2021年6月
High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3.
JACC. Basic to translational science
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- 巻
- 6
- 号
- 6
- 開始ページ
- 507
- 終了ページ
- 523
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jacbts.2021.04.002
- 出版者・発行元
- ELSEVIER SCIENCE INC
Neutrophil adhesion on the atheroprone femoral artery of high-fat diet-fed low-density lipoprotein receptor-null mice was enhanced more than in wild-type mice. The inhibition of histone H3 citrullination of neutrophils reversed the enhancement of neutrophil adhesion, suggesting that hypercitrullination contributes to enhanced neutrophil adhesion. Furthermore, pemafibrate reduced the citrullination of histone H3 in these mice. Therefore, the hypercitrullination of histone H3 in neutrophils contributes to atherosclerotic vascular inflammation.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.jacbts.2021.04.002
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/34222722
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246031
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000667771000004&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85107279640&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85107279640&origin=inward
- ID情報
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- DOI : 10.1016/j.jacbts.2021.04.002
- ISSN : 2452-302X
- PubMed ID : 34222722
- PubMed Central 記事ID : PMC8246031
- SCOPUS ID : 85107279640
- Web of Science ID : WOS:000667771000004