Chayama Kazuaki

J-GLOBAL         Last updated: Oct 18, 2019 at 08:57
 
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Name
Chayama Kazuaki
E-mail
chayamahiroshima-u.ac.jp
Affiliation
Hiroshima University
Degree
Doctor of Philosophy in Medical Sciences(The University of Tokyo)
Research funding number
00211376

Research Areas

 
 

Academic & Professional Experience

 
May 1981
   
 
Clinical Fellow, Medical corporation Dojinkai
 
Apr 1986
   
 
Clinical Fellow, National Public Officers Mutual Aid Association Federation
 
Jul 1996
   
 
Medical director, same
 
Sep 2000
 - 
Mar 2002
Professor, Faculty of Medicine, Hiroshima University
 
Apr 2002
 - 
Mar 2019
Professor, Graduate School of Biomedical Sciences, Hiroshima University
 
Apr 2005
 - 
Mar 2011
Deputy Director, Hospital, Hiroshima University
 
Apr 2009
 - 
Mar 2011
Vice Executive, Hiroshima University
 
Apr 2011
 - 
Mar 2015
Director, Hospital, Hiroshima University
 
Apr 2012
 - 
Mar 2015
Executive and Vice President, Hiroshima University
 
Apr 2015
 - 
Mar 2016
Special Assistant to the President, Hiroshima University
 

Education

 
Apr 1974
 - 
Mar 1981
Faculty of Medicine, Hiroshima University
 

Awards & Honors

 
Nov 1997
The Superiority of Laparoscopic Examination in Predicting Hepatocellular Carcinoma after Interferon Therapy for Chronic, Award of The Japan Gastroenterological Endoscopy Society
 
