論文

査読有り
2013年11月13日

Clinical significance of sIL-2R levels in B-cell lymphomas

PLoS ONE
  • Noriaki Yoshida
  • Miyo Oda
  • Yoshiaki Kuroda
  • Yuta Katayama
  • Yoshiko Okikawa
  • Taro Masunari
  • Megumu Fujiwara
  • Takashi Nishisaka
  • Naomi Sasaki
  • Yoshito Sadahira
  • Keichiro Mihara
  • Hideki Asaoku
  • Hirotaka Matsui
  • Masao Seto
  • Akiro Kimura
  • Koji Arihiro
  • Akira Sakai
  • 全て表示

8
11
開始ページ
e78730
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0078730

Elevated soluble interleukin-2 receptor (sIL-2R) in sera is observed in patients with malignant lymphoma (ML). Therefore, sIL-2R is commonly used as a diagnostic and prognostic marker for ML, but the mechanisms responsible for the increase in sIL-2R levels in patients with B-cell lymphomas have not yet been elucidated. We first hypothesized that lymphoma cells expressing IL-2R and some proteinases such as matrix metalloproteinases (MMPs) in the tumor microenvironment can give rise to increased sIL-2R in sera. However, flow cytometric studies revealed that few lymphoma cells expressed IL-2R α chain (CD25) in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), and most CD25-expressing cells in the tumor were T-cells. Distinct correlations between CD25 expression on B-lymphoma cells and sIL-2R levels were not observed. We then confirmed that MMP-9 plays an important role in producing sIL-2R in functional studies. Immunohistochemical (IHC) analysis also revealed that MMP-9 is mainly derived from tumor-associated macrophages (TAMs). We therefore evaluated the number of CD68 and CD163 positive macrophages in the tumor microenvironment using IHC analysis. A positive correlation between the levels of sIL-2R in sera and the numbers of CD68 positive macrophages in the tumor microenvironment was confirmed in FL and extranodal DLBCL. These results may be useful in understanding the pathophysiology of B-cell lymphomas. © 2013 Yoshida et al.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0078730
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24236041
URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827264/pdf/pone.0078730.pdf
ID情報
  • DOI : 10.1371/journal.pone.0078730
  • ISSN : 1932-6203
  • PubMed ID : 24236041
  • SCOPUS ID : 84893598460

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