SENPUKU Hidenobu

J-GLOBAL         Last updated: Sep 4, 2019 at 11:30
SENPUKU Hidenobu
National Institute of Infectious Diseases
Job title
Doctor of Dentistry(Nihon University)

Research Areas


Academic & Professional Experience

National Institute of Health
Institute of Infectious Diseases
Apr 1992
- Researcher, Department of Oral Science,
Apr 1997
- Chief Researcher, Department of Oral Science,
Apr 1997
Mar 2002
Chief Researcher, Department of Oral Health, National Institute of Infectious Diseases


Faculty of Dentistry, Nihon University
Oral Surgery, Graduate School, Division of Dental Research, Nihon University

Published Papers

Senpuku H, Nakamura T, Iwabuchi Y, Hirayama S, Nakao R, Ohnishi M
Molecules (Basel, Switzerland)   24(17)    Aug 2019   [Refereed]
Senpuku H, Mohri S, Mihara M, Arai T, Suzuki Y, Saeki Y
Archives of oral biology   102 256-265   Jun 2019   [Refereed]
Suzuki I, Shimizu T, Senpuku H
Microorganisms   6(4)    Nov 2018   [Refereed]
Senpuku H, Yonezawa H, Yoneda S, Suzuki I, Nagasawa R, Narisawa N
Molecular oral microbiology   33(1) 47-58   Feb 2018   [Refereed]
Suzuki Y, Nagasawa R, Senpuku H
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   23(9) 634-641   Sep 2017   [Refereed]
Nagasawa R, Sato T, Senpuku H
Applied and environmental microbiology   83(15)    Aug 2017   [Refereed]
Obana N, Nakao R, Nagayama K, Nakamura K, Senpuku H, Nomura N
Infection and immunity   85(5)    May 2017   [Refereed]
Kawarai T, Narisawa N, Yoneda S, Tsutsumi Y, Ishikawa J, Hoshino Y, Senpuku H
Archives of oral biology   68 73-82   Aug 2016   [Refereed]
Nakao R, Hasegawa H, Dongying B, Ohnishi M, Senpuku H
Vaccine   34(38) 4626-4634   Aug 2016   [Refereed]
Merritt J, Senpuku H, Kreth J
Environmental microbiology   18(1) 174-190   Jan 2016   [Refereed]
Senpuku H, Miyazaki H, Yoshihara A, Yoneda S, Narisawa N, Kawarai T, Nakagawa N, Miyachi M, Tada A, Yoshida G, Shimada M, Ohashi M, Nishimuta M, Kimura Y, Yoshitake Y
SpringerPlus   5 244   2016   [Refereed]
Arai T, Kinoshita Y, Senpuku H
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   21(5) 370-375   May 2015   [Refereed]
Bai D, Nakao R, Ito A, Uematsu H, Senpuku H
Pathogens and disease   73(3)    Apr 2015   [Refereed]
Arai T, Ochiai K, Senpuku H
Journal of microbiological methods   109 160-166   Feb 2015   [Refereed]
Tada A, Watanabe M, Senpuku H
American journal of infection control   43(1) 95-97   Jan 2015   [Refereed]
Ohsumi T, Takenaka S, Wakamatsu R, Sakaue Y, Narisawa N, Senpuku H, Ohshima H, Terao Y, Okiji T
PloS one   10(1) e0116647   2015   [Refereed]
Nakao R, Takashiba S, Kosono S, Yoshida M, Watanabe H, Ohnishi M, Senpuku H
Microbes and infection   16(1) 6-16   Jan 2014   [Refereed]
Araki M, Hoshi K, Fujiwara M, Sasaki Y, Yonezawa H, Senpuku H, Iwamoto-Kihara A, Maeda M
Journal of bacteriology   195(21) 4873-4878   Nov 2013   [Refereed]
Satoh K, Narita T, Matsuki-Fukushima M, Okabayashi K, Ito T, Senpuku H, Sugiya H
Pflugers Archiv : European journal of physiology   465(2) 271-281   Feb 2013   [Refereed]
Dynamic changes in the initial colonization of Actinomyces naeslundii and Streptococcus gordonii using a new animal model.
Zhang X, Senpuku H
Japanese journal of infectious diseases   66(1) 11-16   2013   [Refereed]
Kanaguchi N, Narisawa N, Ito T, Kinoshita Y, Kusumoto Y, Shinozuka O, Senpuku H
BMC oral health   12 36   Aug 2012   [Refereed]
Narisawa N, Kawarai T, Suzuki N, Sato Y, Ochiai K, Ohnishi M, Watanabe H, Senpuku H
Journal of bacteriology   193(19) 5147-5154   Oct 2011   [Refereed]
Ogawa A, Furukawa S, Fujita S, Mitobe J, Kawarai T, Narisawa N, Sekizuka T, Kuroda M, Ochiai K, Ogihara H, Kosono S, Yoneda S, Watanabe H, Morinaga Y, Uematsu H, Senpuku H
Applied and environmental microbiology   77(5) 1572-1580   Mar 2011   [Refereed]
Impact of minocycline ointment for periodontal treatment of oral bacteria.
Nakao R, Takigawa S, Sugano N, Koshi R, Ito K, Watanabe H, Senpuku H
Japanese journal of infectious diseases   64(2) 156-160   2011   [Refereed]
Nakao R, Hasegawa H, Ochiai K, Takashiba S, Ainai A, Ohnishi M, Watanabe H, Senpuku H
PloS one   6(10) e26163   2011   [Refereed]
Nishiyama Y, Inaba E, Uematsu H, Senpuku H
Archives of gerontology and geriatrics   51(3) e139-43   Nov 2010   [Refereed]
