Kiyoko Akagawa - My portal

Profile Information

Degree: 医学博士

J-GLOBAL ID: 200901074074867644
researchmap Member ID: 0000023386

Research Interests

Research Areas

Life sciences / Immunology /

Education

Awards

1985

日本細菌学会黒屋奨学賞受賞

Papers

Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process.

Tran DH, Sugamata R, Hirose T, Suzuki S, Noguchi Y, Sugawara A, Ito F, Yamamoto T, Kawachi S, Akagawa KS …

The Journal of antibiotics, 72(10) 759-768, Oct, 2019 Peer-reviewed
Anti-influenza A/H1N1 virus activity by 16-membered macrolide antibiotics and development of novel therapeutic drug based on macrolide derivatives

Sugamata R, Sugawara A, Hirose T, Dat T, Akagawa KS, Omura S, Sunazuka T, Suzuki K

The Japanese Journal of Antibiotics, 70 13-18, Mar, 2017 Invited
Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model

Akihiro Sugawara, Hideaki Shima, Akito Sueki, Tomoyasu Hirose, Hidehito Matsui, Hayato Nakano, Hideaki Hanaki, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka

JOURNAL OF ANTIBIOTICS, 69(4) 319-326, Apr, 2016 Peer-reviewed
Leucomycin A(3), a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression

Ryuichi Sugamata, Akihiro Sugawara, Tomokazu Nagao, Koya Suzuki, Tomoyasu Hirose, Ki-ichi Yamamoto, Masamichi Oshima, Kazuo Kobayashi, Toshiaki Sunazuka, Kiyoko S. Akagawa …

JOURNAL OF ANTIBIOTICS, 67(3) 213-222, Mar, 2014 Peer-reviewed
Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure-activity relationships and in vivo study

Akihiro Sugawara, Akito Sueki, Tomoyasu Hirose, Hideaki Shima, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka

JOURNAL OF ANTIBIOTICS, 65(9) 487-490, Sep, 2012 Peer-reviewed
IgM-type GM-CSF autoantibody is etiologically a bystander but associated with IgG-type autoantibody production in autoimmune pulmonary alveolar proteinosis.

Nei T, Urano S, Motoi N, Takizawa J, Kaneko C, Kanazawa H, Tazawa R, Nakagaki K, Akagawa KS, Akasaka K …

American journal of physiology. Lung cellular and molecular physiology, 302(9) L959-64, May, 2012 Peer-reviewed
Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents.

Sugawara A, Sueki A, Hirose T, Nagai K, Gouda H, Hirono S, Shima H, Akagawa KS, Omura S, Sunazuka T

Bioorganic & medicinal chemistry letters, 21(11) 3373-3376, Jun, 2011 Peer-reviewed
IL-10 inhibits granulocyte-macrophage colony-stimulating factor-dependent human monocyte survival at the early stage of the culture and inhibits the generation of macrophages.

Hashimoto SI, Komuro I, Yamada M, Akagawa KS

Journal of immunology (Baltimore, Md. : 1950), 167(7) 3619-3625, Oct, 2001 Peer-reviewed
Infection of cultured immature dendritic cells with human immunodeficiency virus type 1.（培養した未熟樹状細胞のHIV-1感染）

Hausser,G.A, Hultgren,C, Akagawa,K, Tsunetsugu-Yokota,y, Meyerhans,A

Advanced Experimental Medical Biology, 378 477-479, Jan, 1995 Peer-reviewed
Growth inhibitory factor of human alveolar macrophage

Koh Nakata, Yasunori Yamaguchi, Mitsutaka Kadokura, Noboru Tanio, Kiyoko S. Akagawa

Biochemical and Biophysical Research Communications, 180(3) 1207-1213, Nov 14, 1991 Peer-reviewed
GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR PROMOTES THE PROLIFERATION OF HUMAN ALVEOLAR MACROPHAGES INVITRO

K NAKATA, KS AKAGAWA, M FUKAYAMA, Y HAYASHI, M KADOKURA, T TOKUNAGA

JOURNAL OF IMMUNOLOGY, 147(4) 1266-1272, Aug, 1991 Peer-reviewed
BACTERIAL AMINOLIPIDS INDUCE THE KUPFFER CELL ACTIVATION AND GIVE A SUPPRESSIVE EFFECT ON THE LPS-INDUCED HEPATOCYTE INJURY

K KANEDA, Y MORISAWA, Y KAWAI, K AKAGAWA, K WAKE

CELLS OF THE HEPATIC SINUSOID, VOL 3, 436-438, 1991 Peer-reviewed
REGULATORY MECHANISM OF EXPRESSION OF LPS BINDING SITE(S) AND SIGNALING EVENTS BY LPS IN MACROPHAGES

KS AKAGAWA, K KAMOSHITA, T TOMITA, T YASUDA, T TOKUNAGA

ENDOTOXIN, 256 467-480, 1990 Peer-reviewed
LPS RESPONSE IN MACROPHAGES - PRE-TRANSLATION SUPPRESSION OF TUMOR-NECROSIS-FACTOR EXPRESSION BY LPS