Jan 2008
GlaxoSmithKline Award
 

Published Papers

 
Lupberger, Joachim; Croonenborghs, Tom; Suarez, Armando Andres Roca; Van Renne, Nicolaas; Juhling, Frank; Oudot, Marine A.; Virzi, Alessia; Bandiera, Simonetta; Jamey, Carole; Meszaros, Gergo; Brumaru, Daniel; Mukherji, Atish; Durand, Sarah C.; Heydmann, Laura; Verrier, Eloi R.; El Saghire, Hussein; Hamdane, Nourdine; Bartenschlager, Ralf; Fereshetian, Shaunt; Ramberger, Evelyn; Sinha, Rileen; Nabian, Mohsen; Everaert, Celine; Jovanovic, Marko; Mertins, Philipp; Carr, Steven A.; Chayama, Kazuaki; Dali-Youcef, Nassim; Ricci, Romeo; Bardeesy, Nabeel M.; Fujiwara, Naoto; Gevaert, Olivier; Zeisel, Mirjam B.; Hoshida, Yujin; Pochet, Nathalie; Baumert, Thomas F.
GASTROENTEROLOGY   157(2) 537-+   Aug 2019   [Refereed]
BACKGROUND & AIMS: The mechanisms of hepatitis C virus (HCV) infection, liver disease progression, and hepatocarcinogenesis are only partially understood. We performed genomic, proteomic, and metabolomic analyses of HCV-infected cells and chimeric...
Takaguchi, Koichi; Toyoda, Hidenori; Tsutsui, Akemi; Suzuki, Yoshiyuki; Nakamuta, Makoto; Imamura, Michio; Senoh, Tomonori; Nagano, Takuya; Tada, Toshifumi; Tachi, Yoshihiko; Hiraoka, Atsushi; Michitaka, Kojiro; Shibata, Hiroshi; Joko, Kouji; Okubo, Hironao; Tsuji, Kunihiko; Takaki, Shintaro; Watanabe, Tsunamasa; Ogawa, Chikara; Chayama, Kazuaki; Kumada, Takashi; Kudo, Masatoshi; Kumada, Hiromitsu
JOURNAL OF GASTROENTEROLOGY   54(8) 742-751   Aug 2019   [Refereed]
BackgroundThe virological efficacy and safety of the direct-acting antiviral (DAA) regimen consisting of daclatasvir, asunaprevir, and beclabuvir (DCV/ASV/BCV) for patients chronically infected with hepatitis C virus (HCV) genotype 1 have not been...
Naganuma, Atsushi; Chayama, Kazuaki; Notsumata, Kazuo; Gane, Edward; Foster, Graham R.; Wyles, David; Kwo, Paul; Crown, Eric; Bhagat, Abhi; Mensa, Federico J.; Otani, Tetsuya; Larsen, Lois; Burroughs, Margaret; Kumada, Hiromitsu
JOURNAL OF GASTROENTEROLOGY   54(8) 752-761   Aug 2019   [Refereed]
BackgroundChronic hepatitis C virus (HCV) infection with genotypes (GT) 1 and 2 accounts for over 50% of HCV infections globally, including over 97% of all HCV infections in Japan. Here, we report an integrated analysis of efficacy and safety of 8...
Takigawa, Hidehiko; Masaki, Satoshi; Naito, Toshikatsu; Yuge, Ryo; Urabe, Yuji; Tanaka, Shinji; Sentani, Kazuhiro; Matsuo, Taiji; Matsuo, Keisuke; Chayama, Kazuaki; Kitadai, Yasuhiko
CANCER MEDICINE   8(9) 4370-4379   Aug 2019   [Refereed]
Most patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma are infected with Helicobacter pylori, and eradication therapy is the first-line treatment for localized disease with H pylori infection. However, there were several repo...
Maruhashi, Tatsuya; Kinoshita, Yoshihiko; Kajikawa, Masato; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Takaeko, Yuji; Aibara, Yoshiki; Yusoff, Farina Mohamad; Hidaka, Takayuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Takahashi, Masakazu; Kihara, Yasuki; Higashi, Yukihito; Ozono, Ryoji; Nakamaru, Mitsuaki; Ninomiya, Masanori; Oiwa, Jiro; Sumii, Kotaro; Miho, Narimasa; Kawagoe, Takuji; Takahari, Kousuke; Yoshida, Osamu; Hayashi, Yasuhiko; Okimoto, Tomokazu; Ono, Yujiro; Jo, Hikari; Tsushima, Hiroshi; Fukunaga, Yasuo; Shiode, Nobuo; Higaki, Tadanao; Mitsuda, Hiroki; Matsumoto, Toshiyuki; Sugino, Hiroshi; Ueda, Hironori; Mitsuba, Naoya; Matsuura, Hideo; Kido, Koji; Ueda, Kentaro; Matsumoto, Koji; Watanabe, Mitsuaki; Takaekou, Yuji
HYPERTENSION RESEARCH   42(8) 1175-1185   Aug 2019   [Refereed]
Hypertension is associated with vascular failure, such as increased arterial stiffness, endothelial dysfunction, and vascular smooth muscle dysfunction. The purpose of this study was to investigate the relationship between out-of-office blood pres...
Namba, Maiko; Kawaoka, Tomokazu; Aikata, Hiroshi; Kodama, Kenichiro; Uchikawa, Shinsuke; Ohya, Kazuki; Morio, Kei; Fujino, Hatsue; Nakahara, Takashi; Murakami, Eisuke; Yamauchi, Masami; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Baba, Yasutaka; Awai, Kazuo; Chayama, Kazuaki
CLINICAL JOURNAL OF GASTROENTEROLOGY   12(4) 341-346   Aug 2019   [Refereed]
We report a 74-year-old male patient with compensated cirrhosis after hepatic C virus eradication. After the patient underwent hepatectomy for hepatocellular carcinoma, multiple lung and lymph node metastases were detected by computed tomography. ...
Kajikawa, Masato; Maruhashi, Tatsuya; Hidaka, Takayuki; Matsui, Shogo; Hashimoto, Haruki; Takaeko, Yuji; Nakano, Yukiko; Kurisu, Satoshi; Kihara, Yasuki; Yusoff, Farina Mohamad; Kishimoto, Shinji; Chayama, Kazuaki; Goto, Chikara; Noma, Kensuke; Nakashima, Ayumu; Hiro, Takafumi; Hirayama, Atsushi; Shiina, Kazuki; Tomiyama, Hirofumi; Yagi, Shusuke; Amano, Rie; Yamada, Hirotsugu; Sata, Masataka; Higashi, Yukihito
SCIENTIFIC REPORTS   9    Jul 2019   [Refereed]
The dipeptidyl peptidase-4 inhibitor saxagliptin is a widely used antihyperglycemic agent in patients with type 2 diabetes. The purpose of this study was to evaluate the effects of saxagliptin on endothelial function in patients with type 2 diabet...
Tsushima, Ken; Tsuge, Masataka; Hiraga, Nobuhiko; Uchida, Takuro; Murakami, Eisuke; Makokha, Grace Naswa; Kurihara, Mio; Nomura, Motonobu; Hiyama, Yuichi; Fujino, Hatsue; Ono, Atsushi; Nakahara, Takashi; Yamauchi, Masami; Abe-Chayama, Hiromi; Kawaoka, Tomokazu; Miki, Daiki; Imamura, Michio; Aikata, Hiroshi; Hayes, Clair Nelson; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   54(7) 650-659   Jul 2019   [Refereed]
Background and aimsThe clinical course and responsiveness to antiviral treatments differs among hepatitis B virus (HBV) genotypes. However, the cause of these differences is unclear. In the present study, we compared mRNA expression profiles in hu...
Osawa, Mitsutaka; Uchida, Takuro; Imamura, Michio; Teraoka, Yuji; Fujino, Hatsue; Nakahara, Takashi; Ono, Atsushi; Murakami, Eisuke; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiramatsu, Akira; Abe-Chayama, Hiromi; Hayes, C. Nelson; Makokha, Grace Naswa; Aikata, Hiroshi; Ishida, Yuji; Tateno, Chise; Miyayama, Yohei; Hijikata, Makoto; Chayama, Kazuaki
JOURNAL OF GENERAL VIROLOGY   100(7) 1123-1131   Jul 2019   [Refereed]
Combination therapy with glecaprevir (GLE) and pibrentasvir (PIB) has high efficacy for pan-genotypic hepatitis C virus (HCV)-infected patients. However, the efficacy for patients who acquired potent NS5A inhibitor resistance-associated variants (...
Tanaka, Hidenori; Oka, Shiro; Tanaka, Shinji; Inagaki, Katsuaki; Okamoto, Yuki; Matsumoto, Kenta; Boda, Kazuki; Yamashita, Ken; Sumimoto, Kyoku; Ninomiya, Yuki; Chayama, Kazuaki
JOURNAL OF THE ANUS RECTUM AND COLON   3(3) 128-135   Jul 2019   [Refereed]
Objectives: Surveillance colonoscopy after endoscopic resection (ER) for adenomatous polyps reduces the incidence and mortality of colorectal cancer (CRC). However, its significance in the elderly population is uncertain. The study aimed to determ...
Makokha, Grace Naswa; Abe-Chayama, Hiromi; Chowdhury, Sajeda; Hayes, C. Nelson; Tsuge, Masataka; Yoshimaz, Tadahiko; Ishida, Yuji; Zhang, Yizhou; Uchida, Takuro; Tateno, Chise; Akiyama, Rie; Chayama, Kazuaki
SCIENTIFIC REPORTS   9    Jun 2019   [Refereed]
Hepatitis B virus (HBV) infects the liver and is a key risk factor for hepatocellular carcinoma. Identification of host factors that support viral replication is important to understand mechanisms of viral replication and to develop new therapeuti...
Xue, Ruidong; Chen, Lu; Zhang, Chong; Fujita, Masashi; Li, Ruoyan; Yan, Shu-Mei; Ong, Choon Kiat; Liao, Xiwen; Gao, Qiang; Sasagawa, Shota; Li, Yanmeng; Wang, Jincheng; Guo, Hua; Huang, Qi-Tao; Zhong, Qian; Tan, Jing; Qi, Lisha; Gong, Wenchen; Hong, Zhixian; Li, Meng; Zhao, Jingmin; Peng, Tao; Lu, Yinying; Lim, Kiat Hon Tony; Boot, Arnoud; Ono, Atushi; Chayama, Kazuaki; Zhang, Zemin; Rozen, Steve George; Teh, Bin Tean; Wang, Xin Wei; Nakagawa, Hidewaki; Zeng, Mu-Sheng; Bai, Fan; Zhang, Ning
CANCER CELL   35(6) 932-+   Jun 2019   [Refereed]
We performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcin...
Yen, Chia-Jui; Yang, Shu-Ting; Chen, Ruo-Yu; Huang, Wenya; Chayama, Kazuaki; Lee, Ming-Hao; Yang, Shiang-Jie; Lai, Hong-Sheng; Yen, Hsin-Yi; Hsiao, Yu-Wei; Wang, Ju-Ming; Lin, Yih-Jyh; Hung, Liang-Yi
JOURNAL OF BIOMEDICAL SCIENCE   26    Jun 2019   [Refereed]
BackgroundOur previous report suggested that centrosomal P4.1-associated protein (CPAP) is required for Hepatitis B virus (HBV) encoded non-structure protein X (HBx)-mediated nuclear factor kappa light chain enhancer of activated B cells (NF-B) ac...
Hamdane, Nourdine; Juhling, Frank; Crouchet, Emilie; El Saghire, Houssein; Thumann, Christine; Oudot, Marine A.; Bandiera, Simonetta; Saviano, Antonio; Ponsolles, Clara; Suarez, Armando Andres Roca; Li, Shen; Fujiwara, Naoto; Ono, Atsushi; Davidson, Irwin; Bardeesy, Nabeel; Schmidl, Christian; Bock, Christoph; Schuster, Catherine; Lupberger, Joachim; Habersetzer, Francois; Doffoel, Michel; Piardi, Tullio; Sommacale, Daniele; Imamura, Michio; Uchida, Takuro; Ohdan, Hideki; Aikata, Hiroshi; Chayama, Kazuaki; Boldanova, Tujana; Pessaux, Patrick; Fuchs, Bryan C.; Hoshida, Yujin; Zeisel, Mirjam B.; Duong, Francois H. T.; Baumert, Thomas F.
GASTROENTEROLOGY   156(8) 2313-+   Jun 2019   [Refereed]
BACKGROUND & AIMS: Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is decreased but not eliminated after a sustained virologic respon...
Kajikawa, Masato; Maruhashi, Tatsuya; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Takaeko, Yuji; Yusoff, Farina Mohamad; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Noma, Kensuke; Nakashima, Ayumu; Tomiyama, Hirofumi; Takase, Bonpei; Kohro, Takahide; Suzuki, Toru; Ishizu, Tomoko; Ueda, Shinichiro; Yamazaki, Tsutomu; Furumoto, Tomoo; Kario, Kazuomi; Inoue, Teruo; Koba, Shinji; Watanabe, Kentaro; Takemoto, Yasuhiko; Hano, Takuzo; Sata, Masataka; Ishibashi, Yutaka; Node, Koichi; Maemura, Koji; Ohya, Yusuke; Furukawa, Taiji; Ito, Hiroshi; Ikeda, Hisao; Yamashina, Akira; Higashi, Yukihito
