2007年7月
LPS suppresses expression of asialoglycoprotein-binding protein through TLR4 in thioglycolate-elicited peritoneal macrophages
GLYCOCONJUGATE JOURNAL
- ,
- ,
- ,
- ,
- ,
- 巻
- 24
- 号
- 4-5
- 開始ページ
- 243
- 終了ページ
- 249
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1007/s10719-007-9031-6
- 出版者・発行元
- SPRINGER
Macrophages are known to express various types of endocytosis receptors that mediate the removal of foreign pathogens. Macrophage asialoglycoprotein-binding protein (M-ASGP-BP) is a Gal/GalNAc-specific lectin, which functions as an endocytosis receptor. We found here that LPS is able to down-regulate the mRNA expression of M-ASGP-BP in a time-dependent manner using thioglycolate-elicited rat and mouse peritoneal macrophages. However, LPS does not modulate the mRNA expression of M-ASGP-BP from macrophages of C3H/HeN mice, which have a point mutation of TLR4, the primary LPS receptor. Furthermore, an inhibitor of NF-kappa B was observed to efficiently block the suppressive effect of LPS on M-ASGP-BP as well as to inhibit the phosphorylated I kappa B. These results demonstrate that the mRNA expression of M-ASGP-BP is down-regulated by the LPS-mediated TLR4 pathway involving NF-kappa B activation, suggesting that engagement of M-ASGP-BP by LPS may yield a negative signal that interferes with the LPS-induced positive signals mediated by proinflammatory cytokines.
- リンク情報
- ID情報
-
- DOI : 10.1007/s10719-007-9031-6
- ISSN : 0282-0080
- Web of Science ID : WOS:000247481900006