赤川清子 (Kiyoko Akagawa) - マイポータル

基本情報

学位: 医学博士

J-GLOBAL ID: 200901074074867644
researchmap会員ID: 0000023386

研究キーワード

研究分野

ライフサイエンス / 免疫学 /

学歴

- 1968年

東京教育, 理学部, 生物学科
東京教育, 理学部

受賞

1985年

日本細菌学会黒屋奨学賞受賞

論文

Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process.

Tran DH, Sugamata R, Hirose T, Suzuki S, Noguchi Y, Sugawara A, Ito F, Yamamoto T, Kawachi S, Akagawa KS …

The Journal of antibiotics 72(10) 759-768 2019年10月査読有り
Anti-influenza A/H1N1 virus activity by 16-membered macrolide antibiotics and development of novel therapeutic drug based on macrolide derivatives

Sugamata R, Sugawara A, Hirose T, Dat T, Akagawa KS, Omura S, Sunazuka T, Suzuki K

The Japanese Journal of Antibiotics 70 13-18 2017年3月招待有り
Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model

Akihiro Sugawara, Hideaki Shima, Akito Sueki, Tomoyasu Hirose, Hidehito Matsui, Hayato Nakano, Hideaki Hanaki, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka

JOURNAL OF ANTIBIOTICS 69(4) 319-326 2016年4月査読有り
Leucomycin A(3), a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression

Ryuichi Sugamata, Akihiro Sugawara, Tomokazu Nagao, Koya Suzuki, Tomoyasu Hirose, Ki-ichi Yamamoto, Masamichi Oshima, Kazuo Kobayashi, Toshiaki Sunazuka, Kiyoko S. Akagawa …

JOURNAL OF ANTIBIOTICS 67(3) 213-222 2014年3月査読有り
Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure-activity relationships and in vivo study

Akihiro Sugawara, Akito Sueki, Tomoyasu Hirose, Hideaki Shima, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka

JOURNAL OF ANTIBIOTICS 65(9) 487-490 2012年9月査読有り
IgM-type GM-CSF autoantibody is etiologically a bystander but associated with IgG-type autoantibody production in autoimmune pulmonary alveolar proteinosis.

Nei T, Urano S, Motoi N, Takizawa J, Kaneko C, Kanazawa H, Tazawa R, Nakagaki K, Akagawa KS, Akasaka K …

American journal of physiology. Lung cellular and molecular physiology 302(9) L959-64 2012年5月査読有り
Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents.

Sugawara A, Sueki A, Hirose T, Nagai K, Gouda H, Hirono S, Shima H, Akagawa KS, Omura S, Sunazuka T

Bioorganic & medicinal chemistry letters 21(11) 3373-3376 2011年6月査読有り
IL-10 inhibits granulocyte-macrophage colony-stimulating factor-dependent human monocyte survival at the early stage of the culture and inhibits the generation of macrophages.

Hashimoto SI, Komuro I, Yamada M, Akagawa KS

Journal of immunology (Baltimore, Md. : 1950) 167(7) 3619-3625 2001年10月査読有り
Infection of cultured immature dendritic cells with human immunodeficiency virus type 1.（培養した未熟樹状細胞のHIV-1感染）

Hausser,G.A, Hultgren,C, Akagawa,K, Tsunetsugu-Yokota,y, Meyerhans,A

Advanced Experimental Medical Biology 378 477-479 1995年1月査読有り
Growth inhibitory factor of human alveolar macrophage

Koh Nakata, Yasunori Yamaguchi, Mitsutaka Kadokura, Noboru Tanio, Kiyoko S. Akagawa

Biochemical and Biophysical Research Communications 180(3) 1207-1213 1991年11月14日査読有り
GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR PROMOTES THE PROLIFERATION OF HUMAN ALVEOLAR MACROPHAGES INVITRO

K NAKATA, KS AKAGAWA, M FUKAYAMA, Y HAYASHI, M KADOKURA, T TOKUNAGA

JOURNAL OF IMMUNOLOGY 147(4) 1266-1272 1991年8月査読有り
BACTERIAL AMINOLIPIDS INDUCE THE KUPFFER CELL ACTIVATION AND GIVE A SUPPRESSIVE EFFECT ON THE LPS-INDUCED HEPATOCYTE INJURY

K KANEDA, Y MORISAWA, Y KAWAI, K AKAGAWA, K WAKE

CELLS OF THE HEPATIC SINUSOID, VOL 3 436-438 1991年査読有り
REGULATORY MECHANISM OF EXPRESSION OF LPS BINDING SITE(S) AND SIGNALING EVENTS BY LPS IN MACROPHAGES

KS AKAGAWA, K KAMOSHITA, T TOMITA, T YASUDA, T TOKUNAGA

ENDOTOXIN 256 467-480 1990年査読有り
LPS RESPONSE IN MACROPHAGES - PRE-TRANSLATION SUPPRESSION OF TUMOR-NECROSIS-FACTOR EXPRESSION BY LPS

