MISC

2007年7月

LPS suppresses expression of asialoglycoprotein-binding protein through TLR4 in thioglycolate-elicited peritoneal macrophages

GLYCOCONJUGATE JOURNAL
  • Bruce Yong Ma
  • ,
  • Mio Kaihama
  • ,
  • Motohiro Nonaka
  • ,
  • Shogo Oka
  • ,
  • Nobuko Kawasaki
  • ,
  • Toshisuke Kawasaki

24
4-5
開始ページ
243
終了ページ
249
記述言語
英語
掲載種別
DOI
10.1007/s10719-007-9031-6
出版者・発行元
SPRINGER

Macrophages are known to express various types of endocytosis receptors that mediate the removal of foreign pathogens. Macrophage asialoglycoprotein-binding protein (M-ASGP-BP) is a Gal/GalNAc-specific lectin, which functions as an endocytosis receptor. We found here that LPS is able to down-regulate the mRNA expression of M-ASGP-BP in a time-dependent manner using thioglycolate-elicited rat and mouse peritoneal macrophages. However, LPS does not modulate the mRNA expression of M-ASGP-BP from macrophages of C3H/HeN mice, which have a point mutation of TLR4, the primary LPS receptor. Furthermore, an inhibitor of NF-kappa B was observed to efficiently block the suppressive effect of LPS on M-ASGP-BP as well as to inhibit the phosphorylated I kappa B. These results demonstrate that the mRNA expression of M-ASGP-BP is down-regulated by the LPS-mediated TLR4 pathway involving NF-kappa B activation, suggesting that engagement of M-ASGP-BP by LPS may yield a negative signal that interferes with the LPS-induced positive signals mediated by proinflammatory cytokines.

リンク情報
DOI
https://doi.org/10.1007/s10719-007-9031-6
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000247481900006&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s10719-007-9031-6
  • ISSN : 0282-0080
  • Web of Science ID : WOS:000247481900006

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