TAKAHASHI Chiaki

J-GLOBAL         Last updated: Nov 1, 2019 at 15:49
 
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Name
TAKAHASHI Chiaki
URL
http://www.kanazawa-u.ac.jp/~ganken/index.html
Affiliation
Kanazawa University
Section
Cancer Research Institute
Degree
MD., Ph. D.,(Kyoto University)

Research Areas

 
 

Academic & Professional Experience

 
1996
 - 
2003
: Assistant Professor 
 
2004
 - 
2008
: Associate Professor 
 
2009
   
 
-: Professor 
 

Education

 
 
 - 
1996
Graduate School, Division of Medicine, Kyoto University
 
 
 - 
1990
Faculty of Medicine, Kyoto University
 

Awards & Honors

 
2004
JFCR Young Investigators Award
 

Published Papers

 
Retinoblastoma inactivation induces a protumoral microenvironment via enhanced CCL2 secretion.
Li F, Kitajima S, Kohno S, Yoshida A, Tange S, Sasaki S, Okada N, Nishimoto Y, Muranaka H, Nagatani N, Suzuki M, Masuda S, Thai TC, Nishiuchi T, Tanaka T, Barbie DA, Mukaida M and Takahashi C.
Cancer Research   79(15) 3903-3915.   Jun 2019   [Refereed]
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Nishimura T, NakataA, Xiaoxi C, Nishi K, Meguro-Horike M, Sasaki S,Kita K, Horike S,Saitoh K, Kato K, Kaori I, Murayama T, Kohno S, Takahashi C, Mukaida M, Yano S, Soga T, Tojo A and Gotoh N.
Oncogene   38 2464-2481   2019   [Refereed]
Kitajima S, Asahina H, Chen T, Guo S, Laura GQ, Cavanaugh JD, Merlino AA, Tange S, Terai H, Kim JW, Wang X, Zhou S, Xu N, Wang S, Zhu Z, Thai TC, Takahashi C, Wang Y, Neve R, Stinson S, Tamayo P, Watanabe H, Kirschmeier PT, K Wong KK, and Barbie DA.
Cancer Cell   34(3) 439-452.e6   Sep 2018   [Refereed]
Sasaki S, Baba T, Muranaka H, Tanabe Y, Takahashi C, Matsugo S, Mukaida N
Molecular cancer therapeutics   17(7) 1515-1525   Jul 2018   [Refereed]
Murata T, Yamaguchi M, Kohno S, Takahashi C, Kakimoto M, Sugimura Y, Kamihara M, Hikita K, Kaneda N
FEBS open bio   8(3) 349-360   Mar 2018   [Refereed]
Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, Nishiuchi T, Takuwa Y
PloS one   13(5) e0197604   2018   [Refereed]
Kitajima S, Takahashi C
Cancer science   108(9) 1726-1731   Sep 2017   [Refereed]
Muranaka H, Hayashi A, Minami K, Kitajima S, Kohno S, Nishimoto Y, Nagatani N, Suzuki M, Kulathunga LAN, Sasaki N, Okada N, Matsuzaka T, Shimano H, Tada H, Takahashi C
Oncogenesis   6(6) e350   Jun 2017   [Refereed]
Nagata N, Xu L, Kohno S, Ushida Y, Aoki Y, Umeda R, Fuke N, Zhuge F, Ni Y, Nagashimada M, Takahashi C, Suganuma H, Kaneko S, Ota T
Diabetes   66(5) 1222-1236   May 2017   [Refereed]
Yoshida A, Kitajima S, Li F, Cheng C, Takegami Y, Kohno S, Wan YS, Hayashi N, Muranaka H, Nishimoto Y, Nagatani N, Nishiuchi T, Thai TC, Suzuki S, Nakao S, Tanaka T, Hirose O, Barbie DA, Takahashi C
Oncotarget   8(8) 13872-13885   Feb 2017   [Refereed]
The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity
Kitajima S, Yoshida A, Kohno S, Li F, Suzuki S, Nagatani N, Nishimoto Y, Sasaki N, Muranaka H, Wan Y, Thai T C, Okahashi N, Matsuda F, Shimizu H, Nishiuchi T, Suzuki Y, Tominaga K, Gotoh N, Suzuki M, Ewen M E, Barbie D A, Hirose O, Tanaka T and Takahashi C
Oncogene   36 5145-5157   2017   [Refereed]
Salah M, Nishimoto Y, Kohno S, Kondoh A, Kitajima S, Muranaka H, Nishiuchi T, Ibrahim A, Yoshida A, Takahashi C
Molecular carcinogenesis   55(12) 1974-1989   Dec 2016   [Refereed]
Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C, Hirao A