CIRCULATION JOURNAL   83(5) 1064-+   May 2019   [Refereed]
Background: Circulating triglyceride (TG) levels are a current focus as a residual risk for cardiovascular (CV) events. We evaluated the relationship between circulating TG levels and future CV events in patients with coronary artery disease (CAD)...
Kishimoto, Shinji; Oki, Kenji; Maruhashi, Tatsuya; Kajikawa, Masato; Matsui, Shogo; Hashimoto, Haruki; Takaeko, Yuji; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Yusoff, Farina Mohamad; Nakashima, Ayumu; Noma, Kensuke; Liao, James K.; Higashi, Yukihito
JOURNAL OF HYPERTENSION   37(5) 1083-1095   May 2019   [Refereed]
Objective: Primary aldosteronism is one of the most common cause of secondary hypertension. It is well known that the incidence of cardiovascular events is higher in patients with primary aldosteronism than in patients with essential hypertension....
Nagaoki, Yuko; Imamura, Michio; Nishida, Yuno; Daijo, Kana; Teraoka, Yuji; Honda, Fumi; Nakamura, Yuki; Morio, Kei; Fujino, Hatsue; Nakahara, Takashi; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Kawakami, Yoshiiku; Miki, Daiki; Hiyama, Yuichi; Ochi, Hidenori; Chayama, Kazuaki; Aikata, Hiroshi
JOURNAL OF MEDICAL VIROLOGY   91(4) 650-658   Apr 2019   [Refereed]
Background and Aim To examine the effect on recurrence and survival of treatment by interferon (IFN)-free direct-acting antivirals (DAA) for patients with hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) who underwent primary cura...
Urabe, Yuji; Kagemoto, Kenichi; Nakamura, Koki; Mizumoto, Takeshi; Sanomura, Yoji; Oka, Shiro; Ochi, Hidenori; Tanaka, Shinji; Chayama, Kazuaki
ESOPHAGUS   16(2) 141-146   Apr 2019   [Refereed]
BackgroundPreviously, we identified that rs1229984 in ADH1B, rs671 in ALDH2, and smoking status were independently associated with the risk of developing metachronous squamous cell carcinoma (SCC) after endoscopic resection (ER) for esophageal SCC...
Tateishi, Ryosuke; Uchino, Koji; Fujiwara, Naoto; Takehara, Tetsuo; Okanoue, Takeshi; Seike, Masataka; Yoshiji, Hitoshi; Yatsuhashi, Hiroshi; Shimizu, Masahito; Torimura, Takuji; Moriyama, Mitsuhiko; Sakaida, Isao; Okada, Hiroyuki; Chiba, Tetsuhiro; Chuma, Makoto; Nakao, Kazuhiko; Isomoto, Hajime; Sasaki, Yutaka; Kaneko, Shuichi; Masaki, Tsutomu; Chayama, Kazuaki; Koike, Kazuhiko
JOURNAL OF GASTROENTEROLOGY   54(4) 367-376   Apr 2019   [Refereed]
BackgroundWe previously reported that the incidence of hepatocellular carcinoma (HCC) with non-viral etiologies increased rapidly between 1991 and 2010 in Japan.MethodsTo update this investigation, we enrolled patients who were initially diagnosed...
Kajikawa, Masato; Maruhashi, Tatsuya; Hidaka, Takayuki; Nakano, Yukiko; Kurisu, Satoshi; Matsumoto, Takeshi; Iwamoto, Yumiko; Kishimoto, Shinji; Matsui, Shogo; Aibara, Yoshiki; Yusoff, Farina Mohamad; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Noma, Kensuke; Nakashima, Ayumu; Watanabe, Takuya; Tone, Hiroshi; Hibi, Masanobu; Osaki, Noriko; Katsuragi, Yoshihisa; Higashi, Yukihito
EUROPEAN JOURNAL OF NUTRITION   58(3) 989-996   Apr 2019   [Refereed]
PurposeThe purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction.MethodsThis was a single-blind, randomized, placeb...
Tsuge, Masataka; Uchida, Takuro; Walsh, Kevin; Ishida, Yuji; Tateno, Chise; Kumar, Upendra; Glenn, Jeffrey S.; Koh, Christopher; Heller, Theo; Uprichard, Susan L.; Dahari, Harel; Chayama, Kazuaki
VIRUSES-BASEL   11(3)    Mar 2019   [Refereed]
Backgrounds and Aims: We previously demonstrated that serum hepatitis B virus (HBV) DNA in HBV infected humanized mice exhibited a highly dynamic multiphasic kinetic pattern from infection initiation to steady-state. Here, we investigated whether ...
Amioka, Michitaka; Nakano, Yukiko; Ochi, Hidenori; Onohara, Yuko; Sairaku, Akinori; Tokuyama, Takehito; Motoda, Chikaaki; Matsumura, Hiroya; Tomomori, Shunsuke; Hironobe, Naoya; Okubo, Yousaku; Okamura, Sho; Chayama, Kazuaki; Kihara, Yasuki
PLOS ONE   14(3)    Mar 2019   [Refereed]
Background Atrial fibrillation (AF) recurrence after radiofrequency catheter ablation (RFCA) still remains a serious issue. Ca2+ handling has a considerable effect on AF recurrence. The histidine-rich calcium-binding protein (HRC) genetic single n...
Osawa, Mitsutaka; Imamura, Michio; Teraoka, Yuji; Uchida, Takuro; Morio, Kei; Fujino, Hatsue; Nakahara, Takashi; Ono, Atsushi; Murakami, Eisuke; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiramatsu, Akira; Aikata, Hiroshi; Hayes, C. Nelson; Chayama, Kazuaki; Aimitsu, Shiomi; Azakami, Takahiro; Kamada, Koji; Katamura, Yoshio; Kawakami, Hiroiku; Kawakami, Yoshiiku; Kimura, Takashi; Takahashi, Shoichi; Tsuji, Keiji; Takaki, Shintaro; Mori, Nami; Nagaoki, Yuko; Moriya, Takashi; Yamaguchi, Shuji
JOURNAL OF GASTROENTEROLOGY   54(3) 291-296   Mar 2019   [Refereed]
BackgroundCombination therapy with glecaprevir (GLE) and pibrentasvir (PIB) has high efficacy for pan-genotypic hepatitis C virus (HCV)-infected patients. However, the efficacy of the therapy for failures to prior direct-acting antiviral (DAA) reg...
Hiramatsu, Akira; Aikata, Hiroshi; Uchikawa, Shinsuke; Ohya, Kazuki; Kodama, Kenichiro; Nishida, Yuno; Daijo, Kana; Osawa, Mitsutaka; Teraoka, Yuji; Honda, Fumi; Inagaki, Yuki; Morio, Kei; Morio, Reona; Fujino, Hatsue; Nakahara, Takashi; Murakami, Eisuke; Yamauchi, Masami; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Imamura, Michio; Tanaka, Junko; Chayama, Kazuaki
HEPATOLOGY COMMUNICATIONS   3(3) 348-355   Mar 2019   [Refereed]
Although the effect of levocarnitine (L-carnitine) on hyperammonemia has been reported in patients with liver cirrhosis (LC), its effect on sarcopenia remains to be elucidated. We assessed the effects of L-carnitine on sarcopenia in patients with ...
Hayashi, Ryohei; Ueno, Yoshitaka; Tanaka, Shinji; Wakai, Masaki; Kumada, Junko; Fujita, Akira; Nomura, Motonobu; Oka, Shiro; Ito, Masanori; Chayama, Kazuaki
INTERNAL MEDICINE   58(5) 625-631   Mar 2019   [Refereed]
Objective Rectal lymphoid follicular aphthous (LFA) lesions are related to ulcerative colitis (UC) and can be initial lesions of UC. We investigated the clinical course and prognosis of rectal LFA lesions. Methods This is a retrospective analysis ...
Tanaka, Kenichi; Takahashi, Hirokazu; Hyogo, Hideyuki; Ono, Masafumi; Oza, Noriko; Kitajima, Yoichiro; Kawanaka, Miwa; Chayama, Kazuaki; Saibara, Toshiji; Anzai, Keizo; Eguchi, Yuichiro
HEPATOLOGY RESEARCH   49(3) 296-303   Mar 2019   [Refereed]
Aim The association between glycemia and liver fibrosis was analyzed using hemoglobin A1c (HbA1c) and the Fibrosis-4 (FIB-4) index in a large general population cohort that underwent a health checkup. Methods A total of 6927 subjects without hepat...
Yamashita, Ken; Oka, Shiro; Tanaka, Shinji; Nagata, Shinji; Kuwai, Toshio; Furudoi, Akira; Tamura, Tadamasa; Kunihiro, Masaki; Okanobu, Hideharu; Nakadoi, Koichi; Kanao, Hiroyuki; Higashiyama, Makoto; Arihiro, Koji; Kuraoka, Kazuya; Shimamoto, Fumio; Chayama, Kazuaki
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE   34(3) 481-490   Mar 2019   [Refereed]
Purpose Long-term prognosis of T1 laterally spreading tumors (LSTs) after treatment have not been clarified. This study compared clinicopathological characteristics and long-term prognosis of T1 LSTs. Methods We retrospectively assessed 169 patien...
Hirano, Daiki; Urabe, Yuji; Tanaka, Shinji; Nakamura, Koki; Ninomiya, Yuki; Yuge, Ryo; Hayashi, Ryohei; Oka, Shiro; Kitadai, Yasuhiko; Shimamoto, Fumio; Arihiro, Koji; Chayama, Kazuaki
PLOS ONE   14(2)    Feb 2019   [Refereed]
Serrated adenocarcinoma (SAC) is considered the end stage of the serrated neoplasia pathway. Although SAC prognosis is not widely recognized, the serrated pathway-associated subtype consistently exhibits unfavorable prognosis in genetic studies. H...
Takeuchi, Fumihiko; Ikeda, Sotaro; Tsukamoto, Yuta; Iwasawa, Yoshikazu; Chen Qihao; Otakaki, Yukie; Ryota, Ouda; Yao, Wan-Ling; Narita, Ryo; Makoto, Hijikata; Watashi, Koichi; Wakita, Takaji; Takeuchi, Koh; Chayama, Kazuaki; Kogure, Amane; Kato, Hiroki; Fujita, Takashi
PLOS ONE   14(2)    Feb 2019   [Refereed]
Currently, there is no available therapy to eradicate hepatitis B virus (HBV) in chronically infected individuals. This is due to the difficulty in eliminating viral covalently closed circular (ccc) DNA, which is central to the gene expression and...
Ishii, Yasutaka; Serikawa, Masahiro; Sasaki, Tamito; Fujimoto, Yoshifumi; Yamaguchi, Atsushi; Ogawa, Tsuneyoshi; Noma, Bunjiro; Okazaki, Akihito; Yukutake, Masanobu; Ishigaki, Takashi; Chayama, Kazuaki
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   54(2) 259-264   Feb 2019   [Refereed]
Objectives: Steroids are the first-line drugs for induction of remission in patients with type 1 autoimmune pancreatitis (AIP), and the usefulness of steroid maintenance therapy to prevent relapse has recently been reported. However, even during s...
Tanaka, Hidenori; Oka, Shiro; Tanaka, Shinji; Inagaki, Katsuaki; Okamoto, Yuki; Matsumoto, Kenta; Boda, Kazuki; Yamashita, Ken; Sumimoto, Kyoku; Ninomiya, Yuki; Hayashi, Nana; Chayama, Kazuaki
ENDOSCOPY INTERNATIONAL OPEN   7(2) E130-E137   Feb 2019   [Refereed]
Background and study aims The PCF-H290TI/L produced by Olympus is a novel colonoscope equipped with some advantageous features for endoscopic treatment. It is expected to improve the potential for retroflexion and overall endoscope operability, wh...
Bazerbachi, Fateh; Haffar, Samir; Wang, Zhen; Cabezas, Joaquin; Teresa Arias-Loste, Maria; Crespo, Javier; Darwish-Murad, Sarwa; Ikram, M. Arfan; Olynyk, John K.; Gan, Eng; Petta, Salvatore; Berzuini, Alessandra; Prati, Daniele; de Ledinghen, Victor; Wong, Vincent W.; Del Poggio, Paolo; Chavez-Tapia, Norberto C.; Chen, Yong-Peng; Cheng, Pin-Nan; Yuen, Man-Fung; Das, Kausik; Chowdhury, Abhijit; Caballeria, Llorenc; Fabrellas, Nuria; Gines, Pere; Kumar, Manoj; Sarin, Shiv Kumar; Conti, Fabio; Andreone, Pietro; Sirli, Roxana; Cortez-Pinto, Helena; Carvalhana, Sofia; Sugihara, Takaaki; Kim, Seung Up; Parikh, Pathik; Chayama, Kazuaki; Corpechot, Christophe; Kim, Kang Mo; Papatheodoridis, George; Alsebaey, Ayman; Kamath, Patrick S.; Murad, M. Hassan; Watt, Kymberly D.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   17(1) 54-+   Jan 2019   [Refereed]
