Chayama Kazuaki

J-GLOBAL         Last updated: May 21, 2019 at 02:52
 
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Name
Chayama Kazuaki
E-mail
chayamahiroshima-u.ac.jp
Affiliation
Hiroshima University
Degree
Doctor of Philosophy in Medical Sciences(The University of Tokyo)
Research funding number
00211376

Research Areas

 
 

Academic & Professional Experience

 
May 1981
   
 
Clinical Fellow, Medical corporation Dojinkai
 
Apr 1986
   
 
Clinical Fellow, National Public Officers Mutual Aid Association Federation
 
Jul 1996
   
 
Medical director, same
 
Sep 2000
 - 
Mar 2002
Professor, Faculty of Medicine, Hiroshima University
 
Apr 2002
   
 
Professor, Graduate School of Biomedical Sciences, Hiroshima University
 
Apr 2005
 - 
Mar 2011
Deputy Director, Hospital, Hiroshima University
 
Apr 2009
 - 
Mar 2011
Vice Executive, Hiroshima University
 
Apr 2011
 - 
Mar 2015
Director, Hospital, Hiroshima University
 
Apr 2012
 - 
Mar 2015
Executive and Vice President, Hiroshima University
 
Apr 2015
 - 
Mar 2016
Special Assistant to the President, Hiroshima University
 

Education

 
Apr 1974
 - 
Mar 1981
Faculty of Medicine, Hiroshima University
 

Awards & Honors

 
Nov 1997
The Superiority of Laparoscopic Examination in Predicting Hepatocellular Carcinoma after Interferon Therapy for Chronic, Award of The Japan Gastroenterological Endoscopy Society
 