Okuda K, Hanada N, Usui Y, Takeuchi H, Koba H, Nakao R, Watanabe H, Senpuku H
Archives of oral biology   55(10) 754-762   Oct 2010   [Refereed]
Unique functions of hydroxyapatite with mutans streptococci adherence.
Arakawa T, Fujimaru T, Ishizak T, Takeuchi H, Kageyama M, Ikemi T, Hanada N, Watanabe H, Senpuku H
Quintessence international (Berlin, Germany : 1985)   41(1) e11-9   Jan 2010   [Refereed]
A quick statistically accurate diagnosis for caries risk in the elderly.
Senpuku H, Miyazaki H, Yoneda S, Yoshihara A, Tada A
Clinical laboratory   56(11-12) 505-512   2010   [Refereed]
Inaba E, Uematsu H, Nishiyama Y, Watanabe H, Senpuku H
Gerodontology   26(4) 259-267   Dec 2009   [Refereed]
Matsui-Inohara H, Uematsu H, Narita T, Satoh K, Yonezawa H, Kuroda K, Ito T, Yoneda S, Kawarai T, Sugiya H, Watanabe H, Senpuku H
Experimental biology and medicine (Maywood, N.J.)   234(12) 1525-1536   Dec 2009   [Refereed]
Effects of IgY against Candida albicans and Candida spp. Adherence and Biofilm Formation.
Fujibayashi T, Nakamura M, Tominaga A, Satoh N, Kawarai T, Narisawa N, Shinozuka O, Watanabe H, Yamazaki T, Senpuku H
Japanese journal of infectious diseases   62(5) 337-342   Sep 2009   [Refereed]
Inhibiting effects of Enterococcus faecium non-biofilm strain on Streptococcus mutans biofilm formation.
Kumada M, Motegi M, Nakao R, Yonezawa H, Yamamura H, Tagami J, Senpuku H
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi   42(3) 188-196   Jun 2009   [Refereed]
E2F1-deficient NOD/SCID mice are an experimental model for dry mouth.
Satoh K, Narita T, Matsui-Inohara H, Ito T, Senpuku H, Sugiya H
The journal of medical investigation : JMI   56 Suppl 260-261   2009   [Refereed]
Role of activated natural killer cells in oral diseases.
Kamoda Y, Uematsu H, Yoshihara A, Miyazaki H, Senpuku H
Japanese journal of infectious diseases   61(6) 469-474   Nov 2008   [Refereed]
Impact of routine oral care on opportunistic pathogens in the institutionalized elderly.
Kokubu K, Senpuku H, Tada A, Saotome Y, Uematsu H
Journal of medical and dental sciences   55(1) 7-13   Mar 2008   [Refereed]
Effects of oral care on development of oral mucositis and microorganisms in patients with esophageal cancer.
Yoneda S, Imai S, Hanada N, Yamazaki T, Senpuku H, Ota Y, Uematsu H
Japanese journal of infectious diseases   60(1) 23-28   Feb 2007   [Refereed]
Salam MA, Matin K, Matsumoto N, Tsuha Y, Hanada N, Senpuku H
Journal of immunology (Baltimore, Md. : 1950)   173(8) 4908-4918   Oct 2004   [Refereed]
Relationship between volatile sulphide compounds concentration and oral bacteria species detection in the elderly.
Senpuku H, Tada A, Yamaga T, Hanada N, Miyazaki H
International dental journal   54(3) 149-153   Jun 2004   [Refereed]
Abdus Salam M, Matsumoto N, Matin K, Tsuha Y, Nakao R, Hanada N, Senpuku H
Clinical and diagnostic laboratory immunology   11(2) 379-386   Mar 2004   [Refereed]
Harada S, Kamata Y, Ishii Y, Eda H, Kitamura R, Obayashi M, Ito S, Ban F, Kuranari J, Nakajima H, Kuze T, Hayashi M, Okabe N, Senpuku H, Miyasaka N, Nakamura Y, Kanegane H, Yanagi K
Clinical and diagnostic laboratory immunology   11(1) 123-130   Jan 2004   [Refereed]
Growth-inhibitory effect of antibacterial self-etching primer on mutans streptococci obtained from arrested carious lesions.
Kitasako Y, Senpuku H, Foxton RM, Hanada N, Tagami J
Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]   16(3) 176-82; discussion 183   2004   [Refereed]
Bone regeneration by recombinant human bone morphogenetic protein-2 around immediate implants: a pilot study in rats.
Matin K, Senpuku H, Hanada N, Ozawa H, Ejiri S
The International journal of oral & maxillofacial implants   18(2) 211-217   Mar 2003   [Refereed]
Nomura Y, Takeuchi H, Senpuku H, Ida H, Yoshikawa E, Koyama K, Kanazawa N, Hanada N
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   8(2) 163-167   Jun 2002   [Refereed]
Reproducibility of oral bacterial isolation in the elderly.
Senpuku H, Tada A, Takada M, Sato T, Hanada N
Japanese journal of infectious diseases   55(2) 61-62   Apr 2002   [Refereed]
Hanada N, Fukushima K, Nomura Y, Senpuku H, Hayakawa M, Mukasa H, Shiroza T, Abiko Y
Biochimica et biophysica acta   1570(1) 75-79   Feb 2002   [Refereed]