The Journal of biological chemistry   291(41) 21496-21509   Oct 2016   [Refereed]
[Control of undifferentiated state by RB tumor suppressor].
Kohno S, Kitajima S, Sasaki N, Takahashi C
Seikagaku. The Journal of Japanese Biochemical Society   88(3) 335-341   Jun 2016   [Refereed]
Kohno S, Kitajima S, Sasaki N, Takahashi C
World journal of stem cells   8(4) 170-184   Apr 2016   [Refereed]
Okahashi N, Kohno S, Kitajima S, Matsuda F, Takahashi C, Shimizu H
Journal of bioscience and bioengineering   120(6) 725-731   Dec 2015   [Refereed]
Kitajima S, Kohno S, Kondoh A, Sasaki N, Nishimoto Y, Li F, Abdallah Mohammed MS, Muranaka H, Nagatani N, Suzuki M, Kido Y, Takahashi C
Stem cells (Dayton, Ohio)   33(5) 1657-1669   May 2015   [Refereed]
Gutiérrez J, Droppelmann CA, Contreras O, Takahashi C, Brandan E
PloS one   10(8) e0135005   2015   [Refereed]
Primary Culture of Mouse Thyroid Calcitonin-producing Cell (C cell) Tumors
Kitajima S, Li F, Takahashi C
Bio-Protocol   5    2015   [Refereed]
Pleiotropic functions of RB protein in tumour suppressio
Hayashi N. and Takahashi C
Archives in Cancer Res (on line)      2015   [Refereed]
Rajabi HN, Takahashi C, Ewen ME
The Journal of biological chemistry   289(34) 23417-23427   Aug 2014   [Refereed]
Ali MA, Naka K, Yoshida A, Fuse K, Kasada A, Hoshii T, Tadokoro Y, Ueno M, Ohta K, Kobayashi M, Takahashi C, Hirao A
Biochemical and biophysical research communications   450(1) 837-843   Jul 2014   [Refereed]
Siddesha JM, Valente AJ, Sakamuri SS, Yoshida T, Gardner JD, Somanna N, Takahashi C, Noda M, Chandrasekar B
Journal of molecular and cellular cardiology   65 9-18   Dec 2013   [Refereed]
Hayashi N, Kobayashi M, Shamma A, Morimura Y, Takahashi C, Yamamoto K
Journal of biochemistry   154(5) 429-435   Nov 2013   [Refereed]
Shamma A, Suzuki M, Hayashi N, Kobayashi M, Sasaki N, Nishiuchi T, Doki Y, Okamoto T, Kohno S, Muranaka H, Kitajima S, Yamamoto K, Takahashi C
Molecular and cellular biology   33(16) 3113-3124   Aug 2013   [Refereed]
Takahashi C, Sasaki N, Kitajima S
Cancer science   103(7) 1182-1188   Jul 2012   [Refereed]
Taura M, Suico MA, Koyama K, Komatsu K, Miyakita R, Matsumoto C, Kudo E, Kariya R, Goto H, Kitajima S, Takahashi C, Shuto T, Nakao M, Okada S, Kai H
Molecular and cellular biology   32(8) 1581-1590   Apr 2012   [Refereed]
Chandana EP, Maeda Y, Ueda A, Kiyonari H, Oshima N, Yamamoto M, Kondo S, Oh J, Takahashi R, Yoshida Y, Kawashima S, Alexander DB, Kitayama H, Takahashi C, Tabata Y, Matsuzaki T, Noda M
BMC developmental biology   10 84   Aug 2010   [Refereed]
Noda M, Takahashi C, Matsuzaki T, Kitayama H
Future oncology (London, England)   6(7) 1105-1116   Jul 2010   [Refereed]
Miki T, Shamma A, Kitajima S, Takegami Y, Noda M, Nakashima Y, Watanabe K, Takahashi C
Molecular cancer research : MCR   8(5) 665-676   May 2010   [Refereed]
[Genetic and biochemical interactions of Rb and ras].
Takahashi C, Takegami Y, Shamma A
Seikagaku. The Journal of Japanese Biochemical Society   81(10) 873-883   Oct 2009   [Refereed]
[Regulation of Notch signaling and its polarity mediated by ectodomain shedding of DSL ligands].
Takahashi C, Muraguchi T, Takegami Y, Miki T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   54(13) 1742-1746   Oct 2009   [Refereed]
Omura A, Matsuzaki T, Mio K, Ogura T, Yamamoto M, Fujita A, Okawa K, Kitayama H, Takahashi C, Sato C, Noda M
