Kimihiko Sugaya

Profile Information

Affiliation: National Institute of Radiological Sciences

Degree: 博士（理学）(総合研究大学院大学)

Researcher number: 80280741
J-GLOBAL ID: 200901006174824203
researchmap Member ID: 0000021266

Research Interests

Research Areas

Research History

Apr, 2021 - Present

上席研究員, 分子イメージング診断治療研究部, 量子科学技術研究開発機構量子医科学研究所
Jul, 2018 - Mar, 2021

上席研究員, 分子イメージング診断治療研究部, 量子科学技術研究開発機構放射線医学総合研究所
Apr, 2016 - Jun, 2018

主幹研究員, 分子イメージング診断治療研究部, 量子科学技術研究開発機構放射線医学総合研究所
May, 2012 - Mar, 2016

主任研究員(併任), 福島復興支援本部, 放射線医学総合研究所
Apr, 2006 - Mar, 2016

主任研究員, 放射線防護研究センター, 放射線医学総合研究所
Aug, 2001 - Mar, 2006

主任研究員, 放射線安全研究センター, 放射線医学総合研究所
Apr, 2001 - Jul, 2001

研究員, 放射線安全研究センター, 放射線医学総合研究所
Apr, 1995 - Mar, 2001

研究員, 第２研究グループ, 放射線医学総合研究所
Mar, 1998 - Mar, 2000

JST長期在外若手研究員(２年間), サー・ウィリアム・ダン病理学研究所, 英国オックスフォード大学
Apr, 1991 - Mar, 1992

研究員, 横浜研究所, ポーラ化成工業

Papers

Characterization of cells expressing MRI reporters for the analysis of epigenetics

Kimihiko Sugaya

Analytical Biochemistry, 114395-114395, Sep, 2021 Peer-reviewedLead authorCorresponding author
Changes in characteristics of murine hair follicles and tissue stem cells by aging

Kimihiko Sugaya

Mechanisms of Development, 163 103630-103630, Sep, 2020 Peer-reviewedLead authorCorresponding author
Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin

SEVERINA SEMKOVA, ZHIVKO ZHELEV, THOMAS MILLER, KIMIHIKO SUGAYA, ICHIO AOKI, TATSUYA HIGASHI, RUMIANA BAKALOVA

Anticancer Research, 40(4) 1963-1972, Apr, 2020 Peer-reviewed
Chromosome instability caused by mutations in the genes involved in transcription and splicing

Kimihiko Sugaya

RNA Biology, 16 1521-1525, 2019 Peer-reviewed
Let’s think again about using mammalian temperature-sensitive mutants to investigate functional molecules -The perspectives from the studies on three mutants showing chromosome instability-

Sugaya, K

Journal of Cellular Biochemistry, 119 7143-7150, 2018 Peer-reviewed
Effects of gamma rays on the regeneration of murine hair follicles in the natural hair cycle

Sugaya, K

InternationalJournal of Radiation Biology, 93 937-946, Jun, 2017 Peer-reviewed
Regeneration of Murine Hair Follicles is Inhibited by Low-Dose-Rate Gamma Irradiation

Kimihiko Sugaya, Tomohisa Hirobe, Yoshie Ishihara, Sonoe Inoue

ZOOLOGICAL SCIENCE, 33(5) 461-466, Oct, 2016 Peer-reviewed
The effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles

Kimihiko Sugaya, Yoshie Ishihara, Sonoe Inoue, Tomohisa Hirobe

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 91(12) 957-963, Dec, 2015 Peer-reviewed
Nuclear localization of ubiquitin-activating enzyme Uba1 is characterized in its mammalian temperature-sensitive mutant

Kimihiko Sugaya, Yoshie Ishihara, Sonoe Inoue

GENES TO CELLS, 20(8) 659-666, Aug, 2015 Peer-reviewed
Analysis of a temperature-sensitive mutation in Uba1: Effects of the click reaction on subsequent immunolabeling of proteins involved in DNA replication