BACKGROUND & AIMS: Transient elastography (TE) is a noninvasive technique used to measure liver stiffness to estimate the severity of fibrosis. The range of liver stiffness measurements (LSMs) in healthy individuals is unclear. We performed a syst...
Tanaka, Hidenori; Oka, Shiro; Tanaka, Shinji; Matsumoto, Kenta; Boda, Kazuki; Yamashita, Ken; Hirano, Daiki; Sumimoto, Kyoku; Tamaru, Yuzuru; Ninomiya, Yuki; Hayashi, Nana; Chayama, Kazuaki
DIGESTIVE DISEASES AND SCIENCES   64(1) 224-231   Jan 2019   [Refereed]
BackgroundThe endoscopic lens becomes clouded and its visibility reduces during colorectal endoscopic submucosal dissection (ESD), especially in cases with submucosal fatty tissue. Dual red imaging (DRI) is a novel image-enhanced endoscopic techni...
Takehara, Tetsuo; Sakamoto, Naoya; Nishiguchi, Shuhei; Ikeda, Fusao; Tatsumi, Tomohide; Ueno, Yoshiyuki; Yatsuhashi, Hiroshi; Takikawa, Yasuhiro; Kanda, Tatsuo; Sakamoto, Minoru; Tamori, Akihiro; Mita, Eiji; Chayama, Kazuaki; Zhang, Gulan; De-Oertel, Shampa; Dvory-Sobol, Hadas; Matsuda, Takuma; Stamm, Luisa M.; Brainard, Diana M.; Tanaka, Yasuhito; Kurosaki, Masayuki
JOURNAL OF GASTROENTEROLOGY   54(1) 87-95   Jan 2019   [Refereed]
BackgroundIn Japan, hepatitis C virus (HCV)-infected patients with decompensated cirrhosis currently have no treatment options. In this Phase 3 study, we evaluated sofosbuvir-velpatasvir with or without ribavirin for 12weeks in patients with any H...
Hata, Kosaku; Ito, Masanori; Boda, Tomoyuki; Kotachi, Takahiro; Kiso, Mariko; Masuda, Kazuhiko; Kurihara, Mio; Kuroki, Kazutaka; Yorita, Naoki; Nagasaki, Naoko; Abduwali, Madina; Tanaka, Shinji; Chayama, Kazuaki
DIGESTION   99(1) 59-65   2019   [Refereed]
Background and Aim: The incidence of gastric cancer occurring after successful Helicobacter pylori eradication has been increasing. We aimed to clarify the influence of eradication therapy on the ability to diagnose early gastric cancer after succ...
Tsuboi, Akiyoshi; Oka, Shiro; Tanaka, Shinji; Iio, Sumio; Otani, Ichiro; Kunihara, Sayoko; Chayama, Kazuaki
INTERNAL MEDICINE   58(10) 1375-1381   2019   [Refereed]
Objective The utility of capsule endoscopy (CE) findings in the route selection for double balloon endoscopy (DBE) has not been adequately discussed. The PillCam Progress Indicator in the RAPID 6.5 software program graphically demonstrates the pro...
Tsuboi, Akiyoshi; Oka, Shiro; Tanaka, Shinji; Iio, Sumio; Otani, Ichiro; Kunihara, Sayoko; Hayashi, Ryohei; Chayama, Kazuaki
GASTROENTEROLOGY RESEARCH AND PRACTICE      2019   [Refereed]
Background/Aim. Endoscopic balloon dilation (EBD) has been effective for small-bowel strictures in patients with Crohn's disease (CD). However, its efficacy and indication for small-bowel strictures in non-CD patients have not been established. Th...
Kodama, Kenichiro; Kawaoka, Tomokazu; Namba, Maiko; Uchikawa, Shinsuke; Ohya, Kazuki; Morio, Kei; Nakahara, Takashi; Murakami, Eisuke; Yamauchi, Masami; Hiramatsu, Akira; Imamura, Michio; Chayama, Kazuaki; Aikata, Hiroshi
ONCOLOGY   97(2) 75-81   2019   [Refereed]
Aim: This study investigated early tumor marker response and treatment response in patients with advanced hepatocellular carcinoma (HCC) treated with lenvatinib. Methods: Twenty patients with advanced HCC who received lenvatinib were enrolled in t...
Morio, Kei; Imamura, Michio; Kawakami, Yoshiiku; Nakamura, Yuki; Hatooka, Masahiro; Morio, Reona; Fujino, Hatsue; Nakahara, Takashi; Murakami, Eisuke; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Aikata, Hiroshi; Hayes, C. Nelson; Miki, Daiki; Oc
JOURNAL OF MEDICAL VIROLOGY   90(12) 1834-1840   Dec 2018   [Refereed]
BackgroundMethodsSustained virological response (SVR) rates for the treatment of chronic hepatitis C virus (HCV)-infected patients have drastically improved with the use of direct-acting antiviral (DAA) therapies; however, a small minority of pati...
Nomura, Motonobu; Tsuge, Masataka; Uchida, Takuro; Hiraga, Nobuhiko; Kurihara, Mio; Tsushima, Ken; Fujino, Hatsue; Nakahara, Takashi; Murakami, Eisuke; Abe-Chayama, Hiromi; Kawaoka, Tomokazu; Miki, Daiki; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshi
JOURNAL OF VIRAL HEPATITIS   25(12) 1555-1564   Dec 2018   [Refereed]
The activation of hepatitis B virus (HBV)-related hepatitis is associated with both natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). We analyzed the association between the immune response and changes in the proportion of Pre-S deleti...
Tsuge, Masataka; Hiraga, Nobuhiko; Zhang, Yizhou; Yamashita, Misa; Sato, Ojiro; Oka, Naoya; Shiraishi, Kanma; Izaki, Yu f; Makokha, Grace Naswa; Uchida, Takuro; Kurihara, Mio; Nomura, Motonobu; Tsushima, Ken; Nakahara, Takashi; Murakami, Eisuke; Abe-Chayama, Hiromi; Kawaoka, Tomokazu; Miki, Daiki; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Hayes, C. Nelson; Fujita, Takashi; Chayama, Kazuaki
VIROLOGY   525 48-61   Dec 2018   [Refereed]
The events in the immune response to hepatitis B virus (HBV) remain unclear. We analyzed the direct influence of HBV on gene expression in human hepatocytes under immunodeficient conditions using a human hepatocyte chimeric mouse model. HBV-infect...
Kawaoka, Tomokazu; Aikata, Hiroshi; Kobayashi, Tomoki; Uchikawa, Shinsuke; Ohya, Kazuki; Kodama, Kenichiro; Nishida, Yuno; Daijo, Kana; Osawa, Mitsutaka; Teraoka, Yuji; Inagaki, Yuki; Honda, Fumi; Hatooka, Masahiro; Morio, Kei; Morio, Reona; Fujino, Hatsue; Nakahara, Takashi; Murakami, Eisuke; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Baba, Yasutaka; Awai, Kazuo; Chayama, Kazuaki
HEPATOLOGY RESEARCH   48(13) 1118-1130   Dec 2018   [Refereed]
Aim The aim of this study is to compare the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) between 5-fluorouracil (5-FU)-based continuous infusion chemotherapy and low-dose cisplatin (CDDP) monotherapy in patients with advanc...
Yoshiji, Hitoshi; Karino, Yoshiyasu; Suzuki, Yoshiyuki; Suzuki, Fumitaka; Uejima, Masakazu; Aikata, Hiroshi; Chayama, Kazuaki; Iwai, Hisakazu; Suzuki, Eiji; Kumada, Hiromitsu
HEPATOLOGY RESEARCH   48(13) 1178-1183   Dec 2018   [Refereed]
Aim A novel jelly lactulose preparation (SK-1202) has been developed to improve compliance and reduce the elevation of blood glucose levels in diabetic patients. To compare the equivalence in the efficacy and safety of SK-1202 and an approved comm...
Ishiba, Hiroshi; Sumida, Yoshio; Tanaka, Saiyu; Yoneda, Masato; Hyogo, Hideyuki; Ono, Masafumi; Fujii, Hideki; Eguchi, Yuichiro; Suzuki, Yasuaki; Yoneda, Masashi; Takahashi, Hirokazu; Nakahara, Takashi; Seko, Yuya; Mori, Kojiro; Kanemasa, Kazuyuki; Shimad
JOURNAL OF GASTROENTEROLOGY   53(11) 1216-1224   Nov 2018   [Refereed]
Background The FIB4 index is clinically useful, but because its formula includes age, the appropriate cutoff point may differ by age group. Here, new FIB4 index cutoff points were validated using cohort data from 14 hepatology centers in Japan. Me...
Uchikawa, Shinsuke; Kawaoka, Tomokazu; Aikata, Hiroshi; Kodama, Kenichiro; Inagaki, Yuki; Hatooka, Masahiro; Morio, Kei; Nakahara, Takashi; Murakami, Eisuke; Hiramatsu, Akira; Tsuge, Masataka; Imamura, Michio; Kawakami, Yoshiiku; Chayama, Kazuaki
CLINICAL CASE REPORTS   6(11) 2217-2223   Nov 2018   [Refereed]
Regorafenib became second-line treatment for the patients with sorafenib refractory. In our study, two patients could not continue regorafenib for its adverse effects. It was suggested that appropriate use criteria of regorafenib should be observe...
Tomomori, Shunsuke; Nakano, Yukiko; Ochi, Hidenori; Onohara, Yuko; Sairaku, Akinori; Totokuyama, Takehi; Motoda, Chikaaki; Matsumura, Hiroya; Amioka, Michitaka; Hironobe, Naoya; Okubo, Yousaku; Okamura, Shou; Kawazoe, Hiroshi; Nishiyama, Yukie; Tahara, Hidetoshi; Chayama, Kazuaki; Kihara, Yasuki
SCIENTIFIC REPORTS   8    Oct 2018   [Refereed]
Genome-wide association studies have reported a strong association of the single nucleotide polymorphism (SNP) rs6817105 (T > C) on chromosome 4q25 with atrial fibrillation (AF), but phenotype alterations conferred by this SNP have not been descri...
Kodama, Kenichiro; Kawaoka, Tomokazu; Aikata, Hiroshi; Uchikawa, Shinsuke; Inagaki, Yuki; Hatooka, Masahiro; Morio, Kei; Nakahara, Takashi; Murakami, Eisuke; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Masaki, Keiichi; Honda, Yoji; Mori, Nami; Takaki, Shintaro; Tsuji, Keiji; Kohno, Hirotaka; Kohno, Hiroshi; Moriya, Takashi; Nonaka, Michihiro; Hyogo, Hideyuki; Aisaka, Yasuyuki; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33(10) 1780-1786   Oct 2018   [Refereed]
Background and AimSorafenib is the standard treatment for patients with advanced hepatocellular carcinoma (HCC) with distant metastasis, unresectable HCC, and HCC refractory to transcatheter arterial chemoembolization (TACE) or with macroscopic va...
Shi, Lin; Fujioka, Kurumi; Sakurai-Ozato, Nami; Fukumoto, Wataru; Satoh, Kenichi; Sun, Jiying; Awazu, Akinori; Tanaka, Kimio; Ishida, Mari; Ishida, Takafumi; Nakano, Yukiko; Kihara, Yasuki; Hayes, C. Nelson; Aikata, Hiroshi; Chayama, Kazuaki; Ito, Takashi; Awai, Kazuo; Tashiro, Satoshi
RADIATION RESEARCH   190(4) 424-432   Oct 2018   [Refereed]
The incidence of chromosomal abnormalities and cancer risk correlates well with the radiation dose after exposure to moderate- to high-dose ionizing radiation. However, the biological effects and health risks at less than 100 mGy, e.g., from compu...
Hayes, C. Nelson; Zhang, Peiyi; Zhang, Yizhou; Chayama, Kazuaki
VIRUSES-BASEL   10(10)    Oct 2018   [Refereed]
Despite the success of direct-acting antiviral (DAA) agents in treating chronic hepatitis C virus (HCV) infection, the number of cases of HCV-related hepatocellular carcinoma (HCC) is expected to increase over the next five years. HCC develops ove...
Shiromoto, Fumihiro; Aly, Hussein H.; Kudo, Haruka; Watashi, Koichi; Murayama, Asako; Watanabe, Noriyuki; Zheng, Xin; Kato, Takanobu; Chayama, Kazuaki; Muramatsu, Masamichi; Wakita, Takaji
