清水本武 (Motomu Shimizu) - マイポータル - researchmap

基本情報

所属: 財団法人東京都医学研究機構東京都臨床医学総合研究所がん治療研究室主任研究員

学位: 理学博士

J-GLOBAL ID: 200901064410417800
researchmap会員ID: 0000021733

外部リンク: http://www.rinshoken.or.jp/

研究キーワード

18

研究分野

1

ライフサイエンス / 免疫学 /

学歴

4

MISC

18

Frequency and resistance of CD95 (Fas/Apo-1) gene-transfected tumor cells to CD95-mediated apoptosis by the elimination and methylation of integrated DNA

M Shimizu, T Yoshimoto, M Sato, A Matsuzawa, Y Takeda

INTERNATIONAL JOURNAL OF CANCER 119(3) 585-592 2006年8月
Roles of CXC chemokines and macrophages in the recruitment of inflammatory cells and tumor rejection induced by Fas/Apo-1 (CD95) ligand-expressing tumor

M Shimizu, T Yoshimoto, M Sato, J Morimoto, A Matsuzawa, Y Takeda

INTERNATIONAL JOURNAL OF CANCER 114(6) 926-935 2005年5月
Modification of tumor cells with Fas (CD95) antigen gene and Fas ligand (CD95L) gene transfection by electroporation for immunotherapy of cancer

Motomu Shimizu, Takayuki Yoshimoto, Akio Matsuzawa, Yasutaka Takeda

Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology 25(1) 79-87 2003年9月
Significant role of Fas ligand-binding but defective Fas receptor (CD95) in lymph node hyperplasia composed of abnormal double-negative T cells

Akio Matsuzawa, Motomu Shimizu, Yasutaka Takeda, Hisashi Nagase, Kazutoshi Sayama, Mikio Kimura

Immunology 106(4) 470-475 2002年
Fas/Apo-1 (CD95)-mediated apoptosis of neutrophils with Fas ligand (CD95L)-expressing tumors is crucial for induction of inflammation by neutrophilic polymorphonuclear leukocytes associated with antitumor immunity

Motomu Shimizu, Adriano Fontana, Yasutaka Takeda, Takayuki Yoshimoto, Airo Tsubura, Akio Matsuzawa

Cellular Immunology 207(1) 41-48 2001年1月10日
Antitumor activity exhibited by Fas ligand (CD95L) overexpressed on lymphoid cells against Fas+ tumor cells

Motomu Shimizu, Yasutaka Takeda, Hideo Yagita, Takayuki Yoshimoto, Akio Matsuzawa

Cancer Immunology Immunotherapy 47(3) 143-148 1998年
A trial to kill tumor cells through Fas (CD95)-mediated apoptosis in vivo

Motomu Shimizu, Takayuki Yoshimoto, Shigekazu Nagata, Akio Matsuzawa

Biochemical and Biophysical Research Communications 228(2) 375-379 1996年11月12日
Anti-proliferative activity of IL-27 on melanoma.

Yoshimoto, N. Morishima, I. Mizoguchi, M. Shimizu, H. Nagai, S. Oniki, M. Oka, C. Nishigori, J. Mizuguchi

J. Immunol., 180, 6527-6535, 2008.
Antiangiogenic and antitumor activities of IL-27.

M. Shimizu, M. Shimamura, T. Owaki, M. Asakawa, K. Fujita, M. Kudo, Y. Iwakura, Y. Takeda, A. D. Luster, J. Mizuguchi …

J. Immunol., 176, 7317-7324, 2006.
A novel method for modification of tumor cells with bacterial superantigen by heterobifunctional cross-linking agent in immunotherapy of cancer.

M. Shimizu, A. Matsuzawa, Y. Takeda

Mol. Biotechnol., 25, 89-94, 2003.
Induction of antitumor immunity with Fas/AP0-1 Iigand (CD95L)-transfected neuroblastoma Neur0-2a cells.

M. Shimizu, A. Fontana, Y. Takeda, H. Yagita, T. Yoshimoto, A. Matsuzawa

J. Immunol., 162, 7350-7357, 1999.
In vitro and in vivo antitumor activity of the interferon inducer bropirimine.

M. Shimizu, F. Oh-hashi, S. Tsukagoshi, T. Iwaguchi, T. Kataoka

Anti-Cancer Drugs, 6, 158-162, 1995.
Effect of CD4+ and CD8+ T cells in tumor-bearing mice on antibody production.

M. Shimizu, T. Iwaguchi

Cancer Immunol. Immunother., 38, 272-276, 1994.
Augmentation of antitumor immunity with bacterial superantigen staphylococcal enterotoxin B-bound tumor cells.

M. Shimizu, A. Yamamoto, H. Nakano, A. Matsuzawa

Cancer Res., 56, 3731-3736, 1996.
Induction of antitumor immunity with Fas/AP0-1 Iigand (CD95L)-transfected neuroblastoma Neur0-2a cells.

J. Immunol., 162, 7350-7357, 1999.
In vitro and in vivo antitumor activity of the interferon inducer bropirimine.

Anti-Cancer Drugs, 6, 158-162, 1995.
Effect of CD4+ and CD8+ T cells in tumor-bearing mice on antibody production.

Cancer Immunol. Immunother., 38, 272-276, 1994.
Augmentation of antitumor immunity with bacterial superantigen staphylococcal enterotoxin B-bound tumor cells.

Cancer Res., 56, 3731-3736, 1996.

所属学協会

3

共同研究・競争的資金等の研究課題

2