Jan 2008
GlaxoSmithKline Award
 

Published Papers

 
Morio, Kei; Imamura, Michio; Kawakami, Yoshiiku; Nakamura, Yuki; Hatooka, Masahiro; Morio, Reona; Fujino, Hatsue; Nakahara, Takashi; Murakami, Eisuke; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Aikata, Hiroshi; Hayes, C. Nelson; Miki, Daiki; Oc
JOURNAL OF MEDICAL VIROLOGY   90(12) 1834-1840   Dec 2018   [Refereed]
BackgroundMethodsSustained virological response (SVR) rates for the treatment of chronic hepatitis C virus (HCV)-infected patients have drastically improved with the use of direct-acting antiviral (DAA) therapies; however, a small minority of pati...
Nomura, Motonobu; Tsuge, Masataka; Uchida, Takuro; Hiraga, Nobuhiko; Kurihara, Mio; Tsushima, Ken; Fujino, Hatsue; Nakahara, Takashi; Murakami, Eisuke; Abe-Chayama, Hiromi; Kawaoka, Tomokazu; Miki, Daiki; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshi
JOURNAL OF VIRAL HEPATITIS   25(12) 1555-1564   Dec 2018   [Refereed]
The activation of hepatitis B virus (HBV)-related hepatitis is associated with both natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). We analyzed the association between the immune response and changes in the proportion of Pre-S deleti...
Ishiba, Hiroshi; Sumida, Yoshio; Tanaka, Saiyu; Yoneda, Masato; Hyogo, Hideyuki; Ono, Masafumi; Fujii, Hideki; Eguchi, Yuichiro; Suzuki, Yasuaki; Yoneda, Masashi; Takahashi, Hirokazu; Nakahara, Takashi; Seko, Yuya; Mori, Kojiro; Kanemasa, Kazuyuki; Shimad
JOURNAL OF GASTROENTEROLOGY   53(11) 1216-1224   Nov 2018   [Refereed]
Background The FIB4 index is clinically useful, but because its formula includes age, the appropriate cutoff point may differ by age group. Here, new FIB4 index cutoff points were validated using cohort data from 14 hepatology centers in Japan. Me...
Uchikawa, Shinsuke; Kawaoka, Tomokazu; Aikata, Hiroshi; Kodama, Kenichiro; Inagaki, Yuki; Hatooka, Masahiro; Morio, Kei; Nakahara, Takashi; Murakami, Eisuke; Hiramatsu, Akira; Tsuge, Masataka; Imamura, Michio; Kawakami, Yoshiiku; Chayama, Kazuaki
CLINICAL CASE REPORTS   6(11) 2217-2223   Nov 2018   [Refereed]
Regorafenib became second-line treatment for the patients with sorafenib refractory. In our study, two patients could not continue regorafenib for its adverse effects. It was suggested that appropriate use criteria of regorafenib should be observe...
Tomomori, Shunsuke; Nakano, Yukiko; Ochi, Hidenori; Onohara, Yuko; Sairaku, Akinori; Totokuyama, Takehi; Motoda, Chikaaki; Matsumura, Hiroya; Amioka, Michitaka; Hironobe, Naoya; Okubo, Yousaku; Okamura, Shou; Kawazoe, Hiroshi; Nishiyama, Yukie; Tahara, Hidetoshi; Chayama, Kazuaki; Kihara, Yasuki
SCIENTIFIC REPORTS   8    Oct 2018   [Refereed]
Genome-wide association studies have reported a strong association of the single nucleotide polymorphism (SNP) rs6817105 (T > C) on chromosome 4q25 with atrial fibrillation (AF), but phenotype alterations conferred by this SNP have not been descri...
Kodama, Kenichiro; Kawaoka, Tomokazu; Aikata, Hiroshi; Uchikawa, Shinsuke; Inagaki, Yuki; Hatooka, Masahiro; Morio, Kei; Nakahara, Takashi; Murakami, Eisuke; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Masaki, Keiichi; Honda, Yoji; Mori, Nami; Takaki, Shintaro; Tsuji, Keiji; Kohno, Hirotaka; Kohno, Hiroshi; Moriya, Takashi; Nonaka, Michihiro; Hyogo, Hideyuki; Aisaka, Yasuyuki; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33(10) 1780-1786   Oct 2018   [Refereed]
Background and AimSorafenib is the standard treatment for patients with advanced hepatocellular carcinoma (HCC) with distant metastasis, unresectable HCC, and HCC refractory to transcatheter arterial chemoembolization (TACE) or with macroscopic va...
Shi, Lin; Fujioka, Kurumi; Sakurai-Ozato, Nami; Fukumoto, Wataru; Satoh, Kenichi; Sun, Jiying; Awazu, Akinori; Tanaka, Kimio; Ishida, Mari; Ishida, Takafumi; Nakano, Yukiko; Kihara, Yasuki; Hayes, C. Nelson; Aikata, Hiroshi; Chayama, Kazuaki; Ito, Takashi; Awai, Kazuo; Tashiro, Satoshi
RADIATION RESEARCH   190(4) 424-432   Oct 2018   [Refereed]
The incidence of chromosomal abnormalities and cancer risk correlates well with the radiation dose after exposure to moderate- to high-dose ionizing radiation. However, the biological effects and health risks at less than 100 mGy, e.g., from compu...
Hayes, C. Nelson; Zhang, Peiyi; Zhang, Yizhou; Chayama, Kazuaki
VIRUSES-BASEL   10(10)    Oct 2018   [Refereed]
Despite the success of direct-acting antiviral (DAA) agents in treating chronic hepatitis C virus (HCV) infection, the number of cases of HCV-related hepatocellular carcinoma (HCC) is expected to increase over the next five years. HCC develops ove...
Shiromoto, Fumihiro; Aly, Hussein H.; Kudo, Haruka; Watashi, Koichi; Murayama, Asako; Watanabe, Noriyuki; Zheng, Xin; Kato, Takanobu; Chayama, Kazuaki; Muramatsu, Masamichi; Wakita, Takaji
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   503(3) 1854-1860   Sep 2018   [Refereed]
Hepatitis B virus (HBV) -x protein is a transcriptional regulator required for the HBV life cycle. HBx also induces complications in the host such as hepatocellular carcinoma. We previously showed that HBx mRNA is degraded by the Ski2/RNA exosome ...
Tomomori, Shunsuke; Nakano, Yukiko; Ochi, Hidenori; Onohara, Yuko; Sairaku, Akinori; Tokuyama, Takehito; Motoda, Chikaaki; Matsumura, Hiroya; Amioka, Michitaka; Hironobe, Naoya; Ookubo, Yousaku; Okamura, Shou; Kawazoe, Hiroshi; Chayama, Kazuaki; Kihara, Yasuki
PLOS ONE   13(9)    Sep 2018   [Refereed]
Introduction The single nucleotide polymorphism (SNP) rs2106261 in the transcription factor gene ZFHX3 (16q22), a major regulator of inflammation, has been reported linking to atrial fibrillation (AF) by genome-wide association studies. Inflammati...
Akuta, Norio; Toyota, Joji; Karino, Yoshiyasu; Ikeda, Fusao; Ido, Akio; Tanaka, Katsuaki; Takaguchi, Koichi; Naganuma, Atsushi; Tomita, Eiichi; Chayama, Kazuaki; Fujiyama, Shigetoshi; Inada, Yukiko; Yoshiji, Hitoshi; Watanabe, Hideaki; Ishikawa, Hiroki; McPhee, Fiona; Noviello, Stephanie; Kumada, Hiromitsu
JOURNAL OF GASTROENTEROLOGY   53(9) 1089-1097   Sep 2018   [Refereed]
In the UNITY-3 study, 96% sustained virologic response (SVR12) rate was observed in Japanese patients with hepatitis C virus (HCV) genotype (GT)-1 infection treated for 12 weeks with fixed-dose daclatasvir, asunaprevir, and beclabuvir (DCV-TRIO). ...
Uchikawa, Shinsuke; Kawaoka, Tomokazu; Aikata, Hiroshi; Kodama, Kenichiro; Nishida, Yuno; Inagaki, Yuki; Hatooka, Masahiro; Morio, Kei; Nakahara, Takashi; Murakami, Eisuke; Hiramatsu, Akira; Tsuge, Masataka; Imamura, Michio; Kawakami, Yoshiiku; Chayama, Kazuaki
HEPATOLOGY RESEARCH   48(10) 814-820   Sep 2018   [Refereed]
AimAs second-line therapy, regorafenib has been shown to provide a survival benefit for patients with hepatocellular carcinoma (HCC) who progress on sorafenib. In this retrospective study, we assessed the clinical outcomes of sorafenib treatment f...
Matsui, Shogo; Kajikawa, Masato; Maruhashi, Tatsuya; Hashimoto, Haruki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Yusoff, Farina Mohamad; Kishimoto, Shinji; Nakashima, Ayumu; Noma, Kensuke; Kawaguchi, Tomohiro; Matsumoto, Takeo; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   265 24-29   Aug 2018   [Refereed]
Background: Measurement of flow-mediated vasodilation (FMD) is an established method for assessing endothelial function. Measurement of FMD is useful for showing the relationship between atherosclerosis and endothelial function, mechanisms of endo...
Tari, Akira; Kitadai, Yasuhiko; Mouri, Ritsuo; Takigawa, Hidehiko; Asaoku, Hideki; Mihara, Keiichiro; Takata, Katsuyoshi; Fujihara, Megumu; Yoshino, Tadashi; Koga, Tadashi; Fujimori, Shunji; Tanaka, Shinji; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33(8) 1461-1468   Aug 2018   [Refereed]
Background and AimFew reports have demonstrated the effectiveness of treatments for intestinal follicular lymphoma (FL) because of the limited number of patients who undergo comprehensive small intestinal examinations. This study compared the effi...
Kubo, Katsumaro; Kimura, Tomoki; Aikata, Hiroshi; Takahashi, Shigeo; Takeuchi, Yuki; Takahashi, Ippei; Nishibuchi, Ikuno; Murakami, Yuji; Chayama, Kazuaki; Nagata, Yasushi
HEPATOLOGY RESEARCH   48(9) 701-707   Aug 2018   [Refereed]
AimTo evaluate the long-term outcome of stereotactic body radiotherapy in patients with small hepatocellular carcinoma who were ineligible for resection or ablation therapies. MethodsA total of 65 patients with 74 hepatocellular carcinomas (median...
Teraoka, Yuji; Uchida, Takuro; Imamura, Michio; Hiraga, Nobuhiko; Osawa, Mitsutaka; Kan, Hiromi; Saito, Yuhei; Tsuge, Masataka; Abe-Chayama, Hiromi; Hayes, C. Nelson; Makokha, Grace Naswa; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
JOURNAL OF GENERAL VIROLOGY   99(8) 1058-1065   Aug 2018   [Refereed]
Combined daclatasvir (DCV)/asunaprevir (ASV) plus beclabuvir (BCV) treatment shows a high virological response for genotype 1 b chronic hepatitis C patients. However, its efficacy for patients for whom previous direct-acting antiviral (DAA) therap...
Nakano, Ryosuke; Ohira, Masahiro; Kobayashi, Tsuyoshi; Ide, Kentaro; Tahara, Hiroyuki; Kuroda, Shintaro; Shimizu, Seiichi; Kimura, Tomoki; Nagata, Yasushi; Aikata, Hiroshi; Chayama, Kazuaki; Ohdan, Hideki
SURGERY   164(2) 219-226   Aug 2018   [Refereed]
Objective: To evaluate the efficacy of both surgical resection and stereotactic body radiotherapy for small hepatocellular carcinoma. Background: Although the number of stereotactic body radiotherapies being performed for hepatocellular carcinoma ...