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   503(3) 1854-1860   Sep 2018   [Refereed]
Hepatitis B virus (HBV) -x protein is a transcriptional regulator required for the HBV life cycle. HBx also induces complications in the host such as hepatocellular carcinoma. We previously showed that HBx mRNA is degraded by the Ski2/RNA exosome ...
Tomomori, Shunsuke; Nakano, Yukiko; Ochi, Hidenori; Onohara, Yuko; Sairaku, Akinori; Tokuyama, Takehito; Motoda, Chikaaki; Matsumura, Hiroya; Amioka, Michitaka; Hironobe, Naoya; Ookubo, Yousaku; Okamura, Shou; Kawazoe, Hiroshi; Chayama, Kazuaki; Kihara, Yasuki
PLOS ONE   13(9)    Sep 2018   [Refereed]
Introduction The single nucleotide polymorphism (SNP) rs2106261 in the transcription factor gene ZFHX3 (16q22), a major regulator of inflammation, has been reported linking to atrial fibrillation (AF) by genome-wide association studies. Inflammati...
Akuta, Norio; Toyota, Joji; Karino, Yoshiyasu; Ikeda, Fusao; Ido, Akio; Tanaka, Katsuaki; Takaguchi, Koichi; Naganuma, Atsushi; Tomita, Eiichi; Chayama, Kazuaki; Fujiyama, Shigetoshi; Inada, Yukiko; Yoshiji, Hitoshi; Watanabe, Hideaki; Ishikawa, Hiroki; McPhee, Fiona; Noviello, Stephanie; Kumada, Hiromitsu
JOURNAL OF GASTROENTEROLOGY   53(9) 1089-1097   Sep 2018   [Refereed]
In the UNITY-3 study, 96% sustained virologic response (SVR12) rate was observed in Japanese patients with hepatitis C virus (HCV) genotype (GT)-1 infection treated for 12 weeks with fixed-dose daclatasvir, asunaprevir, and beclabuvir (DCV-TRIO). ...
Uchikawa, Shinsuke; Kawaoka, Tomokazu; Aikata, Hiroshi; Kodama, Kenichiro; Nishida, Yuno; Inagaki, Yuki; Hatooka, Masahiro; Morio, Kei; Nakahara, Takashi; Murakami, Eisuke; Hiramatsu, Akira; Tsuge, Masataka; Imamura, Michio; Kawakami, Yoshiiku; Chayama, Kazuaki
HEPATOLOGY RESEARCH   48(10) 814-820   Sep 2018   [Refereed]
AimAs second-line therapy, regorafenib has been shown to provide a survival benefit for patients with hepatocellular carcinoma (HCC) who progress on sorafenib. In this retrospective study, we assessed the clinical outcomes of sorafenib treatment f...
Matsui, Shogo; Kajikawa, Masato; Maruhashi, Tatsuya; Hashimoto, Haruki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Yusoff, Farina Mohamad; Kishimoto, Shinji; Nakashima, Ayumu; Noma, Kensuke; Kawaguchi, Tomohiro; Matsumoto, Takeo; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   265 24-29   Aug 2018   [Refereed]
Background: Measurement of flow-mediated vasodilation (FMD) is an established method for assessing endothelial function. Measurement of FMD is useful for showing the relationship between atherosclerosis and endothelial function, mechanisms of endo...
Tari, Akira; Kitadai, Yasuhiko; Mouri, Ritsuo; Takigawa, Hidehiko; Asaoku, Hideki; Mihara, Keiichiro; Takata, Katsuyoshi; Fujihara, Megumu; Yoshino, Tadashi; Koga, Tadashi; Fujimori, Shunji; Tanaka, Shinji; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33(8) 1461-1468   Aug 2018   [Refereed]
Background and AimFew reports have demonstrated the effectiveness of treatments for intestinal follicular lymphoma (FL) because of the limited number of patients who undergo comprehensive small intestinal examinations. This study compared the effi...
Kubo, Katsumaro; Kimura, Tomoki; Aikata, Hiroshi; Takahashi, Shigeo; Takeuchi, Yuki; Takahashi, Ippei; Nishibuchi, Ikuno; Murakami, Yuji; Chayama, Kazuaki; Nagata, Yasushi
HEPATOLOGY RESEARCH   48(9) 701-707   Aug 2018   [Refereed]
AimTo evaluate the long-term outcome of stereotactic body radiotherapy in patients with small hepatocellular carcinoma who were ineligible for resection or ablation therapies. MethodsA total of 65 patients with 74 hepatocellular carcinomas (median...
Teraoka, Yuji; Uchida, Takuro; Imamura, Michio; Hiraga, Nobuhiko; Osawa, Mitsutaka; Kan, Hiromi; Saito, Yuhei; Tsuge, Masataka; Abe-Chayama, Hiromi; Hayes, C. Nelson; Makokha, Grace Naswa; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
JOURNAL OF GENERAL VIROLOGY   99(8) 1058-1065   Aug 2018   [Refereed]
Combined daclatasvir (DCV)/asunaprevir (ASV) plus beclabuvir (BCV) treatment shows a high virological response for genotype 1 b chronic hepatitis C patients. However, its efficacy for patients for whom previous direct-acting antiviral (DAA) therap...
Nakano, Ryosuke; Ohira, Masahiro; Kobayashi, Tsuyoshi; Ide, Kentaro; Tahara, Hiroyuki; Kuroda, Shintaro; Shimizu, Seiichi; Kimura, Tomoki; Nagata, Yasushi; Aikata, Hiroshi; Chayama, Kazuaki; Ohdan, Hideki
SURGERY   164(2) 219-226   Aug 2018   [Refereed]
Objective: To evaluate the efficacy of both surgical resection and stereotactic body radiotherapy for small hepatocellular carcinoma. Background: Although the number of stereotactic body radiotherapies being performed for hepatocellular carcinoma ...
Ishida, Yuji; Chung, Tje Lin; Imamura, Michio; Hiraga, Nobuhiko; Sen, Suranjana; Yokomichi, Hiroshi; Tateno, Chise; Canini, Laetitia; Perelson, Alan S.; Uprichard, Susan L.; Dahari, Harel; Chayama, Kazuaki
HEPATOLOGY   68(2) 473-484   Aug 2018   [Refereed]
Chimeric urokinase type plasminogen activator (uPA)/severely severe combined immunodeficiency (SCID) mice reconstituted with humanized livers are useful for studying hepatitis B virus (HBV) infection in the absence of an adaptive immune response. ...
Maruhashi, Tatsuya; Soga, Junko; Fujimura, Noritaka; Idei, Naomi; Mikami, Shinsuke; Iwamoto, Yumiko; Iwamoto, Akimichi; Kajikawa, Masato; Matsumoto, Takeshi; Oda, Nozomu; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Aibara, Yoshiki; Yusoff, Farina Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Tomiyama, Hirofumi; Takase, Bonpei; Kohro, Takahide; Suzuki, Toru; Ishizu, Tomoko; Ueda, Shinichiro; Yamazaki, Tsutomu; Furumoto, Tomoo; Kario, Kazuomi; Inoue, Teruo; Koba, Shinji; Watanabe, Kentaro; Takemoto, Yasuhiko; Hano, Takuzo; Sata, Masataka; Ishibashi, Yutaka; Node, Koichi; Maemura, Koji; Ohya, Yusuke; Furukawa, Taiji; Ito, Hiroshi; Ikeda, Hisao; Yamashina, Akira; Higashi, Yukihito
JOURNAL OF THE AMERICAN HEART ASSOCIATION   7(14)    Jul 2018   [Refereed]
Background-The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. Methods and Results-We measured flow-mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (...
Kunihara, Sayoko; Oka, Shiro; Tanaka, Shinji; Tsuboi, Akiyoshi; Otani, Ichiro; Chayama, Kazuaki
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   11    Jul 2018   [Refereed]
Background: There is no consensus regarding the management of occult obscure gastrointestinal bleeding (OGIB) patients without a confirmed bleeding source. This study aimed to consider the management of occult OGIB patients based on their long-ter...
Kawaguchi, Takumi; Tokushige, Katsutoshi; Hyogo, Hideyuki; Aikata, Hiroshi; Nakajima, Tomoaki; Ono, Masafumi; Kawanaka, Miwa; Sawada, Koji; Imajo, Kento; Honda, Koichi; Takahashi, Hirokazu; Mori, Kohjiroh; Tanaka, Saiyu; Seko, Yuya; Nozaki, Yuichi; Kamada, Yoshihiro; Fujii, Hideki; Kawaguchi, Atsushi; Takehara, Tetsuo; Yanase, Mikio; Sumida, Yoshio; Eguchi, Yuichiro; Seike, Masataka; Yoneda, Masato; Suzuki, Yasuaki; Saibara, Toshiji; Karino, Yoshiyasu; Chayama, Kazuaki; Hashimoto, Etsuko; George, Jacob; Torimura, Takuji
SCIENTIFIC REPORTS   8    Jul 2018   [Refereed]
The prognosis of patients with nonalcoholic fatty liver disease-related hepatocellular carcinoma (NAFLD-HCC) is intricately associated with various factors. We aimed to investigate the prognostic algorithm of NAFLD-HCC patients using a data-mining...
Kimura, Tomoki; Aikata, Hiroshi; Doi, Yoshiko; Imano, Nobuki; Takeuchi, Yuki; Takahashi, Ippei; Nishibuchi, Ikuno; Katsuta, Tsuyoshi; Kenjo, Masahiro; Murakami, Yuji; Kenjo, Masahiro; Murakami, Yuji; Awai, Kazuo; Chayama, Kazuaki; Nagata, Yasushi
TECHNOLOGY IN CANCER RESEARCH & TREATMENT   17    Jul 2018   [Refereed]
Introduction: To compare the efficacy and safety of stereotactic body radiation therapy with or without transcatheter arterial chemoembolization for patients with small hepatocellular carcinoma who were ineligible for resection or ablation therapi...
Yamashita, Ken; Oka, Shiro; Tanaka, Shinji; Boda, Kazuki; Hirano, Daiki; Sumimoto, Kyoku; Mizumoto, Takeshi; Ninomiya, Yuki; Tamaru, Yuzuru; Shigita, Kenjiro; Hayashi, Nana; Sanomura, Yoji; Chayama, Kazuaki
ENDOSCOPY INTERNATIONAL OPEN   6(7) E857-E864   Jul 2018   [Refereed]
Background and study aims Japanese guidelines for gastroenterological endoscopy have recommended temporary withdrawal of anticoagulants (warfarin, direct oral anticoagulants [DOAC], or heparin) to prevent hemorrhagic complications during endoscopi...
Izumi, Namiki; Takehara, Tetsuo; Chayama, Kazuaki; Yatsuhashi, Hiroshi; Takaguchi, Koichi; Ide, Tatsuya; Kurosaki, Masayuki; Ueno, Yoshiyuki; Toyoda, Hidenori; Kakizaki, Satoru; Tanaka, Yasuhito; Kawakami, Yoshiiku; Enomoto, Hirayuki; Ikeda, Fusao; Jiang, Deyuan; De-Oertel, Shampa; McNabb, Brian L.; Camus, Gregory; Stamm, Luisa M.; Brainard, Diana M.; McHutchison, John G.; Mochida, Satoshi; Mizokami, Masashi
HEPATOLOGY INTERNATIONAL   12(4) 356-367   Jul 2018   [Refereed]
In Japan, there is a growing population of patients with chronic hepatitis C virus (HCV) infection who failed a direct-acting antiviral (DAA)-based regimen. In this Phase 3 study, we evaluated sofosbuvir-velpatasvir plus ribavirin in Japanese pati...
Nakano, Yukiko; Ochi, Hidenori; Sairaku, Akinori; Onohara, Yuko; Tokuyama, Takehito; Motoda, Chikaaki; Matsumura, Hiroya; Tomomori, Shunsuke; Amioka, Michitaka; Hironobe, Naoya; Ohkubo, Yousaku; Okamura, Shou; Makita, Naomasa; Yoshida, Yukihiko; Chayama,
CIRCULATION-GENOMIC AND PRECISION MEDICINE   11(7)    Jul 2018   [Refereed]
BACKGROUND: Tachycardia-induced cardiomyopathy (TIC) is a reversible cardiomyopathy induced by tachyarrhythmia, and the genetic background of the TIC is not well understood. The hyperpolarization-activated cyclic nucleotide- gated channel gene HCN...
Mizumoto, T. Hiyama, T. Oka, S. Yorita, N. Kuroki, K. Kurihara, M. Yoshifuku, Y. Sanomura, Y. Urabe, Y. Arihiro, K. Tanaka, S. Chayama, K.
DISEASES OF THE ESOPHAGUS   31(7)    Jul 2018   [Refereed]