KS AKAGAWA, N TAKASUKA, T TOKUNAGA

CELLULAR AND MOLECULAR ASPECTS OF ENDOTOXIN REACTIONS 923 269-277 1990年査読有り
LIPOAMINO ACIDS WHICH ARE SIMILAR TO BACTERIAL-ENDOTOXIN IN BOTH STRUCTURE AND BIOLOGICAL-ACTIVITY RELATED TO PHYSIOLOGICAL-FUNCTION

Y KAWAI, K AKAGAWA, YANO, I

ENDOTOXIN 256 159-162 1990年査読有り
MACROPHAGE ACTIVATION BY MONOSACCHARIDE PRECURSORS OF ESCHERICHIA-COLI LIPID-A

M NISHIJIMA, F AMANO, Y AKAMATSU, K AKAGAWA, T TOKUNAGA, CRH RAETZ

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82(2) 282-286 1985年査読有り
LACK OF BINDING OF BACTERIAL LIPOPOLYSACCHARIDE TO MOUSE LUNG MACROPHAGES AND RESTORATION OF BINDING BY GAMMA-INTERFERON

KS AKAGAWA, T TOKUNAGA

JOURNAL OF EXPERIMENTAL MEDICINE 162(5) 1444-1459 1985年査読有り

MISC

Mechanisms For Excessive Production Of GM-CSF Autoantibody In Autoimmune Pulmonary Alveolar Proteinosis

T. Nei, S. Urano, C. Kaneko, N. Motoi, J. Takizawa, R. Tazawa, K. Nakagaki, K. Akagawa, B. Trapnell, K. Nakata

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 181 2010年
Expression of Th2-skewed pathology mediators in monocyte-derived type 2 of dendritic cells (DC2)

Mitsumi Hata, Seiji Takahara, Hidetoshi Tsuzaki, Yoshiki Ishii, Koh Nakata, Kiyoko S. Akagawa, Kazuki Satoh

IMMUNOLOGY LETTERS 126(1-2) 29-36 2009年9月
Erythromycin-derivatives EM201 and EM703 inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce small isoform of C/EBPβ

KOMURO Iwao, KOMURO Iwao, SUNAZUKA Toshiaki, AKAGAWA Kiyoko S, AKAGAWA Kiyoko S, YOKOTA Yasuko, IWAMOTO Aikichi, OMURA Satoshi

Proc Natl Acad Sci U S A PNAS 105(34) 12509-12514 2008年8月
Unique CD14-positive intestinal macrophages contribute to the pathogenesis of Crohn’s disease via IL-23/IFN-g axis

Kamata, N, Hisamatsu, T, Okamoto. S, Chinen, H, Kobayashi, T, Sato, T, Sakuraba, A, Kitazume, M, Sugita, A, Koganei, K …

J. Clin. Inve. 118(6) 2269-2280 2008年6月
Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages

KS Akagawa, Komuro, I, H Kanazawa, T Yamazaki, K Mochida, F Kishi

RESPIROLOGY 11 S32-S36 2006年1月
Catalase plays a critical role in the CSF-independent survival of human macrophages via regulation of the expression of BCL-2 family

Komuro, I, T Yasuda, A Iwamoto, KS Akagawa

JOURNAL OF BIOLOGICAL CHEMISTRY 280(50) 41137-41145 2005年12月
Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria

N Kamada, T Hisamatsu, S Okamoto, T Sato, K Matsuoka, K Arai, T Nakai, A Hasegawa, N Inoue, N Watanabe …

JOURNAL OF IMMUNOLOGY 175(10) 6900-6908 2005年11月
Immunological detection of severe acute respiratory syndrome coronavirus by monoclonal antibodies

K Ohnishi, M Sakaguchi, T Kaji, K Akagawa, T Taniyama, M Kasai, Y Tsunetsugu-Yokota, M Oshima, K Yamamoto, N Takasuka …

JAPANESE JOURNAL OF INFECTIOUS DISEASES 58(2) 88-94 2005年4月
Macrolides with promotive activity of monocyte to macrophage differentiation

K Yoshida, T Sunazuka, K Nagai, A Sugawara, A Cho, T Nagamitsu, Y Harigaya, K Otoguro, KS Akagawa, S Omura

JOURNAL OF ANTIBIOTICS 58(1) 79-81 2005年1月
Differentiation ability of monocytes from chronic myelomonocytic leukemia into macrophages and multinucleated giant cells.