KS AKAGAWA, N TAKASUKA, T TOKUNAGA

CELLULAR AND MOLECULAR ASPECTS OF ENDOTOXIN REACTIONS, 923 269-277, 1990 Peer-reviewed
LIPOAMINO ACIDS WHICH ARE SIMILAR TO BACTERIAL-ENDOTOXIN IN BOTH STRUCTURE AND BIOLOGICAL-ACTIVITY RELATED TO PHYSIOLOGICAL-FUNCTION

Y KAWAI, K AKAGAWA, YANO, I

ENDOTOXIN, 256 159-162, 1990 Peer-reviewed
MACROPHAGE ACTIVATION BY MONOSACCHARIDE PRECURSORS OF ESCHERICHIA-COLI LIPID-A

M NISHIJIMA, F AMANO, Y AKAMATSU, K AKAGAWA, T TOKUNAGA, CRH RAETZ

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 82(2) 282-286, 1985 Peer-reviewed
LACK OF BINDING OF BACTERIAL LIPOPOLYSACCHARIDE TO MOUSE LUNG MACROPHAGES AND RESTORATION OF BINDING BY GAMMA-INTERFERON

KS AKAGAWA, T TOKUNAGA

JOURNAL OF EXPERIMENTAL MEDICINE, 162(5) 1444-1459, 1985 Peer-reviewed

Misc.

Mechanisms For Excessive Production Of GM-CSF Autoantibody In Autoimmune Pulmonary Alveolar Proteinosis

T. Nei, S. Urano, C. Kaneko, N. Motoi, J. Takizawa, R. Tazawa, K. Nakagaki, K. Akagawa, B. Trapnell, K. Nakata

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 181, 2010
Expression of Th2-skewed pathology mediators in monocyte-derived type 2 of dendritic cells (DC2)

Mitsumi Hata, Seiji Takahara, Hidetoshi Tsuzaki, Yoshiki Ishii, Koh Nakata, Kiyoko S. Akagawa, Kazuki Satoh

IMMUNOLOGY LETTERS, 126(1-2) 29-36, Sep, 2009
Erythromycin derivatives inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce small isoforms of C/EBP beta

Iwao Komuro, Toshiaki Sunazuka, Kiyoko S. Akagawa, Yasuko Yokota, Aikichi Iwamoto, Satoshi Omura

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(34) 12509-12514, Aug, 2008
Unique CD14(+) intestinal macrophages contribute to the pathogenesis of Crohn disease via lL-23/IFN-gamma axis

Nobuhiko Kamada, Tadakazu Hisamatsu, Susumu Okamoto, Hiroshi Chinen, Taku Kobayashi, Toshiro Sato, Atsushi Sakuraba, Mina T. Kitazume, Akira Sugita, Kazutaka Koganei …

JOURNAL OF CLINICAL INVESTIGATION, 118(6) 2269-2280, Jun, 2008
Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages

KS Akagawa, Komuro, I, H Kanazawa, T Yamazaki, K Mochida, F Kishi

RESPIROLOGY, 11 S32-S36, Jan, 2006
Catalase plays a critical role in the CSF-independent survival of human macrophages via regulation of the expression of BCL-2 family

Komuro, I, T Yasuda, A Iwamoto, KS Akagawa

JOURNAL OF BIOLOGICAL CHEMISTRY, 280(50) 41137-41145, Dec, 2005
Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria

N Kamada, T Hisamatsu, S Okamoto, T Sato, K Matsuoka, K Arai, T Nakai, A Hasegawa, N Inoue, N Watanabe …

JOURNAL OF IMMUNOLOGY, 175(10) 6900-6908, Nov, 2005
Immunological detection of severe acute respiratory syndrome coronavirus by monoclonal antibodies

K Ohnishi, M Sakaguchi, T Kaji, K Akagawa, T Taniyama, M Kasai, Y Tsunetsugu-Yokota, M Oshima, K Yamamoto, N Takasuka …

JAPANESE JOURNAL OF INFECTIOUS DISEASES, 58(2) 88-94, Apr, 2005
Macrolides with promotive activity of monocyte to macrophage differentiation

K Yoshida, T Sunazuka, K Nagai, A Sugawara, A Cho, T Nagamitsu, Y Harigaya, K Otoguro, KS Akagawa, S Omura

JOURNAL OF ANTIBIOTICS, 58(1) 79-81, Jan, 2005
Capacity of Monocytes from Patients with Chronic Myelomonocytic Leukemia to Differentiate into Macrophages and Multinucleated Giant Cells

SHODA Eriko, KAWANO Eiji, AOKI Katsunori, AKAGAWA Kiyoko S.