The Journal of biological chemistry   284(6) 3461-3469   Feb 2009   [Refereed]
SHAMMA Awad, TAKEGAMI Yujiro, MIKI Takao, MIKI Takao, KITAJIMA Shunsuke, NODA Makoto, OBARA Takao, OKAMOTO Takahiro, TAKAHASHI Chiaki, TAKAHASHI Chiaki
Cancer Cell   15(4) 255-269   2009
Kawashima S, Imamura Y, Chandana EP, Noda T, Takahashi R, Adachi E, Takahashi C, Noda M
Journal of neurochemistry   104(2) 376-385   Jan 2008   [Refereed]
Noda M, Takahashi C
Cancer science   98(11) 1659-1665   Nov 2007   [Refereed]
Fotiadou PP, Takahashi C, Rajabi HN, Ewen ME
Molecular and cellular biology   27(19) 6742-6755   Oct 2007   [Refereed]
MURAGUCHI Teruyuki, TAKEGAMI Yujiro, OHTSUKA Toshiyuki, KITAJIMA Shunsuke, CHANDANA Ediriweera P S, OMURA Akira, MIKI Takao, TAKAHASHI Rei, MATSUMOTO Naoya, LUDWIG Andreas, NODA Makoto, TAKAHASHI Chiaki
Nature Neuroscience   10(7) 838-845   2007
MIKI Takao, TAKEGAMI Yujiro, OKAWA Katsuya, MURAGUCHI Teruyuki, NODA Makoto, TAKAHASHI Chiaki
J. Biol. Chem.   282(16) 12341-12352   2007
Nakaji K, Ihara M, Takahashi C, Itohara S, Noda M, Takahashi R, Tomimoto H
Stroke   37(11) 2816-2823   Nov 2006   [Refereed]
Takahashi C, Ewen ME
Cancer research   66(19) 9345-9348   Oct 2006   [Refereed]
TAKAHASHI Chiaki, TAKAHASHI Chiaki, CONTRERAS Bernardo, IWANAGA Tsuyoshi, TAKEGAMI Yujiro, BAKKER Anke, BRONSON Roderick T, BRONSON Roderick T, NODA Makoto, LODA Massimo, HUNT Jennifer L, EWEN Mark E
Nature Genetics   38(1) 118-123   2006
Takenaka K, Ishikawa S, Yanagihara K, Miyahara R, Hasegawa S, Otake Y, Morioka Y, Takahashi C, Noda M, Ito H, Wada H, Tanaka F
Annals of surgical oncology   12(10) 817-824   Oct 2005   [Refereed]
Echizenya M, Kondo S, Takahashi R, Oh J, Kawashima S, Kitayama H, Takahashi C, Noda M
Oncogene   24(38) 5850-5857   Sep 2005   [Refereed]
Ihara M, Kinoshita A, Yamada S, Tanaka H, Tanigaki A, Kitano A, Goto M, Okubo K, Nishiyama H, Ogawa O, Takahashi C, Itohara S, Nishimune Y, Noda M, Kinoshita M
Developmental cell   8(3) 343-352   Mar 2005   [Refereed]
Oh J, Seo DW, Diaz T, Wei B, Ward Y, Ray JM, Morioka Y, Shi S, Kitayama H, Takahashi C, Noda M, Stetler-Stevenson WG
Cancer research   64(24) 9062-9069   Dec 2004   [Refereed]
Takahashi C, Contreras B, Bronson RT, Loda M, Ewen ME
Molecular and cellular biology   24(23) 10406-10415   Dec 2004   [Refereed]
Takeuchi T, Hisanaga M, Nagao M, Ikeda N, Fujii H, Koyama F, Mukogawa T, Matsumoto H, Kondo S, Takahashi C, Noda M, Nakajima Y
Clinical cancer research : an official journal of the American Association for Cancer Research   10(16) 5572-5579   Aug 2004   [Refereed]
Takenaka K, Ishikawa S, Kawano Y, Yanagihara K, Miyahara R, Otake Y, Morioka Y, Takahashi C, Noda M, Wada H, Tanaka F
European journal of cancer (Oxford, England : 1990)   40(10) 1617-1623   Jul 2004   [Refereed]
Oh J, Takahashi R, Adachi E, Kondo S, Kuratomi S, Noma A, Alexander DB, Motoda H, Okada A, Seiki M, Itoh T, Itohara S, Takahashi C, Noda M
Oncogene   23(29) 5041-5048   Jun 2004   [Refereed]
Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA
Proceedings of the National Academy of Sciences of the United States of America   100(17) 9855-9860   Aug 2003   [Refereed]
Takahashi C, Bronson RT, Socolovsky M, Contreras B, Lee KY, Jacks T, Noda M, Kucherlapati R, Ewen ME
Molecular and cellular biology   23(15) 5256-5268   Aug 2003   [Refereed]