Ishida, Yuji; Chung, Tje Lin; Imamura, Michio; Hiraga, Nobuhiko; Sen, Suranjana; Yokomichi, Hiroshi; Tateno, Chise; Canini, Laetitia; Perelson, Alan S.; Uprichard, Susan L.; Dahari, Harel; Chayama, Kazuaki
HEPATOLOGY   68(2) 473-484   Aug 2018   [Refereed]
Chimeric urokinase type plasminogen activator (uPA)/severely severe combined immunodeficiency (SCID) mice reconstituted with humanized livers are useful for studying hepatitis B virus (HBV) infection in the absence of an adaptive immune response. ...
Kunihara, Sayoko; Oka, Shiro; Tanaka, Shinji; Tsuboi, Akiyoshi; Otani, Ichiro; Chayama, Kazuaki
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   11    Jul 2018   [Refereed]
Background: There is no consensus regarding the management of occult obscure gastrointestinal bleeding (OGIB) patients without a confirmed bleeding source. This study aimed to consider the management of occult OGIB patients based on their long-ter...
Kawaguchi, Takumi; Tokushige, Katsutoshi; Hyogo, Hideyuki; Aikata, Hiroshi; Nakajima, Tomoaki; Ono, Masafumi; Kawanaka, Miwa; Sawada, Koji; Imajo, Kento; Honda, Koichi; Takahashi, Hirokazu; Mori, Kohjiroh; Tanaka, Saiyu; Seko, Yuya; Nozaki, Yuichi; Kamada, Yoshihiro; Fujii, Hideki; Kawaguchi, Atsushi; Takehara, Tetsuo; Yanase, Mikio; Sumida, Yoshio; Eguchi, Yuichiro; Seike, Masataka; Yoneda, Masato; Suzuki, Yasuaki; Saibara, Toshiji; Karino, Yoshiyasu; Chayama, Kazuaki; Hashimoto, Etsuko; George, Jacob; Torimura, Takuji
SCIENTIFIC REPORTS   8    Jul 2018   [Refereed]
The prognosis of patients with nonalcoholic fatty liver disease-related hepatocellular carcinoma (NAFLD-HCC) is intricately associated with various factors. We aimed to investigate the prognostic algorithm of NAFLD-HCC patients using a data-mining...
Kimura, Tomoki; Aikata, Hiroshi; Doi, Yoshiko; Imano, Nobuki; Takeuchi, Yuki; Takahashi, Ippei; Nishibuchi, Ikuno; Katsuta, Tsuyoshi; Kenjo, Masahiro; Murakami, Yuji; Kenjo, Masahiro; Murakami, Yuji; Awai, Kazuo; Chayama, Kazuaki; Nagata, Yasushi
TECHNOLOGY IN CANCER RESEARCH & TREATMENT   17    Jul 2018   [Refereed]
Introduction: To compare the efficacy and safety of stereotactic body radiation therapy with or without transcatheter arterial chemoembolization for patients with small hepatocellular carcinoma who were ineligible for resection or ablation therapi...
Yamashita, Ken; Oka, Shiro; Tanaka, Shinji; Boda, Kazuki; Hirano, Daiki; Sumimoto, Kyoku; Mizumoto, Takeshi; Ninomiya, Yuki; Tamaru, Yuzuru; Shigita, Kenjiro; Hayashi, Nana; Sanomura, Yoji; Chayama, Kazuaki
ENDOSCOPY INTERNATIONAL OPEN   6(7) E857-E864   Jul 2018   [Refereed]
Background and study aims Japanese guidelines for gastroenterological endoscopy have recommended temporary withdrawal of anticoagulants (warfarin, direct oral anticoagulants [DOAC], or heparin) to prevent hemorrhagic complications during endoscopi...
Izumi, Namiki; Takehara, Tetsuo; Chayama, Kazuaki; Yatsuhashi, Hiroshi; Takaguchi, Koichi; Ide, Tatsuya; Kurosaki, Masayuki; Ueno, Yoshiyuki; Toyoda, Hidenori; Kakizaki, Satoru; Tanaka, Yasuhito; Kawakami, Yoshiiku; Enomoto, Hirayuki; Ikeda, Fusao; Jiang, Deyuan; De-Oertel, Shampa; McNabb, Brian L.; Camus, Gregory; Stamm, Luisa M.; Brainard, Diana M.; McHutchison, John G.; Mochida, Satoshi; Mizokami, Masashi
HEPATOLOGY INTERNATIONAL   12(4) 356-367   Jul 2018   [Refereed]
In Japan, there is a growing population of patients with chronic hepatitis C virus (HCV) infection who failed a direct-acting antiviral (DAA)-based regimen. In this Phase 3 study, we evaluated sofosbuvir-velpatasvir plus ribavirin in Japanese pati...
Nakano, Yukiko; Ochi, Hidenori; Sairaku, Akinori; Onohara, Yuko; Tokuyama, Takehito; Motoda, Chikaaki; Matsumura, Hiroya; Tomomori, Shunsuke; Amioka, Michitaka; Hironobe, Naoya; Ohkubo, Yousaku; Okamura, Shou; Makita, Naomasa; Yoshida, Yukihiko; Chayama,
CIRCULATION-GENOMIC AND PRECISION MEDICINE   11(7)    Jul 2018   [Refereed]
BACKGROUND: Tachycardia-induced cardiomyopathy (TIC) is a reversible cardiomyopathy induced by tachyarrhythmia, and the genetic background of the TIC is not well understood. The hyperpolarization-activated cyclic nucleotide- gated channel gene HCN...
Mizumoto, T.; Hiyama, T.; Oka, S.; Yorita, N.; Kuroki, K.; Kurihara, M.; Yoshifuku, Y.; Sanomura, Y.; Urabe, Y.; Arihiro, K.; Tanaka, S.; Chayama, K.
DISEASES OF THE ESOPHAGUS   31(7)    Jul 2018   [Refereed]
Endoscopic submucosal dissection (ESD) is a widely accepted procedure for superficial esophageal squamous cell carcinoma (SESCC) limited to the epithelium or lamina propria mucosae (EP/LPM). We aimed to compare the efficacy of endoscopic ultrasono...
Matsui, Shogo; Kajikawa, Masato; Maruhashi, Tatsuya; Iwamoto, Yumiko; Oda, Nozomu; Kishimoto, Shinji; Hashimoto, Haruki; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Hida, Eisuke; Goto, Chikara; Aibara, Yoshiki; Nakashima, Ayumu; Yusoff, Farina Mohamad; Noma, Kensuke; Kuwahara, Yoshitaka; Matsubara, Akio; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   261 196-203   Jun 2018   [Refereed]
Background: Lower urinary tract symptoms (LUTS) is not only common symptoms in elderly men and women but also risk of future cardiovascular events. The purpose of this study was to evaluate the relationships of vascular function and structure with...
Hatooka, Masahiro; Kawaoka, Tomokazu; Aikata, Hiroshi; Inagaki, Yuki; Morio, Kei; Nakahara, Takashi; Murakami, Eisuke; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Awai, Kazuo; Masaki, Keiichi; Waki, Koji; Kohno, Hirotaka; Kohno, Hiroshi; Moriya, Takashi; Nagaoki, Yuko; Tamura, Toru; Amano, Hajime; Katamura, Yoshio; Chayama, Kazuaki
BMC CANCER   18    Jun 2018   [Refereed]
Background: In patients with advanced hepatocellular carcinoma (HCC), evidence is unclear as to whether hepatic arterial infusion chemotherapy (HAIC) or sorafenib is superior. We performed a prospective, open-label, non-comparative phase II study ...
Teraoka, Yuji; Uchida, Takuro; Imamura, Michio; Osawa, Mitsutaka; Tsuge, Masataka; Abe-Chayama, Hiromi; Hayes, C. Nelson; Makokha, Grace Naswa; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   500(2) 152-157   Jun 2018   [Refereed]
Patients with chronic hepatitis C virus (HCV) infection who have failed to respond to direct-acting antiviral (DAA) treatment often acquire drug resistance-associated variants (RAVs). The NS5A-P32 deletion (P32del) RAV confers potent resistance to...
Kishimoto, Shinji; Matsumoto, Takeshi; Maruhashi, Tatsuya; Iwamoto, Yumiko; Kajikawa, Masato; Oda, Nozomu; Matsui, Shogo; Hashimoto, Haruki; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Yusoff, Farina Binti Mohamad; Nakashima, Ayumu; Noma, Kensuke; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   260 178-183   Jun 2018   [Refereed]
Background: Although reactive hyperemia-peripheral arterial tonometry (RH-PAT) is widely used for assessment of endothelial function, RH index (RHI) cannot be measured in some cases when pulse wave amplitude (PWA) is very low. Decrease in PWA is m...
Rolt, Adam; Le, Derek; Hu, Zongyi; Wang, Amy Q.; Shah, Pranav; Singleton, Marc; Hughes, Emma; Dulcey, Andres E.; He, Shanshan; Imamura, Michio; Uchida, Takuro; Chayama, Kazuaki; Xu, Xin; Marugan, Juan J.; Liang, T. Jake
JOURNAL OF INFECTIOUS DISEASES   217(11) 1761-1769   Jun 2018   [Refereed]
Hepatitis C virus (HCV) is a small, single-stranded, positive-sense RNA virus that infects more than an estimated 70 million people worldwide. Untreated, persistent HCV infection often results in chronic hepatitis, cirrhosis, or liver failure, wit...
Mizumoto, T.; Hiyama, T.; Oka, S.; Yorita, N.; Kuroki, K.; Kurihara, M.; Yoshifuku, Y.; Sanomura, Y.; Urabe, Y.; Murakami, Y.; Arihiro, K.; Tanaka, S.; Chayama, K.
DIGESTIVE DISEASES AND SCIENCES   63(6) 1605-1612   Jun 2018   [Refereed]
Background According to the Japanese Esophageal Society (JES) guidelines, risk factors for lymph node (LN) metastasis in the muscularis mucosa (MM)/submucosa to a depth of up to 200 mu m (SM1) in cases of esophageal squamous cell carcinomas (ESCCs...
Kaishima, Terumi; Akita, Tomoyuki; Ohisa, Masayuki; Sakamune, Kazuaki; Kurisu, Akemi; Sugiyama, Aya; Aikata, Hiroshi; Chayama, Kazuaki; Tanaka, Junko
HEPATOLOGY RESEARCH   48(7) 509-520   Jun 2018   [Refereed]
AimWe estimated the cost-effectiveness of direct-acting antiviral treatment (DAA) compared to triple therapy (simeprevir, pegylated interferon- [Peg-IFN], and ribavirin [RBV]) (scenario 1), Peg-IFN+RBV (scenario 2), and non-antiviral therapy (scen...
Kawanaka, Miwa; Tomiyama, Yasuyuki; Hyogo, Hideyuki; Koda, Masahiko; Shima, Toshihide; Tobita, Hiroshi; Hiramatsu, Akira; Nishino, Ken; Okamoto, Toshiaki; Sato, Shuichi; Hara, Yuichi; Nishina, Sohji; Kawamoto, Hirofumi; Chayama, Kazuaki; Okanoue, Takeshi; Hino, Keisuke
HEPATOLOGY RESEARCH   48(7) 521-528   Jun 2018   [Refereed]
AimAs it is not practical to perform regular screening for hepatocellular carcinoma (HCC) in all patients with non-alcoholic fatty liver disease (NAFLD), there is a need to identify NAFLD patients who are at high risk for HCC. Wisteria floribunda ...
Yuge, Ryo; Kitadai, Yasuhiko; Takigawa, Hidehiko; Naito, Toshikatsu; Oue, Naohide; Yasui, Wataru; Tanaka, Shinji; Chayama, Kazuaki
TRANSLATIONAL ONCOLOGY   11(3) 575-584   Jun 2018   [Refereed]
Accumulating evidence suggests that a unique set of receptor tyrosine kinases, known as discoidin domain receptors (DDRs), plays a role in cancer progression by interacting with the surrounding collagen matrix. In this study, we investigated the e...
Tsukamoto, Yuta; Ikeda, Sotaro; Uwai, Koji; Taguchi, Riho; Chayama, Kazuaki; Sakaguchi, Takemasa; Narita, Ryo; Yao, Wan-Ling; Takeuchi, Fumihiko; Otakaki, Yukie; Watashi, Koichi; Wakita, Takaji; Kato, Hiroki; Fujita, Takashi