The journal of the Japanese Society of Lymphoreticular Tissue research, 45(2) 89-92, 2005
CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBP beta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection

Komuro, I, Y Yokota, S Yasuda, A Iwamoto, KS Kagawa

JOURNAL OF EXPERIMENTAL MEDICINE, 198(3) 443-453, Aug, 2003
Effect of 14-membered macrolide comp½ounds on monocyte to macrophage differentiation

SUNAZUKA T, YOSHIDA K, OOHORI M, OTOGURO K, HARIGAYA Y, IWAI Y, AKAGAWA K S, OMURA S

J. Antibiotics, 56(8) 721-724, 2003
Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages

KS Akagawa

INTERNATIONAL JOURNAL OF HEMATOLOGY, 76(1) 27-34, Jul, 2002
Eicosapentaenoic acid inhibits CSF-induced human monocyte survival and maturation into macrophage through the stimulation of H2O2 production

S Terada, M Takizawa, S Yamamoto, O Ezaki, H Itakura, KS Akagawa

JOURNAL OF LEUKOCYTE BIOLOGY, 71(6) 981-986, Jun, 2002
Interleukin-10 contributes development of macrophage suppressor activities by macrophage colony-stimulating factor, but not by granulocyte-macrophage colony-stimulating factor

K Mochida-Nishimura, KS Akagawa, EA Rich

CELLULAR IMMUNOLOGY, 214(1) 81-88, Nov, 2001
IL-10 inhibits granulocyte-macrophage colony-stimulating factor-dependent human monocyte survival at the early stage of the culture and inhibits the generation of macrophages

S Hashimoto, Komuro, I, M Yamada, KS Akagawa

JOURNAL OF IMMUNOLOGY, 167(7) 3619-3625, Oct, 2001
Human alveolar macrophages and granulocyte-macrophage colony-stimulating factor-induced manocyte-derived macrophages are resistant to H2O2 via their high basal and inducible levels of catalase activity

Komuro, I, N Keicho, A Iwamoto, KS Akagawa

JOURNAL OF BIOLOGICAL CHEMISTRY, 276(26) 24360-24364, Jun, 2001
Suppressive mechanisms of EPA on human T cell proliferation

S Terada, M Takizawa, S Yamamoto, O Ezaki, H Itakura, KS Akagawa

MICROBIOLOGY AND IMMUNOLOGY, 45(6) 473-481, 2001
Mechanisms of antibacterial activity of human moacrophages against Mycobacterium tuberculosis.

Akagawa, K.S, Iowa, K, Yamazaki, T, Haga, S

Proceedings of Thirty-sixth U.S. -Japan Tuberuculosis and Leprosy Research Conference,, p.34-38,, 2001
Ornithine-containing lipids stimulate CD14-dependent TNF-alpha production from murine macrophage-like J774.1 and RAW 264.7 cells

Y Kawai, N Takasuka, K Inoue, K Akagawa, M Nishijima

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 28(3) 197-203, Jul, 2000

Books and Other Publications

Akagawa, K.S., Takasuka, N., and Tokunaga, T.: LPS response in macrophages: pre-translational suppression of tumor necrosis factor expression by LPS.

Cellular and molecular aspecs of endotoxin reactions.(ed. by A. Nowotony, J.J. Spitzer, E.J. Ziegler), 1990
Akagawa, K.S., Kamoshita, K., Tomita, T., Yasuda, T., and Tokunaga, T.:Regulatory mechanism of expression of LPS binding site(s) and signaling events by LPS in macrophages.

ENDOTOXIN (ed. by H. Friedman, T.W. Klein, M. Nakano and A. Nowotny), 1990
Tokunaga, T., and Akagawa, K.S. : Refractory response of mouse lung macrophages to LPS. In "Mononuclear Phagocytes.

Characteristics, Physiology, and Function" (R. van Furth. ed.) Martinus Nijhoff Publlishers. Bosston, Dordrecht. Lancester., 1985
Tokunaga, T., and Akagawa, K.S.: Appearance of a cell surface antigen associated with the differentiation of mouse macrophages.

In ﾒSELF-DEFENCE MECHANISMS, ROLE OF MACROPHAGESﾓ (Mizuno, D, Cohn, Z.A., Takeya, K, and Ishida, N. ed) University of Tokyo Press, Elsevier Biomedical., 1982

Research Projects

自然抵抗性抗がんエフェクター系の作用機作と、その活性化による制がん効果

科学研究費助成事業, がん特別研究, 日本学術振興会, 1989 - 1989

村松繁, 内田温士, 山崎正利, 赤川清子, 湊長博, 仙道富士郎
自然抵抗性抗がんエフェクター系の作用機作とその活性化による制がん効果

科学研究費助成事業, がん特別研究, 日本学術振興会, 1988 - 1988

村松繁, 内田温士, 山崎正利, 赤川清子, 湊長博, 仙道富士郎
自然抵抗性抗がんエフェクター系の作用機作と,その活性化による制がん効果

科学研究費助成事業, がん特別研究, 日本学術振興会, 1987 - 1987

村松繁, 内田温士, 山崎正利, 赤川清子, 湊長博, 仙道富士郎
宿主細胞に対するマクロライドの作用とその機序の解明
ヒトマクロファージにおけるHIV-1及び結核菌の増殖制御機構の解析
ヒト単球由来マクロファージの多様性と機能に関する研究
マクロファージの分化と活性化
Macrophage heterogeneity
Differentiation and activation of macrophages