ONOE Kazunori

J-GLOBAL         Last updated: Oct 23, 2009 at 00:00
 
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Name
ONOE Kazunori
Affiliation
Hokkaido University
Section
Institute for Genetic Medicine, Research Section of Pathophysiology, Division of Immnunobiology
Job title
Chairman, Professor
Degree
M.D., Ph.D.(Hokkaido University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 1970
   
 
Research Associate, Institute for Tuberculosis
 
 
   
 
Hokkaido University
 
Jun 1974
   
 
Research Associate, Institute of Immunological Science,
 
 
   
 
Hokkaido University
 
Mar 1981
   
 
Associate Professor, Institute of Immunological Science,
 

Education

 
 
   
 
School of Meci cine, Hokkaido University School of Medicine
 

Committee Memberships

 
1993
 - 
1996
Editorial Board, Microbiology and Immunology
 
1995
   
 
Active Member, The New York Academy of Sciences
 
1996
   
 
Grant Referee, JSPS
 
1996
   
 
-Editorial Board, Pathology International
 
1997
 - 
2001
Grnat Referee, Human Frontier Science Program (HFSP)
 

Awards & Honors

 
2007
Akiyama Foundation Award
 
2005
Japan Pthology Award
 

Misc

 
The origin of alveolar macrophages
Onoé, K., and Morikawa, K.
Rec. Adv. RES Res.   12(1) 100-119   1972
Changes in histology of the regional lymph nodes and in the proportions of T and B cell populations by oxazolone painting or LPS injection in guinea pigs
Onoé, K.
Acta Pathol. Jpn.   26(6) 671-691   1976
Histological studies on the adjuvanticity of BCG-cell wall
Okuyama, H., Onoé, K., Takeda, J., and Morikawa, K.
Rec. Adv. RES Res.   16(1) 67-78   1976
Histological studies on adjuvanticity of BCG-cell walls -Comparison of adjuvanticity between oil-in-water and water-in-oil forms-
Okuyama, H., Takeda, J., Onoé, K., and Morikawa, K.
Bull. Inst. Immunol. Sci. Hokkaido Univ.   38(1) 13-23   1978
Impairment of cell-mediated immunity functions by dietary zink deficiency in mice
Fernandes, G., Nair, M., Onoé, K., Tanaka, T., Floyd, R., and Good, R.A.
Proc. Natl. Acad. Sci. USA.   76(1) 457-461   1979

Books etc

 
Kato, K., Mizukoshi, N., Hamada, N., Ishihara, C., Onoé, K., Chen, Y., Kimura, T., Yamamoto, K., Kasai, N., Nishihara, J., Ishibashi, T., and Morita, I.: Staphylococcal enterotoxin A induced interferon γ in high responder mice of BCG induced lung granu・・・
in Basic Mechanisms of Granulomatous Inflammation (ed. T. Yoshida and M. Torisu), Elsevier Science Publishers   1989   
Kato, K., Mizukoshi, N., Hamada, N., Ishihara, C., Onoé, K., Chen, Y., Kimura, T., Yamamoto, K., Kasai, N., Nishihara, J., Ishibashi, T., and Morita, I.: Staphylococcal enterotoxin A induced interferon γ in high responder mice of BCG induced lung ...
Onoé, K.: Clonal elimination of self-reactive T-cells in the thymus of irradiation bone marrow chimeras.
Ocular Immunology Today (Eds. M. Usui, S. Ohno and K. Aoki) Elsevier Science Publishers   1990   
Hirose, S., Sasamoto, Y., Ogasawara, K., Natori, T., Onoé, K., Ohno, S., and Matsuda, H.: Genetic control of experimental autoimmune uveitis in rats: Separation of the MHC and non-MHC gene effects.
Ocular Immunology Today (Eds. M. Usui, S. Ohno, and K. Aoki) Elsevier Science Publishers   1990   
Onoé, K., Gotohda, T., Itoh, Y., and Ogasawara, K.: Generation of the T cell repertoire cross-reactive to a self peptide antigen influenced by the MHC class II mutation. in "Molecular approaches to the study and treatment of human diseases" (・・・
Elsevier Science Publishers   1992   
Onoé, K., Gotohda, T., Itoh, Y., and Ogasawara, K.: Generation of the T cell repertoire cross-reactive to a self peptide antigen influenced by the MHC class II mutation. in "Molecular approaches to the study and treatment of human diseases" (eds. ...
Sasamoto, Y., Kotake, S., Ogasawara, K., Onoé, K., Wiggert, B., Gery, I., and Matsuda, H.: Uveitogenicity and immunogenicity of IRBP-derived peptide in various rat strains. in "Advances in Ocular Immunology" (eds. R.B. Nussenblatt, S.M. Whitc・・・
Elsevier Science B.V.   1994   
Sasamoto, Y., Kotake, S., Ogasawara, K., Onoé, K., Wiggert, B., Gery, I., and Matsuda, H.: Uveitogenicity and immunogenicity of IRBP-derived peptide in various rat strains. in "Advances in Ocular Immunology" (eds. R.B. Nussenblatt, S.M. Whitcup, R...