PLOS ONE   13(5)    May 2018   [Refereed]
Current therapeutics for hepatitis B virus (HBV) patients such as nucleoside analogs (NAs) are effective; however, new antiviral drugs against HBV are still desired. Since the interaction between the epsilon (c) sequence of HBV pregenomic RNA and ...
Boda, Kazuki; Oka, Shiro; Tanaka, Shinji; Tanaka, Hidenori; Matsumoto, Kenta; Yamashita, Ken; Sumimoto, Kyoku; Hirano, Daiki; Tamaru, Yuzuru; Ninomiya, Yuki; Hayashi, Nana; Chayama, Kazuaki
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   11    May 2018   [Refereed]
Background: Few studies have investigated the use of endoscopic submucosal dissection (ESD) for cecal tumors extending into the appendiceal orifice. Herein, we assessed the feasibility and safety of ESD for cecal tumors extending into the appendic...
Van Renne, Nicolaas; Suarez, Armando Andres Roca; Duong, Francois H. T.; Gondeau, Claire; Calabrese, Diego; Fontaine, Nelly; Ababsa, Amina; Bandiera, Simonetta; Croonenborghs, Tom; Pochet, Nathalie; De Blasi, Vito; Pessaux, Patrick; Piardi, Tullio; Sommacale, Daniele; Ono, Atsushi; Chayama, Kazuaki; Fujita, Masashi; Nakagawa, Hidewaki; Hoshida, Yujin; Zeisel, Mirjam B.; Heim, Markus H.; Baumert, Thomas F.; Lupberger, Joachim
GUT   67(5) 953-962   May 2018   [Refereed]
Background and aims HCV infection is a leading risk factor of hepatocellular carcinoma (HCC). However, even after viral clearance, HCC risk remains elevated. HCV perturbs host cell signalling to maintain infection, and derailed signalling circuitr...
Wardell, Christopher P.; Fujita, Masashi; Yamada, Toru; Simbolo, Michele; Fassan, Matteo; Karlic, Rosa; Polak, Paz; Kim, Jaegil; Hatanaka, Yutaka; Maejima, Kazuhiro; Lawlor, Rita T.; Nakanishi, Yoshitsugu; Mitsuhashi, Tomoko; Fujimoto, Akihiro; Furuta, Mayuko; Ruzzenente, Andrea; Conci, Simone; Oosawa, Ayako; Sasaki-Oku, Aya; Nakano, Kaoru; Tanaka, Hiroko; Yamamoto, Yujiro; Michiaki, Kubo; Kawakami, Yoshiiku; Aikata, Hiroshi; Ueno, Masaki; Hayami, Shinya; Gotoh, Kunihito; Ariizumi, Shun-ichi; Yamamoto, Masakazu; Yamaue, Hiroki; Chayama, Kazuaki; Miyano, Satoru; Getz, Gad; Scarpa, Aldo; Hirano, Satoshi; Nakamura, Toru; Nakagawa, Hidewaki
JOURNAL OF HEPATOLOGY   68(5) 959-969   May 2018   [Refereed]
Background & Aims: Biliary tract cancers (BTCs) are clinically and pathologically heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer understanding of their carcinogenesis, classification and treatment strategy. We...
Reddy, K. Rajender; Pol, Stanislas; Thuluvath, Paul J.; Kumada, Hiromitsu; Toyota, Joji; Chayama, Kazuaki; Levin, James; Lawitz, Eric J.; Gadano, Adrian; Ghesquiere, Wayne; Gerken, Guido; Brunetto, Maurizia R.; Peng, Cheng-Yuan; Silva, Marcelo; Strasser, Simone I.; Heo, Jeong; McPhee, Fiona; Liu, Zhaohui; Yang, Rong; Linaberry, Misti; Noviello, Stephanie
LIVER INTERNATIONAL   38(5) 821-833   May 2018   [Refereed]
Background & Aims: Daclatasvir has achieved high sustained virologic response (SVR) rates in diverse hepatitis C virus (HCV) populations. This study evaluated the long-term efficacy and safety of daclatasvir-based regimens administered during clin...
Boot, Arnoud; Huang, Mi Ni; Ng, Alvin W. T.; Ho, Szu-Chi; Lim, Jing Quan; Kawakami, Yoshiiku; Chayama, Kazuaki; Teh, Bin Tean; Nakagawa, Hidewaki; Rozen, Steven G.
GENOME RESEARCH   28(5) 654-665   May 2018   [Refereed]
Cisplatin reacts with DNA and thereby likely generates a characteristic pattern of somatic mutations, called a mutational signature. Despite widespread use of cisplatin in cancer treatment and its role in contributing to secondary malignancies, it...
Honda, Fumi; Hiramatsu, Akira; Hyogo, Hideyuki; Aikata, Hiroshi; Daijo, Kana; Teraoka, Yuji; Inagaki, Yuki; Morio, Kei; Kobayashi, Tomoki; Nakahara, Takashi; Nagaoki, Yuko; Kawaoka, Tomokazu; Yoneda, Masayasu; Tsuge, Masataka; Imamura, Michio; Kawakami, Yoshiiku; Ochi, Hidenori; Chayama, Kazuaki
PLOS ONE   13(4)    Apr 2018   [Refereed]
Background and aims The feature of blood glucose dynamics in patients with chronic liver disease (CLD) is marked blood glucose fluctuations. However, the detail of blood glucose dynamics is not well known. The aim of the present study was to evalu...
Yamauchi, Masami; Urabe, Yuji; Ono, Atsushi; Miki, Daiki; Ochi, Hidenori; Chayama, Kazuaki
INTERNATIONAL JOURNAL OF CANCER   142(7) 1418-1426   Apr 2018   [Refereed]
Understanding the molecular changes in tumors in response to anti-VEGF chemotherapy is crucial for optimization of the treatment strategy for metastatic colorectal cancer. We prospectively investigated changes in the amount and constitution of cir...
Otani, Ichiro; Oka, Shiro; Tanaka, Shinji; Tsuboi, Akiyoshi; Kunihara, Sayoko; Nagaoki, Yuko; Aikata, Hiroshi; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33(4) 825-830   Apr 2018   [Refereed]
Background and AimThe relationship between the presence of villous edema (VE) in portal hypertensive enteropathy and clinical factors remains unclear. The aim of this study was to reveal the clinical factors related to VE in patients with liver ci...
Kawakami, Yoshiiku; Ochi, Hidenori; Hayes, Clair Nelson; Imamura, Michio; Tsuge, Masataka; Nakahara, Takashi; Katamura, Yoshio; Kohno, Hiroshi; Kohno, Hirotaka; Tsuji, Keiji; Takaki, Shintaro; Mori, Nami; Honda, Yohji; Arataki, Keiko; Takahashi, Shoichi; Kira, Shinsuke; Tamura, Toru; Masuda, Kazunari; Nakamura, Toshio; Kikkawa, Masaya; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   53(4) 548-556   Apr 2018   [Refereed]
In Japan, daclatasvir (DCV) and asunaprevir (ASV) therapy was the first IFN-free treatment to be approved, and thousands of patients have since been successfully treated, with an SVR rate of around 90%. The converse, however, is that around 10% of...
Chayama, Kazuaki; Suzuki, Fumitaka; Karino, Yoshiyasu; Kawakami, Yoshiiku; Sato, Ken; Atarashi, Tomofumi; Naganuma, Atsushi; Watanabe, Tsunamasa; Eguchi, Yuichiro; Yoshiji, Hitoshi; Seike, Masataka; Takei, Yoshiyuki; Kato, Koji; Alves, Katia; Burroughs, Margaret; Redman, Rebecca; Pugatch, David L.; Pilot-Matias, Tami J.; Krishnan, Preethi; Oberoi, Rajneet K.; Xie, Wangang; Kumada, Hiromitsu
JOURNAL OF GASTROENTEROLOGY   53(4) 557-565   Apr 2018   [Refereed]
The once-daily, all oral, RBV-free, pangenotypic direct-acting anti-viral regimen consisting of co-formulated NS3/4A protease inhibitor glecaprevir and NS5A inhibitor pibrentasvir (G/P), demonstrated high rates of sustained virologic response (SVR...
Kumada, Hiromitsu; Watanabe, Tsunamasa; Suzuki, Fumitaka; Ikeda, Kenji; Sato, Ken; Toyoda, Hidenori; Atsukawa, Masanori; Ido, Akio; Takaki, Akinobu; Enomoto, Nobuyuki; Kato, Koji; Alves, Katia; Burroughs, Margaret; Redman, Rebecca; Pugatch, David; Pilot-Matias, Tami J.; Krishnan, Preethi; Oberoi, Rajneet K.; Xie, Wangang; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   53(4) 566-575   Apr 2018   [Refereed]
Once-daily, orally administered, co-formulated glecaprevir (NS3/4A protease inhibitor) and pibrentasvir (NS5A inhibitor) (G/P) demonstrated pangenotypic activity and high sustained virologic response (SVR) rates in studies outside Japan. Here we r...
Iwamoto, Yumiko; Maruhashi, Tatsuya; Kajikawa, Masato; Oda, Nozomu; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Aibara, Yoshiki; Yusoff, Farina Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   254 284-290   Mar 2018   [Refereed]
Backgrounds: Nitroglycerine-induced vasodilation (NID) is usually assessed as a control test for flow-mediated vasodilation (FMD). However, NID per se is impaired in patients with high cardiovascular risk. The purpose of this study was to investig...
Boda, Kazuki; Oka, Shiro; Tanaka, Shinji; Nagata, Shinji; Kunihiro, Masaki; Kuwai, Toshio; Hiraga, Yuko; Furudoi, Akira; Terasaki, Motomi; Nakadoi, Koichi; Higashiyama, Makoto; Okanobu, Hideharu; Akagi, Morihisa; Chayama, Kazuaki
GASTROINTESTINAL ENDOSCOPY   87(3) 714-722   Mar 2018   [Refereed]
Background and Aims: Although advanced high-volume centers have reported good outcomes of colorectal endoscopic submucosal dissection (ESD), a limited number of highly skilled experts in specialized institutions performed these procedures. We unde...
Nagaoki, Yuko; Aikata, Hiroshi; Daijyo, Kana; Teraoka, Yuji; Honda, Fumi; Nakamura, Yuki; Hatooka, Masahiro; Morio, Kei; Fujino, Hatsue; Nakahara, Takashi; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Ochi, Hidenori; Chayama, Kazuaki
HEPATOLOGY RESEARCH   48(4) 264-274   Mar 2018   [Refereed]
AimThe aim of this study was to determine the risk factors for worsening of gastroesophageal varices (GEVs) and development of portosystemic encephalopathy in patients with hepatitis B virus (HBV)-related cirrhosis during nucleos(t)ide analog (NA)...
Kumada, Hiromitsu; Mochida, Satoshi; Nakamuta, Makoto; Suzuki, Fumitaka; Yagi, Takashi; Takasaki, Ryuji; Okai, Masao; Kamiya, Naohiro; Okada, Yasushi; Hirota, Saya; Orihashi, Madori; Ochi, Miyoko; Chayama, Kazuaki
HEPATOLOGY RESEARCH   48(2) 184-192   Feb 2018   [Refereed]
AimTo assess the efficacy and safety of telaprevir (TVR) when used in combination with natural human interferon- (IFN-) and ribavirin (RBV) for genotype 1 patients with depression compared to IFN-/RBV therapy in Japan. We also examined the efficac...
Teraoka, Yuji; Kimura, Tomoki; Aikata, Hiroshi; Daijo, Kana; Osawa, Mitsutaka; Honda, Fumi; Nakamura, Yuki; Morio, Kei; Morio, Reona; Hatooka, Masahiro; Kobayashi, Tomoki; Nakahara, Takashi; Murakami, Eisuke; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Nagata, Yasushi; Chayama, Kazuaki
HEPATOLOGY RESEARCH   48(2) 193-204   Feb 2018   [Refereed]