Endoscopic submucosal dissection (ESD) is a widely accepted procedure for superficial esophageal squamous cell carcinoma (SESCC) limited to the epithelium or lamina propria mucosae (EP/LPM). We aimed to compare the efficacy of endoscopic ultrasono...
Matsui, Shogo; Kajikawa, Masato; Maruhashi, Tatsuya; Iwamoto, Yumiko; Oda, Nozomu; Kishimoto, Shinji; Hashimoto, Haruki; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Hida, Eisuke; Goto, Chikara; Aibara, Yoshiki; Nakashima, Ayumu; Yusoff, Farina Mohamad; Noma, Kensuke; Kuwahara, Yoshitaka; Matsubara, Akio; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   261 196-203   Jun 2018   [Refereed]
Background: Lower urinary tract symptoms (LUTS) is not only common symptoms in elderly men and women but also risk of future cardiovascular events. The purpose of this study was to evaluate the relationships of vascular function and structure with...
Hatooka, Masahiro; Kawaoka, Tomokazu; Aikata, Hiroshi; Inagaki, Yuki; Morio, Kei; Nakahara, Takashi; Murakami, Eisuke; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Awai, Kazuo; Masaki, Keiichi; Waki, Koji; Kohno, Hirotaka; Kohno, Hiroshi; Moriya, Takashi; Nagaoki, Yuko; Tamura, Toru; Amano, Hajime; Katamura, Yoshio; Chayama, Kazuaki
BMC CANCER   18    Jun 2018   [Refereed]
Background: In patients with advanced hepatocellular carcinoma (HCC), evidence is unclear as to whether hepatic arterial infusion chemotherapy (HAIC) or sorafenib is superior. We performed a prospective, open-label, non-comparative phase II study ...
Teraoka, Yuji; Uchida, Takuro; Imamura, Michio; Osawa, Mitsutaka; Tsuge, Masataka; Abe-Chayama, Hiromi; Hayes, C. Nelson; Makokha, Grace Naswa; Aikata, Hiroshi; Miki, Daiki; Ochi, Hidenori; Ishida, Yuji; Tateno, Chise; Chayama, Kazuaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   500(2) 152-157   Jun 2018   [Refereed]
Patients with chronic hepatitis C virus (HCV) infection who have failed to respond to direct-acting antiviral (DAA) treatment often acquire drug resistance-associated variants (RAVs). The NS5A-P32 deletion (P32del) RAV confers potent resistance to...
Kishimoto, Shinji; Matsumoto, Takeshi; Maruhashi, Tatsuya; Iwamoto, Yumiko; Kajikawa, Masato; Oda, Nozomu; Matsui, Shogo; Hashimoto, Haruki; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Yusoff, Farina Binti Mohamad; Nakashima, Ayumu; Noma, Kensuke; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   260 178-183   Jun 2018   [Refereed]
Background: Although reactive hyperemia-peripheral arterial tonometry (RH-PAT) is widely used for assessment of endothelial function, RH index (RHI) cannot be measured in some cases when pulse wave amplitude (PWA) is very low. Decrease in PWA is m...
Rolt, Adam; Le, Derek; Hu, Zongyi; Wang, Amy Q.; Shah, Pranav; Singleton, Marc; Hughes, Emma; Dulcey, Andres E.; He, Shanshan; Imamura, Michio; Uchida, Takuro; Chayama, Kazuaki; Xu, Xin; Marugan, Juan J.; Liang, T. Jake
JOURNAL OF INFECTIOUS DISEASES   217(11) 1761-1769   Jun 2018   [Refereed]
Hepatitis C virus (HCV) is a small, single-stranded, positive-sense RNA virus that infects more than an estimated 70 million people worldwide. Untreated, persistent HCV infection often results in chronic hepatitis, cirrhosis, or liver failure, wit...
Mizumoto, T. Hiyama, T. Oka, S. Yorita, N. Kuroki, K, Kurihara, M. Yoshifuku, Y. Sanomura, Y. Urabe, Y. Murakami, Y. Arihiro, K. Tanaka, S. Chayama, K.
DIGESTIVE DISEASES AND SCIENCES   63(6) 1605-1612   Jun 2018   [Refereed]
Background According to the Japanese Esophageal Society (JES) guidelines, risk factors for lymph node (LN) metastasis in the muscularis mucosa (MM)/submucosa to a depth of up to 200 mu m (SM1) in cases of esophageal squamous cell carcinomas (ESCCs...
Kaishima, Terumi; Akita, Tomoyuki; Ohisa, Masayuki; Sakamune, Kazuaki; Kurisu, Akemi; Sugiyama, Aya; Aikata, Hiroshi; Chayama, Kazuaki; Tanaka, Junko
HEPATOLOGY RESEARCH   48(7) 509-520   Jun 2018   [Refereed]
AimWe estimated the cost-effectiveness of direct-acting antiviral treatment (DAA) compared to triple therapy (simeprevir, pegylated interferon- [Peg-IFN], and ribavirin [RBV]) (scenario 1), Peg-IFN+RBV (scenario 2), and non-antiviral therapy (scen...
Kawanaka, Miwa; Tomiyama, Yasuyuki; Hyogo, Hideyuki; Koda, Masahiko; Shima, Toshihide; Tobita, Hiroshi; Hiramatsu, Akira; Nishino, Ken; Okamoto, Toshiaki; Sato, Shuichi; Hara, Yuichi; Nishina, Sohji; Kawamoto, Hirofumi; Chayama, Kazuaki; Okanoue, Takeshi; Hino, Keisuke
HEPATOLOGY RESEARCH   48(7) 521-528   Jun 2018   [Refereed]
AimAs it is not practical to perform regular screening for hepatocellular carcinoma (HCC) in all patients with non-alcoholic fatty liver disease (NAFLD), there is a need to identify NAFLD patients who are at high risk for HCC. Wisteria floribunda ...
Yuge, Ryo; Kitadai, Yasuhiko; Takigawa, Hidehiko; Naito, Toshikatsu; Oue, Naohide; Yasui, Wataru; Tanaka, Shinji; Chayama, Kazuaki
TRANSLATIONAL ONCOLOGY   11(3) 575-584   Jun 2018   [Refereed]
Accumulating evidence suggests that a unique set of receptor tyrosine kinases, known as discoidin domain receptors (DDRs), plays a role in cancer progression by interacting with the surrounding collagen matrix. In this study, we investigated the e...
Tsukamoto, Yuta; Ikeda, Sotaro; Uwai, Koji; Taguchi, Riho; Chayama, Kazuaki; Sakaguchi, Takemasa; Narita, Ryo; Yao, Wan-Ling; Takeuchi, Fumihiko; Otakaki, Yukie; Watashi, Koichi; Wakita, Takaji; Kato, Hiroki; Fujita, Takashi
PLOS ONE   13(5)    May 2018   [Refereed]
Current therapeutics for hepatitis B virus (HBV) patients such as nucleoside analogs (NAs) are effective; however, new antiviral drugs against HBV are still desired. Since the interaction between the epsilon (c) sequence of HBV pregenomic RNA and ...
Boda, Kazuki; Oka, Shiro; Tanaka, Shinji; Tanaka, Hidenori; Matsumoto, Kenta; Yamashita, Ken; Sumimoto, Kyoku; Hirano, Daiki; Tamaru, Yuzuru; Ninomiya, Yuki; Hayashi, Nana; Chayama, Kazuaki
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   11    May 2018   [Refereed]
Background: Few studies have investigated the use of endoscopic submucosal dissection (ESD) for cecal tumors extending into the appendiceal orifice. Herein, we assessed the feasibility and safety of ESD for cecal tumors extending into the appendic...
Van Renne, Nicolaas; Suarez, Armando Andres Roca; Duong, Francois H. T.; Gondeau, Claire; Calabrese, Diego; Fontaine, Nelly; Ababsa, Amina; Bandiera, Simonetta; Croonenborghs, Tom; Pochet, Nathalie; De Blasi, Vito; Pessaux, Patrick; Piardi, Tullio; Sommacale, Daniele; Ono, Atsushi; Chayama, Kazuaki; Fujita, Masashi; Nakagawa, Hidewaki; Hoshida, Yujin; Zeisel, Mirjam B.; Heim, Markus H.; Baumert, Thomas F.; Lupberger, Joachim
GUT   67(5) 953-962   May 2018   [Refereed]
Background and aims HCV infection is a leading risk factor of hepatocellular carcinoma (HCC). However, even after viral clearance, HCC risk remains elevated. HCV perturbs host cell signalling to maintain infection, and derailed signalling circuitr...
Wardell, Christopher P.; Fujita, Masashi; Yamada, Toru; Simbolo, Michele; Fassan, Matteo; Karlic, Rosa; Polak, Paz; Kim, Jaegil; Hatanaka, Yutaka; Maejima, Kazuhiro; Lawlor, Rita T.; Nakanishi, Yoshitsugu; Mitsuhashi, Tomoko; Fujimoto, Akihiro; Furuta, Mayuko; Ruzzenente, Andrea; Conci, Simone; Oosawa, Ayako; Sasaki-Oku, Aya; Nakano, Kaoru; Tanaka, Hiroko; Yamamoto, Yujiro; Michiaki, Kubo; Kawakami, Yoshiiku; Aikata, Hiroshi; Ueno, Masaki; Hayami, Shinya; Gotoh, Kunihito; Ariizumi, Shun-ichi; Yamamoto, Masakazu; Yamaue, Hiroki; Chayama, Kazuaki; Miyano, Satoru; Getz, Gad; Scarpa, Aldo; Hirano, Satoshi; Nakamura, Toru; Nakagawa, Hidewaki
JOURNAL OF HEPATOLOGY   68(5) 959-969   May 2018   [Refereed]
Background & Aims: Biliary tract cancers (BTCs) are clinically and pathologically heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer understanding of their carcinogenesis, classification and treatment strategy. We...
Reddy, K. Rajender; Pol, Stanislas; Thuluvath, Paul J.; Kumada, Hiromitsu; Toyota, Joji; Chayama, Kazuaki; Levin, James; Lawitz, Eric J.; Gadano, Adrian; Ghesquiere, Wayne; Gerken, Guido; Brunetto, Maurizia R.; Peng, Cheng-Yuan; Silva, Marcelo; Strasser, Simone I.; Heo, Jeong; McPhee, Fiona; Liu, Zhaohui; Yang, Rong; Linaberry, Misti; Noviello, Stephanie
LIVER INTERNATIONAL   38(5) 821-833   May 2018   [Refereed]
Background & Aims: Daclatasvir has achieved high sustained virologic response (SVR) rates in diverse hepatitis C virus (HCV) populations. This study evaluated the long-term efficacy and safety of daclatasvir-based regimens administered during clin...
Boot, Arnoud; Huang, Mi Ni; Ng, Alvin W. T.; Ho, Szu-Chi; Lim, Jing Quan; Kawakami, Yoshiiku; Chayama, Kazuaki; Teh, Bin Tean; Nakagawa, Hidewaki; Rozen, Steven G.
GENOME RESEARCH   28(5) 654-665   May 2018   [Refereed]
Cisplatin reacts with DNA and thereby likely generates a characteristic pattern of somatic mutations, called a mutational signature. Despite widespread use of cisplatin in cancer treatment and its role in contributing to secondary malignancies, it...
Honda, Fumi; Hiramatsu, Akira; Hyogo, Hideyuki; Aikata, Hiroshi; Daijo, Kana; Teraoka, Yuji; Inagaki, Yuki; Morio, Kei; Kobayashi, Tomoki; Nakahara, Takashi; Nagaoki, Yuko; Kawaoka, Tomokazu; Yoneda, Masayasu; Tsuge, Masataka; Imamura, Michio; Kawakami, Yoshiiku; Ochi, Hidenori; Chayama, Kazuaki
PLOS ONE   13(4)    Apr 2018   [Refereed]
Background and aims The feature of blood glucose dynamics in patients with chronic liver disease (CLD) is marked blood glucose fluctuations. However, the detail of blood glucose dynamics is not well known. The aim of the present study was to evalu...
Yamauchi, Masami; Urabe, Yuji; Ono, Atsushi; Miki, Daiki; Ochi, Hidenori; Chayama, Kazuaki
INTERNATIONAL JOURNAL OF CANCER   142(7) 1418-1426   Apr 2018   [Refereed]
Understanding the molecular changes in tumors in response to anti-VEGF chemotherapy is crucial for optimization of the treatment strategy for metastatic colorectal cancer. We prospectively investigated changes in the amount and constitution of cir...