Kimihiko Sugaya, Yoshie Ishihara, Sonoe Inoue

FEBS OPEN BIO, 5 167-174, 2015 Peer-reviewed
Characterization of Ubiquitin-Activating Enzyme Uba1 in the Nucleus by Its Mammalian Temperature-Sensitive Mutant

Kimihiko Sugaya, Yoshie Ishihara, Sonoe Inoue, Hideo Tsuji

PLOS ONE, 9(5) e96666, May, 2014 Peer-reviewed
Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

Kimihiko Sugaya, Tomohisa Hirobe

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 90(2) 127-132, Feb, 2014 Peer-reviewed
Effects of low-dose heavy ions on embryonic development in mice and on melanocyte differentiation in the epidermis and hair bulb

Tomohisa Hirobe, Kiyomi Eguchi-Kasai, Kimihiko Sugaya, Masahiro Murakami

JOURNAL OF RADIATION RESEARCH, 54(3) 409-418, May, 2013 Peer-reviewed
Characterization of the role of Smu1 in nuclear localization of splicingfactors in the mammalian temperature-sensitive mutant

Sugaya, K, Ishihara, Y, Sugaya, K, Inoue, S

American Journal of Molecular Biology, 3 38-44, Mar, 2013 Peer-reviewed
Effects of Low-dose gamma-rays on the Embryonic Development of Mouse Melanoblasts and Melanocytes in the Epidermis and Hair Bulbs

Tomohisa Hirobe, Kiyomi Eguchi-Kasai, Kimihiko Sugaya, Masahiro Murakami

ZOOLOGICAL SCIENCE, 28(6) 389-396, Jun, 2011 Peer-reviewed
Effects of Low-dose Heavy Ions on the Postnatal Development of Mice and the Yield of White Spots in the Mid-ventrum and Tail-tips

Tomohisa Hirobe, Kiyomi Eguchi-Kasai, Kimihiko Sugaya, Masahiro Murakami

JOURNAL OF RADIATION RESEARCH, 52(3) 278-286, May, 2011 Peer-reviewed
Enlargement of speckles of SF2/ASF due to loss of function of Smu1 is characterized in the mammalian temperature-sensitive mutant

Kimihiko Sugaya, Yoshie Ishihara, Keiko Sugaya

RNA BIOLOGY, 8(3) 488-495, May, 2011 Peer-reviewed
Characterization of cells expressing RNA polymerase II tagged with green fluorescent protein: Effect of ionizing irradiation on RNA synthesis

Etsuko Hongo, Yoshie Ishihara, Keiko Sugaya, Kimihiko Sugaya

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 84(9) 778-787, 2008 Peer-reviewed
The conserved role of Smu1 in splicing is characterized in its mammalian temperature-sensitive mutant

Kimihiko Sugaya, Etsuko Hongo, Yoshie Ishihara, Hideo Tsuji

JOURNAL OF CELL SCIENCE, 119(23) 4944-4951, Dec, 2006 Peer-reviewed
A temperature-sensitive mutation in the WD repeat-containing protein Smu1 is related to maintenance of chromosome integrity

K Sugaya, E Hongo, H Tsuji

EXPERIMENTAL CELL RESEARCH, 306(1) 242-251, May, 2005 Peer-reviewed

Misc.

The effects of ionizing radiations on the regeneration of hair follicles are carried over to the later generation

Kimihiko Sugaya, Yoshie Ishihara, Sonoe Inoue, Tomohisa Hirobe

GENES & GENETIC SYSTEMS, 89(6) 320-320, Dec, 2014
The effect of ionizing radiation on the regeneration of hair follicle

Kimihiko Sugaya, Yoshie Ishihara, Sonoe Inoue, Hiroko Nakamura, Tomohisa Hirobe

GENES & GENETIC SYSTEMS, 88(6) 392-392, Dec, 2013
Characterization of the enlargement of speckles due to loss of function of Smu1 in the mammalian temperature-sensitive mutant

Kimihiko Sugaya, Yoshie Ishihara, Keiko Sugaya

GENES & GENETIC SYSTEMS, 86(6) 426-426, Dec, 2011
An association of Smu1 with SF2/ASF is characterized in its mammalian temperature-sensitive mutant