Conference Activities & Talks

 
Symposium “Advances in Uveitis Models”, A study on the cellular and molecular basis of a genetic dependency of type II collagen-induced arthritis.
U.S.- Japan Ocular Immunology Meeting,(at Honolulu)   1989   
Symposium “New Immunosuppressive Agents”, Effect of FK-506 on EAU in the rat
U.S.-Japan Ocular Immunology Meeting, (at Honolulu)   1989   
Educational Lecture Animal models: Clonal deletion of self-reactive T cells in the thymus from irradiation bone marrow chimeras
The 5th International Symposium on the Immunology and Immunopathology of the Eye. (at Tokyo)   1990   
Symposium Cell components required for positive and negative selection of T cell repertoire in the thymus
"International Mini-Symposium", Basic studies on bone marrow transplantation. 1990(at Kyoto)   1990   
Symposium Generation of the T cell repertoire cross-reactive to a self peptide antigen influenced by MHC class II mutation
"International symposium on genetic intervention in diseases with unknown etiology". (at Tokyo)   1990   

Works

 
Akiyama Memorial Life Science Foudation, A study of leukemogenesis using chimeric mice
1987
Health Science Fund, Immune system of allogeneic chimeras
1987
Animal model for intractable diseases (Misistry of Health, Welfare Japan)
1990 - 1995
Suhara Memorial Fund, Intrathymic T cell differentiation
1990
Uehara Memorial Life Science Fund, Therapy using allogeneic BMT
1991

Research Grants & Projects

 
Differentiation and function of T cells and NK- T cells
Grant-in-Aid for Scientific Research
Project Year: 1977 - 2009
To elucidate mechanisms underlying differentiation of T cells and NK-T cells mainly in the thymus.
Development of Therapy for Atherosclerosis
Grant-in-Aid for Scientific Research
Project Year: 2002 - 2010
To regulate lipid-reactive NK-T cells.
Negative feedback regulation in interaction between dendritic cells and NK-T cells
Grant-in-Aid for Scientific Research
Project Year: 2004 - 2010
Th1 or Th2 cytokine-treated dendritic cells stimualte NK-T cells to produce opposite type (Th2 or Th1, respectively) cytokine.
Modification of dendritic cell ability to generate appropriate immune responses
Grant-in-Aid for Scientific Research
Project Year: 2003 - 2010
Dendritic cells treated with various components show different stimulatory activity toward NK-T cells and T cells.
Regulation of organ specific autoimmune diseases
Health and Labour Sciences Research Grants
Project Year: 1996 - 2010
To develop regulatory system of organ specific autoimmune diseases focusing on T and NK-T cell functions.