論文

査読有り 最終著者 責任著者 本文へのリンクあり 国際誌
2022年12月1日

Potential Diets to Improve Mitochondrial Activity in Amyotrophic Lateral Sclerosis

Diseases
  • Sayuri Yoshikawa
  • ,
  • Kurumi Taniguchi
  • ,
  • Haruka Sawamura
  • ,
  • Yuka Ikeda
  • ,
  • Ai Tsuji
  • ,
  • Satoru Matsuda

10
4
開始ページ
117
終了ページ
117
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/diseases10040117
出版者・発行元
MDPI AG

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease, the pathogenesis of which is based on alternations in the mitochondria of motor neurons, causing their progressive death. A growing body of evidence shows that more efficient mitophagy could prevent and/or treat this disorder by suppressing mitochondrial dysfunction-induced oxidative stress and inflammation. Mitophagy has been considered one of the main mechanisms responsible for mitochondrial quality control. Since ALS is characterized by enormous oxidative stress, several edible phytochemicals that can activate mitophagy to remove damaged mitochondria could be considered a promising option to treat ALS by providing neuroprotection. Therefore, it is of great significance to explore the mechanisms of mitophagy in ALS and to understand the effects and/or molecular mechanisms of phytochemical action, which could translate into a treatment for neurodegenerative diseases, including ALS.

リンク情報
DOI
https://doi.org/10.3390/diseases10040117 本文へのリンクあり
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/36547203
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777491
URL
https://www.mdpi.com/2079-9721/10/4/117/pdf
ID情報
  • DOI : 10.3390/diseases10040117
  • eISSN : 2079-9721
  • PubMed ID : 36547203
  • PubMed Central 記事ID : PMC9777491

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