Kimihiko Sugaya, Yoshie Ishihara, Keiko Sugaya

GENES & GENETIC SYSTEMS, 85(6) 427-427, Dec, 2010
The conserved role of Smu1 in splicing is characterized in its mammalian temperature-sensitive mutant

Kimihiko Sugaya, Yoshie Ishihara, Keiko Sugaya

GENES & GENETIC SYSTEMS, 84(6) 455-455, Dec, 2009
The conserved role of Smu1 in splicing is characterized in its mammalian temperature-sensitive mutant

Kimihiko Sugaya, Yoshie Ishihara, Keiko Sugaya

GENES & GENETIC SYSTEMS, 83(6) 482-482, Dec, 2008
The role of Smu1 in splicing is conserved through evolution

Kimihiko Sugaya, Etsuko Hongo, Yoshie Ishihara, Hideo Tsuji

GENES & GENETIC SYSTEMS, 81(6) 440-440, Dec, 2006
Analysis of transcription after X-ray irradiation: Comparison with that of after UV irradiation

K Sugaya, E Hongo

MOLECULAR BIOLOGY OF THE CELL, 15 447A-447A, Nov, 2004
Mutant reconstitution of RNA polymerase II largest subunit of S-pombe: Introduction of mutation site related abnormal induction of sister chromatid exchanges.

K Sugaya, M Ajimura, H Tsuji, M Morimyo, K Mita

MOLECULAR BIOLOGY OF THE CELL, 8 809-809, Nov, 1997
Mutation sites of RNA polymerase II largest subunit related to the abnormal induction of sister chromatid exchanges.

K Sugaya, H Tsuji, K Mita

MOLECULAR BIOLOGY OF THE CELL, 7 171-171, Dec, 1996
RNAポリメラーゼIIのどのような遺伝子変異が姉妹染色分体交換誘発に関与するのか?

菅谷公彦, 辻秀雄, 三田和英

日本分子生物学会年会プログラム・講演要旨集, 19 787-787, Aug 1, 1996

Professional Memberships

Research Projects

ゲノム安定性維持機構に関連する遺伝子の分離と機能解析

科学研究費補助金(基盤研究Ｃ), 日本学術振興会, Apr, 2011 - Mar, 2014

菅谷公彦
スプライシング反応に関与するSmu1の染色体安定性維持機構における機能の解明

科学研究費補助金(萌芽研究), 日本学術振興会, Apr, 2007 - Mar, 2009

菅谷公彦
転写共役修復過程におけるRNAポリメラーゼIIのリン酸化の変化の解析

住友財団基礎科学研究助成, 住友財団, Nov, 2003 - Nov, 2004

菅谷公彦
簡便かつ高感度な遺伝子発現プロファイル解析法の開発

科学研究費補助金(萌芽研究), 日本学術振興会, Apr, 2002 - Mar, 2004

菅谷公彦
ゲノムの不安定性と発癌の解析

佐川がん研究助成, 佐川がん研究助成振興財団, Oct, 2000 - Sep, 2001

菅谷公彦
RNAポリメラーゼII変異株を用いたDNA代謝の包括的解析

科学技術振興事業団(JST)長期在外若手研究員, 科学技術振興事業団, Mar, 1998 - Mar, 2000

菅谷公彦
分裂酵母RNAポリメラーゼIIlargest subunit の機能解析(平成10年度は留学のため辞退)

科学研究費補助金(奨励研究Ａ), 日本学術振興会, Apr, 1997 - Mar, 1998

菅谷公彦
RNAポリメラーゼII largestsubunit (RPIILS)の機能解析

科学研究費補助金(奨励研究Ａ), 日本学術振興会, Apr, 1996 - Mar, 1997

菅谷公彦
翻訳伸長因子１，EF-1αの機能解析

科学技術振興調整費(重点基礎研究), 文部科学省, Apr, 1996 - Mar, 1997

菅谷公彦

Industrial Property Rights

特開平05-043418 化粧料

釈政雄, 大倉さゆり, 菅谷公彦
特開平05-124929 化粧料

釈政雄, 大倉さゆり, 菅谷公彦, 松田武久

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Papers

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