Shoda, E, Kawano,, E, Aoki, K, Akagawa, K. S

J. Clin. Exp. Hematopathol. 45(2) 89-92 2005年
CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBP beta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection

Komuro, I, Y Yokota, S Yasuda, A Iwamoto, KS Kagawa

JOURNAL OF EXPERIMENTAL MEDICINE 198(3) 443-453 2003年8月
Effect of 14-membered macrolide comp½ounds on monocyte to macrophage differentiation

SUNAZUKA T, YOSHIDA K, OOHORI M, OTOGURO K, HARIGAYA Y, IWAI Y, AKAGAWA K S, OMURA S

J. Antibiotics 56(8) 721-724 2003年
Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages

KS Akagawa

INTERNATIONAL JOURNAL OF HEMATOLOGY 76(1) 27-34 2002年7月
Eicosapentaenoic acid inhibits CSF-induced human monocyte survival and maturation into macrophage through the stimulation of H2O2 production

S Terada, M Takizawa, S Yamamoto, O Ezaki, H Itakura, KS Akagawa

JOURNAL OF LEUKOCYTE BIOLOGY 71(6) 981-986 2002年6月
Interleukin-10 contributes development of macrophage suppressor activities by macrophage colony-stimulating factor, but not by granulocyte-macrophage colony-stimulating factor

K Mochida-Nishimura, KS Akagawa, EA Rich

CELLULAR IMMUNOLOGY 214(1) 81-88 2001年11月
IL-10 inhibits granulocyte-macrophage colony-stimulating factor-dependent human monocyte survival at the early stage of the culture and inhibits the generation of macrophages

S Hashimoto, Komuro, I, M Yamada, KS Akagawa

JOURNAL OF IMMUNOLOGY 167(7) 3619-3625 2001年10月
Human alveolar macrophages and GM-CSF-induced monocyte-derived macrophages are resistant to H2O2 via their high basal- and inducible-levels of catalase activity、

Komuro, I, Keicho, N, Iwamoto, I, Akagawa, K.S

J. Biol. Chem. 276(26) 24360-24364 2001年6月
Suppressive mechanisms of EPA on human T cell proliferation

S Terada, M Takizawa, S Yamamoto, O Ezaki, H Itakura, KS Akagawa

MICROBIOLOGY AND IMMUNOLOGY 45(6) 473-481 2001年
Mechanisms of antibacterial activity of human moacrophages against Mycobacterium tuberculosis.

Akagawa, K.S, Iowa, K, Yamazaki, T, Haga, S

Proceedings of Thirty-sixth U.S. -Japan Tuberuculosis and Leprosy Research Conference, p.34-38, 2001年
Ornithine-containing lipids stimulate CD14-dependent TNF-alpha production from murine macrophage-like J774.1 and RAW 264.7 cells

Y Kawai, N Takasuka, K Inoue, K Akagawa, M Nishijima

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 28(3) 197-203 2000年7月

もっとみる

書籍等出版物

Akagawa, K.S., Takasuka, N., and Tokunaga, T.: LPS response in macrophages: pre-translational suppression of tumor necrosis factor expression by LPS.

Cellular and molecular aspecs of endotoxin reactions.(ed. by A. Nowotony, J.J. Spitzer, E.J. Ziegler) 1990年
Akagawa, K.S., Kamoshita, K., Tomita, T., Yasuda, T., and Tokunaga, T.:Regulatory mechanism of expression of LPS binding site(s) and signaling events by LPS in macrophages.

ENDOTOXIN (ed. by H. Friedman, T.W. Klein, M. Nakano and A. Nowotny) 1990年
Tokunaga, T., and Akagawa, K.S. : Refractory response of mouse lung macrophages to LPS. In "Mononuclear Phagocytes.

Characteristics, Physiology, and Function" (R. van Furth. ed.) Martinus Nijhoff Publlishers. Bosston, Dordrecht. Lancester. 1985年
Tokunaga, T., and Akagawa, K.S.: Appearance of a cell surface antigen associated with the differentiation of mouse macrophages.

In ﾒSELF-DEFENCE MECHANISMS, ROLE OF MACROPHAGESﾓ (Mizuno, D, Cohn, Z.A., Takeya, K, and Ishida, N. ed) University of Tokyo Press, Elsevier Biomedical. 1982年

共同研究・競争的資金等の研究課題

自然抵抗性抗がんエフェクター系の作用機作と、その活性化による制がん効果

日本学術振興会科学研究費助成事業がん特別研究 1989年 - 1989年

村松繁, 内田温士, 山崎正利, 赤川清子, 湊長博, 仙道富士郎
自然抵抗性抗がんエフェクター系の作用機作とその活性化による制がん効果

日本学術振興会科学研究費助成事業がん特別研究 1988年 - 1988年

村松繁, 内田温士, 山崎正利, 赤川清子, 湊長博, 仙道富士郎
自然抵抗性抗がんエフェクター系の作用機作と,その活性化による制がん効果

日本学術振興会科学研究費助成事業がん特別研究 1987年 - 1987年

村松繁, 内田温士, 山崎正利, 赤川清子, 湊長博, 仙道富士郎
宿主細胞に対するマクロライドの作用とその機序の解明
ヒトマクロファージにおけるHIV-1及び結核菌の増殖制御機構の解析
ヒト単球由来マクロファージの多様性と機能に関する研究
マクロファージの分化と活性化
Macrophage heterogeneity
Differentiation and activation of macrophages