Otani, Ichiro; Oka, Shiro; Tanaka, Shinji; Tsuboi, Akiyoshi; Kunihara, Sayoko; Nagaoki, Yuko; Aikata, Hiroshi; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33(4) 825-830   Apr 2018   [Refereed]
Background and AimThe relationship between the presence of villous edema (VE) in portal hypertensive enteropathy and clinical factors remains unclear. The aim of this study was to reveal the clinical factors related to VE in patients with liver ci...
Kawakami, Yoshiiku; Ochi, Hidenori; Hayes, Clair Nelson; Imamura, Michio; Tsuge, Masataka; Nakahara, Takashi; Katamura, Yoshio; Kohno, Hiroshi; Kohno, Hirotaka; Tsuji, Keiji; Takaki, Shintaro; Mori, Nami; Honda, Yohji; Arataki, Keiko; Takahashi, Shoichi; Kira, Shinsuke; Tamura, Toru; Masuda, Kazunari; Nakamura, Toshio; Kikkawa, Masaya; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   53(4) 548-556   Apr 2018   [Refereed]
In Japan, daclatasvir (DCV) and asunaprevir (ASV) therapy was the first IFN-free treatment to be approved, and thousands of patients have since been successfully treated, with an SVR rate of around 90%. The converse, however, is that around 10% of...
Chayama, Kazuaki; Suzuki, Fumitaka; Karino, Yoshiyasu; Kawakami, Yoshiiku; Sato, Ken; Atarashi, Tomofumi; Naganuma, Atsushi; Watanabe, Tsunamasa; Eguchi, Yuichiro; Yoshiji, Hitoshi; Seike, Masataka; Takei, Yoshiyuki; Kato, Koji; Alves, Katia; Burroughs, Margaret; Redman, Rebecca; Pugatch, David L.; Pilot-Matias, Tami J.; Krishnan, Preethi; Oberoi, Rajneet K.; Xie, Wangang; Kumada, Hiromitsu
JOURNAL OF GASTROENTEROLOGY   53(4) 557-565   Apr 2018   [Refereed]
The once-daily, all oral, RBV-free, pangenotypic direct-acting anti-viral regimen consisting of co-formulated NS3/4A protease inhibitor glecaprevir and NS5A inhibitor pibrentasvir (G/P), demonstrated high rates of sustained virologic response (SVR...
Kumada, Hiromitsu; Watanabe, Tsunamasa; Suzuki, Fumitaka; Ikeda, Kenji; Sato, Ken; Toyoda, Hidenori; Atsukawa, Masanori; Ido, Akio; Takaki, Akinobu; Enomoto, Nobuyuki; Kato, Koji; Alves, Katia; Burroughs, Margaret; Redman, Rebecca; Pugatch, David; Pilot-Matias, Tami J.; Krishnan, Preethi; Oberoi, Rajneet K.; Xie, Wangang; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   53(4) 566-575   Apr 2018   [Refereed]
Once-daily, orally administered, co-formulated glecaprevir (NS3/4A protease inhibitor) and pibrentasvir (NS5A inhibitor) (G/P) demonstrated pangenotypic activity and high sustained virologic response (SVR) rates in studies outside Japan. Here we r...
Karlas, T.; Petroff, D.; Sasso, M.; Fan, J. -G.; Mi, Y. -Q.; de Ledinghen, V.; Kumar, M.; Lupsor-Platon, M.; Han, K. -H.; Cardoso, A. C.; Ferraioli, G.; Chan, W. -K.; Wong, V. W. -S.; Myers, R. P.; Chayama, K.; Friedrich-Rust, M.; Beaugrand, M.; Shen, F.; Hiriart, J. -B.; Sarin, S. K.; Badea, R.; Lee, H. W.; Marcellin, P.; Filice, C.; Mahadeva, S.; Wong, G. L. -H.; Crotty, P.; Masaki, K.; Bojunga, J.; Bedossa, P.; Keim, V.; Wiegand, J.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS   47(7) 989-1000   Apr 2018   [Refereed]
Background: Liver fibrosis is often accompanied by steatosis, particularly in patients with non-alcoholic fatty liver disease (NAFLD), and its non-invasive characterisation is of utmost importance. Vibration-controlled transient elastography is th...
Iwamoto, Yumiko; Maruhashi, Tatsuya; Kajikawa, Masato; Oda, Nozomu; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Aibara, Yoshiki; Yusoff, Farina Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   254 284-290   Mar 2018   [Refereed]
Backgrounds: Nitroglycerine-induced vasodilation (NID) is usually assessed as a control test for flow-mediated vasodilation (FMD). However, NID per se is impaired in patients with high cardiovascular risk. The purpose of this study was to investig...
Boda, Kazuki; Oka, Shiro; Tanaka, Shinji; Nagata, Shinji; Kunihiro, Masaki; Kuwai, Toshio; Hiraga, Yuko; Furudoi, Akira; Terasaki, Motomi; Nakadoi, Koichi; Higashiyama, Makoto; Okanobu, Hideharu; Akagi, Morihisa; Chayama, Kazuaki
GASTROINTESTINAL ENDOSCOPY   87(3) 714-722   Mar 2018   [Refereed]
Background and Aims: Although advanced high-volume centers have reported good outcomes of colorectal endoscopic submucosal dissection (ESD), a limited number of highly skilled experts in specialized institutions performed these procedures. We unde...
Nagaoki, Yuko; Aikata, Hiroshi; Daijyo, Kana; Teraoka, Yuji; Honda, Fumi; Nakamura, Yuki; Hatooka, Masahiro; Morio, Kei; Fujino, Hatsue; Nakahara, Takashi; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Ochi, Hidenori; Chayama, Kazuaki
HEPATOLOGY RESEARCH   48(4) 264-274   Mar 2018   [Refereed]
AimThe aim of this study was to determine the risk factors for worsening of gastroesophageal varices (GEVs) and development of portosystemic encephalopathy in patients with hepatitis B virus (HBV)-related cirrhosis during nucleos(t)ide analog (NA)...
Kumada, Hiromitsu; Mochida, Satoshi; Nakamuta, Makoto; Suzuki, Fumitaka; Yagi, Takashi; Takasaki, Ryuji; Okai, Masao; Kamiya, Naohiro; Okada, Yasushi; Hirota, Saya; Orihashi, Madori; Ochi, Miyoko; Chayama, Kazuaki
HEPATOLOGY RESEARCH   48(2) 184-192   Feb 2018   [Refereed]
AimTo assess the efficacy and safety of telaprevir (TVR) when used in combination with natural human interferon- (IFN-) and ribavirin (RBV) for genotype 1 patients with depression compared to IFN-/RBV therapy in Japan. We also examined the efficac...
Teraoka, Yuji; Kimura, Tomoki; Aikata, Hiroshi; Daijo, Kana; Osawa, Mitsutaka; Honda, Fumi; Nakamura, Yuki; Morio, Kei; Morio, Reona; Hatooka, Masahiro; Kobayashi, Tomoki; Nakahara, Takashi; Murakami, Eisuke; Nagaoki, Yuko; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Nagata, Yasushi; Chayama, Kazuaki
HEPATOLOGY RESEARCH   48(2) 193-204   Feb 2018   [Refereed]
AimTo evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of hepatocellular carcinoma (HCC) in elderly patients. MethodsFrom 2008 to 2015, 117 patients with HCC (3 nodules, 30mm in diameter, Child-Pugh score...
Krishnan, Preethi; Schnell, Gretja; Tripathi, Rakesh; Beyer, Jill; Reisch, Thomas; Dekhtyar, Tatyana; Irvin, Michelle; Xie, Wangang; Fu, Bo; Burroughs, Margaret; Redman, Rebecca; Kumada, Hiromitsu; Chayama, Kazuaki; Collins, Christine; Pilot-Matias, Tami
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   62(2)    Feb 2018   [Refereed]
Glecaprevir and pibrentasvir are hepatitis C virus (HCV) pangenotypic inhibitors targeting NS3/4A protease and NS5A, respectively. This once-daily, fixed-dose combination regimen demonstrated high sustained virologic response 12 weeks postdosing (...
Matsumoto, Akihiro; Nishiguchi, Shuhei; Enomoto, Hirayuki; Kang, Jong-Hon; Tanaka, Yasuhito; Shinkai, Noboru; Kurosaki, Masayuki; Enomoto, Masaru; Kanda, Tatsuo; Yokosuka, Osamu; Yatsuhashi, Hiroshi; Nagaoka, Shinya; Okuse, Chiaki; Kagawa, Tatehiro; Mine, Tetsuya; Takaguchi, Koichi; Saito, Satoru; Hino, Keisuke; Ikeda, Fusao; Sakisaka, Shotaro; Morihara, Daisuke; Miyase, Shiho; Tsuge, Masataka; Chayama, Kazuaki; Hiramatsu, Naoki; Suzuki, Yoshiyuki; Murata, Kazumoto; Tanaka, Eiji
JOURNAL OF GASTROENTEROLOGY   53(2) 247-257   Feb 2018   [Refereed]
This prospective cohort study searched for factors associated with a response to nucleos(t)ide analogue/peg-interferon (NUC/peg-IFN) sequential therapy. A total of 95 patients with chronic hepatitis B being treated with NUCs were enrolled. Immedia...
Nakahara, Takashi; Hyogo, Hideyuki; Ono, Atsushi; Nagaoki, Yuko; Kawaoka, Tomokazu; Miki, Daiki; Tsuge, Masataka; Hiraga, Nobuhiko; Hayes, Clair Nelson; Hiramatsu, Akira; Imamura, Michio; Kawakami, Yoshiiku; Aikata, Hiroshi; Ochi, Hidenori; Abe-Chayama, Hiromi; Furusho, Hisako; Shintani, Tomoaki; Kurihara, Hidemi; Miyauchi, Mutsumi; Takata, Takashi; Arihiro, Koji; Chayama, Kazuaki
JOURNAL OF GASTROENTEROLOGY   53(2) 269-280   Feb 2018   [Refereed]
The risk factors in the progression of nonalcoholic fatty liver disease (NAFLD) have not been fully clarified. Porphyromonas gingivalis (P.g) has been considered to be a confounding risk factor for systemic diseases. We aimed to evaluate the effec...
Toyoda, Hidenori; Chayama, Kazuaki; Suzuki, Fumitaka; Sato, Ken; Atarashi, Tomofumi; Watanabe, Tsunamasa; Atsukawa, Masanori; Naganuma, Atsushi; Notsumata, Kazuo; Osaki, Yukio; Nakamuta, Makoto; Takaguchi, Koichi; Saito, Satoru; Kato, Koji; Pugatch, David; Burroughs, Margaret; Redman, Rebecca; Alves, Katia; Pilot-Matias, Tami J.; Oberoi, Rajneet K.; Fu, Bo; Kumada, Hiromitsu
HEPATOLOGY   67(2) 505-513   Feb 2018   [Refereed]
Glecaprevir (nonstructural protein 3/4A protease inhibitor) and pibrentasvir (nonstructural protein 5A inhibitor) (G/P), a coformulated once-daily, all oral, ribavirin (RBV)-free, direct-acting antiviral regimen, was evaluated for safety and effic...
Schnell, Gretja; Tripathi, Rakesh; Krishnan, Preethi; Beyer, Jill; Reisch, Thomas; Irvin, Michelle; Dekhtyar, Tatyana; Setze, Carolyn; Rodrigues-, Lino, Jr.; Alves, Katia; Burroughs, Margaret; Redman, Rebecca; Chayama, Kazuaki; Kumada, Hiromitsu; Collins, Christine; Pilot-Matias, Tami
JOURNAL OF MEDICAL VIROLOGY   90(1) 109-119   Jan 2018   [Refereed]
Treatment of HCV genotype (GT) 2-infected Japanese patients with paritaprevir (NS3/4A inhibitor boosted with ritonavir) and ombitasvir (NS5A inhibitor) without ribavirin for 12 weeks in the phase 2 study M12-536, and with ribavirin for 16 weeks in...
Suda, Goki; Furusyo, Norihiro; Toyoda, Hidenori; Kawakami, Yoshiiku; Ikeda, Hiroki; Suzuki, Michihiro; Arataki, Keiko; Mori, Nami; Tsuji, Keiji; Katamura, Yoshio; Takaguchi, Koichi; Ishikawa, Toru; Tsuji, Kunihiko; Shimada, Noritomo; Hiraoka, Atsushi; Yamsaki, Sho; Nakai, Masato; Sho, Takuya; Morikawa, Kenichi; Ogawa, Koji; Kudo, Mineo; Nagasaka, Atsushi; Furuya, Ken; Yamamoto, Yoshiya; Kato, Kanji; Ueno, Yoshiyuki; Iio, Etsuko; Tanaka, Yasuhito; Kurosaki, Masayuki; Kumada, Takashi; Chayama, Kazuaki; Sakamoto, Naoya
JOURNAL OF GASTROENTEROLOGY   53(1) 119-128   Jan 2018   [Refereed]
Hepatitis C virus (HCV) infection is common in hemodialysis patients and worsens their prognosis, while antiviral therapy options are limited. Recently, clinical trial and real-world, small-scale studies have reported excellent responses to direct...