AimTo evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of hepatocellular carcinoma (HCC) in elderly patients. MethodsFrom 2008 to 2015, 117 patients with HCC (3 nodules, 30mm in diameter, Child-Pugh score...
Krishnan, Preethi; Schnell, Gretja; Tripathi, Rakesh; Beyer, Jill; Reisch, Thomas; Dekhtyar, Tatyana; Irvin, Michelle; Xie, Wangang; Fu, Bo; Burroughs, Margaret; Redman, Rebecca; Kumada, Hiromitsu; Chayama, Kazuaki; Collins, Christine; Pilot-Matias, Tami
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   62(2)    Feb 2018   [Refereed]
Glecaprevir and pibrentasvir are hepatitis C virus (HCV) pangenotypic inhibitors targeting NS3/4A protease and NS5A, respectively. This once-daily, fixed-dose combination regimen demonstrated high sustained virologic response 12 weeks postdosing (...
Matsumoto, Akihiro; Nishiguchi, Shuhei; Enomoto, Hirayuki; Kang, Jong-Hon; Tanaka, Yasuhito; Shinkai, Noboru; Kurosaki, Masayuki; Enomoto, Masaru; Kanda, Tatsuo; Yokosuka, Osamu; Yatsuhashi, Hiroshi; Nagaoka, Shinya; Okuse, Chiaki; Kagawa, Tatehiro; Mine, Tetsuya; Takaguchi, Koichi; Saito, Satoru; Hino, Keisuke; Ikeda, Fusao; Sakisaka, Shotaro; Morihara, Daisuke; Miyase, Shiho; Tsuge, Masataka; Chayama, Kazuaki; Hiramatsu, Naoki; Suzuki, Yoshiyuki; Murata, Kazumoto; Tanaka, Eiji
JOURNAL OF GASTROENTEROLOGY   53(2) 247-257   Feb 2018   [Refereed]
This prospective cohort study searched for factors associated with a response to nucleos(t)ide analogue/peg-interferon (NUC/peg-IFN) sequential therapy. A total of 95 patients with chronic hepatitis B being treated with NUCs were enrolled. Immedia...
Nakahara, Takashi; Hyogo, Hideyuki; Ono, Atsushi; Nagaoki, Yuko; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiraga, Nobuhiko; Hayes, Clair Nelson; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Abe-Chayama, Hiromi; Furusho, Hisako; Shintani, Tomoaki; Kurihara, Hidemi; Miyauchi, Mutsumi; Takata, Takashi; Arihiro, Koji; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   53(2) 269-280   Feb 2018   [Refereed]
The risk factors in the progression of nonalcoholic fatty liver disease (NAFLD) have not been fully clarified. Porphyromonas gingivalis (P.g) has been considered to be a confounding risk factor for systemic diseases. We aimed to evaluate the effec...
Toyoda, Hidenori; Chayama, Kazuaki; Suzuki, Fumitaka; Sato, Ken; Atarashi, Tomofumi; Watanabe, Tsunamasa; Atsukawa, Masanori; Naganuma, Atsushi; Notsumata, Kazuo; Osaki, Yukio; Nakamuta, Makoto; Takaguchi, Koichi; Saito, Satoru; Kato, Koji; Pugatch, David; Burroughs, Margaret; Redman, Rebecca; Alves, Katia; Pilot-Matias, Tami J.; Oberoi, Rajneet K.; Fu, Bo; Kumada, Hiromitsu
HEPATOLOGY   67(2) 505-513   Feb 2018   [Refereed]
Glecaprevir (nonstructural protein 3/4A protease inhibitor) and pibrentasvir (nonstructural protein 5A inhibitor) (G/P), a coformulated once-daily, all oral, ribavirin (RBV)-free, direct-acting antiviral regimen, was evaluated for safety and effic...
Schnell, Gretja; Tripathi, Rakesh; Krishnan, Preethi; Beyer, Jill; Reisch, Thomas; Irvin, Michelle; Dekhtyar, Tatyana; Setze, Carolyn; Rodrigues-, Lino, Jr.; Alves, Katia; Burroughs, Margaret; Redman, Rebecca; Chayama, Kazuaki; Kumada, Hiromitsu; Collins, Christine; Pilot-Matias, Tami
JOURNAL OF MEDICAL VIROLOGY   90(1) 109-119   Jan 2018   [Refereed]
Treatment of HCV genotype (GT) 2-infected Japanese patients with paritaprevir (NS3/4A inhibitor boosted with ritonavir) and ombitasvir (NS5A inhibitor) without ribavirin for 12 weeks in the phase 2 study M12-536, and with ribavirin for 16 weeks in...
Suda, Goki; Furusyo, Norihiro; Toyoda, Hidenori; Kawakami, Yoshiiku; Ikeda, Hiroki; Suzuki, Michihiro; Arataki, Keiko; Mori, Nami; Tsuji, Keiji; Katamura, Yoshio; Takaguchi, Koichi; Ishikawa, Toru; Tsuji, Kunihiko; Shimada, Noritomo; Hiraoka, Atsushi; Yamsaki, Sho; Nakai, Masato; Sho, Takuya; Morikawa, Kenichi; Ogawa, Koji; Kudo, Mineo; Nagasaka, Atsushi; Furuya, Ken; Yamamoto, Yoshiya; Kato, Kanji; Ueno, Yoshiyuki; Iio, Etsuko; Tanaka, Yasuhito; Kurosaki, Masayuki; Kumada, Takashi; Chayama, Kazuaki; Sakamoto, Naoya
JOURNAL OF GASTROENTEROLOGY   53(1) 119-128   Jan 2018   [Refereed]
Hepatitis C virus (HCV) infection is common in hemodialysis patients and worsens their prognosis, while antiviral therapy options are limited. Recently, clinical trial and real-world, small-scale studies have reported excellent responses to direct...
Tamura, Tomokazu; Fukuhara, Takasuke; Uchida, Takuro; Ono, Chikako; Mori, Hiroyuki; Sato, Asuka; Fauzyah, Yuzy; Okamoto, Toru; Kurosu, Takeshi; Setoh, Yin Xiang; Imamura, Michio; Tautz, Norbert; Sakoda, Yoshihiro; Khromykh, Alexander A.; Chayama, Kazuaki; Matsuura, Yoshiharu
JOURNAL OF VIROLOGY   92(2)    Jan 2018   [Refereed]
The family Flaviviridae consists of four genera, Flavivirus, Pestivirus, Pegivirus, and Hepacivirus, and comprises important pathogens of human and animals. Although the construction of recombinant viruses carrying reporter genes encoding fluoresc...
Maruhashi, Tatsuya; Soga, Junko; Fujimura, Noritaka; Idei, Naomi; Mikami, Shinsuke; Iwamoto, Yumiko; Iwamoto, Akimichi; Kajikawa, Masato; Matsumoto, Takeshi; Oda, Nozomu; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Aibara, Yoshiki; Yusoff, Farina Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Tomiyama, Hirofumi; Takase, Bonpei; Kohro, Takahide; Suzuki, Toru; Ishizu, Tomoko; Ueda, Shinichiro; Yamazaki, Tsutomu; Furumoto, Tomoo; Kario, Kazuomi; Inoue, Teruo; Koba, Shinji; Watanabe, Kentaro; Takemoto, Yasuhiko; Hano, Takuzo; Sata, Masataka; Ishibashi, Yutaka; Node, Koichi; Maemura, Koji; Ohya, Yusuke; Furukawa, Taiji; Ito, Hiroshi; Ikeda, Hisao; Yamashina, Akira; Higashi, Yukihito
ATHEROSCLEROSIS   268 92-98   Jan 2018   [Refereed]
Background and aims: Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovas...
Masuda, Kazuhiko; Ono, Atsushi; Aikata, Hiroshi; Kawaoka, Tomokazu; Hayes, C. Nelson; Teraoka, Yuji; Daijo, Kana; Nakamura-Inagaki, Yuki; Morio, Kei; Fujino, Hatsue; Kan, Hiromi; Uchida, Takuro; Masaki, Keiichi; Kobayashi, Tomoki; Nakahara, Takashi; Makokha, Grace Naswa; Zhang, Yizhou; Nagaoki, Yuko; Miki, Daiki; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Abe-Chayama, Hiromi; Kawakami, Yoshiiku; Ochi, Hidenori; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   53(1) 107-118   Jan 2018   [Refereed]
Biomarkers predicting the response to the anticancer treatment and prognosis in patients with advanced hepatocellular carcinoma (HCC) are required. Recently, high mobility group box 1 (HMGB1) was reported to promote HCC progression and be associat...
Nagaoki, Yuko; Aikata, Hiroshi; Daijyo, Kana; Teraoka, Yuji; Shinohara, Fumi; Nakamura, Yuki; Hatooka, Masahiro; Morio, Kei; Nakahara, Takashi; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Ochi, Hidenori; Chayama, Kazuaki
HEPATOLOGY RESEARCH   48(1) 51-58   Jan 2018   [Refereed]
AimTo compare the efficacy and safety of edoxaban and warfarin for treatment of portal vein thrombosis (PVT) following danaparoid sodium in patients with liver cirrhosis. MethodsFifty cirrhotic patients with PVT treated initially for 2weeks with d...
Nakamura, Yuko; Kawaoka, Tomokazu; Higaki, Toru; Fukumoto, Wataru; Honda, Yukiko; Iida, Makoto; Fujioka, Chikako; Kiguchi, Masao; Aikata, Hiroshi; Chayama, Kazuaki; Awai, Kazuo
EUROPEAN JOURNAL OF RADIOLOGY   98 41-49   Jan 2018   [Refereed]
Objectives: To investigate whether hepatic perfusion CT yields early imaging biomarkers predictive of the prognosis of hepatocellular carcinoma (HCC) patients treated with sorafenib. Methods: We evaluated 36 HCC patients who underwent hepatic perf...
Maruhashi, Tatsuya; Iwamoto, Yumiko; Kajikawa, Masato; Oda, Nozomu; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Aibara, Yoshiki; Yusoff, Farina Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Hida, Eisuke; Higashi, Yukihito
JOURNAL OF THE AMERICAN HEART ASSOCIATION   7(1)    Jan 2018   [Refereed]
Background-Flow-mediated vasodilation (FMD) of the brachial artery has been used for the assessment of endothelial function. Considering the mechanism underlying the vasodilatory response of the brachial artery to reactive hyperemia, hyperemic she...
Kodama, Kenichiro; Kawaoka, Tomokazu; Aikata, Hiroshi; Uchikawa, Shinsuke; Nishida, Yuno; Inagaki, Yuki; Hatooka, Masahiro; Morio, Kei; Nakahara, Takashi; Murakami, Eisuke; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Masaki, Keiichi; Honda, Yoji; Mori, Nami; Takaki, Shintaro; Tsuji, Keiji; Kohno, Hirotaka; Kohno, Hiroshi; Moriya, Takashi; Nonaka, Michihiro; Hyogo, Hideyuki; Aisaka, Yasuyuki; Kimura, Tomoki; Nagata, Yasushi; Chayama, Kazuaki
ONCOLOGY   94(4) 215-222   2018   [Refereed]
Objective: To compare the outcome of hepatic arterial infusion chemotherapy combined with radiotherapy (HAIC + RT) versus sorafenib monotherapy in patients with advanced hepatocellular carcinoma (HCC) and major portal vein tumor thrombosis (PVTT)....
Sanomura, Yoji; Oka, Shiro; Tanaka, Shinji; Yorita, Naoki; Kuroki, Kazutaka; Kurihara, Mio; Mizumoto, Takeshi; Yoshifuku, Yoshikazu; Chayama, Kazuaki
DIGESTION   97(3) 240-249   2018   [Refereed]
Background: Although bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) remains problematic, especially in patients taking anticoagulants, there are differing views on the ideal and optimal management for these pa...
Itsuki, Hiroshi; Serikawa, Masahiro; Sasaki, Tamito; Ishii, Yasutaka; Tsushima, Ken; Furukawa, Yoshinari; Murakami, Yoshiaki; Arihiro, Koji; Chayama, Kazuaki
GASTROENTEROLOGY RESEARCH AND PRACTICE      2018   [Refereed]
