   2018年   
B型肝炎に対するエンテカビル治療
Mebio Graphic Medical Magazine   2018年   

講演・口頭発表等

 
Baselin RAS Test: Clinical practice [招待有り]
The Liver Week 2017   2017年6月   
Targeting Host and Viral Interactions: Insights from Mice Model [招待有り]
Asian Pacific Association for the Study of the Liver 2017(APASL 2017) (アジア太平洋肝臓病学会議)   2017年2月   
Best Strategy for Curing HCV Genotype 1 and 4: East vs. West [招待有り]
2016 APASL Single Topic Conference on Hepatitis C   2016年6月   
HCV Treatiment Update-a New Era of All-oral HCV Treatment [招待有り]
The 46th Annual Meeting of GEST and The 25th Annual Meeting of DEST   2016年3月   
DAA/PR therapy in Asian HCV patients [招待有り]
アジア太平洋消化器病週間(APDW2015)   2015年12月   

競争的資金等の研究課題

 
2本鎖DNAを使用せず高度の安全性を保証する遺伝子治療の開発
研究期間: 2017年   
C型肝炎ウイルス排除後の病態、生命予後、QOLに関する包括的研究
研究期間: 2017年   
高効率感染細胞系と長期持続肝炎マウスモデルを用いたHBV排除への創薬研究
研究期間: 2017年       代表者: 茶山 一彰
マウス肝線維化を抑制する新規インテグリン抗体の作用機序と治療応用への集大成研究
研究期間: 2017年   
ヒト肝細胞キメラマウスを用いた薬剤耐性、臓器不全等治療困難症例に対する病態解析と根治的治療法の開発に関する研究
研究期間: 2016年   

特許

 
特願平09-296042 : ラミブジン耐性B型肝炎ウイルスの高感度検出法
特願2015-072309 : プライマー対、プローブ、薬剤耐性C型肝炎ウイルスの検出キット、薬剤耐性C型肝炎ウイルスの検出方法およびC型肝炎の予後予測方法
特願2014-217516 : 急性重症肝炎モデル非ヒト動物の作製方法、急性重症肝炎モデル非ヒト動物、劇症肝炎治療薬のスクリーニング方法および劇症肝炎治療薬
特願2012-031178 : インターフェロン療法の効果予測用マーカー
特願2013-106476 : HCVの治療剤又は予防剤