Noda M, Oh J, Takahashi R, Kondo S, Kitayama H, Takahashi C
Cancer metastasis reviews   22(2-3) 167-175   Jun 2003   [Refereed]
[The membrane-anchored metalloproteinase inhibitor RECK].
Takahashi C, Junseo O, Noda M
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   47(14) 1889-1895   Nov 2002   [Refereed]
Sasahara RM, Brochado SM, Takahashi C, Oh J, Maria-Engler SS, Granjeiro JM, Noda M, Sogayar MC
Cancer detection and prevention   26(6) 435-443   2002   [Refereed]
RECK gene expression in hepatocellular carcinoma: correlation with invasion-related clinicopathological factors and its clinical significance. Reverse-inducing--cysteine-rich protein with Kazal motifs
Furumoto K, Arii S, Mori A, Furuyama H, Gorrin Rivas M J, Nakao T, Isobe N, Murata T, Takahashi C, Noda M, and Imamura M.
Hepatology   33 189-195   2001   [Refereed]
Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara R M, Nishimura S, Imamura Y, Kitayama H, Alexander D B, Ide C, Horan T P, Arakawa T, Yoshida H, Nishikawa S, Itoh Y, Seiki M, Itohara S, Takahashi C, and Noda M.
Cell   107 789-800   2001   [Refereed]
Sasahara R M, Takahashi C, and Noda M.
Biochem Biophys Res Commun   264 668-675   1999   [Refereed]
Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene
Sasahara R M, Takahashi C, Sogayar M C, and Noda M
Braz J Med Biol Res   32 891-895   1999   [Refereed]
Cystic fibrosis transmembrane conductance regulator mediates sulphonylurea block of the inwardly rectifying K+ channel Kir6.1
Ishida-Takahashi A, Otani H, Takahashi C, Washizuka T, Tsuji K, Noda M, Horie M, and Sasayama S
J Physiol   508 23-30   1998   [Refereed]
Takahashi C, Sheng Z, Horan T P, Kitayama H, Maki M, Hitomi K, Kitaura Y, Takai S, Sasahara R M, Horimoto A, Ikawa Y, Ratzkin B J, Arakawa T, and Noda M.
Proc Natl Acad Sci U S A   95 13221-13226   1998   [Refereed]
Possible involvement of MSX-2 homeoprotein in v-ras-induced transformation
Takahashi C, Akiyama N, Kitayama H, Takai S, and Noda M
Leukemia   11(Suppl 3) 340-343   1997   [Refereed]
Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene
Takahashi C, Akiyama N, Matsuzaki T, Takai S, Kitayama H, and Noda M
Oncogene   12 2137-2146   1996   [Refereed]
Portal hypertension associated with anticardiolipin antibodies in a case of systemic lupus erythematosus
Takahashi C, Kumagai S, Tsubata R, Sorachi K, Ozaki S, Imura H, and Nakao K
Lupus   4 232-235   1995   [Refereed]
Phosphorylation of the Rex protein of human T-cell leukemia virus type I. J Biol Chem
Adachi Y, Copeland T D, Takahashi C, Nosaka T, Ahmed A, Oroszlan S, and Hatanaka M
J Biol Chem   267 21977-21981   1992   [Refereed]
Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells
Adachi Y, Ishida-Takahashi A, Takahashi C, Takano E, Murachi T, and Hatanaka M
J Biol Chem   266 3968-3972   1991   [Refereed]
Tanaka A, Takahashi C, Yamaoka S, Nosaka T, Maki M, and Hatanaka M
Proc Natl Acad Sci U S A   87 1071-1075   1990   [Refereed]
mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.
Thumkeo D, Katsura Y, Nishimura Y, Kanchanawong P, Tohyama K, Ishizaki T, Kitajima S, Takahashi C, Hirata T, Watanabe N, Krummel MF and Narumiya S.
Science Advances (in press)      2019   [Refereed]

Research Grants & Projects

 
The interaction of oncogenic signals/ tumor suppressor pathways and malignant behavior of cancer cells