Aim. We examined the effectiveness of bile juice cytology for distinguishing between benign and malignant gallbladder lesions of the protruding type with various sampling points, sampling methods, and macroscopic forms in order to discuss the effe...
Kunihara, Sayoko; Oka, Shiro; Tanaka, Shinji; Otani, Ichiro; Igawa, Atsushi; Nagaoki, Yuko; Aikata, Hiroshi; Chayama, Kazuaki
DIGESTION   98(1) 33-40   2018   [Refereed]
Background/Aims: The clinical course and exacerbation of portal hypertensive enteropathy (PHE) are yet to be fully clarified. This study aimed to identify factors related to PHE exacerbation in patients with liver cirrhosis (LC). Methods: Fifty pa...
Kotachi, Takahiro; Ito, Masanori; Boda, Tomoyuki; Kiso, Mariko; Masuda, Kazuhiko; Hata, Kosaku; Kawamura, Toru; Sanomura, Yoji; Yoshihara, Masaharu; Tanaka, Shinji; Chayama, Kazuaki
DIGESTION   98(1) 48-55   2018   [Refereed]
Background and Aim: Reddish depressed lesions (RDLs) frequently observed in patients following Helicobacter pylori eradication are indistinguishable from gastric cancer. We examined the clinical and histological feature of RDLs and its relevant en...
Hirano, Daiki; Oka, Shiro; Tanaka, Shinji; Sumimoto, Kyoku; Ninomiya, Yuki; Tamaru, Yuzuru; Shigita, Kenjiro; Hayashi, Nana; Urabe, Yuji; Kitadai, Yasuhiko; Shimamoto, Fumio; Arihiro, Koji; Chayama, Kazuaki
BMC GASTROENTEROLOGY   17    Dec 2017   [Refereed]
Background: Serrated adenocarcinoma (SAC) is a distinct colorectal carcinoma variant that accounts for approximately 7.5% of all advanced colorectal carcinomas. While its prognosis is worse than conventional carcinoma, its early-stage clinicopatho...
Yoshifuku, Yoshikazu; Sanomura, Yoji; Oka, Shiro; Kurihara, Mio; Mizumoto, Takeshi; Miwata, Tomohiro; Urabe, Yuji; Hiyama, Toru; Tanaka, Shinji; Chayama, Kazuaki
BMC GASTROENTEROLOGY   17    Dec 2017   [Refereed]
Background: Blue laser imaging (BLI) and linked color imaging (LCI) are the color enhancement features of the LASEREO endoscopic system, which provide a narrow band light observation function and expansion and reduction of the color information, r...
Canini, Laetitia; Imamura, Michio; Kawakami, Yoshiiku; Uprichard, Susan L.; Cotler, Scott J.; Dahari, Harel; Chayama, Kazuaki
PLOS ONE   12(12)    Dec 2017   [Refereed]
Background & aims High cure rates are achieved in HCV genotype-1b patients treated with daclatasvir and asunaprevir, DCV/ASV. Here we analyzed early HCV kinetics in genotype-1b infected Japanese subjects treated with DCV/ASV and retrospectively pr...
Matsumura, Hiroya; Nakano, Yukiko; Ochi, Hidenori; Onohara, Yuko; Sairaku, Akinori; Tokuyama, Takehito; Tomomori, Shunsuke; Motoda, Chikaaki; Amioka, Michitaka; Hironobe, Naoya; Toshishige, Masaaki; Takahashi, Shinya; Imai, Katsuhiko; Sueda, Taijiro; Chayama, Kazuaki; Kihara, Yasuki
JOURNAL OF BIOMEDICAL SCIENCE   24    Dec 2017   [Refereed]
Background: A common SCN5A polymorphism H558R (c.1673 A > G, rs1805124) improves sodium channel activity in mutated channels and known to be a genetic modifier of Brugada syndrome patients (BrS). We investigated clinical manifestations and underly...
Morio, Kei; Imamura, Michio; Daijo, Kana; Teraoka, Yuji; Honda, Fumi; Nakamura, Yuki; Kobayashi, Tomoki; Nakahara, Takashi; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Kawakami, Yoshiiku; Aikata, Hiroshi; Hayes, Clair Nelson; Tsugawa, Kazuko; Yokozaki, Michiya; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   52(12) 1252-1257   Dec 2017   [Refereed]
Wisteria floribunda agglutinin positive human Mac-2-binding protein glycosylation isomer (M2BPGi) is a novel serum glycomarker for liver fibrosis. However, it is not known whether or not M2BPGi reflects only liver fibrosis. We measured serum M2BPG...
Cheng, Xiaoming; Xia, Yuchen; Serti, Elisavet; Block, Peter Daniel; Chung, Michelle; Chayama, Kazuaki; Rehermann, Barbara; Liang, T. Jake
HEPATOLOGY   66(6) 1779-1793   Dec 2017   [Refereed]
Hepatitis B virus (HBV) infects hepatocytes specifically and causes immune-mediated liver damage. How HBV interacts with the innate immunity at the early phase of infection, either with hepatocytes or other cells in the liver, remains controversia...
Kan, Hiromi; Imamura, Michio; Kawakami, Yoshiiku; Daijo, Kana; Teraoka, Yuji; Honda, Fumi; Nakamura, Yuki; Morio, Kei; Kobayashi, Tomoki; Nakahara, Takashi; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Aikata, Hiroshi; Hayes, Clair Nelson; Miki, Daiki; Ochi, Hidenori; Honda, Yoji; Mori, Nami; Takaki, Shintaro; Tsuji, Keiji; Chayama, Kazuaki
JOURNAL OF MEDICAL VIROLOGY   89(11) 1963-1972   Nov 2017   [Refereed]
Combination of sofosbuvir plus ledipasvir therapy has been expected to enhance sustained virological response (SVR) rates in hepatitis C virus (HCV) genotype 1 chronic infected patients. We analyzed the emergence of drug resistance-associated vari...
Tamaru, Yuzuru; Oka, Shiro; Tanaka, Shinji; Nagata, Shinji; Hiraga, Yuko; Kuwai, Toshio; Furudoi, Akira; Tamura, Tadamasa; Kunihiro, Masaki; Okanobu, Hideharu; Nakadoi, Koichi; Kanao, Hiroyuki; Higashiyama, Makoto; Arihiro, Koji; Kuraoka, Kazuya; Shimamoto, Fumio; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   52(11) 1169-1179   Nov 2017   [Refereed]
We aimed to clarify the long-term outcomes of patients with T1 colorectal carcinoma (CRC) after endoscopic resection (ER) and surgical resection. We examined T1 CRC patients treated during 1992-2008 and who had >= 5 years of follow-up. Patients wh...
Ninomiya, Yuki; Oka, Shiro; Tanaka, Shinji; Boda, Kazuki; Yamashita, Ken; Sumimoto, Kyoku; Hirano, Daiki; Tamaru, Yuzuru; Shigita, Kenjiro; Hayashi, Nana; Matsuo, Taiji; Chayama, Kazuaki
DIGESTIVE ENDOSCOPY   29(7) 773-781   Nov 2017   [Refereed]
Background and Aim: In Western countries, endoscopic removal of all adenomas during colonoscopy is recommended. The present study evaluates the usefulness of magnifying colonoscopy without removal of diminutive (<= 5 mm) colorectal polyps. Methods...
Sumimoto, Kyoku; Tanaka, Shinji; Shigita, Kenjiro; Hayashi, Nana; Hirano, Daiki; Tamaru, Yuzuru; Ninomiya, Yuki; Oka, Shiro; Arihiro, Koji; Shimamoto, Fumio; Yoshihara, Masaharu; Chayama, Kazuaki
GASTROINTESTINAL ENDOSCOPY   86(4) 700-709   Oct 2017   [Refereed]
Backgrounds and Aims: The Japan NBI Expert Team (JNET) classification is the first universal narrow-band imaging magnifying endoscopic classification of colorectal tumors. Considering each type in this classification, the diagnostic ability of Typ...
Maruhashi, Tatsuya; Soga, Junko; Fujimura, Noritaka; Idei, Naomi; Mikami, Shinsuke; Iwamoto, Yumiko; Iwamoto, Akimichi; Kajikawa, Masato; Matsumoto, Takeshi; Oda, Nozomu; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Aibara, Yoshiki; Yusoff, Farina Binti Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Tomiyama, Hirofumi; Takase, Bonpei; Kohro, Takahide; Suzuki, Toru; Ishizu, Tomoko; Ueda, Shinichiro; Yamazaki, Tsutomu; Furumoto, Tomoo; Kario, Kazuomi; Inoue, Teruo; Koba, Shinji; Watanabe, Kentaro; Takemoto, Yasuhiko; Hano, Takuzo; Sata, Masataka; Ishibashi, Yutaka; Node, Koichi; Maemura, Koji; Ohya, Yusuke; Furukawa, Taiji; Ito, Hiroshi; Ikeda, Hisao; Yamashina, Akira; Higashi, Yukihito
HYPERTENSION   70(4) 790-+   Oct 2017   [Refereed]
Hypertension is associated with endothelial dysfunction. Blood pressure significantly correlates with endothelial function in antihypertensive drug-naive subjects. The purpose of this study was to determine whether treatment status affects the rel...
Yamamoto, Hideya; Sugiyama, Eiji; Serikawa, Masahiro; Tatsugami, Fuminari; Yokozaki, Michiya; Kitagawa, Toshiro; Senoo, Atsushi; Nakamoto, Yumiko Kubo; Awai, Kazuo; Chayama, Kazuaki; Kihara, Yasuki
HEART AND VESSELS   32(10) 1176-1185   Oct 2017   [Refereed]
Vascular and/or perivascular involvements of sclerotic inflammation (perivasculitis) are a complication of immunoglobulin G4-related disease (IgG4-RD). We sought to examine clinical manifestations of perivasculitis by computed tomography (CT) in p...
Hamana, Atsushi; Takahashi, Yuki; Uchida, Takuro; Nishikawa, Makiya; Imamura, Michio; Chayama, Kazuaki; Takakura, Yoshinobu
ANTIVIRAL RESEARCH   146 130-138   Oct 2017   [Refereed]
Treatment of hepatitis C virus (HCV) infection has greatly improved in the last 5 years because of the identification of direct-acting antivirals (DAAs). However, concerns exist regarding the emergence of drug resistance-associated substitutions (...
Nagai, Kenta; Ueno, Yoshitaka; Tanaka, Shinji; Hayashi, Ryohei; Shinagawa, Kei; Chayama, Kazuaki
CELLULAR IMMUNOLOGY   320 20-28   Oct 2017   [Refereed]
Non-steroidal anti-inflammatory drugs often cause ulcers in the human small intestine, but few effective agents exist to treat such injury. Ganoderma lucidum Karst, also known as "Reishi" or "Lingzhi", is a mushroom. We previously reported that a ...
Uchida, Takuro; Imamura, Michio; Hayes, C. Nelson; Hiraga, Nobuhiko; Kan, Hiromi; Tsuge, Masataka; Abe-Chayama, Hiromi; Zhang, Yizhou; Makokha, Grace Naswa; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   61(9)    Sep 2017   [Refereed]
Nucleot(s)ide analogues and peginterferon (PEG-IFN) treatment are the only approved therapies for chronic hepatitis B virus (HBV) infection. However, complete eradication of the virus, as indicated by persistent loss of hepatitis B surface antigen...
Matsui, Shogo; Kajikawa, Masato; Maruhashi, Tatsuya; Iwamoto, Yumiko; Iwamoto, Akimichi; Oda, Nozomu; Kishimoto, Shinji; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Nakashima, Ayumu; Noma, Kensuke; Taguchi, Akira; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   241 30-34   Aug 2017   [Refereed]