Misc

 
miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis.
Gut.   67 953-962   2018
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
Nat Genet.   48 500-509   2016   [Refereed]
Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.
Gut.   62 1055-1061   2013   [Refereed]
Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers.
Gastroenterology.   145 658-667   2013
Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.
Nat Med.   18 281-285   2012   [Refereed]
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.
Nat Genet.   44 760-764   2012   [Refereed]
HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.
Gut.   60 261-267   2011   [Refereed]
Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses.
Gastroenterology.   141 e1-5   2011   [Refereed]
Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.
Nat Genet.   43 797-800   2011   [Refereed]
Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations.
Nat Genet.   42 893-896   2010   [Refereed]
ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.
Gastroenterology.   139 1190-1197   2010   [Refereed]
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
Nat Genet.   41 591-595   2009
A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C.
Gastroenterology.   136 1796-1805   2009   [Refereed]
Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry.
Gastroenterology.   137 673-681   2009
Nonpolypoid (flat and depressed) colorectal neoplasms.
Gastroenterology.   130 566-576   2006   [Refereed]
Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats.
Gastroenterology.   128 138-146   2005   [Refereed]
A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers.
Nat Genet.   37 1104-1107   2005   [Refereed]
Endothelial function and oxidative stress in renovascular hypertension.
N Engl J Med.   346 1954-1962   2002   [Refereed]

Books etc

 
Molecular pathologic application as a predictor of lymph node metastasis in submucosal colorectal carcinoma:implication of immunohistochemical alterations at the deepest invasive margin
2006   
Role of invariant natural killer T cells in the regulation of the inflammatory response in experimental colitis in mice
2005   
Methods in molecular medicine-hepatitis C protocols. Genotyping hepatitis C virus by type-specific primers for PCR based on NS5 region.
Humana Press   1998   
Hepatitis C protocols; Genotyping hepatitis C virus by type-specific primers or PCR based on NS5 region
Humana Press   1998   
Viral hepatitis and liver disease. High virus titer, slow virus decrease, genotype(]G0002[), and sequence variability of E2/NS1 HVR predict poor response to interferon therapy in chronic hepatitis C.
Springer Verlag   1994   
High virus titer, slow virus decrease, genotypeII, and sequence variability of E2/NS1 HVR predict poor response to interferon therapy in chronic hepatitis C Viral hepatitis and liver disease
Springer Verlag   1994   
Hepatotos C Virus Treatment
Springer   2017   
Hepatitis B Virus and Liver Desease
Kazuaki Chayama, Nelson Hayes. (Part:Joint Editor)
Springer Nature Singapore Pre Ltd.   Sep 2017   
Management for DAA resistant-associated variants
Sep 2017   
The Liver Cancer Journal
Dec 2017   
Clinics in Gastroenterology
2018   

Conference Activities & Talks

 
DAA/PR therapy in Asian HCV patients [Invited]
4 Dec 2015   
Hepatitis B mouse model involving CTL
23 Apr 2015   
Ombitasvir/Paritaprevir/Ritonavir for treatment of HCV genotype 1b in Japanese patients with or without Cirrhosis: results from GIFT-1
22 May 2015   
All Oral Direct Acting Antiviral Therapy for Chronic Hepatitis C [Invited]
17 Oct 2015   
Circulating Tumor DNA Analysis for HCC. [Invited]
26 Oct 2015   
All-oral Dual Combination of Daclatasvir plus Asunaprevir Compared with Telaprevir plus Peginterferon Alfa/Ribavirin in Treatment-maive Japanese Patients ChronicallyInfected with HCV Genotype 1b:Results from a Phase 3 Study
chayama kazuaki
11 Nov 2014   
Optimizing triple therapy, and IFN/RBV free regimens
chayama kazuaki
12 Mar 2014   

Works

 
広島大学ラグビー部顧問,第32回中国四国医科学生ラグビーフットボール大会 広島大学優勝

Research Grants & Projects

 
Japan Agency for Medical Research and Development: Research Program on Hepatitis
Project Year: Apr 2015 - Mar 2016
Japan Agency for Medical Research and Development: Research Program on Hepatitis
Project Year: Apr 2015 - Mar 2016
Ministry of Health, Labour and Welfare: Health and Labour Sciences Research Grants
Project Year: 2011 - 2013
Ministry of Health, Labour and Welfare: Health and Labour Sciences Research Grants
Project Year: 2012 - 2016
Project Year: 2014 - 2014
MEXT: KAKENHI
Project Year: 2013 - 2013    Investigator(s): CHAYAMA, Kazuaki
Recent research made it clear that there are certain amount of circulating miRNA in serum, which present in serum associated with proteins such as AGO1 and AGO2. Such AGO-protein bound miRNA is quite stable and detectable by polymerase chain react...
MEXT: KAKENHI
Project Year: 2012 - 2012    Investigator(s): CHAYAMA, Kazuaki
We attempted to identify unknown pathogen from a patient with eruption and liver disorder with massive parallel sequencing. We found DNA sequences of cytomegalovirus from this patient. Further assembly of remaining non-human sequence is now going on.
MEXT: KAKENHI
Project Year: 2010 - 2011    Investigator(s): CHAYAMA, Kazuaki
Small animal model such as knockout mouse is a valuable tool to study human diseases. We infected human hepatocyte chimeric mice with hepatitis B virus and administered human peripheral white blood cells. The mice developed fulminant hepatitis lik...
MEXT: KAKENHI
Project Year: 2009 - 2011    Investigator(s): CHAYAMA, Kazuaki
We investigated a mechanism of continuous infection of hepatitis B and hepatitis C virus with high density microarray using human hepatocyte chimeric mice. Induction of interferon stimulated genes were partially inhibited by each of the two viruse...
Project Year: 2007 - 2007
MEXT: KAKENHI
Project Year: 2006 - 2007    Investigator(s): CHAYAMA, Kazuaki
We inflicted human hepatocyte chimerie mice with hepatitis B and hepatitis C viruses by injecting serum samples obtained from serum samples of chronic hepatitis B and hepatitis C virus carriers. After confirming the development of viremia in mice,...
Project Year: 2003 - 2005
MEXT: KAKENHI
Project Year: 2001 - 2003    Investigator(s): CHAYAMA, Kazuaki
Hepatitis C virus infection is a serious health problem worldwide. As the hepatitis C virus infects only humans and chimpanzees, establishment of reliable culture system is necessary to study this important pathogen. We cloned a full length genoty...
MEXT: KAKENHI
Project Year: 2001 - 2003    Investigator(s): CHAYAMA, Kazuaki
Hepatitis B virus infection is a serious health problem worldwide. As the hepatitis B virus infects only humans and chimpanzees, establishment of reliable culture system is necessary to study this important pathogen. We cloned a fu11 length genoty...
MEXT: KAKENHI
Project Year: 1998 - 2000    Investigator(s): CHAYAMA, Kazuaki
Treatment of hepatitis B virus with lamivudine is effective in suppressing virus replication and results in reduced inflammatory activity. However, the emergence of lamivudine-resistant mutant virus, with amino acid substitution in the YMDD motif ...
MEXT: KAKENHI
Project Year: 1994 - 1995    Investigator(s): CHAYAMA, Kazuaki
Hepatitis C virus (HCV) genotype 1b and high pretreatment virus load are prdictive factors of poor response to interferon therapy in patients with chronic hepatitis C.However, few patients with low virus load and genotype 1b show poor response to ...
Ministry of Health, Labour and Welfare: Health and Labour Sciences Research Grants
Project Year: Apr 2014 - Mar 2015
Project Year: 2015 - 2016
Japan Agency for Medical Research and Development: Research Program on Hepatitis
Project Year: Apr 2016 - Mar 2017
Japan Agency for Medical Research and Development: Research Program on Hepatitis
Project Year: Apr 2016 - Mar 2017
JSPS: KAKENHI(Grant-in-Aid for Challenging Research (Pioneering))
Project Year: 2017 - 2019
Hospital, National Center for Geriatrics and Gerontology: Research Program on Hepatitis
Project Year: Apr 2017 - Mar 2018
Hospital, National Center for Geriatrics and Gerontology: Research Program on Hepatitis
Project Year: Apr 2017 - Mar 2018