神奈木玲児 (Reiji Kannagi) - マイポータル - researchmap

基本情報

所属: 愛知県がんセンター研究所分子病態学部部長

学位: 医学博士(京都大学)

J-GLOBAL ID: 200901045019206493
researchmap会員ID: 0000020517

研究キーワード

6

研究分野

3

経歴

2

1985年

京都大学医学部講師
1982年

京都大学医学部助手

学歴

2

委員歴

5

受賞

2

MISC

81

Human B-lymphocytes express alpha 2-6-sialylated 6-sulfo-N-acetyllactosamine serving as a preferred ligand for CD22/Siglec-2

Naoko Kimura, Katsuyuki Ohmori, Keiko Miyazaki, Mineko Izawa, Yuji Matsuzaki, Yosuke Yasuda, Hiromu Takematsu, Yasunori Kozutsumi, Akihiko Moriyama, Reiji Kannagi

JOURNAL OF BIOLOGICAL CHEMISTRY 282(44) 32200-32207 2007年11月
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes

Guo-Yun Chen, Hirotaka Osada, Luis F. Santamaria-Babi, Reiji Kannagi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103(45) 16894-16899 2006年11月
Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS

Mamoru Kyogashima, Keiko Tamiya-Koizumi, Takashi Ehara, Gang Li, Rui Hu, Atsushi Hara, Toshifumi Aoyama, Reiji Kannagi

GLYCOBIOLOGY 16(8) 719-728 2006年8月
Identification of cutaneous lymphocyte-associated antigen as sialyl 6-sulfo Lewis X, a selectin ligand expressed on a subset of skin-homing helper memory T cells

K Ohmori, F Fukui, M Kiso, T Imai, O Yoshie, H Hasegawa, K Matsushima, R Kannagi

BLOOD 107(8) 3197-3204 2006年4月
Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells

J Yin, A Hashimoto, M Izawa, K Miyazaki, GY Chen, H Takematsu, Y Kozutsumi, A Suzuki, K Furuhata, FL Cheng …

CANCER RESEARCH 66(6) 2937-2945 2006年3月
A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules

K Uchimura, JM Gauguet, MS Singer, D Tsay, R Kannagi, T Muramatsu, UH von Andrian, SD Rosen

NATURE IMMUNOLOGY 6(11) 1105-1113 2005年11月
N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing

K Uchimura, K Kadomatsu, FM El-Fasakhany, MS Singer, M Izawa, R Kannagi, N Takeda, SD Rosen, T Muramatsu

JOURNAL OF BIOLOGICAL CHEMISTRY 279(33) 35001-35008 2004年8月
Carbohydrate-mediated cell adhesion in cancer metastasis and angiogenesis.

Cancer Sci. 95: 377-384 2004年
In search of the carbohydrate structures on CD44 critical for hyaluronic acid binding - roles of sialylation and sulfation.

Trends Glycosci. Glycotechnol. 16: 211-223, 2004年
Hypoxia induces adhesion molecules on cancer cells-a missing link between Warburg effect and induction of selectin ligand carbohydrates.

Proc. Natl. Acad. Sci. USA 101: 8132-8137 2004年
Loss of disialyl Lewis a, the ligand for lymphocyte inhibitory receptor Siglec-7, associated with increased sialyl Lewis a expression on human colon cancers.

Cancer Res 64: 4498-4505 2004年
Synthesis of disialyl Lewis a structure in colon cancer cell lines by a sialyltransferase ST6GalNAc VI responsible for the synthesis of α-series gangliosides.

J. Biol. Chem. 278(25) 22787-22794 2003年6月
Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element

N Hiraiwa, T Yabuta, K Yoritomi, M Hiraiwa, Y Tanaka, T Suzuki, M Yoshida, R Kannagi

BLOOD 101(9) 3615-3621 2003年5月
Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression - The Warburg effect revisited

Reiji Kannagi

Glycoconjugate Journal 20(5) 353-364 2003年
Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression

K Uchimura, FM El-Fasakhany, M Hori, S Hemmerich, SE Blink, GS Kansas, A Kanamori, K Kumamoto, R Kannagi, T Muramatsu

JOURNAL OF BIOLOGICAL CHEMISTRY 277(6) 3979-3984 2002年2月
6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells.

Immunity 17: 289-301 2002年
Regulatory roles of carbohydrate ligands for selectins in homing of lymphocytes.

Curr. Opin. Struct. Biol. 12: 599-608 2002年
Distinct sulfation requirements of selectins disclosed using cells which support rolling mediated by all three selectins under shear flow: L-selectin prefers carbohydrate 6-sulfation to tyrosine sulfation whereas P-selectin does not.

J. Biol. Chem. 277: 32578-32586 2002年
Roles of cell adhesion molecules in tumor angiogenesis induced by co-transplantation of cancer and endothelial cells to nude rats.

Cancer Res. 62: 6289-6296 2002年
6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells.

Immunity 17: 289-301 2002年

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書籍等出版物

2

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8

共同研究・競争的資金等の研究課題

2