Background: Periodontal disease is associated with endothelial dysfunction, leading to cardiovascular disease. The effect of detailed tooth brushing behavior, not only frequency but also duration of tooth brushing, on endothelial function is uncle...
Sagami, Shintaro; Ueno, Yoshitaka; Tanaka, Shinji; Fujita, Akira; Hayashi, Ryohei; Oka, Shiro; Hyogo, Hideyuki; Chayama, Kazuaki
HEPATOLOGY RESEARCH   47(9) 872-881   Aug 2017   [Refereed]
Aim: The prevalence of non-alcoholic fatty liver disease (NAFLD) and Crohn's disease (CD) is increasing. The aim of our study was to evaluate the prevalence of NAFLD in patients with CD, as well as to investigate the effect of NAFLD on the disease...
Daijo, Kana; Kawaoka, Tomokazu; Nakahara, Takashi; Nagaoki, Yuko; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Hara, Keiichi; Tajima, Go; Kobayashi, Masao; Chayama, Kazuaki
CLINICAL JOURNAL OF GASTROENTEROLOGY   10(4) 383-387   Aug 2017   [Refereed]
The urea cycle converts ammonia and produces urea. One form of urea cycle abnormality is ornithine transcarbamylase (OTC) deficiency. This hereditary disorder is associated with hyperammonemia. OTC deficiency commonly appears during neonatal and e...
Nakamura, Yuki; Aikata, Hiroshi; Fukuhara, Takayuki; Honda, Fumi; Morio, Kei; Morio, Reona; Hatooka, Masahiro; Kobayashi, Tomoki; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Ochi, Hidenori; Kobayashi, Tsuyoshi; Ohdan, Hideki; Shiroma, Noriyuki; Arihiro, Koji; Chayama, Kazuaki
HEPATOLOGY RESEARCH   47(8) 767-772   Jul 2017   [Refereed]
AimFibroScan is a tool for the non-invasive diagnosis of hepatic fibrosis. Previous studies have compared liver stiffness to percutaneous liver biopsy findings, but no study has compared liver stiffness to liver resection specimen findings. The ai...
Oda, Nozomu; Maruhashi, Tatsuya; Kishimoto, Shinji; Kajikawa, Masato; Iwamoto, Yumiko; Iwamoto, Akimichi; Matsui, Shogo; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Nakashima, Ayumu; Noma, Kensuke; Hirano, Harutoyo; Higashi, Yukihito
AMERICAN JOURNAL OF CARDIOLOGY   119(12) 1983-1988   Jun 2017   [Refereed]
The presence of an earlobe crease (ELC) may be a simple sign to predict atherosclerosis. We evaluated the relation between ELC and vascular function. We measured flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) and ob...
Kajikawa, Masato; Oda, Nozomu; Kishimoto, Shinji; Maruhashi, Tatsuya; Iwamoto, Yumiko; Iwamoto, Akimichi; Matsui, Shogo; Aibara, Yoshiki; Yusoff, Farina Binti Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Noma, Kensuke; Nakashima, Ayumu; Taguchi, Akira; Higashi, Yukihito
CIRCULATION JOURNAL   81(6) 862-+   Jun 2017   [Refereed]
Background: Osteoporosis and cardiovascular disease are major public health problems. A number of clinical studies have shown a link between osteoporosis and cardiovascular disease, but there is no information on the associations of risk of osteop...
Morio, Kei; Imamura, Michio; Kawakami, Yoshiiku; Nakahara, Takashi; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Aikata, Hiroshi; Hayes, Clair Nelson; Makokha, Grace Naswa; Ochi, Hidenori; Amano, Hajime; Arataki, Keiko; Moriya, Takashi; Ito, Hiroyuki; Tsuji, Keiji; Kohno, Hiroshi; Waki, Koji; Tamura, Toru; Nakamura, Toshio; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   52(6) 746-753   Jun 2017   [Refereed]
Polymorphisms in the inosine triphosphatase (ITPA) gene is associated with anemia induced by peg-interferon (PEG-IFN) plus ribavirin (RBV) treatment for patients with chronic hepatitis C virus (HCV) infection. However, the effect of ITPA polymorph...
Sato, Ken; Chayama, Kazuaki; Alves, Katia; Toyoda, Hidenori; Suzuki, Fumitaka; Kato, Koji; Rodrigues, Lino, Jr.; Zhang, Xinyan; Setze, Carolyn; Pilot-Matias, Tami; Burroughs, Margaret; Redman, Rebecca; Kumada, Hiromitsu
ADVANCES IN THERAPY   34(6) 1449-1465   Jun 2017   [Refereed]
Introduction: In Japan, hepatitis C virus (HCV) genotype (GT) 2 accounts for approximately 32% of HCV infections. Limited treatment options exist in Japan for HCV GT2-infected patients. GIFT-II was a phase 3, randomized, open-label study evaluatin...
Tsuge, Masataka; Uchida, Takuro; Hiraga, Nobuhiko; Kan, Hiromi; Makokha, Grace Naswa; Abe-Chayama, Hiromi; Miki, Daiki; Imamura, Michio; Ochi, Hidenori; Hayes, C. Nelson; Shimozono, Rieko; Iwamura, Tomokatsu; Narumi, Hideki; Suzuki, Tomohiko; Kainoh, Mie; Taniguchi, Tadatsugu; Chayama, Kazuaki
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   61(6)    Jun 2017   [Refereed]
Although nucleot(s)ide analogues and pegylated interferon alpha 2a (PEG-IFN-alpha 2a) can suppress hepatitis B virus (HBV) replication, it is difficult to achieve complete HBV elimination from hepatocytes. A novel site-specific pegylated recombina...
Kobayashi, Tomoki; Aikata, Hiroshi; Kobayashi, Tsuyoshi; Ohdan, Hideki; Arihiro, Koji; Chayama, Kazuaki
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL   16(3) 279-288   Jun 2017   [Refereed]
BACKGROUND: Early recurrence (ER) after hepatic resection (HR) is a poor prognostic factor for patients with hepatocellular carcinoma (HCC). This study aimed to identify the clinicopathological features, outcomes, and risk factors for ER after HR ...
Individual patient data meta-analysis of controlled attenuation parameter (CAP) technology for assessing steatosis
Karlas, Thomas; Petroff, David; Sasso, Magali; Fan, Jian-Gao; Mi, Yu-Qiang; de Ledinghen, Victor; Kumar, Manoj; Lupsor-Platon, Monica; Han, Kwang-Hyub; Cardoso, Ana C.; Ferraioli, Giovanna; Chan, Wah-Kheong; Wong, Vincent Wai-Sun; Myers, Robert P.; Chayama, Kazuaki; Friedrich-Rust, Mireen; Beaugrand, Michel; Shen, Feng; Hiriart, Jean-Baptiste; Sarin, Shiv K.; Badea, Radu; Jung, Kyu Sik; Marcellin, Patrick; Filice, Carlo; Mahadeva, Sanjiv; Wong, Grace Lai-Hung; Crotty, Pam; Masaki, Keiichi; Bojunga, Joerg; Bedossa, Pierre; Keim, Volker; Wiegand, Johannes
JOURNAL OF HEPATOLOGY   66(5) 1022-1030   May 2017   [Refereed]
Background & Aims: The prevalence of fatty liver underscores the need for non-invasive characterization of steatosis, such as the ultrasound based controlled attenuation parameter (CAP). Despite good diagnostic accuracy, clinical use of CAP is lim...
Takigawa, Hidehiko; Kitadai, Yasuhiko; Shinagawa, Kei; Yuge, Ryo; Higashi, Yukihito; Tanaka, Shinji; Yasui, Wataru; Chayama, Kazuaki
NEOPLASIA   19(5) 429-438   May 2017   [Refereed]
We previously reported that in an orthotopic nude mouse model of human colon cancer, bone marrow-derived mesenchymal stem cells (MSCs) migrated to the tumor stroma and promoted tumor growth and metastasis. Here, we evaluated the proliferation and ...
Ono, Chikako; Fukuhara, Takasuke; Motooka, Daisuke; Nakamura, Shota; Okuzaki, Daisuke; Yamamoto, Satomi; Tamura, Tomokazu; Mori, Hiroyuki; Sato, Asuka; Uemura, Kentaro; Fauzyah, Yuzy; Kurihara, Takeshi; Suda, Takahiro; Nishio, Akira; Hmwe, Su Su; Okamoto, Toru; Tatsumi, Tomohide; Takehara, Tetsuo; Chayama, Kazuaki; Wakita, Takaji; Koike, Kazuhiko; Matsuura, Yoshiharu
PLOS PATHOGENS   13(5)    May 2017   [Refereed]
miR-122, a liver-specific microRNA, is one of the determinants for liver tropism of hepatitis C virus (HCV) infection. Although miR-122 is required for efficient propagation of HCV, we have previously shown that HCV replicates at a low rate in miR...
Uchida, Takuro; Imamura, Michio; Kan, Hiromi; Hiraga, Nobuhiko; Hayes, C. Nelson; Tsuge, Masataka; Abe-Chayama, Hiromi; Aikata, Hiroshi; Makokha, Grace Naswa; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
JOURNAL OF GENERAL VIROLOGY   98(5) 1040-1047   May 2017   [Refereed]
Urokinase-type plasminogen activator/severe combined immunodeficiency (uPA/SCID) mice transplanted with human hepatocytes are permissive for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. However, one of the problems affecting uPA ...
Morio, Reona; Imamura, Michio; Kawakami, Yoshiiku; Morio, Kei; Kobayashi, Tomoki; Yokoyama, Satoe; Kimura, Yuki; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Hayes, C. Nelson; Aikata, Hiroshi; Takahashi, Shoichi; Miki, Daiki; Ochi, Hidenori; Mori, Nami; Takaki, Shintaro; Tsuji, Keiji; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   52(4) 504-511   Apr 2017   [Refereed]
Background Daclatasvir and asunaprevir combination therapy has shown a high virological response for chronic genotype 1 hepatitis C virus (HCV)-infected patients. However, the safety and efficacy of the therapy for older patients are unknown. Meth...
Kumada, Hiromitsu; Suzuki, Yoshiyuki; Karino, Yoshiyasu; Chayama, Kazuaki; Kawada, Norifumi; Okanoue, Takeshi; Itoh, Yoshito; Mochida, Satoshi; Toyoda, Hidenori; Yoshiji, Hitoshi; Takaki, Shintaro; Yatsuzuka, Naoyoshi; Yodoya, Etsuo; Iwasa, Takashi; Fujimoto, Go; Robertson, Michael N.; Black, Stuart; Caro, Luzelena; Wahl, Janice
JOURNAL OF GASTROENTEROLOGY   52(4) 520-533   Apr 2017   [Refereed]
Background Elbasvir (EBR) in combination with grazoprevir (GZR) has demonstrated efficacy in patients with hepatitis C virus (HCV) infections in trials primarily conducted in the USA and Europe. We investigated the safety and efficacy of EBR in co...
Nakamura, Yuki; Imamura, Michio; Kawakami, Yoshiiku; Teraoka, Yuji; Daijo, Kana; Honda, Fumi; Morio, Kei; Kobayashi, Tomoki; Nakahara, Takashi; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Aikata, Hiroshi; Hayes, C. Nelson; Miki, Daiki; Ochi, Hidenori; Chayama, Kazuaki
JOURNAL OF MEDICAL VIROLOGY   89(4) 665-671   Apr 2017   [Refereed]
Chronic hepatitis C virus (HCV) infection is associated with renal dysfunction. Daclatasvir and asunaprevir combination therapy showed a high virological response for genotype 1 chronic HCV-infected patients with renal dysfunction on hemodialysis....