Books etc

A quick statistically accurate diagnosis system using salivary IgA for oral disease
SENPUKU Hidenobu (Part:Contributor, Chapter 2, Book: Current Trends in Biotechnology, Editted by Tiwari Santosh.)
Lambert Academic Publishing   2012   

Conference Activities & Talks

Oral infection, Physical activity and NK cell activation.
SENPUKU Hidenobu
International Symposium for Global Oral Health Scirnce Niigata 2010   2010   
Role of salivary IgA antibody against surface protein antigen of Streptococcus mutans in diagnosis and preventive treatment. [Invited]
SENPUKU Hidenobu
4th Medical Biotech Forum, Dailian, China   10 Aug 2009   

Research Grants & Projects

Preventive procedure for infectious Diseases by oral
Grant-in-Aid for Scientific Research
Project Year: 1998   
Biofilm Establishment of Model Animal for Infectious
Grant-in-Aid for Scientific Research
Project Year: 1998   
Biofilm Establishment of Model Animal for Infectious
Health and Labour Sciences Research Grants
Project Year: 1998   
Diseases by Oral Biofilm
Health and Labour Sciences Research Grants
Project Year: 1998   
Relation Ship between Oral Infection and Systemic Diseases
Cooperative Research
Project Year: 1999   
Microgravity and Oral Infectious Diseases