Misc

 
miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis.
Gut.   67 953-962   2018
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
Nat Genet.   48 500-509   2016   [Refereed]
Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.
Gut.   62 1055-1061   2013   [Refereed]
Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers.
Gastroenterology.   145 658-667   2013
Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.
Nat Med.   18 281-285   2012   [Refereed]
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.
Nat Genet.   44 760-764   2012   [Refereed]
HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.
Gut.   60 261-267   2011   [Refereed]
Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses.
Gastroenterology.   141 e1-5   2011   [Refereed]
Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.
Nat Genet.   43 797-800   2011   [Refereed]
Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations.
Nat Genet.   42 893-896   2010   [Refereed]
ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.
Gastroenterology.   139 1190-1197   2010   [Refereed]
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
Nat Genet.   41 591-595   2009
A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C.
Gastroenterology.   136 1796-1805   2009   [Refereed]
Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry.
Gastroenterology.   137 673-681   2009
Nonpolypoid (flat and depressed) colorectal neoplasms.
Gastroenterology.   130 566-576   2006   [Refereed]
Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats.
Gastroenterology.   128 138-146   2005   [Refereed]
A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers.
Nat Genet.   37 1104-1107   2005   [Refereed]
Endothelial function and oxidative stress in renovascular hypertension.
N Engl J Med.   346 1954-1962   2002   [Refereed]

Books etc

 
Molecular pathologic application as a predictor of lymph node metastasis in submucosal colorectal carcinoma:implication of immunohistochemical alterations at the deepest invasive margin
2006   
Role of invariant natural killer T cells in the regulation of the inflammatory response in experimental colitis in mice
2005   
Methods in molecular medicine-hepatitis C protocols. Genotyping hepatitis C virus by type-specific primers for PCR based on NS5 region.
Humana Press   1998   
Hepatitis C protocols; Genotyping hepatitis C virus by type-specific primers or PCR based on NS5 region
Humana Press   1998   
Viral hepatitis and liver disease. High virus titer, slow virus decrease, genotype(]G0002[), and sequence variability of E2/NS1 HVR predict poor response to interferon therapy in chronic hepatitis C.
Springer Verlag   1994   
High virus titer, slow virus decrease, genotypeII, and sequence variability of E2/NS1 HVR predict poor response to interferon therapy in chronic hepatitis C Viral hepatitis and liver disease
Springer Verlag   1994   
Hepatotos C Virus Treatment
Springer   2017   
Hepatitis B Virus and Liver Desease
Kazuaki Chayama, Nelson Hayes. (Part:Joint Editor)
Springer Nature Singapore Pre Ltd.   Sep 2017   
Management for DAA resistant-associated variants
Sep 2017   
The Liver Cancer Journal
Dec 2017   
Clinics in Gastroenterology
2018   

Conference Activities & Talks

 
DAA/PR therapy in Asian HCV patients [Invited]
4 Dec 2015   
Hepatitis B mouse model involving CTL
23 Apr 2015   
Ombitasvir/Paritaprevir/Ritonavir for treatment of HCV genotype 1b in Japanese patients with or without Cirrhosis: results from GIFT-1
22 May 2015   
All Oral Direct Acting Antiviral Therapy for Chronic Hepatitis C [Invited]
17 Oct 2015   
Circulating Tumor DNA Analysis for HCC. [Invited]
26 Oct 2015   
All-oral Dual Combination of Daclatasvir plus Asunaprevir Compared with Telaprevir plus Peginterferon Alfa/Ribavirin in Treatment-maive Japanese Patients ChronicallyInfected with HCV Genotype 1b:Results from a Phase 3 Study
chayama kazuaki
11 Nov 2014   
Optimizing triple therapy, and IFN/RBV free regimens
chayama kazuaki
12 Mar 2014   

Works

 
広島大学ラグビー部顧問,第32回中国四国医科学生ラグビーフットボール大会 広島大学優勝

Research Grants & Projects

 
Japan Agency for Medical Research and Development: Research Program on Hepatitis
Project Year: Apr 2015 - Mar 2016
Japan Agency for Medical Research and Development: Research Program on Hepatitis
Project Year: Apr 2015 - Mar 2016
Ministry of Health, Labour and Welfare: Health and Labour Sciences Research Grants
Project Year: 2011 - 2013
Ministry of Health, Labour and Welfare: Health and Labour Sciences Research Grants
Project Year: 2012 - 2016
Project Year: 2014 - 2014
MEXT: KAKENHI
Project Year: 2013 - 2013    Investigator(s): CHAYAMA, Kazuaki
Recent research made it clear that there are certain amount of circulating miRNA in serum, which present in serum associated with proteins such as AGO1 and AGO2. Such AGO-protein bound miRNA is quite stable and detectable by polymerase chain react...
MEXT: KAKENHI
Project Year: 2012 - 2012    Investigator(s): CHAYAMA, Kazuaki
We attempted to identify unknown pathogen from a patient with eruption and liver disorder with massive parallel sequencing. We found DNA sequences of cytomegalovirus from this patient. Further assembly of remaining non-human sequence is now going on.
MEXT: KAKENHI
Project Year: 2010 - 2011    Investigator(s): CHAYAMA, Kazuaki
Small animal model such as knockout mouse is a valuable tool to study human diseases. We infected human hepatocyte chimeric mice with hepatitis B virus and administered human peripheral white blood cells. The mice developed fulminant hepatitis lik...
MEXT: KAKENHI
Project Year: 2009 - 2011    Investigator(s): CHAYAMA, Kazuaki
We investigated a mechanism of continuous infection of hepatitis B and hepatitis C virus with high density microarray using human hepatocyte chimeric mice. Induction of interferon stimulated genes were partially inhibited by each of the two viruse...
Project Year: 2007 - 2007
MEXT: KAKENHI
Project Year: 2006 - 2007    Investigator(s): CHAYAMA, Kazuaki
We inflicted human hepatocyte chimerie mice with hepatitis B and hepatitis C viruses by injecting serum samples obtained from serum samples of chronic hepatitis B and hepatitis C virus carriers. After confirming the development of viremia in mice,...
Project Year: 2003 - 2005
MEXT: KAKENHI
Project Year: 2001 - 2003    Investigator(s): CHAYAMA, Kazuaki
Hepatitis C virus infection is a serious health problem worldwide. As the hepatitis C virus infects only humans and chimpanzees, establishment of reliable culture system is necessary to study this important pathogen. We cloned a full length genoty...
MEXT: KAKENHI
Project Year: 2001 - 2003    Investigator(s): CHAYAMA, Kazuaki
Hepatitis B virus infection is a serious health problem worldwide. As the hepatitis B virus infects only humans and chimpanzees, establishment of reliable culture system is necessary to study this important pathogen. We cloned a fu11 length genoty...
MEXT: KAKENHI
Project Year: 1998 - 2000    Investigator(s): CHAYAMA, Kazuaki
Treatment of hepatitis B virus with lamivudine is effective in suppressing virus replication and results in reduced inflammatory activity. However, the emergence of lamivudine-resistant mutant virus, with amino acid substitution in the YMDD motif ...
MEXT: KAKENHI
Project Year: 1994 - 1995    Investigator(s): CHAYAMA, Kazuaki
Hepatitis C virus (HCV) genotype 1b and high pretreatment virus load are prdictive factors of poor response to interferon therapy in patients with chronic hepatitis C.However, few patients with low virus load and genotype 1b show poor response to ...
Ministry of Health, Labour and Welfare: Health and Labour Sciences Research Grants
Project Year: Apr 2014 - Mar 2015
Project Year: 2015 - 2016
Japan Agency for Medical Research and Development: Research Program on Hepatitis
Project Year: Apr 2016 - Mar 2017
Japan Agency for Medical Research and Development: Research Program on Hepatitis
Project Year: Apr 2016 - Mar 2017
JSPS: KAKENHI(Grant-in-Aid for Challenging Research (Pioneering))
Project Year: 2017 - 2019
Hospital, National Center for Geriatrics and Gerontology: Research Program on Hepatitis
Project Year: Apr 2017 - Mar 2018
Hospital, National Center for Geriatrics and Gerontology: Research Program on Hepatitis
Project Year: Apr 2017 - Mar 2018